European Oral Research最新文献_第4页

Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis. (6)-shogaol 对实验性牙周炎牙槽骨流失的预防和治疗作用。

IF 1

European Oral Research Pub Date : 2024-01-05 DOI: 10.26650/eor.20241248958

Didem Bezirci, Meltem Karsiyaka Hendek, Gonen Ozcan, Oguz Kul, Tugce Anteplioglu, Ebru Olgun

{"title":"Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis.","authors":"Didem Bezirci, Meltem Karsiyaka Hendek, Gonen Ozcan, Oguz Kul, Tugce Anteplioglu, Ebru Olgun","doi":"10.26650/eor.20241248958","DOIUrl":"10.26650/eor.20241248958","url":null,"abstract":"Purpose: (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model.Materials and methods: Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-κB), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed.Results: Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively).Conclusion: The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}