European Oral Research最新文献

{"title":"The effect of manufacturing technique on marginal gap in inlay, onlay, veneer, and endocrown restorations: a systematic review and metaanalysis.","authors":"Osayd Alawawda, Ensar Binici, Ilgınsu Akıncı, Funda Bayindir","doi":"10.26650/eor.20261751100","DOIUrl":"https://doi.org/10.26650/eor.20261751100","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this systematic review and meta-analysis was to compare the marginal fit of indirect partial restorations, such as inlays, onlays, and endocrowns, fabricated using milling (subtractive manufacturing) and 3D printing (additive manufacturing) techniques.</p><p><strong>Materials and methods: </strong>This review was conducted according to the PRISMA guidelines and utilized the PICO framework to define the research question. A comprehensive literature search was performed on PubMed, Scopus, and Web of Science databases for studies published in English between January 1, 2015, and April 1, 2025. The search targeted studies that directly compared milled and 3D-printed indirect partial restorations and reported marginal gap values in a numerical format. Statistical analysis was performed using a random-effects model, and outcomes were synthesized using the Standardized Mean Difference (SMD) with 95% Confidence Intervals (CI).</p><p><strong>Results: </strong>A total of 16 studies, comprising 257 milled samples and 287 3D-printed samples, were included in the meta-analysis. The overall pooled analysis found no statistically significant difference in marginal gap values between milled and 3D-printed partial restorations (p = 0.62). However, subgroup analyses revealed varying trends. For occlusal veneers, milled restorations showed a smaller marginal gap than 3D-printed restorations; however, this difference was not statistically significant (SMD = -1.86, 95% CI: -18.24 to -14.53, p = 0.39). Conversely, inlays and onlays showed a non-significant trend favoring 3D printing (SMD = 0.87, 95% CI: -0.26 to 2.00, p = 0.11).</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis conclude that there is no overall statistically significant difference in marginal fit between milled and 3D-printed indirect partial restorations.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"176-184"},"PeriodicalIF":1.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the effect of using cavity disinfectant on microleakage in composite restorations by micro-CT analysis.","authors":"Burcu Kuş, Numan Aydın, Serpil Karaoğlanoğlu, Bilge Ersöz, Elif Aybala Oktay, Mert Ocak","doi":"10.26650/eor.20261456158","DOIUrl":"https://doi.org/10.26650/eor.20261456158","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to evaluate the effect of the use of cavity disinfectant on the amount of microleakage seen in composite restorations.</p><p><strong>Materials and methods: </strong>Forty caries-free permanent molars extracted due to periodontal or orthodontic problems were used in the study. Class II box cavities were prepared in the mesial and distal of teeth. Then, the teeth were divided into subgroups (n:10) according to the use of universal adhesive and cavity disinfectant. Chlorhexidine digluconate (2%) was used as a cavity disinfectant. In the prepared cavities, universal adhesives were used with total and self-etch modes and restored with posterior composite resin. After the restoration of the teeth was completed, 1000 thermal cycles were applied. Microleakage analysis was performed with a micro-computed tomography device after the teeth were soaked in silver nitrate solution for 24 hours. Two-way analysis of variance test was used in the analysis of microleakage data and Tukey test was used to show the differences between groups in multiple comparisons (p<0.05).</p><p><strong>Results: </strong>Application of universal adhesives to Class II cavities in self-etch mode caused more microleakage than total-etch mode (p<0.05). There was no statistically significant difference between the microleakage values of the universal adhesive (p>0.05). When universal adhesives are used with cavity disinfectants decreased the microleakage value in the self-etch mode (p<0.05), but it did not show a statistically significant decrease in the total etch mode.</p><p><strong>Conclusion: </strong>While the use of cavity disinfectant in teeth restored with composite resin reduces the amount of microleakage in the self-etch mode, the total etch mode does not affect the amount of microleakage.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"185-191"},"PeriodicalIF":1.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of orthognathic surgery planning with artificial intelligence: a prospective, comparative study.","authors":"Enes Temizkan, B Zeynep Yörük, Banu Kılıç","doi":"10.26650/eor.20261702936","DOIUrl":"10.26650/eor.20261702936","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the accuracy of cephalometric analyses performed by deep learning-based AI programs (NemoCeph 2D, OrthoDx, AudaxCeph, and WebCeph) by comparing their results with the gold standard measurements obtained from 3D CT scans in orthognathic surgery patients.</p><p><strong>Materials and methods: </strong>Orthognathic surgery candidates underwent pretreatment 3D CT scans. These scans were manually analyzed using 3D cephalometric software to establish gold-standard landmark positions. Two-dimensional cephalometric images were then derived from the 3D scans, and deep learning-based AI programs automatically identified the landmarks on these images. The AI-generated measurements were compared with the 3D gold standard, and the differences were analyzed statistically.</p><p><strong>Results: </strong>While the ANB angle showed no significant differences between the methods (p=0.061), other measurements-including SNA, SNB, Wits appraisal, Y Axis Angle, and various facial height ratios-showed significant discrepancies (p<0.05).</p><p><strong>Conclusion: </strong>AI-based cephalometric analyses showed notable errors compared with the 3D CT gold standard. These findings suggest that deep learning algorithms require further refinement before they can be reliably used for orthognathic surgery planning.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"169-175"},"PeriodicalIF":1.1,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial properties of nano-poly (d,l- lactic acid) [poly lactic acid] and zinc oxide nanofiller denture base resins: a systematic review and meta-analysis.","authors":"Nikita Parasrampuria, Gopi Chander, Dolanchanpa Dasgupta, Saurav Banerjee, Dipankar Pal","doi":"10.26650/eor.20251555692","DOIUrl":"https://doi.org/10.26650/eor.20251555692","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to evaluate the antimicrobial properties and mechanical performance of denture base resins incorporating nano-poly (D,L-lactic acid) (PLA) and zinc oxide (ZnO) nanofillers compared to conventional denture base materials.</p><p><strong>Materials and methods: </strong>A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, Cochrane Library, Embase, and Google Scholar for studies published between 2017 and 2024. The PICOS framework guided study selection:P: PMMAbased denture base resins; I: PLA/ZnO nanocomposite denture base resins; C: Conventional denture base resins; O: Antimicrobial efficacy, mechanical properties; S: Randomized controlled trials, cohort studies, case-control studies, and in vitro studies. Studies were screened according to PRISMA guidelines. Relevant data were extracted on study design, interventions, antimicrobial testing, microorganisms tested, mechanical outcomes, and biocompatibility. Quality was assessed using the QUIN tool, and risk of bias was evaluated for each domain.</p><p><strong>Results: </strong>From an initial 438 records, 11 studies met inclusion criteria and 8 were eligible for quantitative analysis. The included studies demonstrated that PLA/ZnO nanocomposites significantly reduced microbial growth and biofilm formation against common oral pathogens (Streptococcus mutans, Candida albicans, Escherichia coli). Higher ZnO concentrations correlated with larger inhibition zones and increased antibacterial efficacy. Mechanical properties, including flexural strength and impact strength, were notably improved in PLA/ZnO composites compared to conventional resins, with flexural strength values reaching up to 103.8 MPa. Biocompatibility assessments indicated minimal cytotoxicity and favourable tissue compatibility, with controlled degradation rates between 2-10% over six months. Quality assessment rated most studies as moderate to good quality, although some risk of bias was present.</p><p><strong>Conclusion: </strong>PLA/ZnO nanofiller denture base resins exhibit promising antimicrobial properties and enhanced mechanical performance compared to conventional materials. These findings support their potential for improving denture hygiene, durability, and patient outcomes. Further well-designed clinical trials are needed to confirm long-term safety and effectiveness.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"137-153"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of the 100 most cited articles on pulp vitality devices.","authors":"Kanamarlapudi Venkata Saikiran, Deepa Gurunathan, Sneha S Patil, Sivakumar Nuvvula, Sainath Reddy Elicherla, Niharika Reddy Elicherla","doi":"10.26650/eor.20251528914","DOIUrl":"10.26650/eor.20251528914","url":null,"abstract":"<p><strong>Purpose: </strong>Scientific articles have doubled in number during the past few years, and the number of publications has continuously increased over time. The purpose of this bibliometric analysis was to identify and analyse the top 100 most cited articles published on pulp vitality devices between 1965 and 2024.</p><p><strong>Materials and methods: </strong>The 100 most-cited scientific papers on pulp vitality devices were searched and analysed using Elsevier's Scopus database. The search used the keywords \"Dental Pulp Test,\" \"Pulp Vitality Testing,\" and \"Pulp Vitality Devices,\" with no restrictions on publication date, language, or status. A total of 1,005 articles were retrieved, and all were organized in descending order based on citation count. The articles were ordered in descending order depending on their citation counts after the screening procedure was completed by two independent reviewers. These papers were then cross matched with citations harvested from Google Scholar. The publications were examined, and data such as citation counts, citation density, publication year, authorship, contributing institutions, countries, article topic, study design and keywords were extracted. Using the Visualization of Similarities programme (VOSviewer, version 1.6.13; Leiden University Centre for Science and Technology Studies, Netherlands) collaboration networks were created between authors, nations, and keywords.</p><p><strong>Results: </strong>The literature search identified 1005 articles. Citation counts of the top 100 articles were selected. The most-cited article received 169 total citations in Scopus and 345 citations in Google Scholar. The years 1996 and 2002 had the highest number of publications among the top 100 articles (n = 6). The articles obtained in the search were published in 28 journals, with the Journal of Endodontics contributing the maximum number of articles (n = 31). 318 were the most frequently published authors. The 100 most cited articles on pulp vitality tests originated from 22 different countries. The most common keywords used were \"dental pulp test\", \"tooth pulp disease\", laser doppler flowmetry (LDF).</p><p><strong>Conclusion: </strong>This study illustrates the advancement, communication and research areas in the fields of pulp vitality devices, thereby predicting potential future research directions. The Journal of Endodontics, Oral Surgery, Oral Medicine, Oral Pathology, International Endodontic Journal, and Dental Traumatology were the four main journals in terms of production volume, USA being the most productive country. Among the most-cited articles, randomised clinical trials, systematic reviews, and meta-analyses were rare.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"122-129"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bruxism in children and adolescents with attention deficit hyperactivity disorder due to medication regimen: prevalence, correlates, and consequences a cross-sectional study.","authors":"Mahsa Zohdi, Seyed Gholamreza Noorazar, Katayoun Katebi, Milad Baseri, Neda Yasamineh","doi":"10.26650/eor.20251638869","DOIUrl":"https://doi.org/10.26650/eor.20251638869","url":null,"abstract":"<p><strong>Purpose: </strong>Individuals with Attention Deficit Hyperactivity Disorder (ADHD) exhibit more parafunctional habits such as bruxism. Common medications for ADHD include methylphenidate and atomoxetine. This study aimed to investigate the effects of these medications and the severity of ADHD on bruxism.</p><p><strong>Materials and methods: </strong>A total of 181 individuals aged 5-18 years with ADHD were divided into three groups: methylphenidate, atomoxetine, and drug-naïve. The Bruxism Checklist and the Conners' Questionnaire (for assessing ADHD severity) were completed for each participant. The chi-square test was used to compare the severity of bruxism with both ADHD severity and medication type. A one-way analysis of variance (ANOVA) was conducted to compare bruxism and ADHD scores among the medication groups. Data were analyzed using SPSS version 21.</p><p><strong>Results: </strong>Bruxism scores were higher in males, whereas ADHD scores did not differ significantly between males and females. Participants treated with methylphenidate had the highest mean bruxism scores. As ADHD severity increased, bruxism scores also increased. A statistically significant difference was found in mean ADHD scores across bruxism severity levels (P = 0.004). ADHD scores were significantly lower in the nonbruxism group compared to both the mild bruxism and the moderate-to-severe bruxism groups (p less than 0.05).</p><p><strong>Conclusion: </strong>The severity of bruxism in children with ADHD appears to be related to the severity of ADHD rather than the type of medication. Bruxism is more common in males. Management of bruxism in children with ADHD should adopt a multidisciplinary approach integrating pharmacological, behavioral, and dental strategies.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"154-161"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative pain and quality of life after sonic irrigation with Waterpik dental flosser home care device: a randomized clinical trial.","authors":"Nagamuni Keerthana Laddagiri, Swapna Sannapureddy, Kiranmayi Govula, Lavanya Anumula, Kowmudi Maddineni, Suneelkumar Chinni","doi":"10.26650/eor.20251709594","DOIUrl":"https://doi.org/10.26650/eor.20251709594","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effect of irrigation agitation on postoperative pain (PP) and oral health-related quality of life (OHQoL) in patients undergoing single-visit root canal therapy (RCT).</p><p><strong>Materials and methods: </strong>The study was a double-blind randomized clinical trial where a single-visit RCT was performed on forty patients diagnosed with symptomatic irreversible pulpitis in molars. The study participants were divided into two groups (n=20) based on the final irrigation protocol. Group 1- No agitation (NA), Group 2: Sonic agitation (SA). The pain scores were recorded using the Visual Analogue Rating scale (VAS) preoperatively and postoperative at 6, 12, 24, 48 and 72 hours. The OHQoL scores were recorded before and 72 hours after the treatment using the oral health impact profile (OHIP-14). Statistical analysis was performed for inter- and intra-group comparisons using Mann-Whitney U test and the Wilcoxon Signed Rank Test.</p><p><strong>Results: </strong>Lower pain scores were observed in the sonic agitation group at 12 hours (p=0.03),24 hours(p=0.02),48 hours (p=0.02),72 hours (p=0.04) after RCT. The patient's OHQoL was improved postoperatively (p=0.278), but there was no significant difference between sonic agitation and the control groups.</p><p><strong>Conclusion: </strong>Endodontic treatment improved patients' quality of life, and sonic irrigation agitation using a Waterpik device reduced postoperative pain in patients with symptomatic irreversible pulpitis.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"130-136"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the article: Clinical and demographic profile of oral lichen planus in Sri Lanka: a retrospective study.","authors":"Manas Bajpai","doi":"10.26650/eor.20251649226","DOIUrl":"https://doi.org/10.26650/eor.20251649226","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"121"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New monolithic post-core concept: a comparison of prefabricated and CAD-CAM fabricated post-cores.","authors":"Burcu Kanat Ertürk, Serkan Sarıdağ, Sinem Bayram, Zıya Safarlı, Dilek Helvacıoğlu Yiğit","doi":"10.26650/eor.20251638441","DOIUrl":"https://doi.org/10.26650/eor.20251638441","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this in vitro study was to evaluate the fracture and pull-out strengths of various post-core systems.</p><p><strong>Materials and methods: </strong>Forty-eight endodontically treated maxillary central incisors were assigned to three post-core groups: fiber post-composite core (RelyX) (FC), prefabricated monolithic fiber post-core (FiberSite) (MF), and CAD-CAM fabricated customized monolithic zirconia post-core (InCoris ZI) (MZ). Post-core designs were standardized according to the FiberSite system. After cementation (RelyX U200), the samples were divided into two mechanical test groups-fracture strength and pull-out strength (n = 8 per subgroup). Tests were performed at a crosshead speed of 1 mm/min, and failure types were recorded.</p><p><strong>Results: </strong>For the fracture strength test, the highest values (N) were obtained in the MZ group. The difference between MF and FC was not statistically significant (p = 0.190). For the pull-out test, statistically significant differences (N) were found among all groups (p less than 0.001). The MZ group exhibited predominantly catastrophic failures in both tests, whereas the MF and FC groups mainly showed Type II and Type III failures.</p><p><strong>Conclusion: </strong>Within the limitations of this study, the FiberSite system appears to have clinical potential for restoring severely damaged teeth. This system offers a balance of mechanical strength and favorable failure modes compared with CAD-CAM zirconia post-cores, which demonstrated catastrophic failures, and fiber post-composite cores, which exhibited lower strength values.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"162-168"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of antimicrobial and cytotoxic activity of newly synthesized and characterized nanocurcumin.","authors":"Anila S, Aldrin Antony, Dhanya P Jacob, Ambili Renjith","doi":"10.26650/eor.20251576613","DOIUrl":"10.26650/eor.20251576613","url":null,"abstract":"<p><strong>Purpose: </strong>Curcumin, the principal curcuminoid found in turmeric, demonstrates potent antibacterial and anti-inflammatory characteristics; nevertheless, it possesses restricted solubility and bioavailability. Numerous studies have reported elevated bioavailability and antimicrobial activity of nano-formulations of curcumin. Porphyromonas gingivalis plays a crucial role in triggering dysbiosis in the subgingival milieu, leading to the progression of periodontitis. This work details nanocurcumin preparation, characterization, and in vitro evaluation of antibacterial activity against Porphyromonas gingivalis and its cytotoxic effects on L929 mouse embryo fibroblasts.</p><p><strong>Materials and methods: </strong>Nanocurcumin was prepared using the antisolvent precipitation method and characterized by Scanning electron microscopy, UV-visible spectrophotometry, Fourier transform infrared spectroscopy, and Nuclear Magnetic Resonance. The antimicrobial activity of nanocurcumin against Porphyromonas gingivalis was assessed using the minimum inhibitory concentration (MIC). Cytotoxicity against L929 mouse embryo fibroblasts was evaluated with the MTT assay.</p><p><strong>Results: </strong>Nanocurcumin exhibited significant water solubility, nanoparticle size ranging from 18 to 176 nm, a strong absorbance peak at 425nm, and a comparable chemical structure to curcumin. MIC of nanocurcumin was 6.25 µg/ml compared to 25 µg/ml of curcumin and 3.12 µg/ml of tetracycline. Both nanocurcumin and curcumin demonstrated a dose-dependent negative impact on L929 fibroblasts with IC50 concentrations of 86.16 µg/ml and 45.69 µg/ml respectively.</p><p><strong>Conclusion: </strong>Nanocurcumin in the present study demonstrates well-characterized nanoparticle formation with excellent antimicrobial activity against Porphyromonas gingivalis and minimal cytotoxicity against L929 cell line. Nanocurcumin demonstrates significant promise for integration into drug delivery systems for the management of periodontal disease, subject to additional experimental and clinical trials.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":"60 1","pages":"45-51"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}