Asian Journal of Biological and Life sciences最新文献

{"title":"Exploring the Anti-Inflammatory Effects of Aprepitant: An Antagonist of the Neurokinin-1 Receptor","authors":"Pavithra Pavithra J, Shila Shila G, Maheshwaran Maheshwaran P, John Staines M, Sakthi Sundaram S","doi":"10.5530/ajbls.2023.12.80","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.80","url":null,"abstract":"Aim: Aim: Substance P participates towards pain aetiology by activating on the NK-1R, the neurokinin-1 receptor, which is found on sensory neurons that perceive noxious stimuli. SP is recognised to have biological action through G-protein-coupled neurokinin receptors named Neurokinin 1 Receptor (NK-1R), Neurokinin 2 Receptor (NK-2R) and neurokinin 3 receptors (NK-3R). Among the three, NK-1R has the highest affinity for substance P. The NK-1R receptor is a G-protein-coupled receptor that is involved in inflammatory disorders. Aprepitant is a highly selective non-peptide neurokinin-1 receptor antagonist that is approved to lessen nausea and vomiting brought on by chemotherapy. Materials and Methods: Materials and Methods: The purpose of this study is to see if Aprepitant has any anti-inflammatory activity in the cotton pellet granuloma technique. Pellets with granuloma tissue around them were carefully dissected, cleared of extraneous tissues, and dried at 60ºC at the end of the research. Under both moist and dry circumstances, and each particle’s surrounding granuloma tissue’s mean weight was determined. Results: Results: The study’s goal is to evaluate the anti-inflammatory impact and Aprepitant prevents granuloma formation (48.68%) at a dose of 80 mg/kg to the conventional medicine indomethacin (2.5 mg/kg), which demonstrated the maximum suppression of granuloma tissue development (55.34%). Conclusion: Conclusion: When compared to a control without an ulcerogenic impact, the histology of granuloma in aprepitant treated group tissue indicated considerable prevention of necrosis and exudates.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and Mosquito Repellent Assay of Poly Herbal Oil","authors":"Marivignesh R Marivignesh, MI Zahir Hussain, Vijayalakshmi M Vijayalakshmi, Shajahan A Shajahan, S. R. Kumar, M. S. Jameela","doi":"10.5530/ajbls.2023.12.75","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.75","url":null,"abstract":"Aim:Aim: To evaluate the anti-bacterial and mosquito-repellant activities of herbal skin oil. Materials Materials and Methods: and Methods: The herbs used for the present study were washed well with tap water and weighed. 250 g each of the selected plant leaves was weighed and made into a paste using mortar and pestle. 500 mL of coconut oil was measured in a measuring cylinder transferred to a heating vessel and heated to low flam. The crushed leaf paste of Salvia rosmarinus, Azadirachta indica, and Ocimum basilicum were added to the coconut oil and heated to low flame for 15 min. The oil was cooled down to room temperature and filtered using a fine mesh filter. The filtered herbal oil was stored in glass bottles. Results and Discussion: Results and Discussion: In vitro antimicrobial activity of the Herbal oil was tested against 4 bacterial pathogens using the agar disc diffusion method. The zones of inhibition (in mm) were as follows: The highest inhibition was noted (19 mm) for Streptococcus pyogenes . The Medium inhibition was noted (17 mm) for Staphylococcus aureus and (15 mm) for Aeromonas hydrophila. The lowest inhibition was noted (14 mm) for Pseudomonas aeruginosa . The survey forms were collected from the randomly selected people after 10 days. About 40% of the surveyed people rated 5 out of 5 for the herbal oil. Another 40% of the surveyed people rated above 4.5 out of 5. The remaining 20% is rated above 4 for the herbal oil. From the survey, it is evident that the prepared herbal preparation is an effective mosquito repellent and is also 100% safe for the skin as a topical application. Conclusion:Conclusion: There are many chemical mosquito repellents seen in our market that cause side effects. This paper focuses on herbal mosquito repellent as well as poly herbal skin oil. In the present study, three herbs Salvia rosmarinus, Azadirachta indica, and Ocimum basilicum are selected to come up with an oil-based herbal formulation to be used as mosquito repellent and skin disease cure oil. The antibacterial activity of the herbal oil was good against pathogens causing skin infections and the mosquito-repellent efficiency of the poly-herbal oil is assessed using the Survey method. From the survey conducted, it is evident that the prepared herbal preparation is an effective mosquito repellent and is also 100% safe for the skin as a topical application.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Alpha-Phellandrene on Glucose Uptake and Adipogenesis in Insulin Resistant 3T3-L1 Adipocytes: an in vitro and in silico Approach","authors":"Souprayen Seethalakshmi, Ravishankar Sarumathi, Chandrasekaran Sankaranarayanan","doi":"10.5530/ajbls.2023.12.79","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.79","url":null,"abstract":"Aim: Aim: The present study was designated to investigate the effect of alpha-phellandrene, a monoterpene presents in essential oils of mint, turmeric, black pepper, and cinnamon on adipocyte function under insulin resistant condition. Materials and Methods: Materials and Methods: Mature 3T3-L1 adipocytes were exposed to high glucose (25 mM) and 0.6 nm/L of insulin for 24 hr to convert to IR-3T3-L1 adipocytes. The adipocytes were grouped into group1: normal control, group 2: diabetic control, group 3: diabetic group treated with alpha-phellandrene (65 µM) and group 4: diabetic group treated with rosiglitazone (0.1 µM). Glucose uptake assay, triglyceride accumulation and the activity of glycerol-3-phosphate dehydrogenase were measured. The binding affinity of alpha-phellandrene with PPARγ and SREBP-1c were analysed by docking studies by using Auto Dock vina (V. 4.0) in Pyrx software. Results: Results: Glucose uptake, triglyceride accumulation and activity of glycerol-3-phopshate dehydrogenase were found to be decreased in diabetic control when control to normal control group. Alpha-phellandrene at dose of 65 µM increased glucose uptake, enhanced glycerol-3-phosphate activity and triglyceride accumulation in adipocytes which were found to be comparable with the standard drug rosiglitazone. A high binding affinity of alpha-phellandrene with key transcription factors, PPARγ and SREBP-1c which are associated with adipogenesis and steroidogenesis were observed in molecular docking studies. Conclusion: Conclusion: These results suggest that alpha-phellandrene positively regulates adipocyte function and ameliorate dyslipidaemia and hyperglycaemia in type II diabetes mellitus.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of Immune Response Induced Cytokine Imbalance by MERS-CoV Antigen in Gallus gallus domesticus Model by Ethanolic Extract of Nymphaea caerulea","authors":"D. Chatterjee, Banhishikha Singh, Krishnendu Paira, Satadal Das","doi":"10.5530/ajbls.2023.12.64","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.64","url":null,"abstract":"","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosynthesis and Characterization of Curcuma amada Mediated Silver Nanoparticles","authors":"G. Thiagu, Palusamy Raja, P. Suganthi, C. Thilip, Valiyaparambath Musfir Mehaboob, A. Aslam, A. Shajahan","doi":"10.5530/ajbls.2023.12.27","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.27","url":null,"abstract":"Silver nanoparticles are the glorious metallic material due to their wide applications in the pharmaceutical and industrial sectors. In this study, Curcuma amada rhizome are used for the silver nanoparticle synthesis. C. amada mediated AgNO 3 nanoparticles are synthesized by and characterization studies (UV, FTIR, XRD, DLS, SEM and TEM). In UV spectra, three peaks observed at 413, 418 and 995nm confirmed the presence of silver particles in the green synthesized Ag nanoparticles. FTIR spectra exhibited various functional groups (N-H stretching vibrations, alkane, amide stretching, carboxylic acid, stretching and rocking C-C bonds, NH 2 stretch and S-S stretch) of the nanoparticles. green synthesized Ag NPs electron microscopic analysis revealed agglomerated irregular shape with homogenously. The crystal plane lattice of the nanoparticles is revealed by XRD. Agglomerated irregular structures of silver nanoparticles with average particle size 32-55nm. Our study concluded that Curcuma amada mediated silver nanoparticles exhibited the nanoparticles properties.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125141006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible Cutlery – A Prototype to Combat Malnutrition and Plastic Waste Management","authors":"Krishita Mukherjee, Arivuchudar Raju","doi":"10.5530/ajbls.2023.12.14","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.14","url":null,"abstract":"Background:Background: Edible cutlery is a natural and bio-degradable commodity which can be concocted to be nutritious and replace the usage of plastic cutlery. This study aims at sustainable development, elimination of plastics as cutlery from the food sector, ecological waste management, maintenance of optimal nutritional status and prevention of non-communicable diseases. These edible cutleries, which are made by combining all the five food groups given in the MyPlate, will prodigiously influence the intake of complex carbohydrates, protein, fibre, micronutrients and nutraceuticals on a routine basis. Materials and Methods: Materials and Methods: This report is targeted at the fabrication of edible cutleries using composite flour blends of whole wheat, foxtail millet, and roasted bengal gram, along with enrichment of skimmed milk powder, orange fruit powder and beetroot extract in proportions as suggested in a balanced diet, in order to evaluate its ability to meet the recommended daily allowances, phytochemical profile, functionality and economic competence. Three variations were baked at 180°C for 17 min. Results:Results: According to the results of the analysis, variation 2, with an equimolar ratio of whole wheat flour and foxtail millet flour along with other ingredients, proved to be the most proficient alternative to plastic cutlery. Conclusion:Conclusion: The accepted cutlery indicated to considerably meet the RDA in terms of certain nutrients majorly lacking in the Indian diet, along with catering to the nutraceutical needs of the body. Economically, the cost of these cutleries was found to be lower than those present in the market","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131435740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Toxicity of Antibiotics Used in the Treatment of STIs with Special Emphasis on Web-based Toxicity Analyzing Software","authors":"Juhi Juhi J, Nainsy Baghel, Rambir Singh, Poonam Sharma","doi":"10.5530/ajbls.2023.12.2","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.2","url":null,"abstract":"Aim/Background:Aim/Background: For many years, toxicity tests have been conducted on animals. Long-term use of animal models for toxicity testing has its drawbacks, including time and effort, ethical considerations, and cost. As a result, various computational methods for estimating chemical toxicity and pharmacokinetic properties are thought to be necessary. This study aims to evaluate the toxicity of some commonly used antibiotics in the treatment of sexually transmitted infections, with a special emphasis on web-based toxicity analysis software and a systematic review. Materials Materials and Methods: and Methods: An extensive literature study was done to understand the toxicity of antibiotics. After that, in silico toxicity analysis was performed by STopTox, Lazar, SwissADME, and ProTox II software. Results and Conclusion: Results and Conclusion: The results show that these softwares are helpful in the prediction or evaluation of the toxicity of antibiotic compounds. Hence, in this paper, the toxicity of antibiotics is reviewed with emphasis on in silico perspectives, particularly those used to treat bacterial sexually transmitted infections.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114990212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link between Alcohol Use and Physical Illnesses and Harms Using Network Analysis: A Cross-Sectional Study","authors":"Kimasha Borah, K. Bhuyan, Ujjal Saikia, P. Bora","doi":"10.5530/ajbls.2023.12.15","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.15","url":null,"abstract":"Prolonged use of alcohol is linked to a wide array of adverse health consequences, which are dependent on two factors namely volume and pattern of drinking and the direct biochemical effect of alcohol. In this study, we intended to explore the association between alcohol use and physical illnesses and complications by using a graph-theoretical approach in a population of patients attending drug deaddiction services of two tertiary care hospitals. A total of 180 patients selected randomly were interviewed using specially designed semi-structured proforma. Analysis of data showed regular use and drinking of alcohol once and twice a week have weighted degrees of 360 and 120 respectively and are the most influential factors in the network model and are found to be associated with multiple physical complications like weakness (node strength 108), diabetes (node strength 84) and hypertension (node strength 68). Having “No Problem” is also a common node in all the clusters under examination but the relationship is very weak, suggesting that individuals who drink alcohol might not have any physical consequences. Although this is more likely to be an exceptional discovery than a common one. The main finding of this study was that frequency of drinking is crucial to the physical illnesses and complications associated with alcohol use, so advocating for not drinking regularly or spacing out drinking days can be an ideal strategy to lessen the harms of alcohol use in situations where the ideal scenario of total abstinence may not be feasible.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128567553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syringic Acid Alleviates Hyperglycemia by Regulating Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats","authors":"Shimsa Sahari, M. Saraswathy","doi":"10.5530/ajbls.2023.12.10","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.10","url":null,"abstract":"Background:Background: Diabetes mellitus is a complex metabolic disorder characterized by the development of hyperglycemia due to impaired insulin production, insulin action, or both. The persistent hyperglycemia associated with diabetes can lead to an increased risk of developing severe health problems. This study examines whether the bioactive phenolic compound Syringic Acid (SA) mitigates hyperglycemia in streptozotocin-induced diabetic rats. Materials and Methods: Materials and Methods: A total of 30 male Sprague-Dawley rats were utilized in the investigation, and they were split into five groups: Normal (N), Normal+Syringic Acid (N+SA), Diabetic Control (DC), Diabetic+Syringic Acid (D+SA), and Diabetic+Glimepiride (D+GM). A single dose of streptozotocin (40 mg/kg) injected intraperitoneally was used to induce diabetes. Syringic Acid (SA) was given orally once a day for 60 days at a dose of 50 mg/Kg body weight. The levels of plasma insulin, glucose, glycated haemoglobin, and the activity of carbohydrate metabolizing enzymes were examined. Results were compared with diabetic rats provided with the standard drug glimepiride (0.1 mg/kg). Results:Results: Syringic acid treatment substantially lowered hyperglycemia, enhanced insulin levels, and lowered HbA 1c , in diabetic rats when given at a dose of 50 mg/Kg body weight. Additionally, syringic acid exhibited the ability to considerably lower the activities of fructose 1,6-bisphosphatase and glucose-6 phosphatase while significantly increasing the activities of glycolytic enzymes like pyruvate kinase and hexokinase. Conclusion:Conclusion: These results imply that syringic acid could potentially attenuate hyperglycemia in streptozotocin-induced diabetic rats by modulating carbohydrate","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123378115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production and Optimization of Exopolysaccharides (EPS) Using Low-cost Bagasse as Substrate by Lysinibacillus macroides","authors":"Kartik Andharia, P. Shilpkar, S. Kundu","doi":"10.5530/ajbls.2023.12.8","DOIUrl":"https://doi.org/10.5530/ajbls.2023.12.8","url":null,"abstract":"Exopolysaccharides are the secondary metabolites produced by many microorganisms and play a role as biopolymers extensively to protect living cells in various ways. In the present study, the carbon source was substituted by various cheaper agricultural wastes, investigated for EPS production, and found bagasse more suitable substrate than others. Bagasse at a concentration of 5% gave the highest EPS production of 13.13 ± 0.44 g L -1 . The effect of various parameters like incubation period, agitation speed, inoculum size, pH, and the temperature was also studied and found to have the highest EPS production after an incubation time of 120 hr (15.10 g L -1 ), agitation speed of 100 rpm (12.47 g L -1 ), 10% inoculum size (13.43 g L -1 ), pH 7 (11.47 g L -1 ) and incubation temperature 30°C (13.17 g L -1 ). Thus, the present study confirmed that agricultural wastes could be a cheaper substitute for synthetic and expensive carbon substrates, which economically opens a new door toward EPS production.","PeriodicalId":413740,"journal":{"name":"Asian Journal of Biological and Life sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122568090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}