BJKines National Journal of Basic & Applied Sciences最新文献

{"title":"Coagulation Profile Study in Pregnancy Induced Hypertension","authors":"Hiral R. Kavar, P. Shah, Akshat P Shah","doi":"10.56018/20230616","DOIUrl":"https://doi.org/10.56018/20230616","url":null,"abstract":"Abstract\u0000Background & Aims: Hypertensive disorders represent the most common medical complication of pregnancy. Hypertensive disorders remains leading cause of direct maternal and fetal mortality. Coagulation profile study in pregnancy induced hypertension helps inearly diagnosis of pregnancy induced hypertension and assessing the severity of pregnancy induced hypertension at earlier stage and help to prevent severe complications like disseminated intravascular coagulation and HELLP syndrome. To estimate platelet count, prothrombin time and activated partial thromboplastin time in pregnancy induced hypertension. To estimate above parameters in normal pregnancy. To compare above parameters between normotensive women and women with pregnancy induced hypertension. Material and Method: 100 newly diagnosed patients of pregnancy induced hypertension and 100 normal healthy controls were included in the study. After taking consent, their blood samples were collected. These samples were transported to the laboratory and processed without delay for prothrombin time, activated partial thromboplastin time and platelet count. The results of these parameters were noted, compared and analysed statistically. Result:In our study, we observe that pregnancy induced hypertension is common in primipara. There was a statistically significant difference between study group and control group for all three parameters(p<0.001). Comparison between each study group and control group showed significant difference (p<0.05) between prothrombin time and activated partial thromboplastin time . Prothrombin time and activated partial thromboplastin time showed significant increase value when compared to normal group although the mean value are normal or near normal in range. Conclusions: It can be concluded from this study that the pregnancy induced hypertension causes a significantchanges in haematological parameters. These parameters should be regularly monitored to prevent serious complications like disseminated intravascular coagulation and HELLP syndrome, hence to decrease morbidity and mortality.\u0000Keywords: - Pregnancy induced hypertension, Disseminated intravascular coagulation, activated partial thromboplastin time , prothrombin time.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128464180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Detailed Analysis of the Various Perinatal Factors Influencing Neonatal TSH: Results from a 6 Months Congenital Hypothyroidism Screening Program.","authors":"Vijay R. Bhalodiya, Bhavin B. Padhariya, Niyati Mehta, Lalji G. Valiya","doi":"10.56018/2023069","DOIUrl":"https://doi.org/10.56018/2023069","url":null,"abstract":"Abstract\u0000Background: The aims of this study are to analyse various perinatal factors influencing neonatal cord blood thyroid stimulating hormone (TSH) level and to find out incidence of congenital hypothyroidism in neonates. Material and Methods: A total of 800 newborns whose mother not having any thyroid medications during her pregnancy period were enrolled for the study. Cord blood samples of the neonates were collected for estimation of TSH level at the Laboratory Services of GMERS Medical College, Junagadh. TSH levels above 20mIU/L were considered as having congenital hypothyroidism. The data were compared with other similar international as well as national studies. Result: In present study, there was no significant difference in cord blood TSH level when compared for various mode of delivery of newborn, as well as according to birth weight and gender of newborn. There was a statistically significant higher mean cord blood TSH level in newborns whose mother had a history of pregnancy induced hypertension (PIH). One newborn was found to have congenital hypothyroidism. Conclusions: It was evident from the present study that newborns whose mother having history of PIH had significantly higher cord blood TSH level. Though incidence of congenital hypothyroidism was rare, routine congenital hypothyroidism screening program was advisable.\u0000Keywords: Congenital hypothyroidism, TSH, PIH, Cord blood TSH.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127945696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Maternal Near Miss at a Tertiary Care Hospital in Ahmedabad, Western India","authors":"BM Raval, ST Mehta, PA Yadava, P. Shah, Asheesh Mehta, S. Mittal","doi":"10.56018/2023067","DOIUrl":"https://doi.org/10.56018/2023067","url":null,"abstract":"Abstract\u0000Background: The aim is to study the various demographic characters, etiologies and outcomes of Maternal Near Miss (MNM) in antenatal and postnatal women coming to a Tertiary Care Hospital in Ahmedabad, Gujarat (Western India). Material and Methods: This is a retrospective observational study conducted between June 2021 and July 2022at SVPIMSR, Ahmedabad. 78 pregnant women based on WHO near-miss criteria were included.Details were recorded by studying the case sheets of the patients and asking relevant focused questions to the patients themselves or their relatives regarding the patient’s condition at the time of admission.Detailed history, clinical examination, treatment given, causes of referral in case the patient was referred from outside were noted. Results: In this study, Obstetric Haemorrhage (69.2%) and hypertensive disorders of pregnancy (30.7%) were the leading causes of MNM cases. Majority of the women(56.4%) belonged to the age group of 18-25 years, were multiparous (83.3%). 74.4% cases were emergency cases and 66.7% were referred cases. The maternal near-miss to maternal death ratio in our study is 8.9:1. 66.5% cases were referred due to various causes like lack of HDU facility, blood and blood products, NICU facilities etc from the peripheral centres. 18 near-miss cases (23.1%) were identified to have a delay; maximum was level 1 delay(12.8%). 31.5% of MNM cases required blood and blood product transfusion. 25% were admitted to the intensive care unit.Conclusion: Timely recognition, prompt treatment of MNM cases with availability of essential services like blood banks and obstetric ICUs at the primary level of treatment can help in preventing adverse outcomes. Reviewing near miss cases gives significant information about the three delays in health seeking so that appropriate action is taken. Delay in referral to tertiary care centres can be avoided by proper education to identify warning signs and symptoms and training to give primary treatment amongst primary care doctors. \u0000Keywords: - Maternal Near Miss (MNM), Pregnancy, Obstetric Haemorrhage, Hypertensive disorder of pregnancy, Tertiary care","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130471336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Morbidity Pattern and Quality of Life among Geriatric Fisherman Population in Pondicherry-An Explanatory Sequential Mixed Method Study","authors":"Dr. S. Kirubakaran, Dr. K Logeswari, Dr G Arvind, Dr. M. Janaki, Dr.J. Shanmuga Priya","doi":"10.56018/20230618","DOIUrl":"https://doi.org/10.56018/20230618","url":null,"abstract":"Background: Almost half of the geriatric population in India has chronic morbidity. Health status is an\u0000important factor that has a significant impact on the quality of life of an elderly population. Objectives: To\u0000find out the pattern of chronic morbidities and to explore the coping skills among the Geriatric Population.\u0000Methodology: The study was Explanatory Mixed Methods study design, where a quantitative phase\u0000(Survey) followed by the qualitative phase (In depth interviews [IDI]) is used. A total of 450 patients aged\u000060 and above from the coastal villages were studied and analysed. Socio Demographic details, Morbidity\u0000Patten and the treatment taken. Results: For the 5 item General Health Questionnaire among the 254\u0000Young old 92 (36.2%) were positive and among the 216 Older/Oldest population about 88 (40.7%) were\u0000positive which is statistically significant (p value 0.0224) comparing the two age categories Regarding\u0000Alzheimer‘s disease – 8 item questionnaire positive there is statistically very significant (p value 0.0003)\u0000difference among the Young old 44 (17.6%) and for Older/Oldest population about 64\u0000(29.6%).Conclusion: Hence it is prudent to screen the elderly population for these General health,\u0000Alzheimer‘s diseases spread knowledge, awareness and self-care advice to them among the fisherman\u0000community though their food pattern and physical activity is on positive note. This will help to create ―the\u0000society for ages‖ and to promote the concept of active and healthy ageing.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121724231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Intra-articular Dexmedetomidine Versus Ketamine as an Adjuvant Analgesic after Arthroscopy","authors":"Bhaarat Maheshwari, Ronakkumar Patel, Namrata Kapadiya, Meet A. Moradiya","doi":"10.56018/20230611","DOIUrl":"https://doi.org/10.56018/20230611","url":null,"abstract":"Abstract\u0000\u0000Background: The primary aim of this study was to evaluate the analgesic effect and safety of intra-articular Dexmedetomidine versus Ketamine in patients undergoing knee arthroscopic surgeries.\u0000Material and Methods: A total of 100 patients were allocated into two equal groups (n= 50 in each group) using random numbers, in an allocation ratio of 1:1. Syringes were labelled either D (dexmedetomidine) or K (ketamine) and study drugs were injected via intra-articular route after completion of knee arthroscopy. Analgesic effect of study drugs was compared using VAS score at 6 hrs, 12 hrs and 24 hrs. Safety of study drugs was compared using mean HR, mean BP and adverse events observed. Results: Lower VAS score, increased time for first rescue analgesic requirement and decreased need for postoperative analgesics were observed in the dexmedetomidine group as compared to ketamine group. Mean HR and Mean BP were lower in patients receiving dexmedetomine compared to those receiving ketamine. Hypotension was detected in 2 patients receiving dexmedetomedine while 1 patient on ketamine developed delirium. Conclusion: Intra-articular use of dexmedetomidine is superior to ketamine for post-operative analgesia without significant adverse effects.\u0000Key words: Knee arthroscopy, Intra-articular Dexmedetomidine, Intra-articular Ketamine","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128750131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reticulocyte Hemoglobin Content (CHr): A Reliable indicator in Iron Deficiency Anemia","authors":"SH Tilva, U. Parikh, HM Goswami","doi":"10.56018/bjkines2023063","DOIUrl":"https://doi.org/10.56018/bjkines2023063","url":null,"abstract":"Introduction: To estimate a cut off for Reticulocyte Hemoglobin Content (CHr) and compare it\u0000with Serum Ferritin for diagnosis of Iron Deficiency Anemia (IDA). Material & Methods: A total\u0000of 188 samples were included in the analytical study out of which 126 were categorized as study samples\u0000and 62 as control. CBC and Reticulocyte analysis were carried out and the parameters were compared.\u0000Results: CHr has a better sensitivity and specificity compared to Serum Ferritin. Low CHr is a marker for\u0000early diagnosis of iron deficiency whereas a raised CHr is an early sign of response to iron therapy. A\u0000CHr cut-off of 28.4 pg was established which is comparable with that of other studies. Conclusion: The\u0000study demonstrates that CHr is a useful parameter that can be confidently used in the diagnosis of IDA.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115348656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Profile of Neonatal Septicemia and Antibiotic Susceptibility Pattern of the Isolates at A Tertiary Care Hospital, Western-India","authors":"N. G. Sathwara, Atit Shah, S. Soni, M. Vegad, Dharmishtha G Tada","doi":"10.56018/2023065","DOIUrl":"https://doi.org/10.56018/2023065","url":null,"abstract":"Abstract\u0000Background: The emergence of multidrug-resistant microbial agents in hospitals is a strenuous task for clinicians to treat neonatal septicemia. It is one of the leading causes of mortality and morbidity in developing countries among neonates. Aims: To study the microbial profile of agents causing neonatal septicemia, their susceptibility pattern, risk factors, and review the antibiotic prophylaxis policy to limit the injudicious use of antimicrobial agents. Material &Methods: The present study included 2550 neonates less than 28 days with clinical manifestation of septicemia from neonatal intensive care unit at the Tertiary care teaching center in western India from December 2017 to May 2019. Aseptically collected blood inoculated into BacT/ALERT blood culture bottle. Further isolation, identification, susceptibility testing was done from the positive signal bottle and interpreted susceptibility according to the latest CLSI guidelines. Result: Microbiologically proven neonatal septicemia detected in 675(26.47%) patients. The predominant organisms isolated were Klebsiellapneumoniae 170 (25%). Pan-antibiotic resistance noted among 8(1.83%) gram-negative rods. Conclusion: Overall, increased emergence of resistance to the cephalosporin, penicillin group, and azole group of antibiotics. In the present study, fluoroquinolones, tetracycline and voriconazole are the better preferred.\u0000Keywords: Neonatal septicemia, injudicious use of antimicrobial agents, review the antibiotic prophylaxis policy","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125612256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reticulocyte haemoglobin equivalent (ret-he) as a marker of bioavailability of iron in pregnant female- a study of 75 cases in a tertiary care centre","authors":"D. Trivedi, Alpesh Chavda, D. Savjiyani","doi":"10.56018/20230610","DOIUrl":"https://doi.org/10.56018/20230610","url":null,"abstract":"Abstract\u0000Background: Anaemia is the most frequent derailment of physiology in the world throughout the life of a woman. Women in the gestational period have a higher risk of presenting with iron-deficiency anaemia. The anaemia may occur due to inadequate intake of dietary iron, greater foetal demand and haemodilution, a physiological anaemia common in pregnant women in which changes in the maternal organism, such as changes in blood volume and factors associated with haemostasis, decrease haemoglobin concentration. The aim of study is to utilize Ret-He as a marker of bioavailability of iron in pregnant female. Material and Methods: This was a retrospective and prospective study carried out for a duration of 1 years and included total of 75 cases referred to Pathology Department, M. P. Shah Govt. Medical College and Guru Gobind Singh Hospital, Jamnagar- Gujarat. Clinical history, RET-He and other important parameters as well as findings of all the concerned pregnant females were collected. Results:Age of pregnant females varied from 19 years to 42 years. Mean age being 25.2 years. The reference ranges of RET-Hewas between 32.1 and 38.8 pg with a median of 34.17 pg. Hb and/or ferritin level were low in 3 pregnant women in 1st trimester with anaemia, 7 in 2nd and in 16 patients in 3rd trimester. Conclusions: Early diagnosis of iron deficiency anaemia in pregnancy is essential to prevent damage to both maternal and foetal health. In this study, we showed that the RET-He presents an excellent supplementary tool for the diagnosis of iron deficiency in pregnant women.\u0000Keywords: Anaemia, Iron deficiency, Pregnancy diagnosis, Reticulocytes, RET-He.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120967675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spurious Outlier in Cell Counter for Total White Blood Cell Count Parameter in Laboratory External Quality Assurance Program","authors":"Dinesh A. Rathod, N. Ninama, Viral J Patel, Bipin A. Patel","doi":"10.56018/20230614","DOIUrl":"https://doi.org/10.56018/20230614","url":null,"abstract":"Abstract\u0000Background & Aims: In the External Quality Assessment Program (EQAP), medical laboratories' test results are compared to their peers by statistical analysis. The present study aims to highlight issues related to the root cause for the outliers in EQAP, the factors which lie outside the laboratory operation. Material and Method: Indian Society of Haematology and Blood Transfusion and All India Institute of Medical Science (ISHTM AIIMS) EQAP samples were analyzed in HORIBA Yumizen H 550 and HORIBA Pentra 60 cell counter. Randox international quality assessment scheme hematology (RIQAS) was analyzed on Yumizen H 550 cell counter. Result: All CBC parameters performance except Total WBC were found satisfactory as Z score is below three in ISHTM AIIMS EQAS on Yumizen H 550 in both laboratories. In contrast, Yumizen H 550 cell counter showed unsatisfactory performance as the Z score was more than three in both laboratories. In RIQAS Yumizen H 550 cell, the counter-performance of all CBC parameters is satisfactory for all samples as SDI is less than three. Conclusion: Horiba Yumizen H 550 cell counter gives spurious outlier in the total WBC parameter for ISHTM AIIMS EQAS. Switching to other EQAPs can provide the solution to a constant outlier.\u0000Keywords: Cell counter, External quality assurance, Yumizen H 550, RQAS, Total WBC count","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133221752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Antibiotic susceptibility Pattern of Gram-Negative Bacteria Isolates from Bloodstream infection at Sir Takhtsinhji Hospital, Bhavnagar","authors":"Mihirkumar Oza, B. Jagad, Shirishkumar M. Patel, R. Jadeja, Pooja Dholakiya, K. Desai","doi":"10.56018/2023068","DOIUrl":"https://doi.org/10.56018/2023068","url":null,"abstract":"Abstract\u0000Background: Bacterial bloodstream infections constitute a significant public health problem in recent years. Sepsis is a leading cause of mortality and morbidity in Hospitals. Earlier identification of bacterial profiles and initiation of targeted antibiotic therapy is necessary for effective management of sepsis and preventing antibiotic resistance.Material& Methods: This study was conducted in the Bacteriology section of the Microbiology Laboratory at Sir Takhtsinhji Hospital Bhavnagar from January 2020 to November 2020. Samples received for blood culture were processed and species level identification for isolated Gram-Negative Bacteria by standard laboratory method and processed for antibiotic susceptibility test by modified Kirby Bauer disc diffusion method according to CLSI guideline 2020. Gram-negative bacterial Isolates and their antibiotic susceptibility pattern were recorded and analyzed.Results: There were 3643 blood culture samples, from which 574 (15.75%) showed bacterial growth. Out of 574 positive cultures, Gram Negative Bacteria were 407 (70.90%) and Gram-Positive Bacteria were 167 (29.09%). The most common Gram-negative isolate was Escherichia coli 56.51% followed by klebsiella pneumonia 28.25%. Escherichia coli showed the highest sensitivity to amikacin gentamicin. A high degree of resistance was found to cephalosporin and levofloxacin.Conclusion:The results indicate a high level of prevalence of Gram-negative bacteria among bloodstreaminfections and emerging resistance patterns among commonly used antibiotics. This study suggests continuous monitoring of antimicrobial susceptibility patterns through antibiogram so as to treat patient promptly and to build an effective hospital antibiotic policy.\u0000Keywords: Blood Stream Infections, Gram-negative bacteria, Antimicrobial Susceptibility pattern.","PeriodicalId":430295,"journal":{"name":"BJKines National Journal of Basic &amp; Applied Sciences","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133230536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}