Ukraïnsʹkij žurnal medicini, bìologìï ta sportu最新文献

{"title":"The Greater Omentum of White Rats: Structural and Functional Characteristics and its Role in Peritonitis","authors":"O. Maksymenko, V. Hryn","doi":"10.26693/jmbs08.01.022","DOIUrl":"https://doi.org/10.26693/jmbs08.01.022","url":null,"abstract":"The greater omentum is now recognized as an important organ in the fight against intra-abdominal infections, so it is often called the “policeman of the peritoneal cavity”. The greater omentum plays the most important role in the implementation of immune supervision of the antigenic condition of the peritoneal fluid and rapid response of damage to the gastrointestinal tract, which is often complicated by inflammation of the peritoneum – peritonitis. The purpose of the work was to study the peculiarities of the structure of the greater omentum of white rats and its role in peritonitis by means of a bibliographic analysis of the literature. Materials and methods. This bibliographic analysis is based on published articles, books, textbooks, monographs and dissertation abstracts. For the purposes of this systematic review, a literature search was carried out in the worldwide Internet, domestic sources of literature, scientific and electronic library of Poltava State Medical University using the following key words: “morphology”, “comparative anatomy”, “greater omentum”, “greater omentum of the rats”, “immune system”, “white rats”, “laboratory animals”, “rat anatomy”, “peritonitis”. Results and discussion. The greater omentum of white rats and humans are represented by two different structures: translucent membranous regions and regions rich in adipose tissue. According to the literature, the greater omentum of white rats is the main morphological characteristic (in miniature), homologous to the human one. The main function of the greater omentum, according to the opinion of many authors and ours too, is immunity. Immune structures of the greater omentum of white rats are represented by lymphoid nodules, known in the literature as milky spots, most of which are located near arteries and veins. In pathological conditions, the greater omentum acquires absolutely special properties, such as plasticity, the ability to fuse with a traumatic and inflamed surface, the ability to hemostasis and phagocytosis, the ability to germinate and revascularize, to absorb fluids and microparticles from the peritoneal cavity, and the ability to the immunological response. Conclusion. According to the literature, the greater omentum of white rats is a miniature likeness of the greater omentum of a person. However, unlike the latter, it consists of only one duplication of the visceral peritoneum, between the leaves of which there are blood vessels with deposits of adipose tissue and milk spots. Thus, the greater omentum of white rats is a perfectly acceptable object of experimental research with the subsequent legitimate extrapolation of their results to humans. The greater omentum occupies a central place in the peritoneal defense mechanisms due to its innate immune function, high absorbing capacity, and ability to attach to neighboring structures to close defects of abdominal organs and promote their healing, due to its expressive angiogenic activity","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133958690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Restoration of Teeth from Different Materials","authors":"O. Udod, S. Dramaretska, G. Y. Apiekunov","doi":"10.26693/jmbs08.01.177","DOIUrl":"https://doi.org/10.26693/jmbs08.01.177","url":null,"abstract":"The purpose of the study was a comparative clinical evaluation of direct cervical restorations of teeth made from different materials. Materials and methods. In 49 patients aged from 22 to 37 years, direct restoration of 97 teeth with cervical carious lesions was carried out. Group 1 included 19 people (39.6% of the number of examined) with 35 restorations (36.1% of the number of restorations) from photocomposite, group 2 – 14 people (29.2%), in whom 34 restorations were performed (35.1%) with glass ionomer cement, in 15 patients (31.3%) of group 3 28 restorations (28.9%) were performed with chemically hardening composite. The examination was carried out the next day, after 6 and 12 months according to clinical and aesthetic criteria. Results and discussion. The next day, in patients of group 1, 2 restored teeth (5.7% of their number in patients of the group) had increased sensitivity. After 6 months, 1 restoration (2.9%) was missing in patients of group 1, 2 restorations (5.7%) had marginal fit violations, 1 (2.9%) – had marginal coloration, and 1 restored tooth (2.9%) was diagnosed with hypersensitivity. In patients of group 2, in 5 restorations (14.7%) defects of marginal fit and marginal coloration were detected. In persons of group 3, in 3 restorations (10.7%) the marginal fit was violated, in 4 (14.7%) – coloration. In the period of 12 months, in persons of group 1, 1 restoration (3.2% of their number at this time) was again absent, secondary caries was detected, defects in the marginal fit of the photocomposite were recorded in 3 restorations (8.6%), marginal coloration – in 4 (11.4%). In patients of group 2, in 6 restorations (22.2% of the number in this period), the marginal fit of the glass ionomer was violated, in 8 (29.6%) – marginal coloration. In patients of group 3, defects in the marginal fit of the chemical composite were identified in 7 restorations (29.2% of the number in this period), marginal coloration – in 6 (25%), secondary caries was found along with 1 restoration (4.2%). The undisputed dominance of the photocomposite material in the aesthetic evaluation of the state of restorations was proven, in particular, according to criteria that included color matching and surface roughness, only single deviations were found in photocomposite restorations, and in restorations from glass ionomer cement and chemically hardening composite, they were found several times more. Conclusion. When using photocomposite material to restore teeth with cervical carious lesions, the possibility of the abfraction effect with subsequent loss of restorations and the increased risk of postoperative sensitivity in the restored teeth should be taken into account","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130048909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans","authors":"Galina Traverse, V.I. Horoshko, S. Danylchenko","doi":"10.26693/jmbs08.01.050","DOIUrl":"https://doi.org/10.26693/jmbs08.01.050","url":null,"abstract":"The purpose of the study was to summarize new literature data on the effect of physical activity on the secretory function of skeletal muscles and their relationship with organs. Materials and methods. Analytical methods were used in the study. The search for scientific information was carried out in databases of search systems. Results. Muscles secrete proteins called myokines, which are involved in a variety of processes by interacting with tissues. Current research has shown that exercise, by stimulating the skeletal muscle system in vivo, leads to the release of myokines and causes several effects that explain the positive effect of exercise in the treatment of several diseases of the musculoskeletal system. Skeletal muscles synthesize and secrete a wide range of myokines that contribute to various functions in organs, including the brain. Recent publications have focused much attention on one such myokine, the recently discovered protein irisin, which is secreted into the bloodstream from skeletal muscle during exercise from the membrane-bound precursor fibronectin type III. Irisin promotes metabolic processes such as glucose homeostasis and the darkening of white adipose tissue. Irisin also crosses the blood-brain barrier and initiates a neuroprotective genetic program in the hippocampus, which culminates in increased expression of brain-derived neurotrophic factors. Most studies report that irisin concentration is closely related to health status. For example, irisin levels are significantly lower in patients with obesity, osteoporosis/fracture, muscular atrophy, Alzheimer's disease, and cardiovascular disease. Over the past decade, several myokines have been discovered, expanding our understanding of how muscles interact with other organs. In recent publications, a lot of attention is paid to the recently discovered protein irisin, which contributes to metabolic processes. A series of studies on irisin have provided new insights into the mechanisms of exercise to improve bone density, counteract cartilage degeneration, and maintain overall joint environmental homeostasis. These studies further contribute to the understanding of the role of exercise in the fight against osteoarthritis and may provide important assistance in advancing the prevention and treatment of this common disease. Research on the exercise-induced muscle factor irisin will help to better understand and explain the beneficial effects of exercise on maintaining physical health, especially in the fight against aging and age-related degenerative changes. Conclusion. Thus, exercise-induced stimulation of bioactive cytokines increases muscle anabolism, bone formation, mitochondrial biogenesis, glucose utilization, and fatty acid oxidation, and reduces chronic inflammation","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129391739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern Knowledge of the Pathogenetic Mechanisms of Pulmonary Fibrosis Formation","authors":"A. S. Shapovalova","doi":"10.26693/jmbs08.01.056","DOIUrl":"https://doi.org/10.26693/jmbs08.01.056","url":null,"abstract":"The purpose of the study was to analyze literary sources on the study of modern views on information about the pathogenetic mechanisms of the formation of pulmonary fibrosis. Materials and methods. Analytical and bibliosemantic methods were used in the research. During the scientific search, 39 sources of modern domestic and foreign literature were reviewed and analyzed. Results and discussion. Pulmonary fibrosis is a heterogeneous group of chronic, progressive and incurable interstitial lung diseases characterized by scar formation and irreversible destruction of the lung parenchyma and is accompanied by disorders of elasticity and gas exchange in pathologically altered areas. The mechanism of development of pulmonary fibrosis is determined by its root causes. There are three distinct pathologic patterns of pulmonary fibrosis: usual interstitial pneumonia, fibrotic nonspecific interstitial pneumonia, and airway fibrosis. Their morphological differences are based on the distribution of fibrosis (diffuse or spotty) and anatomical location. The development of pulmonary fibrosis in most cases is a consequence of a previous acute inflammation of the lungs caused by various etiological factors, which in the case of untimely started or incorrectly selected treatment causes the deposition of fibrous tissue in the lungs. It is believed that the appearance and subsequent progression of pulmonary fibrosis can be attributed to reparative processes after repeated injuries of alveolar epithelial cells in response to various stimuli, including injuries. Loss of function or reduction in the number of alveolar epithelial cells can lead to improper repair of the lung parenchyma, which can lead to fibrosis. Various cytokines such as transforming growth factor-β1, tumor necrosis factor-α, and platelet-derived growth factor can be released when alveolar epithelial cells are damaged. These cytokines can promote the accumulation of fibroblasts. In addition to the cytokine response, the lung’s response to injury includes the stimulation of myofibroblasts, which when activated serve as the primary collagen-producing cell. This leads to massive deposition of collagen and subsequently affects the normal structure and function of lung tissue. Conclusion. Pulmonary fibrosis is a progressive lung disease that leads to morpho-functional restructuring of lung tissue. In the course of the work, the presence of three models of the development of pulmonary fibrosis were analyzed. Despite the long history of study and good coverage of the problem in the scientific literature, currently the mechanisms of formation of pulmonary fibrosis remain insufficiently studied","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124948834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of The Adhesion Strength of Photocomposite Enamel Sealants to the Tooth Surface","authors":"I. Noenko, O. Pavlenko, Yu. O. Mochalov","doi":"10.26693/jmbs08.01.171","DOIUrl":"https://doi.org/10.26693/jmbs08.01.171","url":null,"abstract":"The purpose of the study was to compare an adhesion strength of some modern enamel sealants to the enamel of a developing tooth which occurs without adhesive preparation of tooth surface. Materials and methods. In laboratory the shear adhesion strength to human teeth enamel without adhesive system application was compared for “Fissurit FX” (VOCO), “Clinpro™ Sealant” (3M™ ESPE™) and “Jen-Fissufil” (Jendental-Ukraine LLC). 30 samples were tested on tensometric system. Tests were performed according to requirements of ISO 4049:2019 “Dentistry – Polymer-based restorative materials” and ISO 6874:2005 “Dentistry – Polymer-based pit and fissure sealants”. Results and discussion. Performed experimental studies of sealant adhesion (without the use of adhesive systems, only with acid etching) showed that it was the largest in the domestic “Jen-Fissufil” – 9.80 ± 1.17 MPa (M=10.42 MPa, min – 7.41 MPa, max – 11.07 MPa); less in “Fissurit FX” – 9.78 ± 1.33 MPa (M=9.43 MPa, min – 8.23 MPa, max – 12.62 MPa) and “Clinpro™ Sealant” – 9.55 ± 1.88 MPa (М=8.69 MPa, min – 6.35 MPa, and max – 14.73 MPa). The performed statistical tests did not reveal any significant differences between the adhesion strength in all three subgroups. Due to the changes in the concept of dental caries development and approaches to its control that have taken place in dentistry over the past 30 years, the role of enamel sealants in achieving caries control in individual and communal prevention of dental diseases has significantly increased. The tendency to expand the indications for the use of photocomposite enamel sealants in clinical practice is also worth noting. In addition to their direct purpose, the materials can be used for “repair” and restoration of individual photocomposite fillings with minor wear and used as a lining material for the restoration of teeth with carious cavities with a high C-factor. Conclusion. In modern dentistry the use of enamel photocomposite sealants is one of the most effective and reliable methods of preventing caries of the occlusal surfaces of teeth. The study of shear adhesion to acid-etched enamel for photocomposite materials “Fissurit FX”, “Clinpro™ Sealant” and “Jen-Fissufil” did not reveal any significant differences. The technology of composite tooth enamel sealants is currently successful in clinical practice and continues to improve and develop. The development of new and quality improvement of such materials is an urgent issue for science and technology","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"273 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132829969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Indicators of Qualified Runners in Sprint Events at the Special Preparatory Stage of the Annual Macrocycle","authors":"Yaroslav Svyshch, T. Dukh","doi":"10.26693/jmbs07.06.213","DOIUrl":"https://doi.org/10.26693/jmbs07.06.213","url":null,"abstract":"The purpose of the study was to analyze the indicators of functional readiness of qualified runners in sprint events at the special preparatory stage of the annual training cycle. Materials and methods. The methods of theoretical analysis and generalization of data from scientific and methodological literature and Internet resources, pedagogical experiment, instrumental methods such as anthropometric measurements, research of indicators of the cardiovascular and respiratory systems and methods of mathematical statistics were used in the study. 28 sprint-distance track and field athletes between the ages of 18 and 24 with sports qualifications, candidates for masters of sports and masters of sports, with experience in athletics from 4 to 9 years took part in the study. Surveys were conducted at the special preparatory stage of the annual macrocycle. The functional state was assessed by the method of indices (Robinson index, Skibinski index, hypoxia index, Quetelet index, cardiac index, vital index). Results and discussion. The most informative indicators have been established that characterize the level of functional fitness in sprint events runners. The Quetelet index of our studied athletes is 22.13 ± 0.56 units, which indicates their optimal body weight and corresponds to age norms. The indicators of the cardiovascular and respiratory systems correspond to the appropriate norms, and some of them exceed the limits of norms for untrained individuals. According to our results, the indicator of the proper vital capacity of the lungs is 4.97 ± 0.13 l, and the deviation of the vital capacity of the lungs is 8.0%, which corresponds to the limits of the physiological norm. Almost all indicators are characterized by a low coefficient of variation, except for the Skibinski index (14%) and the hypoxia index (10%). The indicators of the functional tests of Shtange (74.73 ± 4.65 s), Genchi (48.47 ± 4.23 s), Skibinsky (52.54 ± 6.98 c.u.) are above the average level. Conclusion. It has been established that the eukinetic type of blood circulation is characteristic of qualified sprint events runners. According to the Robinson index, the average level of functioning of the cardiovascular system in sprint events runners was found to be 82.61 ± 3.51 units. According to the hypoxia index, a high level of the body's resistance to oxygen deficiency (0.73 ± 0.08 с.u.) was established in qualified sprint events runners. Analysis of the functional fitness of track and field athletes will allow to adjust and optimize the construction of the training process in order to achieve maximum sports results","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114421357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of Somatic and Gynecological Status of Women with Abnormal Uterine Bleeding with Autoimmune Thyroiditis","authors":"O. Alekseeva, V. Lazurenko","doi":"10.26693/jmbs07.06.062","DOIUrl":"https://doi.org/10.26693/jmbs07.06.062","url":null,"abstract":"The purpose of the study was to determine the peculiarities of somatic and gynecological status of women with abnormal uterine bleeding, who have autoimmune thyroiditis. Materials and methods. 120 women of reproductive age, of whom there were 90 patients with abnormal uterine bleeding and 30 women without gynecological pathology (control group), were examined. Patients from the main group were divided into 2 clinical groups: 60 women with autoimmune thyroiditis were included in the main group and 30 women without signs of thyroid gland pathology made up the comparison group. The research was conducted and the results of anamnestic data, somatic and gynecological status, clinical laboratory and ultrasound examinations, conservative and operative treatment were analyzed. The study was conducted in the gynecological department of the Communal Non-Commercial Enterprise of the Kharkiv Regional Council “Kharkiv Regional Clinical Hospital” during 2019-2022. Statistical processing of the obtained data was performed using the “Statistica 6.0” program. Results and discussion. As a result of the analysis of the anamnesis data of the patients of the main group, a hereditary predisposition to thyroid gland diseases was revealed in the closest relatives of every fifth patient with autoimmune thyroiditis. Among the concomitant gynecological pathology, such diseases as uterine leiomyoma, endometriosis of various localization, endometrial hyperplasia were more common in patients with uterine bleeding in combination with autoimmune thyroiditis (38.3%). In addition, fibrocystic mastopathy was also observed almost twice as often in patients with abnormal uterine bleeding against the background of autoimmune thyroiditis (25%) than in the group without thyroid gland pathology, which may be due to the hormonal dependence of the above-mentioned diseases, and is a predictor of the development of hereditary endocrine dysfunction and greater susceptibility of the reproductive system to exogenous and endogenous factors. When studying the somatic status of patients with abnormal uterine bleeding in combination with autoimmune thyroiditis, a significant prevalence of comorbid somatic pathology was noted. Among women with 2-3 concomitant diseases, the following combinations were most common: hypertension and obesity (13%); hypertension, chronic pancreatitis, varicose veins of the lower extremities (7%), chronic pyelonephritis, fibrocystic mastopathy. Every third patient had a combination of obesity, liver disease, and hypertension. It should be noted that in women with abnormal uterine bleeding without autoimmune thyroiditis, the accompanying pathology was twice as low as in the group suffering from the specified thyroid disease. Menstrual cycle disorders of various nature were detected. Irregular menstrual cycle occurred twice as often in women with abnormal uterine bleeding against the background of autoimmune thyroiditis than in women without concomitant thyroid disease – i","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121956849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Heredity in the Development of Anxiety Disorders among Patients with a Difficult Family History of Dementia","authors":"К. V. Hryn","doi":"10.26693/jmbs07.06.070","DOIUrl":"https://doi.org/10.26693/jmbs07.06.070","url":null,"abstract":"Dementia has a physical, psychological, social and economic impact not only on the sick person, but also on the people who care for him / her, on family members and society as a whole. Family members are prone to the development of anxiety and depressive disorders, and are often in \"anxious anticipation\" of the development of dementia in themselves, since the role of genetic burden in the etiology of this pathological process is undeniable. The purpose of the study was to analyze the degree of depth of anxiety disorders in first-line descendants of patients with dementia. Materials and methods. The study used clinical and anamnestic, clinical and psychopathological research methods, the syndromic approach to establishing a diagnosis and the genealogical method with the construction and analysis of a family tree. After obtaining informed consent, 26 patients (all female patients) who sought medical help from a psychiatrist during 2021-2022 with symptoms of anxiety disorder were examined. Results and discussion. Clinical and anamnestic analysis revealed a 100% hereditary susceptibility to dementia. In the genealogical analysis of pedigrees, in 65.4% of cases, the hereditary burden was traced in two previous generations, in 11.5% ‒ in three previous generations. Analyzing the results of the clinical-psychopathological examination of the level of anxiety according to the General Anxiety Disorder-7 scale, it was found that all patients had signs of generalized anxiety disorder (medium – 10–14 points and high level – 15–21 points). The results of anxiety analysis according to the Hamilton Anxiety Rating Scale confirmed the clinical results. The anxiety indicators of all patients reached from 20 to 25 points, which corresponds to an anxious state. At the same time, a clear correlation was found between the hereditary burden and the level of anxiety: patients with a hereditary burden for dementia in three generations had the highest level of anxiety, patients with a hereditary burden in two generations had a slightly lower level of anxiety, a moderate level of anxiety was detected in patients with a family history of dementia no more than in one of the previous generations. Conclusion. Considering the polygenic nature of dementia, it can be concluded that not only the genetic component plays a role in the development of certain multifactorial diseases, in particular dementia. Given the presence of an environmental component, a patient with a hereditary predisposition and genealogical burden of this disease must make efforts to minimize environmental influences. The identification of a clear correlation between the hereditary burden of dementia in generations and the severity of an anxiety disorder makes it possible to understand the approaches to pharmaco- and psychotherapeutic interventions in this contingent of individuals","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114064889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Stress-Induced Disorders in Women with Uterus Leiomyoma on the Background of Hormone Therapy during the Wartime","authors":"O. Doroga, N. M. Ovodyuk, N. Shestak, S. P. Hlabets, V. S. Matsyshyn","doi":"10.26693/jmbs07.06.081","DOIUrl":"https://doi.org/10.26693/jmbs07.06.081","url":null,"abstract":"The purpose of the study was to assess psychosomatic changes and determine clinical and laboratory indicators in women with uterine fibroids under the conditions of using hormonal therapy and a drug with anxiolytic effect. Materials and methods. The study analyzed the results of 60 women with uterine fibroids who had anxiety disorder symptoms. The patients were divided into two groups: Group I – patients with uterine fibroids who took combined oral contraceptives (n=30); Group II – patients with uterine fibroids who took the anxiolytic medication fabomotizole concurrently with combined oral contraceptives (n=30). Results and discussion. The research established that patients with uterine fibroids had a change in their psycho-emotional state with a tendency to a high level of anxiety and depression. Treatment with combined oral contraceptives and fabomotizole demonstrated a more stable emotional background as compared to patients who took only combined oral contraceptives. The percentage of patients with the low level anxiety increased and the percentage of patients with the high level anxiety decreased. Among women who were treated with combined oral contraceptives only, there was still a considerable proportion of patients with high levels of anxiety and depression. It was found that the use of combined oral contraceptives in combination does not result in changes regrading the size of the tumor compared to the indicators of patients who did not take the drug with an anxiolytic effect. However, this group of patients demonstrated a tendency to stabilize the growth of nodes, to decrease clinical manifestations in the form of pain and intermenstrual bleeding in the first months of taking combined oral contraceptives. It should be noted that in patients who were not administered fabomotizole, the studied indicators remained at a lower level compared to the indicators of patients who were prescribed this drug. Probably, restoration of the psycho-emotional state in women with uterine fibroids under the influence of fabomotizole increases the effectiveness of hormonal therapy. Conclusion. The patients of both studied groups were shown to have developed pronounced anemia, which was confirmed by low values of hemoglobin in the blood, and the levels of ferritin and transferrin in the blood serum decreased. An increase in the studied indicators was observed after combined oral contraceptive treatment, and specifically after treatment with a combination of combined oral contraceptives and fabomotizole. However, the levels of ferritin and transferrin remained at a lower level compared to normal values","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116371689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of Treatment Tactics for Patients with Trunk Lesions of Coronary Arteries","authors":"O. Levchyshyna, E. V. Aksyonov, S. V. Salo","doi":"10.26693/jmbs07.06.023","DOIUrl":"https://doi.org/10.26693/jmbs07.06.023","url":null,"abstract":"Damage to the trunk of the left coronary artery is the most dangerous manifestation of coronary atherosclerosis. Mortality with this type of lesions occurs by 3–4 times more often compared to lesions of other segments of coronary arteries. On the basis of previous clinical studies demonstrating advantages of coronary artery bypass grafting over drug therapy in terms of patient survival, coronary artery bypass grafting has long been considered the gold standard for the treatment of these lesions. The purpose of the work was to study the literature data on the evolution and peculiarities of the choice of methods of surgical treatment of coronary heart disease in patients with severe lesions of the trunk of the left coronary artery. Results and discussion. Along with the improvement of endovascular instrumentation, stenting procedures, antithrombotic agents, as well as concomitant drug therapy, percutaneous coronary interventions for lesions of the left trunk are becoming more and more widespread and show favorable clinical results in these patients. This is evidenced by the data of many randomized multicenter studies (SYNTAX, EXCEL). Based on the results of these studies, ESC/EACTS approved the following guidelines for myocardial revascularization in 2018. Percutaneous coronary interventions are indicated in the case of damage to the left trunk with scores on the SYNTAX scale less than 22 – class I, scores on the SYNTAX scale 23–32 – class IIa, and scores on the SYNTAX scale greater than 32 – class III. However, it is worth noting that both the American and the European guidelines recommend a discussion by a team of endovascular surgeons, cardiologists and cardiac surgeons (Heart Team) when choosing a treatment strategy for coronary artery disease patients with lesions of the trunk of the left coronary artery. Since the data of many studies on the treatment of patients with lesions of the trunk of the left coronary artery remain quite contradictory and ambiguous. Conclusion. Current literature data have shown that left coronary artery stenting is a fairly safe procedure, with a high rate of immediate success, low mortality, and few complications, especially in low-risk surgical patients. The use of stents with medical coating made it possible to reduce the frequency of repeated interventions to 10–12%. A number of issues remain, the solution of which would allow optimizing the application of this technique. These include: development of indications for surgical or endovascular treatment of lesions of the left coronary artery trunk, optimization of stenting techniques, assessment of the significance of concomitant pathology in the effectiveness of treatment of patients with lesions of the left coronary artery trunk","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129291448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}