Precision and Future Medicine最新文献_第2页

Comparison of survival outcomes between de novo and recurrent stage IV gastric cancers: A retrospective cohort study 一项回顾性队列研究:新生期和复发期胃癌的生存结局比较

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Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00051

J. Ji, Kwang Min Kim, B. Kwan, Sung Kim, Y. S. Kim, Seong Hee Choi, M. H. Jin, B. Ha, Jinah Kim, Jeff Liang, N. Kim, Daniela Lee, J. D. Yang

{"title":"Comparison of survival outcomes between de novo and recurrent stage IV gastric cancers: A retrospective cohort study","authors":"J. Ji, Kwang Min Kim, B. Kwan, Sung Kim, Y. S. Kim, Seong Hee Choi, M. H. Jin, B. Ha, Jinah Kim, Jeff Liang, N. Kim, Daniela Lee, J. D. Yang","doi":"10.23838/pfm.2023.00051","DOIUrl":"https://doi.org/10.23838/pfm.2023.00051","url":null,"abstract":"Purpose: This study analyzes the characteristics and prognosis of patients with de novo and recurrent metastatic gastric cancers.Methods: This retrospective study included 301 advanced, pathologically confirmed gastric cancer patients who received palliative chemotherapy between 2012 and 2022. The de novo cohort included patients who presented with distant metastasis at diagnosis, and the recurrent metastatic cohort was composed of patients with metastasis after curative gastrectomy. We analyzed prognostic association by Cox regression and compared survival time of both cohorts using the Kaplan-Meier survival analysis.Results: The study included 167 de novo and 112 recurrent patients. No differences were noted among the patients with de novo disease and recurrent metastatic disease concerning age, sex, Eastern Cooperative Oncology Group scores, primary cancer location, and pathologic features. Patients in the recurrent group versus the de novo group had a longer duration of chemotherapy (1.16±1.18 years vs. 0.85±0.84 years, P= 0.01) and lower mean body mass index (20.22±2.78 kg/m2 vs. 21.93±3.38 kg/m2, P< 0.001). The median overall survival in the de novo group was 11.6 versus 14.4 months in the recurrent group (P= 0.02).Conclusion: De novo and recurrent metastatic gastric cancer are characterized by distinct subpopulations. Advanced gastric cancer patients with recurrence have significantly better survival versus those in the de novo cohort. The differences between de novo and recurrent gastric cancer patient outcomes could facilitate discussions about the selection of the clinical trial of each patient and help with their personalized treatment.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42688199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report of trans-renal ablation procedures for a recurrent pheochromocytoma in von Hippel-Lindau disease 经肾消融术治疗希佩尔-林道病复发性嗜铬细胞瘤病例报告

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Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00058

B. K. Park

{"title":"Case report of trans-renal ablation procedures for a recurrent pheochromocytoma in von Hippel-Lindau disease","authors":"B. K. Park","doi":"10.23838/pfm.2023.00058","DOIUrl":"https://doi.org/10.23838/pfm.2023.00058","url":null,"abstract":"Pheochromocytoma is one of recurrent tumors in patients with von Hippel-Lindau (VHL) disease. For patients with bilateral adrenal glands, unilateral adrenalectomy is the treatment of choice; however, for patients with a single adrenal gland, hemiadrenalectomy or tumorectomy can be performed instead of adrenalectomy to preserve adrenal function. Currently, adrenalectomy is recommended even if recurrent pheochromocytomas occur in the residual adrenal tissue. Consequently, adrenal insufficiency cannot be avoided in these patients. Percutaneous radiofrequency ablation (RFA) is used as an alternative treatment for preserving adrenal function; however, RFA is difficult to perform when major organs are present in the approaching pathway. The trans-hepatic approach is the only reported safe route to approach a right adrenal tumor to avoid pneumothorax. In this case report, we performed percutaneous RFA and hydrodissection through the left renal parenchyma to treat a recurrent pheochromocytoma in the small residual left adrenal tissue, which is surrounded by several critical organs. Our goal was to show our experience of image-guided trans-renal RFA and hydrodissection in a patient with VHL disease.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41576254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and test indications of 11,087 patients undergoing cardiac magnetic resonance imaging during a decade in a tertiary referral center: A retrospective observational study 十年来在三级转诊中心接受心脏磁共振成像的11087例患者的临床特征和检查指征:一项回顾性观察研究

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Precision and Future Medicine Pub Date : 2023-06-30 DOI: 10.23838/pfm.2023.00023

S. Jang, Junghyun Kim, Yiseul Kim, Young Ae Chang, W. Jung, Hwang Og Kim, K. Yoo, Eun Kyoung Kim, Sung‐A Chang, Sung-Ji Park, S. Park, Duk-Kyung Kim, S. Kim, J. Huh, Jinyoung Song, I. Kang, S. Cho, J. Oh, Sang-Chol Lee, Yeonhyeon Choe

{"title":"Clinical features and test indications of 11,087 patients undergoing cardiac magnetic resonance imaging during a decade in a tertiary referral center: A retrospective observational study","authors":"S. Jang, Junghyun Kim, Yiseul Kim, Young Ae Chang, W. Jung, Hwang Og Kim, K. Yoo, Eun Kyoung Kim, Sung‐A Chang, Sung-Ji Park, S. Park, Duk-Kyung Kim, S. Kim, J. Huh, Jinyoung Song, I. Kang, S. Cho, J. Oh, Sang-Chol Lee, Yeonhyeon Choe","doi":"10.23838/pfm.2023.00023","DOIUrl":"https://doi.org/10.23838/pfm.2023.00023","url":null,"abstract":"Purpose: We evaluated the clinical characteristics of patients undergoing cardiac magnetic resonance (CMR) examinations over 10 years at a tertiary referral hospital.Methods: This retrospective study included 11,087 CMR examinations performed between November 2009 and September 2020. The number of adults aged ≥20 years was 10,648 (72.8% males). A total of 439 children or young adults aged < 20 years underwent CMR (66.5% males). Indications for CMR examinations were classified according to the Consensus Panel recommendations of the Society for Cardiovascular Magnetic Resonance (SCMR).Results: The mean age was 55.9±12.4 years for adults. Forty percent of patients were obese. Leading cardiovascular risk factors were hypertension, dyslipidemia, diabetes mellitus, and current smoking status in 28.2%, 19.1%, 13.8%, and 25.4% of patients, respectively. The proportion of stress CMR examinations performed was 57.2%. For children, the mean age was 12.6±5.3 years. Most children underwent a non-stress CMR test. In adults without congenital heart disease, indication numbers for SCMR classes were 5,682 for class I (49.4%), 772 for class II (6.7%), 313 for class III (0.3%), and 4,714 for investigational group (41.1%). In pediatric patients and adults with congenital heart disease, indication numbers for SCMR classes were 539 for class I (80.3%), 62 for class II (9.2%), and 70 for the investigational group (10.4%).Conclusion: CMR is most commonly performed in men in their 50s or 60s. CMR may be used as the first-line imaging technique (SCMR class I) in around a half of adult patients and in most pediatric patients.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45782908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of renal artery ultrasound for detecting stenosis or obstruction A narrative review 肾动脉超声检查狭窄或梗阻的应用综述

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Precision and Future Medicine Pub Date : 2023-04-07 DOI: 10.23838/pfm.2023.00009

B. K. Park

引用次数: 0

Angiogenesis effect of udenafil in a caveolin-1 deficient moyamoya disease model: A pre-clinical animal study 乌地那非对caveolin-1缺陷型烟雾病模型血管生成作用的临床前动物研究

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Precision and Future Medicine Pub Date : 2023-03-31 DOI: 10.23838/pfm.2022.00135

Dong Hee Kim, Jeong Pyo Son, Y. Cho, Eun Hee Kim, Gyeong Joon Moon, Oh Young Bang

{"title":"Angiogenesis effect of udenafil in a caveolin-1 deficient moyamoya disease model: A pre-clinical animal study","authors":"Dong Hee Kim, Jeong Pyo Son, Y. Cho, Eun Hee Kim, Gyeong Joon Moon, Oh Young Bang","doi":"10.23838/pfm.2022.00135","DOIUrl":"https://doi.org/10.23838/pfm.2022.00135","url":null,"abstract":"Purpose: Although pathogenic mechanisms of moyamoya disease (MMD) remain unknown, recent studies suggest that it is a caveolae disease. This study evaluated the effect of udenafil, a phosphodiesterase-5 inhibitor, on angiogenesis in in vitro and in vivo MMD models.Methods: Angiogenesis and vessel maturation were assessed in in vitro models, caveolin- 1 (Cav-1) knockdown human umbilical vessel endothelial cells (HUVECs) and coronary artery smooth muscle cells (CASMCs), and in in vivo model of bilateral internal carotid artery occlusion (bICAo). Udenafil was administered (1,3,10, and 30 μM) in cell culture conditions, and functional studies (migration and tube formation assay) were performed and vessel maturation factors and cyclic guanosine monophosphate (cGMP) accumulation were measured.Results: Udenafil (3 and 10 mg/kg) was orally administered once daily for 4 weeks in bICAo rat model, and histological analysis for angiogenesis and vessel maturation was performed. Udenafil increased vessel formation in both Cav-1 knockdown HUVEC and bICAo models without increased migration/proliferation of HUVECs and CASMCs. Udenafil increased CD31+ vessel density and NG2/Col4+ mural cell density in bICAo models. Cav-1 knockdown inhibited accumulation of cGMP, and udenafil treatment restored cGMP levels in Cav-1 knockdown HUVEC models. Vessel maturation factors (angiopoietin- 1 and platelet-derived growth factor receptor-β) and angiogenic factors (endothelial nitric oxide synthase) were increased after treatment with udenafil in vitro.Conclusion: Our results indicate that udenafil reversed cellular levels of cGMP related to Cav-1 deficiency and induced angiogenesis and vessel maturation. Further studies are warranted to confirm the therapeutic effects of this strategy in MMD.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44587108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signatory metabolomics biomarkers of stress, anxiety, and depression: a proof of concept for precision health among university students: A cross-sectional study 压力、焦虑和抑郁的标志性代谢组学生物标志物:大学生精确健康概念的证明:一项横断面研究

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Precision and Future Medicine Pub Date : 2023-03-31 DOI: 10.23838/pfm.2022.00128

Nur Izzati Umar Zaman, T. L. Kek, Rohana Ahmad, Mohd Nur Fakhruzzaman Noorizhab, M. Rofiee, R. James, N. M. Nor, Mawarni Mohamed, Teoh Sian Hoon, P. Singh, R. Janor, S. H. A. Bakar, M. Z. Salleh

{"title":"Signatory metabolomics biomarkers of stress, anxiety, and depression: a proof of concept for precision health among university students: A cross-sectional study","authors":"Nur Izzati Umar Zaman, T. L. Kek, Rohana Ahmad, Mohd Nur Fakhruzzaman Noorizhab, M. Rofiee, R. James, N. M. Nor, Mawarni Mohamed, Teoh Sian Hoon, P. Singh, R. Janor, S. H. A. Bakar, M. Z. Salleh","doi":"10.23838/pfm.2022.00128","DOIUrl":"https://doi.org/10.23838/pfm.2022.00128","url":null,"abstract":"Purpose: The highly competitive nature of tertiary education and the pressure to perform academically have increased psychological morbidity like emotional distress. Untargeted metabolomics was used to analyze serum samples of university students for biomarkers and perturbated metabolism due to stress, anxiety, and depression (SAD).Methods: Depression, Anxiety, Stress Scale 21 (DASS-21) was used to assess the severity of SAD in university students. The metabolite fingerprint of each subject was obtained using liquid chromatography-mass spectrometry quadrupole time-of-flight (LC/MS QTOF). The signature metabolites for each trait were determined by projections to latent structures discriminant analysis (PLS-DA) with variable importance for the projection (VIP) score > 1.0 (P<0.05) and subjected to analysis using the area under the receiver operating characteristic curve (AUROC). Potential biomarkers with an area under the curve (AUC) value exceeding 0.65 were identified.Results: Various groups of glycerophospholipids were upregulated in the studied traits. On the other hand, metabolites such as glycocholic acid was upregulated in depression, while hypoxanthine was upregulated in anxiety, and PE-Cer(d14:1(4E)/22:1(13Z)) was upregulated in stress.Conclusion: To our knowledge, this is the first study to assess the relationship of the differentially expressed metabolites in university students of different categories of SAD using the DASS-21 screening tool in Malaysia as we move forward with precision health.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43542235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stages of renal artery stenosis: a hypothesis based on ultrasound findings: A narrative review 肾动脉狭窄的分期：基于超声结果的假说：叙述性综述

IF 0.5

Precision and Future Medicine Pub Date : 2023-03-31 DOI: 10.23838/pfm.2022.00149

B. K. Park

引用次数: 0

Tau positron emission tomography in tauopathies: A narrative review Tau正电子发射断层扫描在Tau病中的应用：叙述性综述

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Precision and Future Medicine Pub Date : 2023-03-31 DOI: 10.23838/pfm.2023.00016

Hyunjong Lee, Yuna Gu, S. Seo, S. Moon

{"title":"Tau positron emission tomography in tauopathies: A narrative review","authors":"Hyunjong Lee, Yuna Gu, S. Seo, S. Moon","doi":"10.23838/pfm.2023.00016","DOIUrl":"https://doi.org/10.23838/pfm.2023.00016","url":null,"abstract":"Aggregation of misfolded tau in the brain is a major pathological feature common in various neurodegenerative disorders known as tauopathies, including Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, and dementia with Lewy bodies. Tauopathies are collection of diseases with varied overlapping symptoms and complicated manifestations. Consequently, it is crucial to be able to assess tau deposits in vivo. Over the past decade, tau-specific radioligands for positron emission tomography (PET) have been developed and tested, including first-generation compounds (e.g., 18F-THK5317, 18F-THK5351, 18F-AV1451, and 11C-PBB3) and second-generation compounds (18F-MK-6240, 18F-RO-948, and 18F-PI-2620). With the recent advances of tau PET tracers, assessing the pattern of tau deposition in vivo is possible. These methods will allow accurate diagnosis of tauopathies and monitoring of disease progression. In this mini review, we summarize current findings from studies using tau PET tracers regarding neuropathological characteristics, clinical implications, and potential applications of tau PET. We also discuss methodological considerations for appropriate use of these technologies and discuss what has been learned from these findings.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45057077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Message from the Precision and Future Medicine editors to our ad hoc reviewers Precision和Future Medicine编辑给我们的特别评审员的信息

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Precision and Future Medicine Pub Date : 2023-03-31 DOI: 10.23838/pfm.2023.00030

H. Jeon

引用次数: 0

Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study 配对活检中EGFR酪氨酸激酶抑制剂治疗的EGFR突变型癌症患者MET改变的评估：一项回顾性队列研究

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Precision and Future Medicine Pub Date : 2022-12-31 DOI: 10.23838/pfm.2022.00058

B. Ku, Sungwon Park, Sehhoon Park, H. Jung, Jong-Mu Sun, Se-Hoon Lee, J. Ahn, Yoon-La Choi, M. Ahn

{"title":"Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study","authors":"B. Ku, Sungwon Park, Sehhoon Park, H. Jung, Jong-Mu Sun, Se-Hoon Lee, J. Ahn, Yoon-La Choi, M. Ahn","doi":"10.23838/pfm.2022.00058","DOIUrl":"https://doi.org/10.23838/pfm.2022.00058","url":null,"abstract":"Purpose: Mesenchymal-epithelial transition tyrosine kinase receptor (MET) amplification is one of the common acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). To evaluate the usefulness of screening methods for MET status, we studied the impact of MET amplification or protein overexpression in EGFR-mutant non-small cell lung cancer patients who were treated with EGFR TKI.Methods: A total of 214 patients treated with EGFR TKI as first-line therapy with available tissue biopsy was analyzed. Paired biopsies were obtained from 111 patients at baseline and at onset of resistance. MET status was determined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).Results: Among 111 patients with paired samples, incidence of MET alteration was increased according to both MET overexpression by IHC (14.4% to 22.5%) and MET amplification by FISH (1.8% to 8.1%) with moderated to strong IHC intensity samples after EGFR TKI treatment. In patients treated with 1st-generation EGFR TKI, MET amplification by FISH was significantly related to shorter progression-free survival (P=0.04) and overall survival (P=0.01). In contrast, there was no difference in clinical outcomes according to MET intensity of IHC. Patients harboring MET amplification by FISH were associated with poor clinical outcomes compared to those with T790M mutation at progression.Conclusion: These results suggest that FISH is more informative than IHC for identification of patients with MET amplification as an EGFR TKI resistance mechanism. Given the poor outcome in patients who developed MET amplification, combinational trials with more active MET inhibitor are needed to overcome resistance.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46428670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0