Naltrexone alters cardiovascular function following acute forced swimming in mice

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
C. Longoria, Qudratullah S. Qadiri, E. Matthews, S. Campbell, J. Guers
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引用次数: 1

Abstract

Purpose Naltrexone (NTX) is an opioid antagonist that can reverse the physiological effects of opioid receptors when bound. Opioid receptors have been found to play a role in cardiovascular (CV) function, and thus, binding of NTX may alter CV activity at rest and in response to acute and chronic exercise (EX). We hypothesized that opioid receptor blockade will alter the typical CV responses following acute EX. Methods We assessed the effects of opioid receptor blockade on CV function via echocardiography in mice following an acute bout of forced swimming (FSw), a model of rodent EX. We administered opioid receptor antagonist, NTX, or saline in mice before FSw and in the absence of an FSw perturbation. Furthermore, we assessed how NTX can influence maximal EX capacity on a rodent treadmill. Results Our data shows that NTX administration does not decrease maximal EX capacity in mice (P > 0.05). However, NTX attenuated cardiac output following FSw (FSw = 52.5 ± 2.5 ml/min vs. FSw + NTX = 32.7 ± 5.2 ml/min; P < 0.05) when compared with saline control (33.5 ± 3.8 ml/min). Further, the administration of NTX in the non-EX condition significantly (P < 0.05) reduced ejection fraction. Conclusion These data suggest that normal opioid receptor activation is necessary for typical CV function following FSw.
纳曲酮改变小鼠急性强迫游泳后的心血管功能
目的纳曲酮(NTX)是一种阿片受体拮抗剂,结合后可逆转阿片受体的生理作用。阿片受体已被发现在心血管(CV)功能中发挥作用,因此,NTX的结合可能会改变心血管在休息时以及对急性和慢性运动(EX)的反应。我们假设阿片受体阻断将改变急性EX后典型的CV反应。方法我们通过超声心动图评估阿片受体阻断对小鼠急性强迫游泳(FSw)后CV功能的影响,这是一种啮鼠EX模型。我们在FSw前和没有FSw扰动的情况下给药阿片受体拮抗剂、NTX或生理盐水。此外,我们评估了NTX如何影响啮齿动物跑步机上的最大EX能力。结果NTX对小鼠的最大EX容量无显著影响(P < 0.05)。然而,NTX降低FSw后的心输出量(FSw = 52.5±2.5 ml/min vs. FSw + NTX = 32.7±5.2 ml/min;P < 0.05),与生理盐水对照组(33.5±3.8 ml/min)比较。此外,在非ex状态下给予NTX显著降低射血分数(P < 0.05)。结论正常的阿片受体激活是FSw后典型CV功能的必要条件。
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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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