应用经典遗传学方法建立小鼠模型，分析小鼠对感染性病原体的免疫反应

IF 0.2 Q4 INFECTIOUS DISEASES

Infektsiya i Immunitet Pub Date : 2014-07-01 DOI:10.15789/2220-7619-2011-4-293-302

A. Poltorak

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USING OF MOUSE MODEL TO ANALYZE IMMUNE RESPONSE TO INFECTIOUS PATHOGENS BY THE METHODS OF CLASSICAL GENETICS

Abstract. Identification and studying of numerous functions of all genes of the human beings is one of the main objects of modern biological science. Due to high level of homology between mouse and human genomes the important role to reach above mentioned goal belongs to the mouse model which using in the classical genetics increase in connection with appearance of different inbred mouse lines. For instance, the differences in immune response to infectious pathogens in various mouse lines were used many times to determine immunologically competent genes. That is why the contribution of mouse model in understanding of the mechanisms of immune response to infectious pathogens is difficult to overestimate. In the current review some of the most successful and well known examples of mouse using in studies of anti-infectious response are described.

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来源期刊

Infektsiya i Immunitet INFECTIOUS DISEASES-

CiteScore

1.40

自引率

50.00%

发文量

审稿时长

10 weeks

期刊介绍： Journal "Infektsiya i immunitet" ("Russian Journal of Infection and Immunity") established by Northwest Branch of RAMS, St. Petersburg Pasteur Institute and the St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, with the participation of the St. Petersburg branch of All-Russian Practical Society of epidemiologists, microbiologists and parasitologists at St. Petersburg and Leningrad region. The journal is devoted to numerous aspects of the interaction between different microorganisms and the host organism. Journal is of interest for microbiologists, immunologists, epidemiologists and clinicians. The most detailed discussion of the following questions: • molecular basis of infections caused by pathogenic bacteria, fungi and parasites; • mechanisms of pathogenicity of microorganisms; • the impact of microbial virulence factors on host cells; • factors and mechanism to protect the host from infection; • factors of nonspecific and specific immunity; • experimental models of infectious disease; • development of vaccines and nonspecific anti-infectious defense.