Precision and Future Medicine最新文献_第2页

Pyogenic liver abscess as an extra-intestinal manifestation of pediatric Crohn’s disease 化脓性肝脓肿作为儿童克罗恩病的肠外表现

Precision and Future Medicine Pub Date : 2023-11-03 DOI: 10.23838/pfm.2023.00135

Ju Yeon Bae, Hansol Kim, Seon Young Kim, So Yeong Yoo, Tae Yeon Jeon, Inwoo Hwang, Soomin Ahn, Yon Ho Choe, Mi Jin Kim, Yoon Zi Kim

引用次数: 0

Co-occurrence of leukemia, Crohn’s disease, and tuberous sclerosis in one patient 白血病、克罗恩病和结节性硬化症同时发生于一名患者

Precision and Future Medicine Pub Date : 2023-11-02 DOI: 10.23838/pfm.2023.00128

Yoon Ji Ahn, Dasom Park, Mi Jin Kim, Yon Ho Choe, Youngse Kwon, Yiyoung Kwon

引用次数: 0

Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review 长骨生长和软骨细胞调控的分子机制:综述

Precision and Future Medicine Pub Date : 2023-09-30 DOI: 10.23838/pfm.2023.00100

Eungu Kang

{"title":"Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review","authors":"Eungu Kang","doi":"10.23838/pfm.2023.00100","DOIUrl":"https://doi.org/10.23838/pfm.2023.00100","url":null,"abstract":"Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. This review provides an overview of the structural aspects of the growth plate, factors influencing chondrocyte function, and their impact on longitudinal bone growth. Systemic factors, including growth hormone, sex hormones, thyroid hormone, glucocorticoids, leptin, and insulin significantly affect chondrocyte proliferation and hypertrophy. Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. These factors regulate gene expression, cell differentiation, and extracellular matrix synthesis. Additionally, Indian hedgehog (Ihh) and C-type natriuretic peptide (CNP) are involved in the complex signaling network governing chondrocyte function. Understanding molecular mechanisms underlying normal growth plate function has provided valuable insights into the genetic defects that impact growth and foundation for the development of effective therapeutic strategies for individuals with growth disorders.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review 牙周病和双相情感障碍之间的联系:治疗干预的意义:一篇叙述性综述

Precision and Future Medicine Pub Date : 2023-09-30 DOI: 10.23838/pfm.2023.00086

Ji Hyun Baek, Sun Jae Jung, Amy Peters, Alpdogan Kantarci, Andrew A. Nierenberg

{"title":"Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review","authors":"Ji Hyun Baek, Sun Jae Jung, Amy Peters, Alpdogan Kantarci, Andrew A. Nierenberg","doi":"10.23838/pfm.2023.00086","DOIUrl":"https://doi.org/10.23838/pfm.2023.00086","url":null,"abstract":"Chronic low-grade inflammation plays a role in the pathophysiology of bipolar disorder. Recent studies have shown that periodontitis can affect the central nervous system by activating inflammatory mediators in the brain. However, only a few studies have examined the association between periodontitis and bipolar disorder. Here, we aimed to review the current evidence on the association between periodontal diseases and bipolar disorder, its potential mechanisms, and future research directions. Studies so far suggested that periodontal diseases were more common in patients with bipolar disorder than in the general population. Patients with bipolar disorder generally have poor oral hygiene owing to poor self-care, smoking, alcohol abuse, and the effects of psychotropic medications. Proposed mechanisms underlying this association include the effects of inflammatory mediators, direct invasion of oral microbiota, modulation of the neurotransmitter system, and impact on the vagus nerve and hypothalamus-pituitary- adrenal axis. Additional clinical studies examining the prevalence of periodontal diseases and their association with the clinical features of bipolar disorder are necessary. Clinical studies targeting the treatment of periodontal diseases for primary or secondary prevention of bipolar disorder are warranted.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rigid bronchoscopic intervention for malignant central airway obstruction: A narrative review 硬支气管镜介入治疗恶性中央气道阻塞:综述

Precision and Future Medicine Pub Date : 2023-09-30 DOI: 10.23838/pfm.2023.00072

Byeong-Ho Jeong, Hojoong Kim

引用次数: 0

Prader-Willi syndrome and growth hormone therapy: exploring the precise management of hypothalamic short stature: A review prander - willi综合征和生长激素治疗:探索下丘脑身材矮小的精确管理:综述

Precision and Future Medicine Pub Date : 2023-09-30 DOI: 10.23838/pfm.2023.00079

Aram Yang

引用次数: 0

Added values of transrectal ultrasonography to magnetic resonance imaging in characterizing prostate cancer: A narrative review 经直肠超声对磁共振成像诊断前列腺癌的附加价值:述评

Precision and Future Medicine Pub Date : 2023-09-30 DOI: 10.23838/pfm.2023.00107

Byung Kwan Park

引用次数: 0

A novel etiological classification in patients with intracranial large vessel occlusion and endovascular treatment: discordance with the classic and SSS TOAST systems: A retrospective cohort study 颅内大血管闭塞和血管内治疗患者的一种新的病因分类:与经典和SSS TOAST系统不一致:一项回顾性队列研究

IF 0.5

Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00065

Min Kim, Seong-Joon Lee, So-Young Park, Jiman Hong, J. S. Lee

{"title":"A novel etiological classification in patients with intracranial large vessel occlusion and endovascular treatment: discordance with the classic and SSS TOAST systems: A retrospective cohort study","authors":"Min Kim, Seong-Joon Lee, So-Young Park, Jiman Hong, J. S. Lee","doi":"10.23838/pfm.2023.00065","DOIUrl":"https://doi.org/10.23838/pfm.2023.00065","url":null,"abstract":"Purpose: Among patients with acute ischemic stroke (AIS), those with intracranial large vessel occlusion (LVO) should undertake endovascular treatment (EVT) based on mechanical thrombectomy. Although the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system has been used in overall population of patients with AIS, especially for secondary prevention. In the current study, a new classification system for the LVO population is proposed.Methods: The classic TOAST and Stop Stroke Study TOAST (SSS TOAST) were applied to the LVO population. Based on discordance with those systems, a new LVO classification system was developed and applied to the LVO population. The new system comprised extracranial atherosclerosis (ECAS), intracranial atherosclerosis (ICAS), cardioembolism (CE), cryptogenic embolism, stroke of undetermined etiology (SUE; two or more etiologies), and stroke of other determined etiology (SOE) where small artery occlusion was removed.Results: The LVO classification system comprised 43 ECAS (6.52%), 141 ICAS (21.36%), 303 CE (45.91%), 75 cryptogenic embolism (11.36%), 75 SUE (11.36%; cardioembolic source in 98.67%), and 23 SOE (3.48%) patients. The ICAS group had a significantly longer median onset-to-puncture time than the other groups. In the ICAS group, 102 of 141 (72.34%) remained partial recanalization after EVT.Conclusion: The LVO classification system differentiating ECAS and ICAS in patients with large artery atherosclerosis and classifying cryptogenic embolism is more suitable for patients with EVT for intracranial LVO. Further studies for predicting underlying ICAS and planning treatment strategy should be performed.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47870807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and test indications of 11,087 patients undergoing cardiac magnetic resonance imaging during a decade in a tertiary referral center: A retrospective observational study 十年来在三级转诊中心接受心脏磁共振成像的11087例患者的临床特征和检查指征:一项回顾性观察研究

IF 0.5

Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00023

S. Jang, Junghyun Kim, Yiseul Kim, Young Ae Chang, W. Jung, Hwang Og Kim, K. Yoo, Eun Kyoung Kim, Sung‐A Chang, Sung-Ji Park, S. Park, Duk-Kyung Kim, S. Kim, J. Huh, Jinyoung Song, I. Kang, S. Cho, J. Oh, Sang-Chol Lee, Yeonhyeon Choe

{"title":"Clinical features and test indications of 11,087 patients undergoing cardiac magnetic resonance imaging during a decade in a tertiary referral center: A retrospective observational study","authors":"S. Jang, Junghyun Kim, Yiseul Kim, Young Ae Chang, W. Jung, Hwang Og Kim, K. Yoo, Eun Kyoung Kim, Sung‐A Chang, Sung-Ji Park, S. Park, Duk-Kyung Kim, S. Kim, J. Huh, Jinyoung Song, I. Kang, S. Cho, J. Oh, Sang-Chol Lee, Yeonhyeon Choe","doi":"10.23838/pfm.2023.00023","DOIUrl":"https://doi.org/10.23838/pfm.2023.00023","url":null,"abstract":"Purpose: We evaluated the clinical characteristics of patients undergoing cardiac magnetic resonance (CMR) examinations over 10 years at a tertiary referral hospital.Methods: This retrospective study included 11,087 CMR examinations performed between November 2009 and September 2020. The number of adults aged ≥20 years was 10,648 (72.8% males). A total of 439 children or young adults aged < 20 years underwent CMR (66.5% males). Indications for CMR examinations were classified according to the Consensus Panel recommendations of the Society for Cardiovascular Magnetic Resonance (SCMR).Results: The mean age was 55.9±12.4 years for adults. Forty percent of patients were obese. Leading cardiovascular risk factors were hypertension, dyslipidemia, diabetes mellitus, and current smoking status in 28.2%, 19.1%, 13.8%, and 25.4% of patients, respectively. The proportion of stress CMR examinations performed was 57.2%. For children, the mean age was 12.6±5.3 years. Most children underwent a non-stress CMR test. In adults without congenital heart disease, indication numbers for SCMR classes were 5,682 for class I (49.4%), 772 for class II (6.7%), 313 for class III (0.3%), and 4,714 for investigational group (41.1%). In pediatric patients and adults with congenital heart disease, indication numbers for SCMR classes were 539 for class I (80.3%), 62 for class II (9.2%), and 70 for the investigational group (10.4%).Conclusion: CMR is most commonly performed in men in their 50s or 60s. CMR may be used as the first-line imaging technique (SCMR class I) in around a half of adult patients and in most pediatric patients.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45782908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of survival outcomes between de novo and recurrent stage IV gastric cancers: A retrospective cohort study 一项回顾性队列研究:新生期和复发期胃癌的生存结局比较

IF 0.5

Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00051

J. Ji, Kwang Min Kim, B. Kwan, Sung Kim, Y. S. Kim, Seong Hee Choi, M. H. Jin, B. Ha, Jinah Kim, Jeff Liang, N. Kim, Daniela Lee, J. D. Yang

{"title":"Comparison of survival outcomes between de novo and recurrent stage IV gastric cancers: A retrospective cohort study","authors":"J. Ji, Kwang Min Kim, B. Kwan, Sung Kim, Y. S. Kim, Seong Hee Choi, M. H. Jin, B. Ha, Jinah Kim, Jeff Liang, N. Kim, Daniela Lee, J. D. Yang","doi":"10.23838/pfm.2023.00051","DOIUrl":"https://doi.org/10.23838/pfm.2023.00051","url":null,"abstract":"Purpose: This study analyzes the characteristics and prognosis of patients with de novo and recurrent metastatic gastric cancers.Methods: This retrospective study included 301 advanced, pathologically confirmed gastric cancer patients who received palliative chemotherapy between 2012 and 2022. The de novo cohort included patients who presented with distant metastasis at diagnosis, and the recurrent metastatic cohort was composed of patients with metastasis after curative gastrectomy. We analyzed prognostic association by Cox regression and compared survival time of both cohorts using the Kaplan-Meier survival analysis.Results: The study included 167 de novo and 112 recurrent patients. No differences were noted among the patients with de novo disease and recurrent metastatic disease concerning age, sex, Eastern Cooperative Oncology Group scores, primary cancer location, and pathologic features. Patients in the recurrent group versus the de novo group had a longer duration of chemotherapy (1.16±1.18 years vs. 0.85±0.84 years, P= 0.01) and lower mean body mass index (20.22±2.78 kg/m2 vs. 21.93±3.38 kg/m2, P< 0.001). The median overall survival in the de novo group was 11.6 versus 14.4 months in the recurrent group (P= 0.02).Conclusion: De novo and recurrent metastatic gastric cancer are characterized by distinct subpopulations. Advanced gastric cancer patients with recurrence have significantly better survival versus those in the de novo cohort. The differences between de novo and recurrent gastric cancer patient outcomes could facilitate discussions about the selection of the clinical trial of each patient and help with their personalized treatment.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42688199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0