Medical Perspectives-Medicni Perspektivi最新文献

{"title":"Evaluation of the main parameters of the compartmental model of the epidemic development based on the example of the spread of the COVID-19 pandemic in Chernivtsi region","authors":"V. Nahirniak","doi":"10.26641/2307-0404.2023.1.276215","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276215","url":null,"abstract":"The paper considers the application of the theoretical model of epidemiological development of COVID-19 disease among the regional population based on the statistical data in Chernivtsi region of Ukraine for the period from March 2020 to June 2021. Using these data, a mathematical assessment of the values of the main parameters of the compartmental model (SIR) β and γ was performed and the analysis of the relationship between the values of β and γ and antiepidemiological measures was carried out for the region. Determining the parameters β and γ based on available statistics allows us to predict the duration of precautionary measures such as quarantine, lockdown, border closure and predict the effectiveness of their implementation as well. The analysis of statistical data showed the moderate effectiveness of quarantine and lockdown in changing the daily rates of infected and recovered people, while the dynamics of the epidemic development during these periods changed from negative to positive. The introduction of vaccination has shown the significant reduction in the daily rate of infected people and the substantial increase in the daily rate of the recovered people.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"25 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76582874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems of physical rehabilitation of movement disorders in the pathology of the hip joint in patients with the consequences of a cerebral stroke","authors":"О.І. Shkurupіi, І.М. Olexenko, О. Smirnova, N.Y. Gryshunina, K. O. Yaroshenko","doi":"10.26641/2307-0404.2023.1.275872","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.275872","url":null,"abstract":"The purpose of the work was to analyze the experience of foreign specialists regarding movement and structural disorders of the proximal part of the femur in patients with the consequences of stroke and their impact on the effectiveness of rehabilitation programs for hip joint pathology. To fulfill the goal, an analysis of foreign literary sources was carried out in modern databases: Google Scholar, Web of Science, PubMed, Medline, Cochrane, Pedro. The search depth is 22 years (from January 2000 to October 2021). The analysis of literature sources indicated that limitation of motor activity and axial loads in patients after acute cerebrovascular accident, in particular limitation of mobility in the hip joint, impairment of muscle strength and tone due to hemiparesis can lead to the development of osteoporosis. Particularly important from the point of view of adverse consequences is a decrease in mineral density and fractures of the proximal part of the femur. On the other hand, disturbed biomechanics of movements in the hip joint in persons with the consequences of a cerebral stroke, under the condition of axial load on the limb, can lead to the development of osteoarthritis of the hip joint. Osteoarthritis results in limited mobility of the hip joint, which leads to secondary immobilization of the hip joint and, as a result, can also lead to further osteoporosis. Existing disorders of neuromuscular control, muscle tone and strength, limitation of mobility of the hip joint, including due to spasticity, problems with static and dynamic balance, and, as a result, an increased risk of falling in patients with the consequences of a stroke, can negatively affect the recovery of motor functions, activity limitation, and, as a result, reduce the effectiveness of rehabilitation of patients after hip joint replacement. Existing movement disorders, as a result of a stroke, require the development and justification of new rehabilitation programs, including the use of modern technical means and virtual reality.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"7 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74258837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern approach to infusion therapy of pregnant women with gestational hypertension","authors":"O. Vaskiv, A. Grigorenko, O.G. Gorbatyuk, A. Shatkovska, A. Binkovska, I.A. Priymak","doi":"10.26641/2307-0404.2023.1.276021","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276021","url":null,"abstract":"To date, there are no effective treatment for placental dysfunction in pregnant women with gestational hypertension. Therefore, the purpose of our study was to investigate the clinical efficacy of proposed method of infusion therapy for pregnant women with gestational hypertension, which included a complex of drugs: pentoxifylline, arginine hydrochloride with levocarnitine and rheosorbilact. We observed 73 pregnant women with single fetation, starting from 28 weeks of gestation, who were observed before and during childbirth, and in the postpartum period by the time of discharge from the hospital. All examined women were divided into 3 groups. The first group included 30 pregnant women with gestational hypertension, who received (along with the basic therapy of methyldopa drugs) a complex of infusion solutions: pentoxifylline 0.05% – 100 ml; solution containing arginine hydrochloride 4.2% and levocarnitine 2.0% – 100 ml; reosorbilact preparation – 100 ml. The infusion was carried out once a day in the specified sequence for 10 days. The second group included 20 patients with gestational hypertension on basic therapy with methuldopa only. The control group included 23 women with physiological pregnancy. The data of our study show that in patients receiving the proposed infusion therapy there was a significant decrease in the development of placental dysfunction by 38.3%, the threat of premature birth – by 18.3% and fetal distress – by 30.0%, premature rupture of the membranes – by 35.0%, weakness of labor – by 28.3%, a decrease in the risk of perinatal central nervous system damage – by 33.3% and the frequency of cephalohematomas – by 30.0% compared with women who received only antihypertensive therapy.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84956599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological changes of liver and spleen under the impact of dextran-polyacrylamide polymers and their effects as carriers of silver and gold nanoparticles","authors":"О.М. Kaleinikova, Valentina Kurovska, І.V. Byelinska, N. Kutsevol, Т.V. Blashkiv","doi":"10.26641/2307-0404.2023.1.275855","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.275855","url":null,"abstract":"The possibility of usage of polymer nanocomposites is being intensively studied today with a purpose of their application in medicine, espessialy in oncology. At the experimental stage it is important to determine the mechanisms of the influence of such compounds on the body and their own possible undesirable effects. Aim – to study the effect of the treatment with maximal doses of the dextran-polyacrylamide polymers and their effect as carriers of silver and gold nanoparticles on the spleen and liver. Histological examination of micropreparations of the spleen and liver by the standard method with hematoxylin-eosin staining was made. As a result of the treatment with nonionic (D-g-PAA) and anionic (D-g-PAA (PE)) polymer matrices, changes which occurred in the spleen indicate an increase in the production of all blood cells. These phenomena were absent when silver and gold nanoparticles were included in the matrix. In the liver, treatment with D-g-PAA and D-g-PAA (PE) caused a disorder of hepatic circulation, focal infiltration by inflammatory cells and death of hepatocytes by necrosis. The addition of nanoparticles triggered other mechanisms of alteration, which manifested themselves in excessive accumulation of glycogen, fatty infiltration of hepatocytes, and cell death, mainly through apoptosis. However, along with this, signs of an incomplete regenerative response of the liver were revealed. Morphological changes caused by the treatment with maximal doses of the tested substances indicate their toxic effect, especially on the liver. Further researches are needed to establish the optimal doses and the frequency of their administration, which can be used for therapeutic purposes, including the interaction of studied polymers with blood cells.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"206 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72973602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The benefits of coordinated rehabilitation in the treatment of stroke patients: A literature review","authors":"L. Shuranova, J. Vacková, M. Míková","doi":"10.26641/2307-0404.2023.1.275869","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.275869","url":null,"abstract":"The article reveals the features of coordinated rehabilitation – a process that leads to rehabilitating of people with neurological damage that limits their functionality. The purpose of the article is a literature review within the framework of GAJU 066/2022/S, funded by the grant agency of the South Bohemian University of Czech Budejovice, Czech Republic, examining the effectiveness of coordinated rehabilitation in patients recovering from strokes and the use of the standardized Functional Independence Measure (FIM) test to assess the patient’s condition. Data come from current Czech and foreign publications. The EDS multi-finder was used to search for literary sources. Document searches were from 2016-2022 in Czech and English. Search terms include post-stroke rehabilitation, FIM, rehabilitation after stroke, neurorehabilitation, and community based rehabilitation. The start of coordinated rehabilitation of stroke patients should be timely, long-term, comprehensive, and effective, involving a multidisciplinary approach and teamwork. It is essential to develop an individual approach and create a suitable individual plan that allows the use of the FIM test. This is the only way to establish long-term and mutually beneficial cooperation. As the cost of rehabilitation increases, the financial burden on the healthcare system also increases. Caring for a stroke patient also puts various burdens on the family. Successful rehabilitation can reduce the use of costly medicines and materials and decrease the need for nursing care and the term of hospital stay. The social costs of strokes are associated with long-term dependence and a low degree of resocialization. Considering the frequency of strokes and the associated disability, there is an increasing need for coordinated services within coordinated rehabilitation. Gaps in data on coordinated stroke rehabilitation should be filled by providing necessary information about long-term participation in community-based programs.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"62 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88769780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of a pelvic fracture with massive retroperitoneal hematoma","authors":"D. Krishtafor, A. Krishtafor, A. Tsarev, D. Balyk, A.Y. Halushchak, V.A. Pelekh","doi":"10.26641/2307-0404.2023.1.276259","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276259","url":null,"abstract":"Pelvic fracture is a serious injury that carries a significant risk of mortality. The cause of death in these victims is the formation of a retroperitoneal hematoma and massive bleeding. The article presents a clinical case of a pelvic fracture with a massive retroperitoneal hematoma in a 30-year-old man who was brought to the regional hospital in hemorrhagic shock 5 hours after falling from the 5th floor. Upon admission, computed tomography (CT) showed a rupture of the pubic joint, a multifragmentary fracture of the sacrum, and the presence of a hematoma in the right parts of the pelvic cavity. Despite immobilization of the fracture and massive transfusion, it was not possible to stabilize the patient's hemodynamics and improve the parameters of the patient's general blood analysis. Due to the clinic of active bleeding, the patient repeatedly underwent control ultrasound examinations of the abdominal cavity and pleural sinuses, but the presence of free fluid in the abdominal cavity could be confirmed only after 12 hours of treatment. At the emergency laparotomy, a hematoma was found, which spread through the retroperitoneal space to the level of the diaphragmatic crura and the root of the small-bowel mesentery in a relatively thin layer, which explained the impossibility of its visualization by ultrasound or CT. Despite the intensive care measures, over the next few days the patient's condition gradually worsened, multiple organ failure developed. On the 3rd day after the operation, the patient died due to progressive multiple organ failure. The described case demonstrates the severity of the condition of victims with a traumatic retroperitoneal hematoma and the difficulty of diagnosis and effective treatment using conservative methods.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"23 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78586967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling of wound ballistics in biological tissues simulators","authors":"","doi":"10.26641/2307-0404.2023.1.275866","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.275866","url":null,"abstract":"Modern weapons cause severe damage, accompanied by high rates of complications and mortality. The investigation of such kinds of weapons is in high demand considering the ongoing active phase of russia's war against Ukraine since February 2022. In order to understand the pathological processes that occur in and outside the gunshot wound, we conducted an experimental study using mathematical simulation. The results presented in the article will help to choose the appropriate surgical management and improve the results of treatment. The aim of this study was to investigate and evaluate the damaging effect of a 5.45 mm 7N6M bullet and a 5.45 mm V-max expansive bullet using numerical modeling of wound canals in ballistic plasticine. The Ansys Explicit Dynamics engineering complex was used to simulate the dynamics of the bullet’s motion. The basic equations, solved by the explicit dynamic analysis, express the conservation of mass, momentum, and energy in Lagrange coordinates. Together with the material model and the set of initial and boundary conditions, they determine the complete solution to the problem. Taking into account that the initial velocity of the bullet is 1185 m/s at a mass of 3.9 g, we obtain energy 2740 J. All this energy acts at the area of the wound canal with a depth of 150 mm. Injury with a conventional 7N6M bullet is characterized by the fact that it passes through the block and loses only part of the kinetic energy. The simulation results showed that the velocity of the bullet at the outlet is 220 m/s. Taking into account the initial velocity of the bullet 918 m/s with a mass of 3.4 g, we obtain the kinetic energy acting on the walls of the wound canal with a depth of 200 mm of about 830 J. Mathematic analyses showed that the expansive bullet has a soft core that deforms and transfers all the kinetic energy to the tissues immediately after penetration into the tissues. The loss of kinetic energy of the bullet (ΔE, J) is defined as the difference between the kinetic energy at the time of injury (Ec, J) and the residual energy of the bullet when leaving the material (Er, J). Numerical modeling of wound ballistics in biological tissue simulators allows us to determine with high accuracy the features of wound canal formation and tissue response to damage of bullets having different kinetic energy, which contributes to the choice of adequate surgical management during surgery for gunshot wounds.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"58 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90979425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of comorbid profile, quality of life and social functioning in patients with schizophrenia and schizotypal disorders","authors":"I. Romash","doi":"10.26641/2307-0404.2023.1.276043","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276043","url":null,"abstract":"One of the most common mental illnesses is schizophrenia and schizotypal disorders. According to the literature data, mortality among patients with schizophrenia is 1.5-2 times higher than among the general population. Patients with schizophrenia have a higher prevalence of cardiovascular disease, obesity, diabetes, osteoporosis in comparison with the general population. Such comorbid somatic diseases in the case of schizophrenia have a more acute course, a significant impact on the course of the underlying disease, the development of complications, decrease in quality of life and social functioning. The aim of the study was to study the presence and features of comorbidity, its impact on the quality of life and social functioning of patients with schizophrenia and schizotypal disorders. 100 patients were included in the study. They were divided into two groups: experimental (Group I) with schizophrenia and comparison (Group II), with other schizophrenic diseases, such as schizoaffective and schizotypal disorder. All patients were scaled according to the following methods: The Cumulative Illness Rating Scale (CIRS), Clinical Global Impression – Severity Scale (CGI-S), The Personal Social Performance Scale (PSP), CGI-S, and a short form of the questionnaire Medical Outcomes Study 36-Item Short-Form Health Status (SF-36). Charlson Index was also calculated for all patients included in the study. Due to CIRS, we detected undiagnosed comorbidity that aggravated the course of the underlying disease: 38% in Group I and 26% in Group II. The most common components in the structure of comorbidity in the patients with schizophrenia were diabetes mellitus, musculoskeletal diseases, cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD). Patients with schizotypal disorders were more often diagnosed with peripheral vascular diseases, chronic lung diseases, chronic kidney diseases, and upper gastrointestinal tract disorders. A com­pre­hensive approach to be important in the treatment of such patients. The nature and extent of comorbidity should be definitely taken into account. This will promote the compliance and improve the indicators in the examined category of patients.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"41 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84854543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular cell adhesion molecule‑1 levels in patients with coronary artery disease with type 2 diabetes mellitus","authors":"S. Serik, N. Mavrycheva","doi":"10.26641/2307-0404.2023.1.276010","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276010","url":null,"abstract":"Chronic systemic inflammation is a key component of the pathogenesis of both type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). Soluble vascular cell adhesion molecule‑1 (sVCAM‑1) is considered as the indicator of vascular inflammation and endothelial activation. The aim of our study was to investigate sVCAM‑1 levels in patients with CAD with T2DM and to determine their dependence on a previous history of myocardial infarction (MI). The study included 52 patients with stable CAD with T2DM, 20 CAD patients without diabetes and 14 control group persons. sVCAM-1 levels were measured in serum by the enzyme-linked immunosorbent assay. sVCAM‑1 levels in patients with CAD with T2DM and patients with CAD without diabetes were higher than in the control group (p<0,001 and p<0,001, respectively). The difference in sVCAM‑1 levels between CAD patients with T2DM and without diabetes was not significant (p=0,355). There were no significant correlations of sVCAM‑1 levels with glucometabolic indices in any group. Only in patients with CAD with T2DM sVCAM‑1 level negatively correlated with high-density lipoprotein cholesterol. CAD patients with and without T2DM with a history of myocardial infarction (MI) had higher sVCAM‑1 levels than patients without previous MI (p=0,038, р=0,043, respectively). Only in diabetic CAD patients sVCAM‑1 levels were increased in those without a history of MI (р=0,036, in comparison with the controls). There were no correlations between sVCAM‑1 levels and left ventricular remodeling indices in patients either with or without MI. Conclusions. In patients with CAD with T2DM and patients with CAD without T2DM, sVCAM‑1 levels increased in comparison with the controls. However, in patients without diabetes sVCAM‑1 level was increased only in those with previous MI. In patients with T2DM, sVCAM‑1 level increased in the absence of previous MI and there was the further significant increase of its level in postinfarction cardiosclerosis.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"68 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85797602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of correlation relationships between the level of mortality of the population of Zhytomyr region of Ukraine from non-infectious diseases and sanitary-chemical indicators of safety and quality of drinking water","authors":"О. Zablotska, І.M. Кyrytchuk, N. Shcherba, І.М. Nikolaieva","doi":"10.26641/2307-0404.2023.1.276204","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.1.276204","url":null,"abstract":"The purpose of the publication was to assess the strength and direction of correlation relationships between mortality rates from non-communicable diseases of the population of Zhytomyr region of Ukraine and sanitary-chemical indicators of safety and quality of drinking water. The need for this study was determined by the necessity to adjust existing and develop new strategic approaches to the prevention of non-communicable diseases that depend on the level of chemical contamination of drinking water. The study was conducted in 2016-2020. Standardized indicators of mortality from non-communicable diseases (per 100,000 population) were analyzed. 25375 water samples were studied, among them 8339 belonged to centralized and 17036 – to decentralized water supply. The strength and direction of correlation relationships between population mortality rates from non-communicable diseases and the average values of sanitary-chemical indicators of drinking water were determined by Pearson's linear correlation coefficients and the Chaddock scale. The statistical significance of the correlation coefficients was determined by Student's t-test. In the process of research work such methods as: bibliographic, medical and sociological, retrospective, epidemiological, statistical, system analysis and generalization were used. Statistically significant (p˂0.05) strong direct correlations were found between mortality rates of the urban population of Zhytomyr region from diseases of the circulatory system (I00-I99) (including myocardial infarction) (I21-I22), coronary heart disease (I20-I25), of digestive organs (K00-K93) and average total iron and total hardness values; between nervous system diseases (G00-G99) and average values of manganese in drinking water of centralized water supply, as well as between mortality rates of rural population from diseases of the circulatory system (I00-I99) and average values of total hardness, total iron and nitrates in drinking water of decentralized water supply. The urgent need to develop new strategic approaches to improve the quality of drinking water in the region as one of the factors in the prevention of non-communicable diseases has been proved.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79653410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}