Infektsiya i Immunitet最新文献_第3页

ЭТИОЛОГИЯ СЕЗОННЫХ ПОДЪЕМОВ ЗАБОЛЕВАЕМОСТИ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ В АРХАНГЕЛЬСКОЙ ОБЛАСТИ 大天使地区肠病毒感染季节性上升病理

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Infektsiya i Immunitet Pub Date : 2014-07-07 DOI: 10.15789/2220-7619-2013-1-65-72

Л. А. Шишко, Н. И. Романенкова, М. А. Бичурина, Татьяна Александровна Гордиенко, Н. Р. Розаева, Л. Н. Голицына, Л. Б. Фомина, О. И. Канаева, Людмила Лялина, Н. А. Новикова

{"title":"ЭТИОЛОГИЯ СЕЗОННЫХ ПОДЪЕМОВ ЗАБОЛЕВАЕМОСТИ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ В АРХАНГЕЛЬСКОЙ ОБЛАСТИ","authors":"Л. А. Шишко, Н. И. Романенкова, М. А. Бичурина, Татьяна Александровна Гордиенко, Н. Р. Розаева, Л. Н. Голицына, Л. Б. Фомина, О. И. Канаева, Людмила Лялина, Н. А. Новикова","doi":"10.15789/2220-7619-2013-1-65-72","DOIUrl":"https://doi.org/10.15789/2220-7619-2013-1-65-72","url":null,"abstract":"Abstract. The etiology of seasonal increasing of enteroviral infection incidence in Arkhangelsk oblast in 2008–2011 has been studied. The ECHO 6, ECHO 9 and ECHO 30 viruses were isolated and identified from patients with enteroviral infection in this period. The highest enteroviral infection incidence rate in Arkhangelsk oblast which was 5,1 times higher in compare with average country index was registered in 2008. It was proved by the virological and molecular biological methods that the main etiological agent caused enteroviral meningitis cases in the seasonal outbreak in 2008 was ECHO 30 virus which was very similar to the ECHO 30 strain identified in the Veliky Novgorod in 2008. In 2009 from patients in enteroviral meningitis epidemic focus the ECHO 9 viruses were isolated. These viruses were similar to the ECHO 9 strains circulated in Russia in 2009. It was established that in the period of seasonal increasing of enteroviral infection in Arkhangelsk oblast in 2010–2011 in general circulated ECHO 6 viruses which clustered in 3 separate phylogenetic groups. Viruses ECHO 6 detected in Arkhangelsk oblast in 2011 were different from viruses identified in 2010. Results of the study confirm that monitoring of viruses in case of enteroviral infection remains the one of the important types of additional measures in the frame of Global Program of poliomyelitis eradication. This monitoring is absolutely necessary to define characteristics of epidemic process of enteroviral infection.","PeriodicalId":42907,"journal":{"name":"Infektsiya i Immunitet","volume":"3 1","pages":"65-72"},"PeriodicalIF":0.4,"publicationDate":"2014-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67113455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Взаимодействия патогенных бактерий с врожденными иммунными реакциями хозяина 病原体细菌与宿主先天性免疫反应的相互作用

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Infektsiya i Immunitet Pub Date : 2014-07-02 DOI: 10.15789/2220-7619-2012-3-581-596

F. Yu. Garib, A. P. Rizopulu

{"title":"Взаимодействия патогенных бактерий с врожденными иммунными реакциями хозяина","authors":"F. Yu. Garib, A. P. Rizopulu","doi":"10.15789/2220-7619-2012-3-581-596","DOIUrl":"https://doi.org/10.15789/2220-7619-2012-3-581-596","url":null,"abstract":"Abstract. «Efficacy» of pathogens interaction with the immunity system is manifested by broad spreading of many bacterial infections including tuberculosis first of all and in activation of known and emergent pathogens. The refined mechanisms of avoiding of bacteria from recognizing by immune system as creation of obstacles for phagocytosis and intracellular killing, using of secretory systems like “syringe” for inoculation into host cells deregulated substances, suppression or enhancing of inflammatory response, activation of inhibitory receptors to suppress respiratory explosion in phagosome, decreasing of synthesis of proinflammatory cytokines by influences to inflammasomes, stimulation of cytokines production suppres sed of innate response, damage of key molecules on intracellular signal routes, manipulation with apoptosis and auto phagia with the aim of surviving and replication inside the host cells, blocking of processing and presentation of bacterial antigens have been evolutionary developed. The study of interaction between host and parasite allows to understand new facts characterized “logic of live being” on the pathogen level and to use their mechanisms of evasion for resolving of actual problems raised in human society, for example, development of original vaccines and principally new drugs for immune system correction in case of diseases such as oncogenic tumors, autoimmune and allergic diseases as well as infectious diseases which are difficult to prevent and treat. Moreover, it was proved that permanent interaction with microorganisms including pathogenic ones is useful for human being because bacterial substances “train” immune system of people and assist its evolutionary improvement.","PeriodicalId":42907,"journal":{"name":"Infektsiya i Immunitet","volume":"2 1","pages":"581-596"},"PeriodicalIF":0.4,"publicationDate":"2014-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67112552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Эколого-эпидемиологическая характеристика клещевого энцефалита и иксодовых клещевых боррелиозов (болезни Лайма) в Калининградской области 在加里宁格勒地区，蜱脑炎和鱼子病流行病学特征

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Infektsiya i Immunitet Pub Date : 2014-07-01 DOI: 10.15789/2220-7619-2011-4-319-330

N. K. Tokarevich, A. A. Tronin, V. N. Seljuk, T. P. Grunicheva, E. A. Babura

{"title":"Эколого-эпидемиологическая характеристика клещевого энцефалита и иксодовых клещевых боррелиозов (болезни Лайма) в Калининградской области","authors":"N. K. Tokarevich, A. A. Tronin, V. N. Seljuk, T. P. Grunicheva, E. A. Babura","doi":"10.15789/2220-7619-2011-4-319-330","DOIUrl":"https://doi.org/10.15789/2220-7619-2011-4-319-330","url":null,"abstract":"Abstract. Results of monitoring of tick-borne encephalitis (TBE) and tick borreliosis (TB) in the western enclave of Russia in Kaliningrad oblast in 1999-2008 are presented in the article. The number of basic vector of the agents of these infections — I. ricinus during the analyzing period in the territory of Kurshskaya spit increased. The number of tick attacked persons in the oblast also increased. Despite these events the TBE incidence rates remained not so high and have tendency to decrease. At the same time the TB morbidity has moderate trend to increase. The link between increase of average annual air temperature and incidence of \"tick\" infections was not proved for the studying period of time. The people of pre-pension and pension ages living in cities more often suffer from TBE and TB. The most part of patients are exposed to tick attack during visiting of rest places. It was determined that eastern districts of Kaliningrad oblast are more problematic on \"tick\" infections.","PeriodicalId":42907,"journal":{"name":"Infektsiya i Immunitet","volume":"1 1","pages":"319-330"},"PeriodicalIF":0.4,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67112412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

USING OF MOUSE MODEL TO ANALYZE IMMUNE RESPONSE TO INFECTIOUS PATHOGENS BY THE METHODS OF CLASSICAL GENETICS 应用经典遗传学方法建立小鼠模型，分析小鼠对感染性病原体的免疫反应

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Infektsiya i Immunitet Pub Date : 2014-07-01 DOI: 10.15789/2220-7619-2011-4-293-302

A. Poltorak

引用次数: 0

ПРИМЕНЕНИЕ СОВРЕМЕННЫХ СТАТИСТИЧЕСКИХ МЕТОДОВ ДЛЯ ОЦЕНКИ ВЗАИМОСВЯЗИ ИНТЕРФЕРОНОВОГО СТАТУСА ЗДОРОВОГО НОВОРОЖДЕННОГО И ЕГО МАТЕРИ 使用现代统计方法来评估干扰素新生儿和母亲健康状况的关系

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Infektsiya i Immunitet Pub Date : 2014-07-01 DOI: 10.15789/2220-7619-2011-4-331-340

S. A. Sel’kov, L. I. Koroleva, A. V. Tishkov, V. B. Anikin, N. Khromov-Borisov

引用次数: 4

ETHICAL AND LEGAL ASPECTS OF INFECTIOUS DISEASES AND VACCINATION Part 3. Ethical principals of eradication of infectious diseases 传染病和疫苗接种的伦理和法律问题第3部分。根除传染病的伦理原则

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Infektsiya i Immunitet Pub Date : 2014-07-01 DOI: 10.15789/2220-7619-2013-3-205-212

O. Kubar, M. Bichurina, N. Romanenkova, A. Asatrian

引用次数: 0

ВИРУС КРАСНУХИ И ЕГО ТЕРАТОГЕННОЕ ДЕЙСТВИЕ. ПАТОГЕНЕЗ, КЛИНИКА, ДИАГНОСТИКА, ПРОФИЛАКТИКА СИНДРОМА ВРОЖДЕННОЙ КРАСНУХИ. Часть 3. Диагностика и профилактика краснухи и СВК 风疹病毒和畸胎瘤病毒。病原体，诊所，诊断，预防先天性风疹综合征。第三部分。风疹诊断和预防

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Infektsiya i Immunitet Pub Date : 2014-06-30 DOI: 10.15789/2220-7619-2011-3-231-242

А. Ю. Антипова

引用次数: 1

Продукция проММП-1 культивируемыми клетками сосудистого эндотелия in vitro и в организме человека prommp -1在体外和人体中培养血管内皮细胞

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Infektsiya i Immunitet Pub Date : 2014-06-30 DOI: 10.15789/2220-7619-2011-3-271-274

N. N. Scliankina, N. V. Boldyreva, A. A. Babayants, I. S. Frolova, D. L. Belyaev, Yu. A. Portnova, O. N. Scheglovitova

{"title":"Продукция проММП-1 культивируемыми клетками сосудистого эндотелия in vitro и в организме человека","authors":"N. N. Scliankina, N. V. Boldyreva, A. A. Babayants, I. S. Frolova, D. L. Belyaev, Yu. A. Portnova, O. N. Scheglovitova","doi":"10.15789/2220-7619-2011-3-271-274","DOIUrl":"https://doi.org/10.15789/2220-7619-2011-3-271-274","url":null,"abstract":"Abstract. Matrix metalloproteinases (MMP) are structurally related endopeptidase composed of active sites which include ions Zn2+ and Ca2+. Cultured cells of human blood vessels produce MMP-1, proteolytic effect is aimed at splitting the collagen I and III types, and subsequent vascular remodeling. MMP-1 is synthesized as an inactive zymogen proMMP-1. It was shown that interferon alpha, beta and gamma inhibited production by culture of HUVEC proenzyme MMP-1, which seems to characterize their anti-angiogenic action. The effect of immunomodulators is more difficult to explain: perhaps inhibiting effect of imunofan and, as well as activating effect of cycloferon due to their internal structural peculiarities. The action of interferon alpha, beta and gamma, used as HUVEC before infection with HSV-1, and after it led to decrease in production proMMP-1. Apparently, the antiangiogenic effect of IFN is saved in the case of infection of cultures of vascular endothelium with HSV-1. Scatter in the content of proMMP-1 in the serum of blood donors was 1.625–11.8 ng/ml and in patients with chronic microbial-viral infections was 1.22–21.16 ng/ml. Higher rates of proMMP-1 were in older patients group. To estimate the system of MMP in vitro, and in the body a comprehensive study must be conducted, including proMMP-1, the active form of proenzyme and specific inhibitor of MMP-1.","PeriodicalId":42907,"journal":{"name":"Infektsiya i Immunitet","volume":"1 1","pages":"271-274"},"PeriodicalIF":0.4,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67112032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ЭТИЧЕСКИЕ И ПРАВОВЫЕ АСПЕКТЫ ИНФЕКТОЛОГИИ И ВАКЦИНОПРОФИЛАКТИКИ. Часть 1. Биоэтика и социальная справедливость в инфекционной патологии 感染学和疫苗预防的伦理和法律方面。第1部分。传染病病理学中的生物伦理和社会正义

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Infektsiya i Immunitet Pub Date : 2014-06-26 DOI: 10.15789/2220-7619-2011-2-107-112

Ольга Иосифовна Кубарь

引用次数: 0

EFFICIENCY OF IMMUNOCORRECTION IN СHRONIC VIRAL HEPATITIS C PATIENTS TREATED BY ANTIVIRALS 抗病毒药物治疗Сhronic病毒性丙型肝炎患者免疫矫正效果观察

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Infektsiya i Immunitet Pub Date : 2013-01-01 DOI: 10.15789/2220-7619-2013-1-59-64

L. Sklyar, E. Markelova, I. Gorelova

引用次数: 1