间变性和低分化甲状腺癌症的溶瘤病毒治疗：前景还是临床现实？

IF 1.2

International Journal of Endocrine Oncology Pub Date : 2018-11-01 DOI:10.2217/IJE-2017-0028

C. Passaro, S. D. Somma, A. Malfitano, G. Portella

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引用次数: 1

摘要

溶瘤病毒（OVs）选择性地感染和裂解癌症细胞。OVs的直接裂解作用在最初的研究中已被理论化；然而，OVs的抗肿瘤作用也是由于对癌症细胞的免疫反应的诱导。无定形甲状腺癌症是人类最具侵袭性的恶性肿瘤之一，从诊断到存活时间短约6-12个月。缺乏有效的治疗方法促使人们研究OVs在间变性甲状腺癌中的疗效。不同的OV已经在临床前研究中进行了测试，无论是作为单一药物还是组合治疗。在这篇综述中，对这些研究的结果进行了总结，并对未来的发展前景进行了展望。

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Oncolytic virotherapy for anaplastic and poorly differentiated thyroid cancer: a promise or a clinical reality?

Oncolytic viruses (OVs) selectively infect and lyse cancer cells. A direct lytic effect of OVs has been theorized in the initial studies; however, the antineoplastic effect of OVs is also due to the induction of an immune response against cancer cells. Anaplastic thyroid cancer is one of the most aggressive human malignancies with a short survival time of about 6–12 months from the diagnosis. The lack of effective therapies has prompted to investigate the efficacy of OVs in anaplastic thyroid carcinoma. Different OVs have been tested in preclinical studies, either as single agents or in combinatorial treatments. In this review, the results of these studies are summarized and future perspective discussed.

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来源期刊

International Journal of Endocrine Oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.