发布求助
文献互助 智能选刊 最新文献

Precision and Future Medicine最新文献

筛选
英文 中文
Silent brain infarction: a quiet predictor of future stroke 无症状性脑梗死：未来中风的安静预测因素
IF 0.5
Precision and Future Medicine Pub Date : 2018-09-14 DOI: 10.23838/PFM.2018.00086
O. Bang
{"title":"Silent brain infarction: a quiet predictor of future stroke","authors":"O. Bang","doi":"10.23838/PFM.2018.00086","DOIUrl":"https://doi.org/10.23838/PFM.2018.00086","url":null,"abstract":"","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Current advances in combining stem cell and gene therapy for neurodegenerative diseases 干细胞与基因联合治疗神经退行性疾病的研究进展
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-29 DOI: 10.23838/PFM.2018.00037
Ji-Yoon Hwang, Jeong-Seob Won, Hyun Nam, H. Lee, K. Joo
{"title":"Current advances in combining stem cell and gene therapy for neurodegenerative diseases","authors":"Ji-Yoon Hwang, Jeong-Seob Won, Hyun Nam, H. Lee, K. Joo","doi":"10.23838/PFM.2018.00037","DOIUrl":"https://doi.org/10.23838/PFM.2018.00037","url":null,"abstract":"Neuronal death is the common final pathologic pathway of various neurodegenerative diseases (NDs). Although central nervous system has little regenerative potential, it is expected that damaged neural tissue can be recovered by exogenous supplementation of stem cells; however, stem cell therapy cannot modulate specific causes of NDs, such as accumulation of extracellular amyloid peptides in Alzheimer’s disease. In contrast, gene therapy can deliver therapeutic genes to specific ND targets. Therefore, combining stem cell and gene therapy would have dual treatment mechanisms (regenerating damaged neural tissue and modifying specific causes of NDs) and lead to better clinical outcomes. In this review, we discuss various therapeutic genes that can be used to develop stem cell gene therapy for various NDs and the techniques for how therapeutic genes can be integrated into stem cells.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48103314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neuropsychological test-based risk prediction of conversion to dementia in amnestic mild cognitive impairment patients: a personal view 基于神经心理学测试的健忘轻度认知障碍患者转化为痴呆的风险预测:个人观点
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-29 DOI: 10.23838/PFM.2018.00065
Jun Pyo Kim, Hye-ryeon Jang, Hee Jin Kim, D. Na, S. Seo
{"title":"Neuropsychological test-based risk prediction of conversion to dementia in amnestic mild cognitive impairment patients: a personal view","authors":"Jun Pyo Kim, Hye-ryeon Jang, Hee Jin Kim, D. Na, S. Seo","doi":"10.23838/PFM.2018.00065","DOIUrl":"https://doi.org/10.23838/PFM.2018.00065","url":null,"abstract":"The amnestic form of mild cognitive impairment (aMCI) is understood to be a prodromal state of Alzheimer’s disease dementia. As recent studies and clinical trials have started to focus on the early detection of and intervention for Alzheimer’s disease, aMCI has become an important area of study. Due to the heterogeneous clinical course of aMCI, it is often more challenging for a clinician to predict the prognosis of aMCI patients than of those with Alzheimer’s disease dementia patients. Therefore, the ability to predict the clinical course of an aMCI patient based on the patient’s clinical data is crucial in both clinical and research settings. In the current study, we present our findings on the structural and prognostic differences between aMCI and Alzheimer’s disease dementia according to neuropsychological test results. Additionally, we introduce a neuropsychological test-based risk prediction model of the conversion to dementia.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68884400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospects of deep learning for medical imaging 深度学习在医学成像中的应用前景
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-20 DOI: 10.23838/PFM.2018.00030
Jonghoon Kim, Jisu Hong, Hyunjin Park
{"title":"Prospects of deep learning for medical imaging","authors":"Jonghoon Kim, Jisu Hong, Hyunjin Park","doi":"10.23838/PFM.2018.00030","DOIUrl":"https://doi.org/10.23838/PFM.2018.00030","url":null,"abstract":"","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45222642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
FGFR3-TACC3: A novel gene fusion in malignant melanoma FGFR3-TACC3:恶性黑色素瘤中一种新的基因融合
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-20 DOI: 10.23838/PFM.2018.00044
J. Lee, Jeeyun Lee, S. Hong, K. Jang, Su Jin Lee
{"title":"FGFR3-TACC3: A novel gene fusion in malignant melanoma","authors":"J. Lee, Jeeyun Lee, S. Hong, K. Jang, Su Jin Lee","doi":"10.23838/PFM.2018.00044","DOIUrl":"https://doi.org/10.23838/PFM.2018.00044","url":null,"abstract":"Oncogenic gene fusions have been identified in many cancers, and many serve as druggable targets for therapy. Fibroblast growth factor receptor (FGFR) gene aberration is known to be associated with tumor progression and resistance to anticancer therapy. Here we report the first case of malignant melanoma harboring a FGFR3-TACC3 (transforming acidic coiled-coil containing protein 3) fusion, which appears to be a promising potential therapeutic target.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47828105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Stem cell therapy for stroke: lessons learned from recent successful randomized trials ofinterventional therapy for stroke 脑卒中的干细胞治疗：近期脑卒中介入治疗随机试验的成功经验
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-20 DOI: 10.23838/PFM.2018.00058
O. Bang
{"title":"Stem cell therapy for stroke: lessons learned from recent successful randomized trials of\u0000interventional therapy for stroke","authors":"O. Bang","doi":"10.23838/PFM.2018.00058","DOIUrl":"https://doi.org/10.23838/PFM.2018.00058","url":null,"abstract":"Cell-based therapy is a promising approach for treating acute stroke patients as well as those with fixed neurological deficits, and therefore, the number of stem cell trials conducted on stroke patients is increasing. However, more studies are needed to conclude the efficacy of stem cell therapy because while several studies showed a beneficial effect, there was significant bias in subsequent studies. Meanwhile, there have been recent advances in stroke treatment such as endovascular therapy for acute ischemic stroke and catheter-based closing of a patent foramen ovale in cryptogenic stroke. Clinical trials of the latter two interventional therapies have very similar histories of consistent success after repeated failures. In this review, the factors related to the success of these interventional therapies are discussed and applied to stem cell therapy for stroke patients. Through continued efforts, there is hope for success in stem cell therapy for stroke patients.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42259393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pulmonary sclerosing pneumocytoma with multiple satellite nodules mimicking tuberculosis 肺硬化性肺细胞瘤伴多个类似结核的卫星结节
IF 0.5
Precision and Future Medicine Pub Date : 2018-06-20 DOI: 10.23838/PFM.2018.00051
Min A Lee, Tae Jung Kim, Joungho Han, K. Lee
{"title":"Pulmonary sclerosing pneumocytoma with multiple satellite nodules mimicking tuberculosis","authors":"Min A Lee, Tae Jung Kim, Joungho Han, K. Lee","doi":"10.23838/PFM.2018.00051","DOIUrl":"https://doi.org/10.23838/PFM.2018.00051","url":null,"abstract":"Pulmonary sclerosing pneumocytoma is a rare, benign lung tumor commonly seen in women in the fifth decade of life. It usually manifests as a solitary, well-circumscribed juxtapleural nodule or mass with intense, homogeneous enhancement on computed tomography scans. Herein, we report a case of sclerosing pneumocytoma presenting as main nodule with satellite nodules, mimicking tuberculosis.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43735091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信