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International Journal of Endocrine Oncology最新文献

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Applying the use of novel biomarkers for neuroendocrine tumors in the clinic: where are we now? 应用新型生物标志物在临床神经内分泌肿瘤中的应用:我们现在在哪里?
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2019-03-01 DOI: 10.2217/IJE-2017-0012
K. Daskalakis, O. Norlén, P. Hellman, P. Stålberg
{"title":"Applying the use of novel biomarkers for neuroendocrine tumors in the clinic: where are we now?","authors":"K. Daskalakis, O. Norlén, P. Hellman, P. Stålberg","doi":"10.2217/IJE-2017-0012","DOIUrl":"https://doi.org/10.2217/IJE-2017-0012","url":null,"abstract":"Applying the use of novel biomarkers for neuroendocrine tumors in the clinic : where are we now?","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43326643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Welcome to Volume 6 of International Journal of Endocrine Oncology 欢迎来到《国际内分泌肿瘤学杂志》第六卷
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2019-03-01 DOI: 10.2217/IJE-2018-0005
Jennifer Straiton
{"title":"Welcome to Volume 6 of International Journal of Endocrine Oncology","authors":"Jennifer Straiton","doi":"10.2217/IJE-2018-0005","DOIUrl":"https://doi.org/10.2217/IJE-2018-0005","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46205660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncolytic virotherapy for anaplastic and poorly differentiated thyroid cancer: a promise or a clinical reality? 间变性和低分化甲状腺癌症的溶瘤病毒治疗：前景还是临床现实？
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-11-01 DOI: 10.2217/IJE-2017-0028
C. Passaro, S. D. Somma, A. Malfitano, G. Portella
{"title":"Oncolytic virotherapy for anaplastic and poorly differentiated thyroid cancer: a promise or a clinical reality?","authors":"C. Passaro, S. D. Somma, A. Malfitano, G. Portella","doi":"10.2217/IJE-2017-0028","DOIUrl":"https://doi.org/10.2217/IJE-2017-0028","url":null,"abstract":"Oncolytic viruses (OVs) selectively infect and lyse cancer cells. A direct lytic effect of OVs has been theorized in the initial studies; however, the antineoplastic effect of OVs is also due to the induction of an immune response against cancer cells. Anaplastic thyroid cancer is one of the most aggressive human malignancies with a short survival time of about 6–12 months from the diagnosis. The lack of effective therapies has prompted to investigate the efficacy of OVs in anaplastic thyroid carcinoma. Different OVs have been tested in preclinical studies, either as single agents or in combinatorial treatments. In this review, the results of these studies are summarized and future perspective discussed.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46798615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Metastatic medullary thyroid cancer to the brain: a case report and review of the literature 癌症髓样癌脑转移1例报告及文献复习
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-08-01 DOI: 10.2217/IJE-2017-0024
R. Sastry, E. Williams, Robert M. Koffie, K. Fehnel, L. Wirth, B. Nahed
{"title":"Metastatic medullary thyroid cancer to the brain: a case report and review of the literature","authors":"R. Sastry, E. Williams, Robert M. Koffie, K. Fehnel, L. Wirth, B. Nahed","doi":"10.2217/IJE-2017-0024","DOIUrl":"https://doi.org/10.2217/IJE-2017-0024","url":null,"abstract":"Medullary thyroid cancer rarely metastasizes to the brain. Presentation and optimal treatment approaches vary widely. We present a 53-year-old male, diagnosed with medullary thyroid cancer 21 years prior, who was presented with at least seven metastases in his brain. He underwent two craniotomies for two large, hemorrhagic metastases followed by whole brain radiation therapy. Tumor genotyping revealed a somatic C634R mutation in the RET proto-oncogene. Subsequently, he was started on multikinase inhibitor therapy. He ultimately passed away 10 months after his surgery. Complete resection may be a reasonable approach for patients with one or more cerebral or cerebellar metastases when feasible. Further analysis is necessary to understand the specific mutations that predispose medullary thyroid cancer to central nervous system metastasis.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43098175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The recent European approval of lutetium (177Lu) oxodotreotide increases treatment options for gastroenteropancreatic neuroendocrine tumors 最近欧洲批准的lutetium (177Lu) oxodotreotide增加了胃肠胰腺神经内分泌肿瘤的治疗选择
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-05-01 DOI: 10.2217/IJE-2018-0002
M. Caplin
{"title":"The recent European approval of lutetium (177Lu) oxodotreotide increases treatment options for gastroenteropancreatic neuroendocrine tumors","authors":"M. Caplin","doi":"10.2217/IJE-2018-0002","DOIUrl":"https://doi.org/10.2217/IJE-2018-0002","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2018-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47111672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Ovarian adult-type granulosa cell tumor: focusing on endocrine-based therapies 卵巢成人型颗粒细胞瘤：基于内分泌的治疗
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-05-01 DOI: 10.2217/IJE-2017-0021
Annie Yang, J. Curtin, F. Muggia
{"title":"Ovarian adult-type granulosa cell tumor: focusing on endocrine-based therapies","authors":"Annie Yang, J. Curtin, F. Muggia","doi":"10.2217/IJE-2017-0021","DOIUrl":"https://doi.org/10.2217/IJE-2017-0021","url":null,"abstract":"• FOXL2 mutation is diagnostic, and, if pathology is in doubt, it should be performed. • Surgical resection and staging is key to assess prognosis. • Platinum-based adjuvant chemotherapy such as with carboplatin plus paclitaxel is a reasonable step for women diagnosed with distant recurrences or poor prognostic initial features. However, evidence for improved outcome is lacking. • Hormone-based therapies, especially with aromatase inhibitors, have shown activity and future studies may lead to further insight on the relationship of inhibition of hormonal pathways and tumor progression.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44826987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor. 68- DOTATATE镓扫描在解剖成像阴性但怀疑神经内分泌肿瘤的症状患者中的应用。
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-02-02 eCollection Date: 2018-02-01 DOI: 10.2217/ije-2017-0005
Jasmine Shell, Xavier M Keutgen, Corina Millo, Naris Nilubol, Dhaval Patel, Samira Sadowski, Myriem Boufraqech, Lily Yang, Roxanne Merkel, Christine Atallah, Peter Herscovitch, Electron Kebebew
{"title":"68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor.","authors":"Jasmine Shell,&nbsp;Xavier M Keutgen,&nbsp;Corina Millo,&nbsp;Naris Nilubol,&nbsp;Dhaval Patel,&nbsp;Samira Sadowski,&nbsp;Myriem Boufraqech,&nbsp;Lily Yang,&nbsp;Roxanne Merkel,&nbsp;Christine Atallah,&nbsp;Peter Herscovitch,&nbsp;Electron Kebebew","doi":"10.2217/ije-2017-0005","DOIUrl":"https://doi.org/10.2217/ije-2017-0005","url":null,"abstract":"<p><strong>Aim: </strong>The study's aim was to determine the utility of 68-Gallium DOTATATE positron emission tomography (PET)-CT scanning in patients with carcinoid-like symptoms and negative anatomical imaging.</p><p><strong>Methods: </strong>Retrospective analysis of 22 of 196 patients with carcinoid-like symptoms and no evidence of primary neuroendocrine tumor (NET) based on anatomical imaging and endoscopy who underwent 68-Gallium DOTATATE PET-CT as part of a prospective clinical trial.</p><p><strong>Results: </strong>Of the biochemically positive patients (n = 11), 18% (n = 2) had additional evidence of NETs based on 68-Gallium DOTATATE PET-CT. Of the patients identified by 68-Gallium DOTATATE PET-CT, 50% (n = 1) had a treatment change and 100% showed symptom improvement. Of the biochemically negative patients (n = 11), 68-Gallium DOTATATE PET-CT identified NETs in 64% (n = 7). Change in management occurred in 71% patients, and 57% of patients showed symptom improvement.</p><p><strong>Conclusion: </strong>68-Gallium DOTATATE PET-CT imaging is useful in detecting NETs in symptomatic patients with negative anatomical imaging and changes the treatments in these patients.</p>","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/ije-2017-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36401644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Endoscopic thyroid surgery requires surgeons, patient candidacy & neural monitoring 甲状腺内窥镜手术需要外科医生、患者资格和神经监测
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-02-01 DOI: 10.2217/IJE-2018-0001
Hui Sun, G. Dionigi
{"title":"Endoscopic thyroid surgery requires surgeons, patient candidacy & neural monitoring","authors":"Hui Sun, G. Dionigi","doi":"10.2217/IJE-2018-0001","DOIUrl":"https://doi.org/10.2217/IJE-2018-0001","url":null,"abstract":"“ Surgeons cannot apply a new approach without a perfect grasp of the laryngeal nerves [7] . This would be in contrast with commonly performed routine, conventional surgery.","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2018-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42112308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Exploiting RET isoforms in managing medullary and papillary thyroid cancer 利用RET异构体治疗甲状腺髓质和乳头状癌症
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-02-01 DOI: 10.2217/IJE-2017-0029
Eric Y. Lian, S. Moodley, L. Mulligan
{"title":"Exploiting RET isoforms in managing medullary and papillary thyroid cancer","authors":"Eric Y. Lian, S. Moodley, L. Mulligan","doi":"10.2217/IJE-2017-0029","DOIUrl":"https://doi.org/10.2217/IJE-2017-0029","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49463171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Current and future treatments for parathyroid carcinoma 甲状旁腺癌的当前和未来治疗
IF 1.2
International Journal of Endocrine Oncology Pub Date : 2018-02-01 DOI: 10.2217/IJE-2017-0011
Kristin L. Long, R. Sippel
{"title":"Current and future treatments for parathyroid carcinoma","authors":"Kristin L. Long, R. Sippel","doi":"10.2217/IJE-2017-0011","DOIUrl":"https://doi.org/10.2217/IJE-2017-0011","url":null,"abstract":"","PeriodicalId":42691,"journal":{"name":"International Journal of Endocrine Oncology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/IJE-2017-0011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48337118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
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