卵巢成人型颗粒细胞瘤：基于内分泌的治疗

IF 1.2

International Journal of Endocrine Oncology Pub Date : 2018-05-01 DOI:10.2217/IJE-2017-0021

Annie Yang, J. Curtin, F. Muggia

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引用次数: 12

摘要

•FOXL2突变是诊断性的，如果病理有疑问，应该进行检查。•手术切除和分期是评估预后的关键。•以铂为基础的辅助化疗，如卡铂加紫杉醇，是诊断为远处复发或预后不良的初始特征的妇女的合理步骤。然而，缺乏改善结果的证据。•以激素为基础的治疗，特别是芳香化酶抑制剂，已经显示出活性，未来的研究可能会进一步了解激素途径抑制与肿瘤进展的关系。

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Ovarian adult-type granulosa cell tumor: focusing on endocrine-based therapies

• FOXL2 mutation is diagnostic, and, if pathology is in doubt, it should be performed. • Surgical resection and staging is key to assess prognosis. • Platinum-based adjuvant chemotherapy such as with carboplatin plus paclitaxel is a reasonable step for women diagnosed with distant recurrences or poor prognostic initial features. However, evidence for improved outcome is lacking. • Hormone-based therapies, especially with aromatase inhibitors, have shown activity and future studies may lead to further insight on the relationship of inhibition of hormonal pathways and tumor progression.

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来源期刊

International Journal of Endocrine Oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.