Cardiovascular Endocrinology & Metabolism最新文献

{"title":"The association between a genetic variant in the <i>SULF2</i> gene, metabolic parameters and vascular disease in patients at high cardiovascular risk.","authors":"Britt E Heidemann,&nbsp;Frank Lj Visseren,&nbsp;Jessica van Setten,&nbsp;A David Marais,&nbsp;Charlotte Koopal","doi":"10.1097/XCE.0000000000000278","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000278","url":null,"abstract":"<p><p>Clearance of triglyceride-rich lipoproteins (TRLs) is mediated by several receptors, including heparan sulfate proteoglycans (HSPGs). Sulfate glucosamine-6-O-endosulfatase-2 is a gene related to the regulation of HSPG. A variant in this gene, rs2281279, has been shown to be associated with triglycerides and insulin resistance.</p><p><strong>Objective: </strong>To determine the relationship between rs2281279, metabolic parameters and vascular events, and type 2 diabetes mellitus (T2DM) in patients at high cardiovascular risk and whether <i>APOE</i> genotype modifies this relationship.</p><p><strong>Methods: </strong>Patients (<i>n</i> = 4386) at high cardiovascular risk from the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease study were stratified according to their imputed rs2281279 genotype: AA (<i>n</i> = 2438), AG (<i>n</i> = 1642) and GG (<i>n</i> = 306). Effects of rs2281279 on metabolic parameters, vascular events and T2DM were analyzed with linear regression and Cox models.</p><p><strong>Results: </strong>There was no relationship between imputed rs2281279 genotype and triglycerides, non-high-density lipoprotein (HDL)-cholesterol, insulin and quantitative insulin sensitivity check index. During a median follow-up of 11.8 (IQR, 9.3-15.5) years, 1026 cardiovascular events and 320 limb events occurred. The presence of the G allele in rs2281279 did not affect the risk of vascular events [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.94-1.14] or limb events (HR, 0.92; 95% CI, 0.77-1.10). The presence of the G allele in rs2281279 did not affect the risk of T2DM (HR, 1.09; 95% CI, 0.94-1.27). The presence of the minor G allele of rs2281279 was associated with a beneficial risk profile in ε2ε2 patients, but not in ε3ε3 patients.</p><p><strong>Conclusions: </strong>Imputed rs2281279 genotype is not associated with metabolic parameters and does not increase the risk of vascular events or T2DM in patients at high risk for cardiovascular disease.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0278"},"PeriodicalIF":2.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/49/xce-12-e0278.PMC9870215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic syndrome in HIV-positive and HIV-negative patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia: a comparative cohort study.","authors":"Minyahil Woldu,&nbsp;Omary Minzi,&nbsp;Workineh Shibeshi,&nbsp;Aster Shewaamare,&nbsp;Ephrem Engidawork","doi":"10.1097/XCE.0000000000000273","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000273","url":null,"abstract":"<p><p>Cardiometabolic syndrome (CMetS) has recently emerged as a serious public health concern, particularly for individuals living with chronic conditions. This study aimed to determine the incidence and prevalence of CMetS, as well as the risk factors linked with it, in HIV-positive and HIV-negative adult patients.</p><p><strong>Methods: </strong>A comparative cohort study was designed. The National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) tools were used to determine the outcome variables. Association studies were done using logistic regression.</p><p><strong>Result: </strong>CMetS was found to have a greater point and period prevalence, and incidence estimation in HIV-negative than HIV+ patients using both the NCEP and the IDF tools. Using the NCEP tool, the risk of obesity was 44.1% [odds ratio (OR) = 0.559, 95% confidence interval (CI), (0.380-0.824); <i>P</i> = 0.003] lower in HIV+ than in HIV-negative participants. By contrast, no apparent difference was noted using the IDF tool. Similarly, hyperglycemia [OR = 0.651, 95% CI (0.457-0.926); <i>P</i> = 0.017], and hypertension [OR = 0.391, 95% CI (0.271-0.563); <i>P</i> < 0.001] were shown to be lower in HIV+ patients than HIV-negative patients by 34.9% and 60.9%, respectively. The study revealed significant variation in all biomarkers across the follow-up period in both HIV+ and HIV-negative participants, except for SBP.</p><p><strong>Conclusions: </strong>CMetS caused more overall disruption in HIV-negative people with chronic diseases than in HIV-positive people. All of the indicators used to assess the increased risk of CMetS were equally meaningful in HIV+ and HIV-negative subjects.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0273"},"PeriodicalIF":2.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/27/xce-12-e0273.PMC9750611.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the triglyceride-glucose index and the SYNTAX score 2 in patients with non-ST elevation myocardial infarction.","authors":"Onur Baydar,&nbsp;Alparslan Kilic,&nbsp;Erol Gursoy","doi":"10.1097/XCE.0000000000000277","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000277","url":null,"abstract":"<p><p>We evaluated if admissiontriglyceride-glucose index (TyG index) correlated with the anatomical synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score 2 in non-ST elevation myocardial infarction (NSTEMI), nondiabetic patients.</p><p><strong>Methods: </strong>SYNTAX score 2 (SSII) was retrospectively evaluated in 260 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. We stratified patients according to tertiles of SSII (≤21.5, 21.5-30.6, and ≥30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively.</p><p><strong>Results: </strong>The average age of the patients was 57.2 ± 10.9 years; 135 patients (52.2%) were males. The average TyG index was 8.68 ± 0.12, and SSII was 18.9 ± 9.9. A moderate correlation was found between TyG index and SSII (<i>r</i> = 0.347; <i>P</i> < 0.001) and TyG index was independent risk factors for SSII high [odds ratio (OR), 6.0; 95% CI, 2.7-17.0; <i>P</i> < 0.001].</p><p><strong>Conclusion: </strong>In nondiabetic patients with NSTEMI, TyG index correlated with the SSII.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0277"},"PeriodicalIF":2.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes and mortality in females versus males in England: the Salford diabetes cohort.","authors":"Adrian H Heald,&nbsp;Mike Stedman,&nbsp;Ian Laing,&nbsp;Martin Gibson,&nbsp;Martin Whyte","doi":"10.1097/XCE.0000000000000276","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000276","url":null,"abstract":"Adrian H. Heald, Mike Stedman, Ian Laing, Martin Gibson and Martin Whyte The School of Medicine and Manchester Academic Health Sciences Centre, Manchester University, Manchester, Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, Res Consortium, Andover, Hampshire; University of Manchester, Manchester, Department of Biochemistry, Royal Preston Hospital, Preston and Clinical and Experimental Medicine, University of Surrey, Guildford, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0276"},"PeriodicalIF":2.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10510019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritizing obesity treatment: expanding the role of cardiologists to improve cardiovascular health and outcomes.","authors":"Donna H Ryan, John E Deanfield, Stephan Jacob","doi":"10.1097/XCE.0000000000000279","DOIUrl":"10.1097/XCE.0000000000000279","url":null,"abstract":"<p><p>Obesity is a major risk factor for cardiovascular disease, yet management remains poor. Cardiologists and healthcare professionals treating people with high cardiovascular risk are in a position to address overweight and obesity to improve cardiovascular health. There are several treatment options for obesity, which are associated with numerous health benefits. Modest weight reductions of 5-10% improve cardiovascular risk factors, with greater weight loss bringing about greater benefits. Anti-obesity medications can support weight reduction when lifestyle modifications alone are insufficient. The weight loss induced by these treatments can improve cardiovascular risk, and some therapies - such as glucagon-like-peptide-1 analogues - may promote these benefits independently of weight loss. Bariatric surgery can induce greater weight losses than other treatment modalities and is associated with numerous health benefits, but newer medications such as semaglutide and those in development, such as tirzepatide, produce robust weight loss efficacy that is approaching that of bariatric surgery. Healthcare professionals must approach this disease with compassion and collaborate with patients to develop sustainable plans that improve health and maintain weight loss over the long term.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0279"},"PeriodicalIF":1.3,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/28/xce-12-e0279.PMC9911203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world demographic patterns of users of a digital primary prevention service for diabetes.","authors":"Preetha Balakrishnan, Elizabeth Jacyshyn-Owen, Markus Eberl, Benjamin Friedrich, Tobias Etter","doi":"10.1097/XCE.0000000000000275","DOIUrl":"10.1097/XCE.0000000000000275","url":null,"abstract":"<p><p>Rapid urbanization has led to an exponential increase in lifestyle-associated metabolic disorders presenting a huge socioeconomic burden. Waya is a digital prevention program that guides overweight and obese individuals to maintain a healthy lifestyle through exercise, diet, and educational videos.</p><p><strong>Objectives and aims: </strong>We aimed to study the demographic patterns of the Waya cohort and examine the prevalence of diabetes (the most common lifestyle-associated metabolic disorder) and its risk factors in comparison to the GEDA 2014/2015-European Health Interview Survey population.</p><p><strong>Methods: </strong>Waya participants who registered by 1 October 2020 and who answered at least one health survey question were included in this study. Factors such as obesity, hypertension, and diabetes between the two populations were compared using Chi-square test.</p><p><strong>Results: </strong>Of the 837 participants, 86.1% were women. The proportion of obese participants was higher in Waya than in the German Health Update (GEDA) cohort (women: 39.4% vs. 18%, <i>P</i> < 0.05; men: 37.1% vs. 18.3%, <i>P</i> < 0.05), whereas the proportion of participants with hypertension (women: 12.1% vs. 30.9% in GEDA, <i>P</i> < 0.05; men: 22.4% vs. 32.8% in GEDA, <i>P</i> < 0.05) was lower. The proportion of women with diabetes was low in our cohort (3.9% vs. 7% in GEDA, <i>P</i> < 0.05); however, the proportion of men with diabetes remained the same between the two groups. We observed significant differences between the GEDA and Waya cohorts due to changes in the prevalence pattern over time or target bias of the digital program.</p><p><strong>Conclusion: </strong>These findings showcase the usability of Waya in collecting real-world insights, which will be beneficial in monitoring the prevalence of chronic metabolic disorders and associated risk factors over time.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0275"},"PeriodicalIF":1.3,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/59/xce-12-e0275.PMC9750647.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does food responsiveness change in people with first-episode psychosis over a period of 3 months after commencing antipsychotics? Preliminary results.","authors":"Adrian Heald,&nbsp;Mark Shakespeare,&nbsp;Adrian Phillipson,&nbsp;Janet Cade,&nbsp;Petra Netter,&nbsp;Suzanne Higgs","doi":"10.1097/XCE.0000000000000274","DOIUrl":"10.1097/XCE.0000000000000274","url":null,"abstract":"Adrian H. Heald, Mark Shakespeare, Adrian Phillipson, Janet Cade, Petra Netter and Suzanne Higgs Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford, The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Rotherham, Doncaster and South Humber (RDASH) NHS Foundation Trust, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, Department of Psychology, University of Giessen, Germany, School of Psychology, College of Life and Environmental Sciences, University of Birmingham, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"12 1","pages":"e0274"},"PeriodicalIF":2.3,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National level prescribing of psychotropic medication in primary care during the COVID-19 pandemic in England: potential implications for cardiometabolic health.","authors":"Unaiza Waheed,&nbsp;Mike Stedman,&nbsp;Mark Davies,&nbsp;Andreas Walther,&nbsp;Emma Solomon,&nbsp;Bill Ollier,&nbsp;Adrian H Heald","doi":"10.1097/XCE.0000000000000270","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000270","url":null,"abstract":"2574-0954 Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Correspondence","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"11 4","pages":"e0270"},"PeriodicalIF":2.3,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/79/xce-11-e0270.PMC9451603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33461178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help in mitigating the risk of atrial fibrillation in patients with diabetes?","authors":"S. Thotamgari, U. Grewal, A. Sheth, Akhilesh Babbili, Paari Dominic","doi":"10.1097/XCE.0000000000000265","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000265","url":null,"abstract":"The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in mitigating the risk of atrial fibrillation (AF) remains unknown. We interrogated the Food and Drug Administration’s Adverse Event Reporting System (FAERS) database to study the association between AF-related adverse events and the use of GLP-1 RA and DPP-4i. A signal of disproportionate reporting of AF was detected with the DPP-4i group compared with all the other drugs in the FAERS database [ROR, 2.56; 95% confidence interval (CI), 2.10–3.12], whereas there was no disproportionality signal detected with the GLP-1 RA group (ROR, 0.90; 95% CI, 0.78–1.03) although liraglutide showed a significant disproportionality signal (ROR, 2.51; 95% CI, 2.00–3.15). Our analysis supports the existing body of literature demonstrating the cardiac safety of GLP-1 RA but raises concerns about the apparent increase in the risk of AF associated with DPP-4i. Further clinical and translational studies are needed to validate these findings.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45104890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose dysregulation and repolarization variability markers are short-term mortality predictors in decompensated heart failure","authors":"G. Piccirillo, F. Moscucci, M. Carnovale, A. Corrao, I. Di Diego, I. Lospinuso, S. Sciomer, P. Rossi, D. Magrí","doi":"10.1097/XCE.0000000000000264","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000264","url":null,"abstract":"Objective As recently reported, elevated fasting glucose plasma level constitutes a risk factor for 30-day total mortality in acutely decompensated chronic heart failure (CHF). Aim of this study was to evaluate the 30-day mortality risk in decompensated CHF patients by fasting glucose plasma level and some repolarization ECG markers. Method A total of 164 decompensated CHF patients (M/F: 94/71; mean age, 83 ± 10 years) were studied; Tend (Te), QT interval (QT) and 5 min of ECG recordings were obtained, studying mean, SD and normalized index of the abovementioned ECG intervals. These repolarization variables and fasting glucose were analyzed to assess the 30-day mortality risk among these patients. Results Thirty-day mortality rate was 21%, deceased subjects showed a significant increase in N terminal-pro-brain natriuretic peptide (P < 0.001), higher sensitivity cardiac troponin, fasting glucose, creatinine clearance, QTSD, QTVN, Te mean, TeSD and TeVN than the survivals. Multivariable regression analysis reported that fasting glucose (hazard ratio, 1.59; 95% confidence interval, 1.09–2.10; P < 0.01), Te mean (hazard ratio, 1.03; 95% confidence interval, 1.01–1.05; P < 0.01) and QTSD (hazard ratio, 1.17; 95% confidence interval, 1.01–1.36; P < 0.05) were significantly related to higher mortality risk, whereas only fasting glucose (hazard ratio, 1.84; 95% confidence interval, 1.12–3.02; P < 0.05) and Te mean (hazard ratio, 1.07; 95% confidence interval, 1.02–1.11; P < 0.01) were associated to cardiovascular mortality. Conclusion Data suggest that two simple, inexpensive, noninvasive markers, as fasting glucose and Te, were capable to stratify the short-term total and cardiovascular mortality risk in acutely decompensated CHF.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44535102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}