Ovarian adult-type granulosa cell tumor: focusing on endocrine-based therapies

Abstract

• FOXL2 mutation is diagnostic, and, if pathology is in doubt, it should be performed. • Surgical resection and staging is key to assess prognosis. • Platinum-based adjuvant chemotherapy such as with carboplatin plus paclitaxel is a reasonable step for women diagnosed with distant recurrences or poor prognostic initial features. However, evidence for improved outcome is lacking. • Hormone-based therapies, especially with aromatase inhibitors, have shown activity and future studies may lead to further insight on the relationship of inhibition of hormonal pathways and tumor progression.