Progress in Particle and Nuclear Physics最新文献

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Novel approaches in hadron spectroscopy 强子光谱学的新方法
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-11-01 DOI: 10.1016/j.ppnp.2022.103981
Miguel Albaladejo , Łukasz Bibrzycki , Sebastian M. Dawid , César Fernández-Ramírez , Sergi Gonzàlez-Solís , Astrid N. Hiller Blin , Andrew W. Jackura , Vincent Mathieu , Mikhail Mikhasenko , Victor I. Mokeev , Emilie Passemar , Alessandro Pilloni , Arkaitz Rodas , Jorge A. Silva-Castro , Wyatt A. Smith , Adam P. Szczepaniak , Daniel Winney , (Joint Physics Analysis Center)
{"title":"Novel approaches in hadron spectroscopy","authors":"Miguel Albaladejo ,&nbsp;Łukasz Bibrzycki ,&nbsp;Sebastian M. Dawid ,&nbsp;César Fernández-Ramírez ,&nbsp;Sergi Gonzàlez-Solís ,&nbsp;Astrid N. Hiller Blin ,&nbsp;Andrew W. Jackura ,&nbsp;Vincent Mathieu ,&nbsp;Mikhail Mikhasenko ,&nbsp;Victor I. Mokeev ,&nbsp;Emilie Passemar ,&nbsp;Alessandro Pilloni ,&nbsp;Arkaitz Rodas ,&nbsp;Jorge A. Silva-Castro ,&nbsp;Wyatt A. Smith ,&nbsp;Adam P. Szczepaniak ,&nbsp;Daniel Winney ,&nbsp;(Joint Physics Analysis Center)","doi":"10.1016/j.ppnp.2022.103981","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103981","url":null,"abstract":"<div><p>The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons<span>. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy.</span></p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"127 ","pages":"Article 103981"},"PeriodicalIF":9.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3139627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Holographic approach to compact stars and their binary mergers 致密恒星及其双星合并的全息方法
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-09-01 DOI: 10.1016/j.ppnp.2022.103972
Carlos Hoyos , Niko Jokela , Aleksi Vuorinen
{"title":"Holographic approach to compact stars and their binary mergers","authors":"Carlos Hoyos ,&nbsp;Niko Jokela ,&nbsp;Aleksi Vuorinen","doi":"10.1016/j.ppnp.2022.103972","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103972","url":null,"abstract":"<div><p>In this review article, we describe the role of holography in deciphering the physics of dense QCD matter, relevant for the description of compact stars and their binary mergers. We review the strengths and limitations of the holographic duality in describing strongly interacting matter at large baryon density, walk the reader through the most important results derived using the holographic approach so far, and highlight a number of outstanding open problems in the field. Finally, we discuss how we foresee holography contributing to compact-star physics in the coming years.</p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"126 ","pages":"Article 103972"},"PeriodicalIF":9.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3270352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Nuclear weak rates and nuclear weak processes in stars 恒星中的核弱速率和核弱过程
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-09-01 DOI: 10.1016/j.ppnp.2022.103974
Toshio Suzuki
{"title":"Nuclear weak rates and nuclear weak processes in stars","authors":"Toshio Suzuki","doi":"10.1016/j.ppnp.2022.103974","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103974","url":null,"abstract":"&lt;div&gt;&lt;p&gt;&lt;span&gt;&lt;span&gt;Nuclear weak rates in stellar environments are obtained by taking into account recent advances in shell-model studies of spin-dependent excitation modes in nuclei including Gamow–Teller (GT) and spin-dipole transitions. They are applied to nuclear weak processes in stars such as cooling and heating of the cores of stars and nucleosynthesis in supernovae. The important roles of accurate weak rates for the study of &lt;/span&gt;astrophysical processes are pointed out in the following cases. (1) The electron-capture (e-capture) and &lt;/span&gt;&lt;span&gt;&lt;math&gt;&lt;mi&gt;β&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;-decay rates in &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;d&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;-shell are evaluated with the USDB Hamiltonian and used to study the evolution of O-Ne-Mg cores in stars with 8–10 M&lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mo&gt;⊙&lt;/mo&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;. The important roles of the &lt;span&gt;&lt;math&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt; &lt;span&gt;&lt;math&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;/math&gt;&lt;/span&gt;&lt;span&gt; 23 and 25 pairs of nuclei for the cooling of the cores by nuclear Urca processes are investigated. (2) They are also used to study heating of the O-Ne-Mg core by double e-captures on &lt;/span&gt;&lt;sup&gt;20&lt;/sup&gt;Ne in later stages of the evolution. Especially, the e-capture rates for a second-forbidden transition in &lt;sup&gt;20&lt;/sup&gt;&lt;span&gt;Ne are evaluated with the multipole expansion method by Walecka as well as the method of Behrens–B&lt;/span&gt;&lt;span&gt;&lt;math&gt;&lt;mover&gt;&lt;mrow&gt;&lt;mtext&gt;u&lt;/mtext&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mo&gt;̈&lt;/mo&gt;&lt;/mrow&gt;&lt;/mover&gt;&lt;/math&gt;&lt;/span&gt;hring. Possible important roles of the transition in heating the O-Ne-Mg cores and implications on the final fate of the cores (core-collapse or thermonuclear explosion) are discussed. (3) The weak rates in &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;&lt;span&gt;&lt;span&gt;-shell nuclei are evaluated with a new Hamiltonian, GXPF1J, and applied to nucleosynthesis of iron-group elements in Type Ia supernova explosions. The over-production problem of neutron-rich &lt;/span&gt;iron isotopes&lt;span&gt; compared with the solar abundances, which remained for the rates according to Fuller, Fowler and Newman, is much improved, and the over-production is now reduced to be within a factor of two. (4) The weak rates for nuclei with two-major shells are evaluated. For &lt;/span&gt;&lt;/span&gt;&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;d&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;-&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mi&gt;f&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt; shell in the island of inversion, the weak rates for the &lt;span&gt;&lt;math&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt; &lt;span&gt;&lt;math&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;/math&gt;&lt;/span&gt; 31 pair of nuclei, which are important for nuclear Urca processes in neutron-star crusts, are evaluated with the effective interaction obtained by the extended Kuo–Krenciglowa (EKK) method. Neutron-rich nuclei with and near neutron number (&lt;span&gt;&lt;math&gt;&lt;mi&gt;N&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;) of 50 are important for core-collapse processes in supernova explosions. The transition strengths and e-capture rates in &lt;sup&gt;78&lt;/sup&gt;Ni are evaluated with a new shell-model Hamiltonian for the &lt;span&gt;&lt;math","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"126 ","pages":"Article 103974"},"PeriodicalIF":9.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3270353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Transport model comparison studies of intermediate-energy heavy-ion collisions 中能量重离子碰撞输运模型比较研究
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-07-01 DOI: 10.1016/j.ppnp.2022.103962
Hermann Wolter , Maria Colonna , Dan Cozma , Pawel Danielewicz , Che Ming Ko , Rohit Kumar , Akira Ono , ManYee Betty Tsang , Jun Xu , Ying-Xun Zhang , Elena Bratkovskaya , Zhao-Qing Feng , Theodoros Gaitanos , Arnaud Le Fèvre , Natsumi Ikeno , Youngman Kim , Swagata Mallik , Paolo Napolitani , Dmytro Oliinychenko , Tatsuhiko Ogawa , Wen-Jie Xie
{"title":"Transport model comparison studies of intermediate-energy heavy-ion collisions","authors":"Hermann Wolter ,&nbsp;Maria Colonna ,&nbsp;Dan Cozma ,&nbsp;Pawel Danielewicz ,&nbsp;Che Ming Ko ,&nbsp;Rohit Kumar ,&nbsp;Akira Ono ,&nbsp;ManYee Betty Tsang ,&nbsp;Jun Xu ,&nbsp;Ying-Xun Zhang ,&nbsp;Elena Bratkovskaya ,&nbsp;Zhao-Qing Feng ,&nbsp;Theodoros Gaitanos ,&nbsp;Arnaud Le Fèvre ,&nbsp;Natsumi Ikeno ,&nbsp;Youngman Kim ,&nbsp;Swagata Mallik ,&nbsp;Paolo Napolitani ,&nbsp;Dmytro Oliinychenko ,&nbsp;Tatsuhiko Ogawa ,&nbsp;Wen-Jie Xie","doi":"10.1016/j.ppnp.2022.103962","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103962","url":null,"abstract":"<div><p><span><span>Transport models are the main method to obtain physics information on the nuclear </span>equation of state and in-medium properties of particles from low to relativistic-energy heavy-ion collisions. The Transport Model Evaluation Project (TMEP) has been pursued to test the robustness of transport model predictions in reaching consistent conclusions from the same type of physical model. To this end, calculations under controlled conditions of physical input and set-up were performed with various participating codes. These included both calculations of nuclear matter in a box with </span>periodic boundary conditions<span>, which test separately selected ingredients of a transport code, and more realistic calculations of heavy-ion collisions. Over the years, six studies have been performed within this project. In this intermediate review, we summarize and discuss the present status of the project. We also provide condensed descriptions of the 26 participating codes, which contributed to some part of the project. These include the major codes in use today. After a compact description of the underlying transport approaches, we review the main results of the studies completed so far. They show, that in box calculations the differences between the codes can be well understood and a convergence of the results can be reached. These studies also highlight the systematic differences between the two families of transport codes, known under the names of Boltzmann–Uehling–Uhlenbeck (BUU) and Quantum Molecular Dynamics (QMD) type codes. However, when the codes were compared in full heavy-ion collisions using different physical models, as recently for pion production, they still yielded substantially different results. This calls for further comparisons of heavy-ion collisions with controlled models and of box comparisons of important ingredients, like momentum-dependent fields, which are currently underway. Our evaluation studies often indicate improved strategies in performing transport simulations and thus can provide guidance to code developers. Results of transport simulations of heavy-ion collisions from a given code will have more significance if the code can be validated against benchmark calculations such as the ones summarized in this review.</span></p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"125 ","pages":"Article 103962"},"PeriodicalIF":9.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3270355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Coupled-channels calculations for nuclear reactions: From exotic nuclei to superheavy elements 核反应的耦合通道计算:从外来核到超重元素
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-07-01 DOI: 10.1016/j.ppnp.2022.103951
K. Hagino , K. Ogata , A.M. Moro
{"title":"Coupled-channels calculations for nuclear reactions: From exotic nuclei to superheavy elements","authors":"K. Hagino ,&nbsp;K. Ogata ,&nbsp;A.M. Moro","doi":"10.1016/j.ppnp.2022.103951","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103951","url":null,"abstract":"<div><p><span>Atomic nuclei are composite systems, and they may be dynamically excited during nuclear reactions. Such excitations are not only relevant to inelastic scattering but they also affect other reaction processes such as elastic scattering and fusion. The coupled-channels approach is a framework which can describe these reaction processes in a unified manner. It expands the total wave function of the system in terms of the ground and excited states of the colliding nuclei, and solves the coupled Schrödinger equations to obtain the </span><span><math><mi>S</mi></math></span><span><span>-matrix, from which several cross sections can be constructed. This approach has been a standard tool to analyze experimental data for nuclear reactions. In this paper, we review the present status and the recent developments of the coupled-channels approach. This includes the microscopic coupled-channels method and its application to cluster physics, the continuum discretized coupled-channels (CDCC) method for breakup reactions, the semi-microscopic approach to heavy-ion subbarrier fusion reactions, the channel coupling effects on </span>nuclear astrophysics and syntheses of superheavy elements, and inclusive breakup and incomplete fusion reactions of weakly-bound nuclei.</span></p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"125 ","pages":"Article 103951"},"PeriodicalIF":9.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1869836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Light Baryon Spectroscopy 光重子光谱学
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-07-01 DOI: 10.1016/j.ppnp.2022.103949
A. Thiel, F. Afzal, Y. Wunderlich
{"title":"Light Baryon Spectroscopy","authors":"A. Thiel,&nbsp;F. Afzal,&nbsp;Y. Wunderlich","doi":"10.1016/j.ppnp.2022.103949","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103949","url":null,"abstract":"<div><p>This review treats the advances in <span><em>Light </em><em>Baryon</em><em> Spectroscopy</em></span> of the last two decades, which were mainly obtained by measuring meson-production reactions at photon facilities all over the world. We provide a consistent compendium of experimental results, as well as a review of the theoretical methods of amplitude analysis used to analyze the data. The most significant datasets are presented in detail and are listed in combination with a full set of the relevant references. In addition, a brief summary of spin-formalisms, which are ubiquitous in <em>Light Baryon Spectroscopy</em>, as well as a review on complete experiments, are provided. The synthesis of the reviewed knowledge is presented in a full interpretation of the new results on the <em>Light Baryon Spectrum</em>.</p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"125 ","pages":"Article 103949"},"PeriodicalIF":9.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1869835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Neutrinos and their interactions with matter 中微子及其与物质的相互作用
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-06-28 DOI: 10.1016/j.ppnp.2022.103984
M. Sajjad Athar, A. Fatima, S.K. Singh
{"title":"Neutrinos and their interactions with matter","authors":"M. Sajjad Athar, A. Fatima, S.K. Singh","doi":"10.1016/j.ppnp.2022.103984","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103984","url":null,"abstract":"","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45857779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
An experimental view on shape coexistence in nuclei 原子核形状共存的实验观点
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-05-01 DOI: 10.1016/j.ppnp.2021.103931
Paul E. Garrett , Magda Zielińska , Emmanuel Clément
{"title":"An experimental view on shape coexistence in nuclei","authors":"Paul E. Garrett ,&nbsp;Magda Zielińska ,&nbsp;Emmanuel Clément","doi":"10.1016/j.ppnp.2021.103931","DOIUrl":"https://doi.org/10.1016/j.ppnp.2021.103931","url":null,"abstract":"<div><p>Nuclear shape coexistence is the phenomenon in which distinct shapes occur within the same nucleus and at a similar energy. In this work, we provide an overview of the experimental investigations of shape coexistence, focusing on those regions of the nuclear chart that have been the most actively investigated within the past decade. In particular, we focus on coexistence phenomena at low angular momentum and on the new experimental information, placed within the context of previous results. We first give a summary of the experimental signatures that can be used for assessing shape coexistence, and then discuss the evidence for shape coexistence from experimental results, with particular attention paid to regions where its presence has been suggested along isotopic or isotonic chains, and in regions where “islands” of such structures have been proposed. We conclude with an overview, with an emphasis on the emerging regions where indications for multiple shape coexistence exist.</p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"124 ","pages":"Article 103931"},"PeriodicalIF":9.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2142387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Studying the QGP with Jets at the LHC and RHIC 在大型强子对撞机和强子对撞机上用喷流研究QGP
IF 9.6 2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-05-01 DOI: 10.1016/j.ppnp.2022.103940
Leticia Cunqueiro , Anne M. Sickles
{"title":"Studying the QGP with Jets at the LHC and RHIC","authors":"Leticia Cunqueiro ,&nbsp;Anne M. Sickles","doi":"10.1016/j.ppnp.2022.103940","DOIUrl":"https://doi.org/10.1016/j.ppnp.2022.103940","url":null,"abstract":"<div><p><span>We review the current status of jet measurements in heavy-ion collisions at the Large Hadron Collider (LHC) and the Relativistic </span>Heavy Ion Collider (RHIC). We discuss how the current measurements provide information about the quark-gluon plasma and discuss near future opportunities at both RHIC and the LHC.</p></div>","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"124 ","pages":"Article 103940"},"PeriodicalIF":9.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2900151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial. 晚期或转移性雌激素受体阳性、HER2 阴性乳腺癌(BOOSTER):一项随机、开放标签的 2 期试验。
2区 物理与天体物理
Progress in Particle and Nuclear Physics Pub Date : 2022-05-01 Epub Date: 2022-04-08 DOI: 10.1016/S1470-2045(22)00196-6
Shigehira Saji, Naruto Taira, Masahiro Kitada, Toshimi Takano, Masahiro Takada, Tohru Ohtake, Tatsuya Toyama, Yuichiro Kikawa, Yoshie Hasegawa, Tomomi Fujisawa, Masahiro Kashiwaba, Takanori Ishida, Rikiya Nakamura, Yutaka Yamamoto, Uhi Toh, Hiroji Iwata, Norikazu Masuda, Satoshi Morita, Shinji Ohno, Masakazu Toi
{"title":"Switch maintenance endocrine therapy plus bevacizumab after bevacizumab plus paclitaxel in advanced or metastatic oestrogen receptor-positive, HER2-negative breast cancer (BOOSTER): a randomised, open-label, phase 2 trial.","authors":"Shigehira Saji, Naruto Taira, Masahiro Kitada, Toshimi Takano, Masahiro Takada, Tohru Ohtake, Tatsuya Toyama, Yuichiro Kikawa, Yoshie Hasegawa, Tomomi Fujisawa, Masahiro Kashiwaba, Takanori Ishida, Rikiya Nakamura, Yutaka Yamamoto, Uhi Toh, Hiroji Iwata, Norikazu Masuda, Satoshi Morita, Shinji Ohno, Masakazu Toi","doi":"10.1016/S1470-2045(22)00196-6","DOIUrl":"10.1016/S1470-2045(22)00196-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Anticancer treatment regimens typically cause unpleasant side-effects. We aimed to investigate the benefit of switch maintenance endocrine therapy plus bevacizumab after fixed cycles of first-line induction chemotherapy with weekly paclitaxel plus bevacizumab in patients with oestrogen receptor (ER)-positive, HER2-negative advanced or metastatic breast cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;BOOSTER was a prospective, open-label, multicentre, randomised, controlled, phase 2 study done in 53 hospitals in Japan. Eligible patients were women aged 20-75 years, with an Eastern Cooperative Oncology Group performance status of 0-1, who had not received chemotherapy for ER-positive, HER2-negative advanced or metastatic breast cancer. All patients received four to six cycles (in which 4 weeks of treatment constitute one cycle) of weekly paclitaxel plus bevacizumab induction therapy (weekly paclitaxel 90 mg/m&lt;sup&gt;2&lt;/sup&gt;, administered intravenously on days 1, 8, and 15 of each cycle, plus bevacizumab 10 mg/kg administered intravenously on days 1 and 15 of each cycle; first registration). Patients with a complete response, partial response, or stable disease after induction therapy (responders) were then randomly assigned (1:1) using the randomisation enrolment form to either continue weekly paclitaxel plus bevacizumab or switch to maintenance endocrine therapy (an aromatase inhibitor or fulvestrant with or without ovarian-function suppression) plus bevacizumab. Randomisation was stratified by induction therapy period, response to induction therapy, age, history of endocrine therapy, and study site. Patients could receive weekly paclitaxel plus bevacizumab reinduction if they had disease progression with maintenance endocrine therapy plus bevacizumab. The primary endpoint was time to failure of strategy (TFS). Efficacy and safety analyses were done in all treated patients (full analysis set). This study is registered with ClinicalTrials.gov, NCT01989780, and registration and follow-up are closed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Findings: &lt;/strong&gt;Between Jan 1, 2014, and Dec 31, 2015, we enrolled 160 patients who began weekly paclitaxel plus bevacizumab induction therapy. 125 (78%) patients (responders) were randomly assigned to endocrine therapy plus bevacizumab (n=62; n=61 in the full analysis set) or weekly paclitaxel plus bevacizumab (n=63; n=63 in the full analysis set). Among 61 patients in the switch maintenance endocrine therapy plus bevacizumab group, 32 (52%) were reinitiated on weekly paclitaxel plus bevacizumab. At a median follow-up of 21·3 months (IQR 13·0-28·2), TFS was significantly longer in the endocrine therapy plus bevacizumab group than in the weekly paclitaxel plus bevacizumab group (median 16·8 months [95% CI 12·9-19·0] vs 8·9 months [5·7-13·8]; hazard ratio 0·51 [0·34-0·75]; p=0·0006). The most common grade 3-4 non-haematological adverse events after randomisation were proteinuria (in ten [16%] of 61 patients in the end","PeriodicalId":412,"journal":{"name":"Progress in Particle and Nuclear Physics","volume":"20 1","pages":"636-649"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75508152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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