Ewha Medical Journal最新文献_第7页

Imaging findings of intrahepatic cholangiocarcinoma for prognosis prediction and treatment decision-making: a narrative review. 肝内胆管癌的影像学表现对预后预测和治疗决策：一篇叙述性综述。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e66

Jun Gu Kang, Taek Chung, Dong Kyu Kim, Hyungjin Rhee

{"title":"Imaging findings of intrahepatic cholangiocarcinoma for prognosis prediction and treatment decision-making: a narrative review.","authors":"Jun Gu Kang, Taek Chung, Dong Kyu Kim, Hyungjin Rhee","doi":"10.12771/emj.2024.e66","DOIUrl":"10.12771/emj.2024.e66","url":null,"abstract":"Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous bile duct adenocarcinoma with a rising global incidence and a poor prognosis. This review aims to present a comprehensive overview of the most recent radiological research on iCCA, focusing on its histopathologic subclassification and the use of imaging findings to predict prognosis and inform treatment decisions. Histologically, iCCA is subclassified into small duct (SD-iCCA) and large duct (LD-iCCA) types. SD-iCCA typically arises in the peripheral small bile ducts and is often associated with chronic hepatitis or cirrhosis. It presents as a mass-forming lesion with a relatively favorable prognosis. LD-iCCA originates near the hepatic hilum, is linked to chronic bile duct diseases, and exhibits more aggressive behavior and poorer outcomes. Imaging is essential for differentiating these subtypes and assessing prognostic factors like tumor size, multiplicity, vascular invasion, lymph node metastasis, enhancement patterns, and intratumoral fibrosis. Imaging-based prognostic models have demonstrated predictive accuracy comparable to traditional pathological staging systems. Furthermore, imaging findings are instrumental in guiding treatment decisions, including those regarding surgical planning, lymphadenectomy, neoadjuvant therapy, and the selection of targeted therapies based on molecular profiling. Advancements in radiological research have improved our understanding of iCCA heterogeneity, facilitating prognosis prediction and treatment personalization. Imaging findings assist in subclassifying iCCA, predicting outcomes, and informing treatment decisions, thus optimizing patient management. Incorporating imaging-based approaches into clinical practice is crucial for advancing personalized medicine in the treatment of iCCA. However, further high-level evidence from international multicenter prospective studies is required to validate these findings and increase their clinical applicability.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e66"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Septic cerebral embolism following lumbar spine surgery in a 69-year-old man with a lumbar epidural abscess in Korea: a case report. 韩国一名69岁男性腰椎硬膜外脓肿手术后脓毒性脑栓塞1例报告。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e57

Yo Seob Lee

引用次数: 0

[The McCusker Subjective Cognitive Impairment Inventory (McSCI): a novel measure of perceived cognitive decline - a Korean translation]. [McCusker主观认知障碍量表（McSCI）：一种感知认知衰退的新测量方法-韩文翻译]。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e74

Hamid R Sohrabi, Brandon E Gavett, Michael Weinborn, Craig P Speelman, Romola S Bucks, Ralph N Martins

引用次数: 0

Halted medical education in Korea amid Nobel Prizes in deep learning and machine learning research, tribute to a leader of Ewha Womans University College of Medicine, and highlights from this issue. 在深度学习和机器学习研究领域获得诺贝尔奖的情况下，韩国医学教育中断，向梨花女子大学医学部负责人致敬，这一问题的亮点。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e71

Sun Huh

引用次数: 0

Pathogenesis and management of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma: a narrative review. 代谢功能障碍相关脂肪性肝炎相关肝细胞癌的发病机制和治疗：一项叙述性综述。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e65

Han Ah Lee

{"title":"Pathogenesis and management of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma: a narrative review.","authors":"Han Ah Lee","doi":"10.12771/emj.2024.e65","DOIUrl":"10.12771/emj.2024.e65","url":null,"abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) is increasingly recognized as a leading cause of hepatocellular carcinoma (HCC), the third-leading cause of cancer mortality worldwide, driven by the global obesity epidemic. Projected to become the primary cause of HCC by 2030, MASH-HCC presents unique clinical challenges. This review examines its clinical management, including surveillance strategies and treatment advances, and discusses prospects to overcome existing challenges. MASH-HCC accounts for 10%-20% of HCC cases, particularly in Western countries, with a rising incidence due to obesity. Risk factors include cirrhosis, diabetes, obesity, alcohol, smoking, genetic polymorphisms (e.g., PNPLA3), and microbiome alterations. The pathogenesis involves fibrosis, immune dysfunction (e.g., T-cell impairment), and molecular changes. Prevention focuses on lifestyle modifications. Surveillance in patients with MASH cirrhosis is crucial but is hindered by poor ultrasound sensitivity in obese patients, necessitating alternative methods. Treatment mirrors that of other HCC types, but comorbidities and potentially reduced efficacy of immunotherapy necessitate tailored approaches. MASH is becoming the leading cause of HCC, necessitating lifestyle interventions for prevention. Improved surveillance and early detection are critical but challenging due to obesity-related factors. Treatments align with those for other HCC types, but comorbidities and potential differences in immunotherapy efficacy due to T-cell dysfunction require careful consideration. Key needs include identifying molecular drivers in non-cirrhotic metabolic dysfunction-associated steatotic liver disease, developing preventive therapies, refining surveillance methods, and tailoring treatments. Trials should specifically report MASH-HCC outcomes to enable personalized therapies. Further research is needed to understand T-cell dysfunction, optimize immunotherapies, and identify predictive biomarkers.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e65"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical indications and future directions of carbon-ion radiotherapy: a narrative review. 碳离子放射治疗的临床适应症和未来发展方向：叙述性回顾。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e56

Seo Hee Choi, Woong Sub Koom, Hong In Yoon, Kyung Hwan Kim, Chan Woo Wee, Jaeho Cho, Yong Bae Kim, Ki Chang Keum, Ik Jae Lee

{"title":"Clinical indications and future directions of carbon-ion radiotherapy: a narrative review.","authors":"Seo Hee Choi, Woong Sub Koom, Hong In Yoon, Kyung Hwan Kim, Chan Woo Wee, Jaeho Cho, Yong Bae Kim, Ki Chang Keum, Ik Jae Lee","doi":"10.12771/emj.2024.e56","DOIUrl":"10.12771/emj.2024.e56","url":null,"abstract":"Carbon-ion radiotherapy (CIRT) offers superior dose distributions and greater biological effectiveness than conventional photon-based radiotherapy (RT). Due to its higher linear energy transfer and relative biological effectiveness, CIRT is particularly effective against radioresistant tumors and those located near critical organs. Since the first dedicated CIRT facility was established in Japan in 1994, CIRT has demonstrated remarkable efficacy against various malignancies, including head and neck tumors, skull base and upper cervical spine tumors, non-small-cell lung cancer, hepatocellular carcinoma, pancreatic cancer, prostate cancer, and bone and soft tissue sarcomas. This narrative review provides a comprehensive overview of the current status of CIRT, highlighting its clinical indications and future directions. According to clinical studies, CIRT achieves high local control rates with manageable toxicity across multiple cancer types. For instance, in head and neck tumors (e.g., adenoid cystic carcinoma and mucosal melanoma), CIRT has achieved local control rates exceeding 80%. In early-stage non-small-cell lung cancer, CIRT has resulted in local control rates over 90% with minimal toxicity. Moreover, CIRT has shown promise in treating challenging cases of hepatocellular carcinoma and pancreatic cancer, where conventional therapies are limited. Nonetheless, the global adoption of CIRT remains limited due to high costs and complexity. Future directions include conducting randomized controlled trials to establish high-level evidence, integrating new technologies such as ultrahigh-dose-rate (FLASH) therapy, and expanding CIRT facilities globally with strategic planning and cost-effectiveness analyses. If these challenges are addressed, CIRT is poised to play a transformative role in cancer treatment, improving survival rates and the quality of life.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e56"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcomes and future directions of enhanced recovery after surgery in colorectal surgery: a narrative review. 结直肠手术中增强术后恢复的临床结果和未来方向：叙述性回顾。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e69

Ji Hyeong Song, Minsung Kim

{"title":"Clinical outcomes and future directions of enhanced recovery after surgery in colorectal surgery: a narrative review.","authors":"Ji Hyeong Song, Minsung Kim","doi":"10.12771/emj.2024.e69","DOIUrl":"10.12771/emj.2024.e69","url":null,"abstract":"Enhanced recovery after surgery (ERAS) protocols are designed to minimize surgical stress, preserve physiological function, and expedite recovery through standardized perioperative care for primary colorectal surgery patients. This narrative review explores the benefits of current ERAS protocols in improving outcomes for these patients and provides insights into future advancements. Numerous studies have shown that ERAS protocols significantly reduce the length of hospital stays by several days compared to conventional care. Additionally, the implementation of ERAS is linked to a reduction in postoperative complications, including lower incidences of surgical site infections, anastomotic leaks, and postoperative ileus. Patients adhering to ERAS protocols also benefit from quicker gastrointestinal recovery, marked by an earlier return of bowel function. Some research indicates that colorectal cancer patients undergoing surgery with ERAS protocols may experience improved overall survival rates. High compliance with ERAS protocols leads to better outcomes, yet achieving full adherence continues to be a challenge. Despite these advantages, implementation challenges persist, with compliance rates affected by varying clinical practices and resource availability. However, the future of ERAS looks promising with the incorporation of prehabilitation strategies and technologies such as wearable devices and telemedicine. These innovations provide real-time monitoring, enhance patient engagement, and improve postoperative follow-up, potentially transforming perioperative care in colorectal surgery and offering new avenues for enhanced patient outcomes.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e69"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart. 七氟醚对兔离体灌注心脏远端缺血预处理与麻醉诱导预处理相互作用的探讨。

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e68

Seung-Hee Yoo, Sooyoung Cho, Yoonsun Won, Jong Wha Lee

{"title":"Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart.","authors":"Seung-Hee Yoo, Sooyoung Cho, Yoonsun Won, Jong Wha Lee","doi":"10.12771/emj.2024.e68","DOIUrl":"10.12771/emj.2024.e68","url":null,"abstract":"Objectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC) utilizes volatile anesthetics to protect multiple organs from ischemia-reperfusion injury. Both methods are easily integrated into various clinical scenarios for cardioprotection. However, it remains unclear whether simultaneous application of these techniques could result in complementary, additive, synergistic, or adverse effects. Methods: An adult rabbit heart Langendorff model of global ischemia/reperfusion injury was used to compare the cardioprotective effect of rIPC and APC alone and in combination relative to untreated (control) hearts. The rIPC group underwent four cycles of 5-minute ischemia on the hind limb, each followed by 5 minutes of reperfusion. The APC group received 2.5 vol% sevoflurane for 20 minutes via a face mask, followed by a 20-minute washout period. Results: Both in vivo rIPC, induced by four 5-minute cycles of ischemia/reperfusion on the hind limb, and APC, administered as 2.5 vol% sevoflurane via a mask, significantly reduced the size of myocardial infarction following 30 minutes of global ischemia by >50% compared to the untreated control group (rIPC, 12.1±1.7%; APC, 13.5±2.1%; P<0.01 compared to control, 31.3±3.0%). However, no additional protective effect was observed when rIPC and APC were combined (rIPC+APC, 14.4±3.3%). Conclusion: Although combining rIPC and APC did not provide additional protection, there was no inhibitory effect of one intervention on the other.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e68"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and associated factors of ADHD-like symptoms among pharmacy students at Prince of Songkla University, Thailand in 2024: a cross-sectional study. 2024年泰国宋卡王子大学药学专业学生adhd样症状的患病率及相关因素：一项横断面研究

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Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e70

Krittiya Rakchat, Saranan Eadcharoen, Amarawan Pentrakan

{"title":"Prevalence and associated factors of ADHD-like symptoms among pharmacy students at Prince of Songkla University, Thailand in 2024: a cross-sectional study.","authors":"Krittiya Rakchat, Saranan Eadcharoen, Amarawan Pentrakan","doi":"10.12771/emj.2024.e70","DOIUrl":"10.12771/emj.2024.e70","url":null,"abstract":"Objectives: This study investigated the prevalence of attention-deficit hyperactivity disorder (ADHD) and its associated factors among pharmacy students at Prince of Songkla University in 2024. It was hypothesized that the prevalence of ADHD would be associated with various demographic, socioeconomic, historical, and behavioral factors. Methods: This cross-sectional descriptive study involved pharmacy students from years 1-5 at Prince of Songkla University in Thailand. Data were gathered from 761 students using a self-administered questionnaire that included the Adult ADHD Self-Report Scale (ASRS Screener V1.1). Descriptive statistics, the chi-square test, the Fisher exact test, and multiple logistic regression were employed for data analysis. Results: In total, 526 students participated in the study (participation rate: 69%), with an average age of 21±1.57 years. The risk of ADHD was prevalent in 14.4% of the respondents (76 students; 95% CI: 11.4%-17.5%). Significant factors associated with an increased risk of ADHD included identifying as not disclosed or preferring not to report gender (adjusted OR [ORadj], 3.32; 95% CI, 1.04-10.57), having insufficient monthly income (ORadj, 2.02; 95% CI, 1.13-3.61), and recent traffic violations (ORadj, 2.02; 95% CI, 1.09-3.76). It was also found that difficulties with executive functioning, such as organization and procrastination, were highly prevalent among pharmacy students. Conclusion: The study identified a substantial prevalence of ADHD risk among pharmacy students, with factors including gender, financial challenges, and behavioral patterns such as traffic violations significantly associated with this risk. These findings underscore the necessity for targeted mental health interventions in university settings.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e70"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on sexually transmitted infections in Korea: a narrative review. 韩国性传播感染的最新情况：叙述性回顾。

IF 0.3

Ewha Medical Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.12771/emj.2024.e52

Chung-Jong Kim

{"title":"Update on sexually transmitted infections in Korea: a narrative review.","authors":"Chung-Jong Kim","doi":"10.12771/emj.2024.e52","DOIUrl":"10.12771/emj.2024.e52","url":null,"abstract":"Sexually transmitted infections (STIs) continue to pose significant public health challenges in Korea, with syphilis, gonorrhea, chlamydia, Mycoplasma genitalium, and herpes simplex virus (HSV) being the most prevalent. This review provides an updated overview of the epidemiology, diagnosis, and treatment of these significant STIs in Korea, highlighting recent trends and concerns. Syphilis incidence rates have fluctuated due to changes in surveillance systems. Starting in 2024, syphilis will be reclassified as a nationally notifiable infectious disease (category 2). Gonorrhea remains a concern due to increasing antibiotic resistance, including the emergence of extensively drug-resistant Neisseria gonorrhoeae strains, underscoring the need for vigilant antimicrobial stewardship. Chlamydia continues to be the most commonly reported STI, although its incidence has declined during the COVID-19 pandemic. M. genitalium has gained attention as a significant STI with rising antibiotic resistance issues, necessitating updated treatment guidelines and consideration of resistance testing. HSV-2 remains a common cause of genital herpes, with steady incidence rates reported. Updated diagnostic methods, including nucleic acid amplification tests, and revised treatment guidelines are presented to effectively address these infections. The impact of the COVID-19 pandemic on other STIs within Korea remains unclear, necessitating further research. Changes in treatment guidelines, such as the recommendation of doxycycline as first-line therapy for chlamydia, reflect evolving evidence and resistance patterns. The importance of updated diagnostic tools, including resistance testing for M. genitalium, is emphasized to improve treatment outcomes. Continued efforts in education, prevention, and research are essential to manage and mitigate the impact of STIs on public health in Korea.","PeriodicalId":41392,"journal":{"name":"Ewha Medical Journal","volume":"47 4","pages":"e52"},"PeriodicalIF":0.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0