Journal of Contemporary Medical Sciences最新文献

{"title":"The impact of the ERCC2 Lys751Gln polymorphism on the risk of acute myeloid leukemia in an Iraqi patients","authors":"Thamer Mouhi Jasiem, R. Al-Hussaini","doi":"10.22317/jcms.v9i1.1308","DOIUrl":"https://doi.org/10.22317/jcms.v9i1.1308","url":null,"abstract":"Objectives: AML is the only type of acute leukemia diagnosed in adults and is less common in children. It has the lowest survival rate. This study aimed to investigate the epidemiological risk factors for AML expansion comprise environmental factors, for instance, smoking , and therapy-related factors.\u0000Methods :The study was conducted on 70 acute myeloid leukemia patients—37 females and 33 males and on 30 healthy people—12 females and 18 males—as a control group. DNA was extracted from the study groups' whole blood samples using the gSYNCTM DNA Extraction Kit. The T751G polymorphism of the ERCC2 gene was determined by the PCR-RFLP technique.\u0000Results: In genetic analysis, it was shown that the carriers of allele Lys and genotype Lys/Lys have a lower risk of developing AML, while allele carriers Gln have an increased risk. The results showed the ERCC2 gene, Lys 751 Gln (T/G) heterozygous TG genotypes, and the G allele were significantly higher (P<0.05) in AML patients compared to the control group. In the sequencing of the region we studied, it was found that there is a site of diversity that is located between the CTTCAG and CTGCAG, where a change in nucleotides (T to G) represents the restriction site of the restriction enzyme.\u0000Conclusion : The polymorphic marker 751 Gln> Lys of the ERCC2 gene was associated with the development of AML in Iraqi patients. It was discovered that allele Lys genotype Lys/Lys carriers have a lower risk of developing AML, whereas allele Gln carriers have an increased risk. ","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48257371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced oxidation protein products levels and Paraoxonase 1(Arylesterase) activity in patients with thyrodisim","authors":"Hadeel Abdul Latif Jouad, Shatha Abdul Wadood AL- Shammaree","doi":"10.22317/jcms.v9i1.1317","DOIUrl":"https://doi.org/10.22317/jcms.v9i1.1317","url":null,"abstract":"Objectives: The purpose of study was to explore the correlation of advanced oxidation protein products (AOPP), which reflect the oxidation of protein and the oxidative stress status, and the activity of antioxidant enzyme of Paraoxonase (PON1), using its arylesterase activity in patients with thyrodisim. \u0000Methods: The study included 100 women with newly diagnosed thyrodisim were subdivided in two groups according to thyroid hormones levels: hyperthyroidism group (50 female patients, age range 18-60 years); and hypothyroidism group (50 female patients, age range 18-75 years). A control group (30 healthy females, age range 18–70 years) was also included for comparison. Demographic and clinical measurements for all participants were recorded which include: Body mass index (BMI), age, weight, height, lipid profile, vitamin D, thyroid hormones (TSH, T3, and T4, FT3, FT4), AOPP levels, and arylesterase activity. \u0000Results: The serum level of AOPP in hypothyroidism group (71.92±19.04 μmol/L) and in hyperthyroidism group (30.41±4.72 μmol/L) were significantly higher than controls (13.12±2.50 μmol/L) (P<0.05). In contrast, lower aryl esterase activity was found in hypothyroidism (5.03±0.50 U/L), and hyperthyroidism (3.64±0.40 U/L) when compared to control group (6.78±0.62 Ku/L) with significant values (P< 0.05). \u0000Conclusions: these results disclosed a significant role of protein oxidation in patients with hypothyroidism as well as the oxidative stress status.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42983895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular studies of CAPN-10 gene (rs2975760) and its association with Insulin Resistance in Polycystic Ovarian Syndrome of Iraqi women","authors":"Hadbaa H. Al-Murshedi, Ammar Fadhil Jawad, F. J. Al-Tu’ma, E. Hadi, M. M. K. Al-Tu’ma","doi":"10.22317/jcms.v8i6.1298","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1298","url":null,"abstract":"Objectives: To explore an association between CAPN10, SNP-44 (rs2975760) with IR condition in women with PCOS. \u0000Methods: A study included 120 participants of which 68 women have PCOS subdivide according to their body mass index (BMI) into 45 obese (BMI≥30) and 23 non-obese (BMI<30). The remaining 52 represent the control group who were apparently healthy women with normal weight and normal menstrual cycle. Patients with PCOS were selected from the Infertility Department, Gynecology and Obstetrics Teaching Hospital, Kerbala Health Directorate / Kerbala-Iraq between Nov., 2021 and June, 2022. Diagnosis of PCOS is based on 2 of 3 findings: oligo/anovulation, hyperandrogenism, polycystic ovaries in ultrasound (Rotterdam criteria). Patients were interviewed and examined for weight, height, waist circumference, and hip circumference. Venous blood samples were collected at 9 AM after an overnight fast. IR was assessed by calculating homeostatic model assessment of insulin resistance (HOMA-IR) using the formula (fasting glucose mg/dl x fasting insulin µU/ml)/405, taking normal value <2.7. Genotypes of CAPN10, SNP-44 has been identified using Allele-specific polymerase chain reaction (AS-PCR) technique. \u0000Results: The prevalence of IR based on HOMA-IR was (80%) in obese PCOS and (48%) in non-obese PCOS women. CAPN10, SNP-44 has been reconstructed and analyzed in patients and controls. Genotypes of 45 obese PCOS subjects (TT, N=26; TC, N=12; and CC, N=7), 23 non-obese PCOS subjects (TT, N=15; TC, N=6; and CC, N=2) and control subjects (TT, N=39; TC, N=11; and CC, N=2) were identified. The genotype distribution was statistically different between obese PCOS women and controls (OR=5.25, P=0.048). The association of SNP-44 allele with IR status was detected. HOMA-IR was greater in CC (10.54 ± 1.29, 9.88 ± 1.41) than in TT (3.30 ± 1.52, P<0.001; 2.82 ± 1.45, P<0.001) and TC (3.76 ± 1.58, P<0.001; 4.10 ±1.57, P<0.05) in obese PCOS and non-obese PCOS subjects respectively. \u0000Conclusion: In obese PCOS, the C allele was associated with higher insulin secretion and HOMA-IR compared with the T allele. The increased HOMA-IR is an indicator of IR. In this scenario, the C allele might be involved in the pathophysiology of insulin resistance in PCOS.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41389668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Shifting Environment of Medical Knowledge and the Necessity for Professional Adjustment","authors":"A. M. Mohammad","doi":"10.22317/jcms.v8i2.1089","DOIUrl":"https://doi.org/10.22317/jcms.v8i2.1089","url":null,"abstract":"","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43902836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Strategies for Inhibition of Listeria monocytogenes and Klebsiella pneumoniae Biofilm Formation and Persistence","authors":"S. Jastaniah, Taghreed Yasir Jamal, Reda H. Amashah, M. Aly","doi":"10.22317/jcms.v8i6.1302","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1302","url":null,"abstract":"Objective: This study aimed to find new strategies for the prevention of bacterial biofilms and investigate the effect of some plant extracts on the biofilm formation by certain pathogenic bacterial strains in-vitro. \u0000Methods: Fourteen different biofilm forming bacterial isolates were collected   and their biofilm were quantitatively measured under different temperature, pH and growth medium using Crystal violet staining method.  Exopolysaccharides (EPS) produced by the isolates were estimated and a comparison between the tested isolates was made. The effect of some plant extracts on bacterial growth, biofilm formation and exopolysaccharide quantity was determined. \u0000Results: The two isolates, Listeria monocytogenes (ATCC13932) and Klebsiella pneumoniae (ATCC700613) were among the most active biofilm forming bacterial isolates.  The optimum temperature, pH and media for EPS production and biofilm formation were determined. The effect of some plant extracts of Cranberry; Pomegranate peel and, Arak on growth and formation of biofilm and EPS were recorded. Moreover, minimum inhibition concentration of each plant extract was performed. \u0000Conclusion: EPS quantity produced from the tested isolates depends on some effective factors such temperature, media contents and pH. Aqueous-Cranberry, aqueous-Pomegranate Peel and methanolic-Arak extracts have antibacterial and antibiofilm activities on L. monocytogenes and K.  pneumonia. Thus, application of new natural approaches for inhibiting bacterial biofilm is important to prevent persistent and recurrent biofilm related infections.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49343644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social factors affecting relapse of severe mental illness: A qualitative analysis of healthcare team's perceptions","authors":"N. Seyedfatemi, S. Saber","doi":"10.22317/jcms.v8i6.1294","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1294","url":null,"abstract":"Objective: Relapse is a challenge for patients with severe mental illness (SMI). The purpose of present study was to explain the health care team’s perception of social factors affecting SMI relapse. \u0000Methods: In this qualitative content analysis study, semi-structured interviews have been conducted with 23 members of healthcare team. Content analysis was used to categorize the data. \u0000Results: The social factors affecting the relapse of SMI could be classified in three categories of community-related factors, cultural factors, and family-related factors. The first category included low socioeconomic status, lack of community support for SMI patients, and insufficient awareness of community about SMI. The second category included false beliefs and misconceptions, and negative attitudes towards SMI. The third category also included dysfunctional family and non-supportive family. \u0000Conclusion: In order to deal with cultural misconceptions that lead to the relapse of SMI, it is necessary to implement culture-based interventions to correctly confront negative attitudes and stigmatized beliefs and fight against cultural taboos that govern the phenomenon of SMI relapse in Iran. It seems that the implementation of family-centered interventions for the family of patients with SMI can reduce the burden of family-related factors in disease relapse.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43059144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of blood components inventory management during Hajj and Umrah season at Makkah hospitals","authors":"Saeed M Kabrah","doi":"10.22317/jcms.v8i6.1303","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1303","url":null,"abstract":"Objectives: The current study aims to utilize blood bank data collected from the Army forces hospital in Makkah to improve transfusion services at Makkah hospitals and evaluate the inventory system during the Hajj season. \u0000Methods: Three years' results showed that blood centre production is not constant, with an average of 1800 units during Hajj season that includes Cryo (450), FFP (450), PLT (450), and PRBC (450) units. Moreover, data indicated that the average usage of units is 1119 during the same season (120 Cryo, 424 FFP, 207 PLT and 368 PRBC). \u0000Results: This demonstrated that the inventory of blood units fluctuates during the year with an overproduction of Cryo (80%), FFP (67%), PLT (83%) and PRBC (57%) units in Hajj Season. It can be concluded that the manner and effectiveness with which the present issues in Makkah blood banking are having a major impact on the current system used to obtain the nation's blood supply and the safety, adequacy, and operational cost of that supply. \u0000Conclusion: The current study recommends building a generic data warehouse with smart decision support systems that use artificial intelligence to maintain blood bank production and inventory system during the year, especially during Hajj and Umrah seasons.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46394816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study interplay between Asprosin with Vitamin D in metabolic syndrome","authors":"Shahabas Mohammed, T. A. Allwsh","doi":"10.22317/jcms.v8i6.1300","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1300","url":null,"abstract":"Objective: The study aims to in investigating the role of the asprosin hormone and its relationship with vitamin D in patients with metabolic syndrome and clinical parameters.               Methods: The study included measurement asprosin hormone, vitamin D, and some biochemical variable levels in metabolic syndrome patients with age matching to the control group (35 - 65 years). The study includes (95) samples of metabolic syndrome patients [49female, 46 males] who were attending the abdominal consultation unit at the Ibn Sina Teaching Hospital in Mosul, Iraq . MetS were diagnosed in compliance with the criteria of the NCEP (ATP III) and AHA/ NHLB . Samples were collected during the period from January 2021 to December 2021. Also, the study was carried out on 76 samples of apparently healthy (40 female, 36 male) as a control group. Results: The findings revealed a significant increase in the concertation of the asprosin hormone in metabolic syndrome patients compared to the control group. Also, it has been found that was a significant increase in the concertation of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Triglycerides , low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol , total cholesterol and urea. In addition to a decline in high-density lipoprotein cholesterol , non-high-density lipoprotein cholesterol (Non-HDL),  (HOMA-B ), vitamin D and Calcium among metabolic syndrome patients. there is also a significant inverse correlation between asprosin hormone with the Vitamin D. Conclusion:  The study concluded that the hormone asprosin is a good indicator that reflects the                 status of metabolic syndrome patients and vitamin D appeared to be associated with MetS, as well as the Insulin resistance (IR) and lipid profile.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44998184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of topical Arnebia euchroma Oil in the treatment of Pressure Ulcer: A Case Report","authors":"Hoorieh Mohhamadi Kenari, Sakineh Erabi, A. Ghobadi","doi":"10.22317/jcms.v8i6.1276","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1276","url":null,"abstract":"Decreased tissue blood flow causes pressure ulcers due to prolonged pressure on the area, which becomes problematic for immobile individuals. The medical community has often been involved in curing such a problem in individuals with disabilities and immobility.  To alleviate this problem, therefore, plenty of investigations are always seeking novel methods. Furthermore, herbal plants are increasingly used owing to the accepted status of plant-derived drugs in recent years. Our female case aged 52 years that was referred to the wound clinic complaining sensory and motor weakness of the upper extremity and sudden paralysis of the lower extremity as of 1 year ago, which was diagnosed as myelitis. She complained of two wounds on both sides of the right and left buttocks with a size of 9 × 5 and another 6 × 4.5 cm from 3 months ago, and a wound with a size of 5 × 4.5 in the sacral area (sacrum) from 20 days prior to the admission. There was tissue necrosis without muscle engagement, osteomyelitis, or tunneling; besides, nasty odors and sludge were absent accounted for in class 3 in the group of wounds. She received starting therapy using Arnebia euchroma oil. As of the 2nd week onward, she was treated very successfully, and the complete wound healing occurred in 8 weeks. The use of A. euchroma for wound healing and reducing infection and inflammation can greatly contribute to the cure of pressure ulcers and can be properly suggested in healing these ulcers.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42060098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charcterization of COVID-19 hospitalized adult patients, vaccinated vs non-vaccinated in Duhok province","authors":"Paiman Abdulsalam Mohammed, Muayad Aghali Merza","doi":"10.22317/jcms.v8i6.1272","DOIUrl":"https://doi.org/10.22317/jcms.v8i6.1272","url":null,"abstract":"Objectives: First, to determine prevalence of vaccinated COVID-19 patients among hospitalized patients; Second, to determine the epidemiological, clinical, and laboratory characteristics of vaccinated and unvaccinated COVID-19 patients.\u0000Methods: The study was carried out on 300 adult COVID-19 hospitalized patients at Duhok COVID-19 health facilities. A prospective cross-sectional study was used as the study design. Between October 1, 2021, and March 31, 2022, all patients with PCR-confirmed COVID-19 were enrolled.\u0000Results:  The majority of people in this study were unvaccinated. Pfizer was most popular among people who had received vaccination. The majority of hospitalized patients were old ages, the mean age was 60.73 ± 15.83 yr. In our study, the unvaccinated females had higher infection rates while vaccinated males had higher hospital admission rates. In our study, vaccinated patients had shorter hospital duration stays. In both vaccinated and unvaccinated patients, predominated cases were severe cases. D dimer was significantly higher among vaccinated patients. The mortality rate was relatively high among both groups. Patients who had received vaccinations tended to experience vomiting and flu-like symptoms more frequently than those who had not. In terms of comorbidities, smoking and malignancy were significant risk factors for COVID-19 infection in unvaccinated patients.\u0000Conclusion: We looked at 300 COVID-19 hospitalized patients. In this study, the majority of people were unvaccinated. Pfizer, had higher prevalence among vaccinated individuals. Majority were elderly. The unvaccinated cases had a higher rate of female hospital admissions than male. The D.Dimer level was significantly different between the two groups. Vomiting and flu-like illness showed higher prevalence in vaccinated cases with significant difference. Smoking and malignancy were significant risk factors for COVID-19 infection in unvaccinated patients. In the fight against a public health disaster like a COVID-19 pandemic, the availability of a COVID-19 vaccines campaign are crucial.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46383718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}