Research Reports in Clinical Cardiology最新文献

{"title":"QT Interval Prolongation Among Patients with Chronic Liver Disease Attending Jimma Medical Center Gastroenterology Clinic, Southwest Ethiopia","authors":"Tadelle Amanuel, Banjaw Zelalem","doi":"10.2147/rrcc.s345825","DOIUrl":"https://doi.org/10.2147/rrcc.s345825","url":null,"abstract":"","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45926449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Mutation in the TRPM4 Gene Associated with Congenital Long QT Syndrome: A Case Report","authors":"Rui Huang, Yi-bin Luo, Yuhua Lei, Yuanhong Li","doi":"10.2147/rrcc.s346943","DOIUrl":"https://doi.org/10.2147/rrcc.s346943","url":null,"abstract":": It is reported that the incidence of congenital long QT syndrome (cLQTS) is very low, with the incidence of LQTS caused by transient receptor potential melastatin 4 (TRPM4) being even lower, leading to less research on the gene TRPM4. We reported a case of an elderly male patient presenting with frequent syncopal episodes since the age of 20. Electrocardiography showed sinus bradycardia (mean heart rate 59 beats), prolonged QT interval (540ms), and torsade de pointes. His sister also had experienced an episode of syncope, but his other families had not. A novel mutation in the TRPM4 gene was discovered in this patient and his sister, according to genetic analysis. All in all, we provided a new heterozygous shift mutation (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) on TRPM4, which has never been reported in the past and thus may hopefully serve as useful feedback information for genetic pathogenesis of cLQTS caused by TRPM4 variants.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45424833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaggeration of Non-Culprit Coronary Artery Stenosis in the Setting of Primary Percutaneous Coronary Intervention: A Single Center Observational Study","authors":"Fahmi Othman, A. Abid, A. AlQahtani, A. Gehani, J. Al Suwaidi, A. Arabi","doi":"10.2147/rrcc.s280661","DOIUrl":"https://doi.org/10.2147/rrcc.s280661","url":null,"abstract":"Objective: We sought to evaluate if the non-culprit coronary artery stenosis severity is affected by primary percutaneous coronary intervention (PPCI) compared with non-PPCI settings. Methods: Review of all the PPCI angiograms was performed at our catheterization laboratory between 15th October 2013 and 15th October 2014. All patients with severe multi-vessel coronary artery disease (MV CAD) who underwent second angiograms (either during the same admission or after discharge) were analyzed. Non-culprit lesions in the PPCI and non-PPCI angiograms were compared. Two investigators blinded to the procedure dates analyzed the severity of the lesions using validated quantitative coronary angiography software (QCA). Results: Among 777 patients who underwent PPCI, 458 had multi-vessel disease. Additional angiography to treat non-culprit lesions was performed in 104, of these, 69 patients had a combined total of 74 lesions suitable for QCA analysis. The second angiogram was performed during the same admission (mean 4±2.7 days) and after discharge (mean 115±84 days) for 48 and 21 patients, respectively. Compared to PPCI angiograms, the non-PPCI angiograms showed a statistically significant reduction in the percentage of stenosis (71.6±14.4% vs 64.5±14.4%, p ≤0.001), and an increase in minimal luminal diameter (0.82±0.45 mm vs 1.00±0.44 mm, p ≤0.001) of non-culprit lesion. However, no significant difference was observed in the reference diameter (2.89±0.69 mm vs 2.83±0.64 mm, p =0.1) of the non-culprit lesion in both angiograms. Furthermore, these differences in the lesion parameters remain constant whether the second angiogram was performed during the same admission or performed after discharge (73.3±14% and 66.2±12.9% vs 68.4±15% and 61.2±16%, p =0.1). Conclusion: The severity of non-culprit lesion is exaggerated in the PPCI setting. The nonculprit lesion exaggeration remains constant whether the second angiogram was performed early within a few days or later after several weeks.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44271798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Young Male Patient with Subaortic Membranous Stenosis and Left Ventricular NonCompaction Cardiomyopathy: A Case Report","authors":"Said Abdirahman Ahmed, Mohamed Farah Yusuf Mohamud, Mohamed Abdullahi mohamud","doi":"10.2147/rrcc.s313151","DOIUrl":"https://doi.org/10.2147/rrcc.s313151","url":null,"abstract":": Left ventricular noncompaction cardiomyopathy (LVNC) is a relatively rare primary genetic cardiomyopathy and increased in the frequency of detection. LVNC is characterized by prominent wall trabeculations and intertrabecular recesses that communi-cate with the ventricular cavity. It could be in isolated form or coexists with other congenital heart diseases including valvular heart disease. The prevalence of adult LVNC ranges from 0.01% to 0.27%. This present case is a 19-year-old male patient who presents as a cardiology outpatient with progressive dyspnea for one month. Physical examination revealed tachycardia and third heart sound on auscultation. A complete left bundle branch block was detected on electrocardiography, and chest X-ray showed an enlarged cardiac shadow (cardiomegaly). Echocardiography revealed left ventricular systolic dysfunction (LVEF: 25%), a noncompact layer, hypertrabeculation, and subaortic membranous stenosis with P-mean of 32 mmHg. The patient had started heart failure management and scheduled cardiac resynchronization therapy (CRT) for life-saving and recommended to search for either left ventricular assist device (LVAD) or heart transplantation where he can. In conclusion, the symptoms of heart failure and cardiac arrhythmias should be considered significant in apparently healthy young patients. Besides, intensive medical treatment has indicated the implantation of cardiac resynchronization therapy (CRT) “life-saving” and advanced cases of heart transplantation.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44989656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Management, and Length of Hospital Stay Between Patients with New-Onset and Acute Decompensated Chronic Heart Failure: A Prospective Cohort Study in Ethiopia","authors":"Bekalu Kebede, Bekalu Dessie, Melese Getachew, Yalew Molla, Bereket Bahiru, Haile Amha","doi":"10.2147/rrcc.s337047","DOIUrl":"https://doi.org/10.2147/rrcc.s337047","url":null,"abstract":"Background: Because heart failure with de novo and acute decompensated chronic heart failure are different clinical entities, clinical characteristics, management, and length of hospital stay may also vary accordingly. Objective: To compare clinical characteristics, management, and length of hospital stay among adult heart failure patients with new-onset and acute decompensated chronic heart. Prospective cohort study was conducted from 01 November 2019 to 30 April 2021 at Debre Markos Comprehensive Specialized Hospital. A total of 228 heart failure patients who fulfill inclusion criteria were included in this study. A structured data collection tool was used to collect all necessary data. Data were analyzed using Statistical Package for Social Science (SPSS) version 21.0. Bivariate and multivariate logistic regression analyses were used and P-value, <0.05 was considered statistically significant. Results: Among the 228 participants, 126 (55.3%) were females with a mean age of 53.31 ± 15.68 years. Of the study participants, 131 (57.5%) were presented with acute decompensated chronic heart failure. The median length of hospital stay was 12 days (interquartile range, 8–18). De novo heart failure patients spent less time in hospital [11 days (interquartile range, 6–16) vs 13 days (interquartile range, 9–20) in acute decompensated chronic heart failure, P = 0.004]. Mean systolic blood pressure (P = 0.006), acute decompensated chronic heart failure (P < 0.000), diabetes mellitus comorbidity (P = 0.025), and the use of angiotensin receptor blockers (P = 0.042) were independent predictors of prolonged hospital stay. During hospitalization, digoxin (61.1%) was the most frequently prescribed in de novo heart failure while diuretics (63.3%) were the most common in acute decompensated chronic heart failure at discharge. Conclusion: Heart failure patients were presented with diverse clinical characteristics. Length of hospital stay was higher in patients with acute decompensated chronic heart failure. Initiation of treatment must take into account the heterogeneity of each patient. blood glucose; COPD, chronic obstructive pulmonary disease; IQR, interquartile range.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46036186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Modeling of Longitudinal Pulse Rate and Time-to-Default from Treatment of Congestive Heart Failure Patients","authors":"Yikeber Abebaw, K. Yusuf, Ademe Aragaw, Bezanesh Melese","doi":"10.2147/rrcc.s326229","DOIUrl":"https://doi.org/10.2147/rrcc.s326229","url":null,"abstract":"Background: Globally, heart failure is a rapidly growing public health problem with an estimated prevalence of >37.7 million. It is a shared chronic phase of cardiac functional loss secondary to many etiologies. Objective: The main purpose of this study was to investigate the risk of longitudinal change in pulse rate on time to default from treatment among congestive heart failure patients. Methods: Hospital-based retrospective studies were conducted among 302 congestive heart failure patients who were 15 years old or older and who were on treatment follow-up from the 1 February 2016 to 31 December 2018 in Felege-Hiwot Referral Hospital, Bahir Dar, Ethiopia. Data were entered using SPSS version 23 and analyzed using SAS and R software. First, data were analyzed using linear mixed model and survival models separately, and then the joint models of both sub-models were analyzed using joint model analysis. Results: Out of the total of 302 respondents, 34.1% of the respondents defaulted from treatment. About 55.2% male respondents are defaulting and the remaining were censored. The results for separate and joint models were quite similar to each other but not identical. However, the estimated association parameter (α) in the joint model is (HR = 1.0311, 95% CI: 1.0033, 1.0597, P = 0.0278), providing there is evidence of a positive significant relationship between the survival and the longitudinal sub-models. Thus, defaulting is more likely to occur in patients with higher pulse rates. A patient, who are male, New York Heart Association class IV, had low left ventricular ejection fraction and comorbid with hypertensive, chronic kidney disease, pneumonia were risk factors of pulse rate change and defaulting from treatment of congestive heart failure patients. Conclusion: The joint model was preferred for simultaneous analyses of repeated measurement and survival data. Thus, the longitudinal measure pulse rate had a positive significant effect on time to default from treatment of patients.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44236910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dasatinib-Induced Pulmonary Arterial Hypertension: A Case Report","authors":"Ru Liu, Yinjiang Tang, T. Fu, Jianli Zhou, Lijiao Ma, Jinqing Yuan, Ou Xu","doi":"10.2147/rrcc.s316980","DOIUrl":"https://doi.org/10.2147/rrcc.s316980","url":null,"abstract":"","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":"50 2","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41295736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Specificity of an Electrocardiogram to Detect Echocardiographic Left Ventricular Hypertrophy in a Sample of 326 Tanzanian Adults: Differences in Men and Women","authors":"P. Chillo","doi":"10.2147/RRCC.S313115","DOIUrl":"https://doi.org/10.2147/RRCC.S313115","url":null,"abstract":"","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47708732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Troponin-I Status of Type-2 Diabetic Patients on Anti-Diabetic Drugs Treatment at Jimma Medical Center, Jimma, Southwest Ethiopia","authors":"Alemayehu Babusha Wega, Endriyas Kelta Wabalo, Chala Kenenisa Edae, Gesese Bogale Awgichew","doi":"10.2147/rrcc.s313432","DOIUrl":"https://doi.org/10.2147/rrcc.s313432","url":null,"abstract":"","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45667355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery Rate and Predictors Among Patients with Acute Coronary Syndrome in Addis Ababa, Ethiopia: A Retrospective Cohort Study","authors":"Tigist Tsegaye, Teshome Gishu, Mekdes Hailegebriel Habte, Z. Bitew","doi":"10.2147/rrcc.s307151","DOIUrl":"https://doi.org/10.2147/rrcc.s307151","url":null,"abstract":"Background: Coronary artery disease (CAD) is the leading cause of mortality and morbidity in the world, including Ethiopia. Over seven million people die annually due to acute coronary syndrome (ACS) secondary to CAD. Despite this fact, studies are scant in Ethiopia. Objective: To determine recovery rate and predictors of time to recovery among ACS patients in St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia from October 2017 to October 2019. Methodology: A retrospective cohort study was conducted among ACS patients. Patient charts were reviewed using a structured checklist. The Kaplan–Meier survival curve was used to estimate the survival time. Log–log plots were used to check proportional hazard assumption among categorical predictors. Bivariable and multivariable Cox regression ana-lyses were performed to identify predictors of time to recovery. In bivariable analysis, variables with P ≤0.25 were fitted for multivariable Cox regression. Factors with P <0.05 in the multivariable Cox regression were independent predictors of time to recovery. Results: A total of 471 patient charts with a diagnosis of ACS were reviewed. The mean length of hospital stay was 2.98 ±1.30 days with a total follow-up time of 1397 person-days. The recovery rate was 61.8%. The incidence density rate of recovery was found to be 20.5 per 100 person-days. Percutaneous coronary intervention (PCI) (AHR = 2.08, 95% CI: 1.57, 2.74) and absence of major bleeding (AHR = 1.44, 95% CI: 1.11, 1.87) were predictors of time to recovery. Conclusion: In the current study, a considerable number of patients recovered within the first few days of admission. Absence of major bleeding and PCI were found to enhance early recovery of patients. Hence, early implementation of PCI and treatment of major bleeding may be vital to augment early recovery of patients with ACS. This can be achieved through involving case managers who can enhance the quality of treatment.","PeriodicalId":42306,"journal":{"name":"Research Reports in Clinical Cardiology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46908775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}