Journal of Contemporary Medical Sciences最新文献

{"title":"Circulating levels of Interferon regulatory Factor-5 correlates with disease activity in Systemic Lupus Erythematosus Iraqi patients","authors":"Zainab M. Dahham, N. I. Haddad","doi":"10.22317/jcms.v8i6.1299","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1299","url":null,"abstract":"Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a diversity of the phenotypes among the patients. SLE is still one of the great challenges due to the lacking of specific biomarkers for diagnosis, assessing disease activity, and prediction of response to therapy. This study aimed to investigate the role of circulating levels of IRF5 protein in sample of SLE Iraqi patients and its correlation with disease activity, to identify a potential immunological biomarker to mirror disease activity. \u0000Methods: Blood samples were taken from 59 participants diagnosed with SLE cases classified according to the American College of Rheumatology (ACR) criteria. They were scored through the SLE disease activity index 2000 (SLEDAI-2K) to estimate the disease activity, and according to it they were subdivided into “SLE-1 group” (SLEDAI-2k ≤5), and “SLE-2 group” (SLEDAI-2k >5), as well as age and gender matched healthy control group. Circulating levels of IRF5 protein were measured in sera samples by ELISA method. \u0000Results: Our result revealed that the circulating levels of IRF5 protein were significantly higher in the SLE-2 group rather than control group (p<0.01), while there was a non-significant difference between SLE-1 group and control group (p>0.05), as well as between both SLE patient groups. Moreover, the circulating IRF5 protein levels were found to be correlated positively and significantly with disease activity index in both SLE patient groups. The correlation between the circulating levels of IRF5 protein with other parameters revealed that a significant positive correlation was found in SLE-1 group with ESR and globulins, and negative correlation with Hb and (albumin/ globulin) ratio, while in SLE-2 group were positively correlated with urea, creatinine, and uric acid. The analysis of receiver operator curves (ROC) for circulating levels of IRF5 protein in SLE-1 and SLE-2 groups showed a good accuracy to distinguish SLE patients from healthy individuals (AUC=0.758, sensitivity=65.5%, and specificity=69%,), and (AUC=0.788, sensitivity=77.3%, and specificity=72.0%,), respectively. \u0000Conclusions: The circulating levels of IRF5 protein correlate with disease activity in SLE patients reflects the possibility of using it as a potential immunological biomarker for diagnosis, and monitoring the disease activity.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46135736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Gastro-floating drug delivery system by 3D Printing: Impact of formulation and design on the release profile of Baclofen","authors":"Nuha Mohammed Abdulkhaleq, M. M. Ghareeb","doi":"10.22317/jcms.v8i6.1304","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1304","url":null,"abstract":"Objectives: Baclofen is a skeletal muscle relaxant with a short half-life and a narrow absorption window in the upper part of the gastrointestinal tract, and this study aims to formulate a sustained-release tablet of baclofen and 3D printing of gastro-floating device and study the effect of various polymers and device design on the release profile of baclofen. \u0000Method: Firstly, four formulas were produced through the hot-melt extrusion and direct compression of the extrudate to produce 30 mg baclofen tablets, then four gastro-floating devices (A, B, C, and D) were designed with two air pockets to enable the floating of the device and have drug-releasing windows with total surface area 4, 10, 20, and 40 mm2 respectively, for drug release. 3D printing of the devices was done by an FDM printer and the tablets were inserted into each device and test it for drug release. \u0000Results: Decreasing the surface area of the drug releasing windows revealed a significant reduction in the dissolution of baclofen irrespective of the type of polymers and useful for sustained release formulation but may be associated with lag time. Devices with one and two releasing windows (Device B and C respectively) sometimes revealed similar dissolution profiles and this related to the position of the window regarding the surface of the dissolution media. Device D with four windows and a 40 mm2 surface area was found to produce more reliable results. F3 which contains Eudragit RS-100 as the main polymer showed sustained release in device D where the complete dissolution of the drug occurred in 12 hours, and the gastro-floating device remained floating all the time and was assayed for drug content, FT-IR, and DSC study. \u0000Conclusion: Hot-melt extrusion was successfully employed to produce sustained release tablets of baclofen. FDM 3D printers are considered a potential tool to produce gastro-floating devices with the required design and release profile.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46057797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Link of gut microbiome with risk of type 2 diabetes mellitus","authors":"Alhanouf M. Alkhammash, W. Alshehri, A. Alhozali, A. Bahieldin","doi":"10.22317/jcms.v8i6.1305","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1305","url":null,"abstract":"The gut microbiota presented in the human digestive system plays an active role in maintaining host health. Recent studies that rely on the use of high throughput metagenomic sequencing (MGS) revealed the association of dysbiosis in the intestinal microbial community and many chronic diseases, specifically type 2 diabetes (T2D). This disease is considered one of the most prevalent metabolic diseases worldwide comprising up to 90%. This article presents the most prominent research in this field and summarizes the method used to study the diversity of the gut microbiome through the use bioinformatics tools. We highlight the role of gut metabolic products in the development of T2D, as many studies have proven the influence of microbial metabolite products, such as LPS and SCFAs, on blood glucose levels through the microbial-host cross-talk. In addition, this article underlines the interaction of epigenetic mechanisms and the gut microbiome in regulating and developing T2D. The latter can be an appropriate preventative or therapeutic approach for several human metabolic diseases. Therefore, future research is required to build new type of T2D therapy based on epigenetic mechanisms, microbial composition, and microbial metabolites.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48777511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofeedback of Heart Rate Variability in the treatment of chronic diseases: A Systematic Review","authors":"Saad Majeed Al-Tamimi","doi":"10.22317/jcms.v8i5.1289","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1289","url":null,"abstract":"Background: HRVB (heart rate variability biofeedback) is a non-pharmacological method for chronic diseases evaluation. \u0000Method: Adults chronic sufferers, HRVB as the primary therapy with or without controlled circumstances, and psycho - physiological results as regression analysis were all included in a systematic search. \u0000Results: There were 21 publications in overall. HRVB was found to be feasible in chronic patients with no adverse reactions, according to the findings. Significant favourable impacts on hypertension and cardiovascular prognostic, inflammation condition, asthma issues, depression and anxiety, sleeping disruptions, cognitive function, and pain were reported in diverse patient characteristics that could be linked to enhanced quality of life. Increases in treatment practice were accompanied by increases in heart rate variability, implying that HRVB may have a regulatory influence on autonomic function. \u0000Conclusions: HRVB has the potential to help individuals with chronic conditions. More research is needed to reinforce these findings as well as identify the most efficient strategy.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42841291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation of serum and follicular level of BMP15 with Oocyte quality, embryo grading and pregnancy rate","authors":"Z. Hashim, Lubna Amer, E. Al-Wasiti","doi":"10.22317/jcms.v8i5.1283","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1283","url":null,"abstract":"Objectives: Use of serum and follicular fluid concentration of oocyte secreted factors BMP15 as biomarkers of oocyte quality, embryo quality and it's relation to pregnancy rate. \u0000Methods: Eighty eight women were included in this study; they were selected from those undergoing intra-cytoplasmic sperm injection. \u0000Results: Positive pregnancy was achieved by 14 women accounting for 19.0 % (total number of women that reach embryo transfer was 72). No significant difference in mean serum BMP15 between pregnant and non- pregnant women, but the level of follicular fluid BMP15 was significantly higher in pregnant women. MI oocyte count was not significantly correlated to serum or follicular fluid BMP15 (p > 0.05). MII oocyte count showed highly significant positive correlation to serum and follicular fluid BMP15 (p < 0.01). Grade1 embryo count showed highly significant positive correlation to serum and follicular fluid BMP15 (p < 0.01), Grade 2 embryo count showed significant positive correlation to serum BMP15 (p = 0.032), but the grade 2 embryo count showed non- significant correlation to follicular BMP15 (p > 0.05). Also grade 3 embryo count showed non- significant correlation to serum and follicular BMP15 (p > 0.05). \u0000Conclusions: The current study revealed that  serum and follicular BMP15 could be used as indicator for oocyte maturity, and serum BMP15 could be used as indicator of good quality embryos.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48668068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Knowledge and Screening Practice among Women in Makkah, Saudi Arabia","authors":"A. Flemban, Saeed M Kabrah, S. Alfaifi, Ahmed Alsubhi, A. Alzahrani, K. Alhazmi, S. Alharbi","doi":"10.22317/jcms.v8i5.1286","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1286","url":null,"abstract":"Objectives: This study aimed to estimate the level of current knowledge regarding breast cancer in Saudi Arabia. We assessed the knowledge of breast cancer risks, the knowledge regarding the BSE and mammogram in Saudi Arabian females using a survey-based study. \u0000Methods:  A cross-sectional study was conducted using a self-administered survey to assess the knowledge and practice of Saudi women toward Brest cancer examination. Collected data were analyzed using SPSS program. \u0000  \u0000Results: A total number of 499 surveys were collected. The data showed that there was general lack of practice of BSE in the sample only 186 (37%) reported that they practiced regular BSE and only 16 (3%) reported that they went to the clinic for breast examination. Among all participants around 54% had poor overall knowledge of breast cancer 65% had poor knowledge regarding breast cancer risk and 93% had poor knowledge regarding clinical examination. Surprisingly, 56% had good knowledge regarding the clinical picture of breast cancer. \u0000Conclusion: This clearly showed that the lack of breast self-examination, mammogram and clinical examination is not a result of total lack of knowledge but due to lack of knowledge regarding risks and examination. This set of data provide a guideline for the focus and planning of future breast cancer awareness campaigns.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46046494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the HER2, PDL1 and oxidative stress levels at the menopausal status of newly diagnosed breast cancer patients","authors":"Baraa R. Mahmood, Thikra A. Allwsh","doi":"10.22317/jcms.v8i5.1288","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1288","url":null,"abstract":"Objective: This study aimed to estimate the levels of HER2, PD-L1 and oxidative stress in newly diagnosed breast cancer patients. Also, to estimate the probability of using HER2 and PD-L1 as a predictive marker on the occurrence of breast cancer in addition to study the effect of menopausal status at the level of HER2, PD-L1, oxidative stress and breast cancer risk factor. \u0000Methods: This study included 125 newly diagnosed breast cancer patients (53 premenopausal and 72 postmenopausal) from Oncology and Nuclear Medicine Hospital in Mosul, Iraq, and 100 apparently healthy women as a control group (44 premenopausal and 56 postmenopausal), during the period from Jan. 2021 to Jun. 2021. The ages of patients and control are matched, and it is ranged from 30-60 years. \u0000In this study we estimate the level of Human Epidermal Growth Factor Receptor 2 (HER2), Programmed Death -Ligand 1(PD-L1), total antioxidant capacity (T-AOC), arylesterase activity, uric acid level, malondialdehyde (MDA) level, peroxidase activity, lactoperoxidase activity and iron level at breast cancer patients and control. \u0000Results: The results show that there is a significant elevation in the level of HER2, PD-L1, malondialdehyde, peroxidase, lactoperoxidase and iron, and a significant decrease in the level of T-AOC, arylesterase and uric acid in the serum of breast cancer patients (pre and postmenopausal) compared with the control group (pre and postmenopausal). \u0000 Also, increase the level of HER2 and oxidative stress at postmenopausal status for the control and patient groups. while PD-L1 level does not affect by menopausal status for both control and patient groups. \u0000Conclusion: The level of HER2, PD-L1, and oxidative stress was significantly increased in newly diagnosed breast cancer patients compared with the control group at the same menopausal status.  Increase breast cancer risk factor at the postmenopausal status.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41437671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women","authors":"Hiba Aqeel Muslem Al-Quraishy, H. Ali, F. J. Al-Tu’ma, M. Ali, A. F. Al-Tu’ma","doi":"10.22317/jcms.v8i5.1285","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1285","url":null,"abstract":"Objectives: To determine the level of interleukin-10 as inflammatory marker in PCOS patients and compared with healthy control and explore the correlation between IL-10 level and other biochemical markers in PCOS patients. \u0000Methods: Whole blood samples of 80 PCOS obese patients and 80 healthy people were collected in duration from Dec., 2021 to April, 2022, at the gynecological and obstetric teaching hospital, Kerbala health directorate, Iraq. The Rotterdam criteria-2003 was accepted to PCOS females with age range between (18-40 years), while the apparently control group with age ranged between (18-40 years). BMI and WHR and hormonal status (LH, FSH, LH/FSH ratio, Prolactin, Free Testosterone) were determined. Elabscience/USA ELISA kit uses the Sandwich-ELISA principle was used to determined IL-10 level in serum. \u0000Results: The obese PCOS women had a seriously decrease in IL-10 (pg/ml) level when compare with apparently healthy control group with mean ± SD for patients (2.192 ± 0.47) and for control group (4.532 ± 0.75) P value < 0.0001, and there are significant negative correlations between IL-10 and (BMI p<0.0001, r= -0.66), (WHR p<0.0001, r= -0.66), (LH p<0.0001, r= -0.63), (LH: FSH ratio p<0.0001, r= -0.72), (Prolactin p=0.008, r= -029).   \u0000Conclusion: Our findings indicate that the IL-10 level decrease in PCOS obese patients and has significant association with pathogenesis and progression of disease.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46013021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docking study, Synthesis, Characterization and Preliminary cytotoxic evaluation of new 1,2,3,4-tetrahydroppyrimidine derivatives","authors":"Noor M. Mohammed","doi":"10.22317/jcms.v8i5.1281","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1281","url":null,"abstract":"Objective: This study resolved that1 these anew synthesized analogs1 may 1be embodied as1 an 1exploitable foundation of new 1anticancer1 1agents to competition breast 1cancer \u0000Methods: By means of The crystal1 structure of Histone deacetylases (HDACs-8) with Vorinostat (SAHA) as 1a co-crystalized1 ligand 1was gained1 from 1the protein 1data-bank 1 (PDB 1code 4QA0) as a result 1of 1docking the compounds (V a,s, V b,s, V a,t and V b,t) give 1good docking 1scores compared1 to the standard. 1 Compounds (V a,s, V b,s, V a,t and V b,t) was synthesized1 by multistep procedures1 from the reaction of  intermediate derivatives (IV a,b) and the thiosemicarbazide or semicarbazide . The chemical1 structures1 of the1 target compounds11 and 1their intermediates1 were1 confirmed by 1FT-IR and1H 1NMR \u0000Results: The in-vitro cytotoxicity1 assay (MTT assay) demonstrated1 that compounds1 V a,t and V b,t showed1 good inhibition 1ratios in Breast1 cancer cell line1 (MCF-7) and human colon adenocarcinoma (HRT-18) 1comparable with drug1 control Vorinostat (SAHA). \u0000Conclusion: 1From the docking1 study, it was1 concluded1 that C=S moiety were very1 1successful to bind 1tightly to the zinc binding group of HDAC enzyme by making numerous 1interaction modes.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46332394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining the conceptual considerations of virtual university in medical education: a systematic review","authors":"S. Ahmady, A. Habibi, Zohreh Koshgoftar","doi":"10.22317/jcms.v8i5.1253","DOIUrl":"https://doi.org/10.22317/jcms.v8i5.1253","url":null,"abstract":"Aim: Most of existing literature on the concept of virtual university of medical sciences have been collected in a non-systematic manner. This issue highlights the need to conduct research on virtual university-related topics through systematic research evidence and empirical evaluations. The aim of the present study is to investigate the real complexity and diversity of the concept of virtual university of medical sciences. Method: This was a systematic review with the BeHEMoTH approach and aimed to identify, review, analyze and integrate models, theories and frameworks related to the concept of virtual university of medical sciences. Eligible articles were searched in PubMed, ERIC, IEEE، ISI ،Scopus, Ecampus research unit from 2001 to 2022 using related keywords in three stages. Results: A total of 13 articles were finally identified according to inclusion and exclusion criteria. Pedagogical, technology, managerial, educational design, technology implementation, and educational-administrative management components were referred to in 5, 5, 4, 7, 6 and 4 articles, respectively. Thematic analysis of the models was carried out in two theoretical dimensions (pedagogical component, managerial component and technological component) and operational dimension (educational design, administrative-educational management and technology implementation). Conclusion: The results of the present study emphasize the need to pay attention to these six components in the establishment and development of virtual universities of medical sciences. In order to improve the education process in virtual universities, the process quality evaluation framework can be used.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49612136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}