Medical Perspectives-Medicni Perspektivi最新文献

{"title":"Aseptic inflammation as the essential link in the pathogenesis of endometrioid disease","authors":"Yu.A. Orlova, A.M. Hromova, O.M. Ketova, T.Yu. Liakhovska, V.B. Martynenko, E.I. Krutikova","doi":"10.26641/2307-0404.2023.3.288961","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288961","url":null,"abstract":"The paper was aimed at deter­mination of the quantitative activity of iNOS and Arg1, as well as M1 and M2 phenotype macrophages in women with endometrioid disease to establish their role in the pathogenesis of endometriosis. A prospective study was performed in gynecological units of the medical facilities of Poltava city. 140 women of reproductive age who made up the main group (110 women with endometrioid disease) and the control group (30 women without endometrioid disease) voluntarily participated in the study. All women underwent planned surgical treatment for existing gynecological pathology. Before surgical treatment, women were examined in accordance with the current Orders of the Ministry of Health of Ukraine. The spectrophotometric method was used to determine the enzymatic markers of macrophages (in the endometrium and peritoneal fluid) polarized into M1(iNOS) and M2 (Arg1) phenotypes. The type of macrophages was determined individually in each patient according to the ratios: in iNOS>Arg1, the M1 macrophage type prevailed; in Arg1>iNOS, the M2 macrophage type prevailed. When examining endometrial samplings in women from the main group, the iNOS indicator was by 1.4 times higher compared to women from the control group. The obtained results at the stage of entry into the abdominal cavity showed that mostly women from the main group suffered from the pelvic adhesion, especially stage 3 and stage 4. Among the obtained results, the increased quantitative activity in the peritoneal fluid of both iNOS and Arg1 in women of the main group was significant compared to the control group. When comparing the stages of endometrioid disease to the rates of quantitative activity of macrophage enzyme markers (in peritoneal fluid), it was found that the increase in the stage of the disease (from stage 3 to stage 4) caused an increase in the quantitative activity of Arg1 by 1.9 times and a decrease in the quantitative activity of iNOS by 2.9 times. Therefore, the planning of surgical intervention for women with endometrioid disease should consider a significant percentage of the pelvic adhesive disease, especially at the severe stages. Initiation of the chronic aseptic inflammatory process in endometrioid disease is caused by an increased quantitative activity of iNOS in the endometrium. In the pathogenesis of endometrioid disease, the presence of M2 phenotype macrophages in the peritoneal fluid is important, while the switching of macrophage phenotypes from a pro-inflammatory subpopulation to an anti-inflammatory one is crucial.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the dynamics of occupational morbidity and its consequences in Ukraine in comparison with other countries of the world","authors":"M.H. Prodanchuk, A.V. Basanets, O.P. Kravchuk, K.Y. Hashynova, V.A. Hvozdetskyy","doi":"10.26641/2307-0404.2023.3.289217","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289217","url":null,"abstract":"In general, 5-7% of global deaths are related to occupational diseases and industrial injuries. The social expenses related to occupational diseases reach 2-14% of the gross national product (GNP) in different countries. The aim of the investigation is to analyze the indicators and dynamics of occupational morbidity, related incapacity for work and disability in Ukraine in comparison with other countries of the world. The analysis of reporting materials of the State Labor Service of Ukraine, reports of the World Health Organization, and the International Labor Organization was carried out. According to the State Statistics Committee of Ukraine, the number of people working in the main sectors of the economy in conditions that do not meet sanitary and hygienic standards and requirements is 836,600 people, or 28.4% of the registered number of full-time employees. The results obtained in the study indicate the discrepancy of statistical data on occupational morbidity and its consequences with the real situation: the level of occupational morbidity in Ukraine is 17 times lower than the European average, despite the fact that the working conditions in most of them do not meet hygienic standards. The most common occupational diseases in Ukraine are diseases caused by dust exposure: pneumoconiosis, chronic bronchitis, COPD, which make up 39% of the occupational morbidity structure. The global indicator of Disability Adjusted Life Year (DALYs) from the occupational exposure factors in the world (5.1%) is 3 times higher than the similar one in Ukraine (1.53%). The rate of Years lived with disability (YLDs) caused by occupatipnal factors in Ukraine is 0.38 per 100,000 population, and is significantly lower than the similar rate in most European countries and the USA as well. Obvious distortion of statistical indicators on occupational morbidity and related consequences leads to inconsistency in determining priority areas of health care activity. Due to the process of reintegration of Ukraine into the European Union, the requirements for sanitary and hygienic working conditions, medical and sanitary services for workers, the system of recognition, registration and prevention of occupational diseases should definitely be adapted to international requirements and recommendations as well.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complicated caries of permanent teeth in children: status of the problem and modern solution ways","authors":"N.S. Proshchenko, H.V. Sorochenko, O.I. Ostapko, O.M. Plyska, Yu.V. Trokhimets","doi":"10.26641/2307-0404.2023.3.289211","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289211","url":null,"abstract":"The issue of improving dental care protocols for children with multiple (decompensated) and complicated caries of permanent teeth, their full rehabilitation is particularly relevant, especially in periods of social cataclysms (the COVID-19 pandemic, martial law, etc.). The purpose of this study was an assessment of the dental caries experience, analysis of modern approaches to diagnosis, treatment, prevention and rehabilitation of complicated caries of permanent teeth among children in Kyiv. The material of the study was data from medical histories of 236 children aged 7-18 years. During the analysis of the obtained data, the dental caries experience, % of cases of toothache complaints and part of the need for replacement or correction of restorations after the treatment of complicated caries were calculated. The prevalence of caries of permanent teeth among 7-18-year-old children (n=236) in the period 2020-2023 was 42-95%, the dental caries experience – 1.73-6.4, the frequency of diagnosis of complicated caries – 4.8-37,1%, the prevalence of toothache – 31%, the part of the need for replacement of restorations after treatment of complicated caries – 62%. The obtained indicators confirm the absence of a downward trend compared to similar data for more than 15 years of observation. Diagnosis, treatment and full rehabilitation of complicated caries of permanent teeth in children is complex, multi-stage and requires the practical experience and patience of a dentist and the usage of the most modern materials and technologies. To date, there are no clear scientifically based protocols for the restoration of permanent teeth, in particular with incomplete root formation, after endodontic treatment. The usage of modern technologies of orthopedic dentistry and materials science (3D scanner, 3D printer, T-scan, polymers) will allow to significantly improve the quality of comprehensive treatment and rehabilitation of children with complications of caries of permanent teeth.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state and prospects of implementation of data standardization in the health care system of Ukraine (literature review)","authors":"D.Ye. Kaduk, T.M. Aleksandrova, P.S. Talapova, I.B. Agieieva, M.M. Ved, M.O. Trofymenko, M.R. Kolesnyk, T.S. Nesmiian","doi":"10.26641/2307-0404.2023.3.289226","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289226","url":null,"abstract":"The orientation of the world medical community, and Ukraine in particular, towards the improvement of the quality of medical services includes the introduction of modern tools and methods for quality regulation in the healthcare system. The focus of research on the modernization of medical services, methods and forms of treatment and diagnosis, as well as focus on global experience in regulating the quality of services provided by relevant institutions, undoubtedly contributes to the transition of the Ukrainian healthcare system to a new level. One of the most powerful and modern ways to improve the medical health care system is to introduce the standardization of the format and content of medical data. Quality implementation of the standardization program is a leading factor in the improvement of the quality of medical services, such as: early detection of diseases and emergencies, setting new therapeutic goals, improving the quality of clinical trials, improving of assessment of the quality of medical services and work of the doctors and nursing staff, improving the efficiency of health care programs, improving the safety of use of medical devices, forecasting medical consequences, reducing administrative costs, integrating artificial intelligence into the healthcare system, etc.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of the treatment of patients with severe chronic urticaria","authors":"Ye.M. Dytiatkovska, N.O. Nedohybchenko","doi":"10.26641/2307-0404.2023.3.288930","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288930","url":null,"abstract":"Severe chronic urticaria (SCU) is a common disease that burdens the lives of millions of people, reduces their quality of life, and imposes a significant economic burden not only on the health care system, but also directly on the patient. To date, a single approach regarding the optimal dosing of omalizumab in this cohort of patients has not been determined. The purpose of the work: based on the assessment of the quality of life of patients with SCU and dynamic clinical and laboratory observation, to study the effectiveness and prove the feasibility of using the minimum dose of 150 mg for omalizumab according to the scheme every 21 days intramuscularly three times, which will allow to optimize the treatment tactics of these patients and reduce the economic burden of the cost of their treatment. In a prospective single-center study lasting 33 weeks, 104 patients with a diagnosis of SCU were included. All patients underwent a general clinical examination, quality of life indicators using the SKINDEX-29 questionnaire were studied; blood tryptase level once before the start of treatment using ImmunoCAP was determined, the level of total IgE in blood serum using an immunochemical method with electrochemiluminescence detection before and after the end of treatment was determined. The patients were divided into two groups: Group 1 (54 people) had a relapse of urticaria within 3 to 6 months after completing a course of second-generation histamine H1-receptor blockers and received a course of omalizumab at a dose of 150 mg intramuscularly every three weeks three times. Group 2 (50 people) had a relapse of urticaria no earlier than 6 months after the previous course of second-generation histamine H1-receptor blockers and received desloratadine, 5 mg during the first four weeks and 20 mg during the next four weeks. Indicators of urticaria activity (UAS7) and quality of life (SKINDEX-29) in patients were determined before the start of treatment and at each of the visits (on the 10th, 31st and 52nd days of therapy when treated with omalizumab and five and nine weeks after initiation of desloratadine therapy), and UAS7 was assessed six months after the end of treatment. Methods of descriptive and analytical statistics were used to process the obtained data. According to our data, patients with SCU are mostly people of working age, more than half of whom have a history of the disease for five years or more, in 70% of cases of a valid study, they are characterized by an increased content of total IgE and have a low level of indicators according to the questionnaire SKINDEX-29 at the level of physical symptoms, emotional sphere and functioning. We found that in patients of observation Groups 1 and 2, after the treatment, the level of total IgE in blood serum decreased statistically significantly. In patients of Group 1, the appointment of omalizumab in the minimum dose made it possible to ensure the control of urticaria symptoms already after the first injection","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of urban air pollution on human health","authors":"N. Komilova, K. Egamkulov, M. Hamroyev, K. Khalilova, D. Zaynutdinova","doi":"10.26641/2307-0404.2023.3.289221","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289221","url":null,"abstract":"Atmospheric air can be polluted as a result of the ingress of various chemicals into it, which have a harmful effect on human health, causing an exacerbation of cardiovascular, airborne diseases, diseases of the gastrointestinal tract and the endocrine system, and exceeding the norms of dust content in the air leads to an increase in incidence of allergies and bronchial asthma. The relevance of the subject under study lies in the investigation of the sources of air pollution, as they lead to an increase in the degree of morbidity and mortality among the population. This, in turn, requires a radical change in the way people live, as well as the adoption of specific measures to ensure the reduction of air pollution. In this regard, the objective of this study was to perform a comprehensive analysis of the ecological and hygienic conditions of atmospheric air and evaluate its impact on human health due to pollution. The study incorporated empirical research methods such as empirical description and comparison to analyze emissions of pollutants, assess population morbidity rates, and conduct correlation and regression analyses. Official data from the State Committee of Uzbekistan on Statistics and scientific papers were utilized, alongside statistical analysis techniques and logical reasoning to investigate atmospheric air pollution and its impact on public health. The study analysed the indicators of emissions of pollutants into the atmosphere in the Republic of Uzbekistan as a whole and by regions. Furthermore, the paper provides a detailed analysis of the general morbidity of the population of the Republic of Uzbekistan and indicators of the incidence of cardiovascular diseases, based on which a correlation and regression analysis was performed. In addition, the morbidity rates of the population with diseases of the respiratory system and eye diseases throughout the Sirdaryo Region were analysed. The study revealed that Uzbekistan experiences high levels of environmental pollution, with a direct correlation found between atmospheric pollutants and the incidence of cardiovascular diseases, respiratory organ issues, and eye conditions. To protect the atmosphere, reducing pollutant emissions and implementing sustainable development principles, such as industrial modernization and the use of alternative energy sources, are necessary. The results highlight the importance of identifying pollutant types, their properties, and release conditions for effective pollution assessment. The practical significance of this study is to optimize the data of environmental monitoring of urban air pollution in the Republic of Uzbekistan, where in general there is a high level of pollutants in the atmosphere, which affects the health of the population.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The values of indices of non-specific resistance and cytokine regulation for early diagnosis of secondary peritonitis","authors":"M.M. Droniak, I.M. Shevchuk, S.S. Snizhko, I.Ya. Sadovyi, N.B. Fedorkiv, R.T. Kuzenko","doi":"10.26641/2307-0404.2023.3.288963","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288963","url":null,"abstract":"The aim of the work is to study the changes in indices of non-specific resistance and cytokine regulation, relevant for the early diagnosis of secondary peritonitis. During the period 2016-2022, in the Surgery Department of the Communal Non-Profit Enterprise “Regional Clinical Hospital, Ivano-Frankivsk Regional Council” there were treated 192 patients with postoperative peritonitis. Of them, in 69 (35.9%) patients the changes in indices of non-specific resistance and cytokine regulation were studied. These studies were performed in the laboratory of the Department of Biological and Medical Chemistry of the Ivano-Frankivsk National Medical University. The content of CD3+-lymphocytes in the blood of patients with secondary peritonitis on admission to the hospital was 35.49±3.39%, which is 1.8-fold less than in the comparison group (p<0.002), with their subsequent drop up to 31.00±2.88% (p<0.002) during the third day of the disease. When determining CD4+-lymphocytes during the first day of observation, their indices were 21.49±3.11%, by 56% less than in the comparison group (p<0.002). During the third day of the disease, we observed a slight increase in this index – up to 23.90±3.26% (p<0.01). The study of the level of CD8+-lymphocytes showed that, on admission to the hospital, their level in blood serum was 13.92±1.05%, which is 1.6-fold lower than in patients of the comparison group (p<0.002). Their decrease was observed further, and during the third day this index was 8.08±2.28% (p<0.002). The content of CD11a+-cells on hospitalization was 11.32±0.54%, which is more than 6-fold less than in the comparison group (p<0.002). The content of CD162+-cells in the blood on hospitalization was 21.49±3.11%, which is 3.1-fold less than in the comparison group (p<0.002). The content of CD16+-cells in the blood on hospitalization was 10.83±0.87% (p<0.002). A significant increase in the content of IL in the blood serum at the initial stage of secondary peritonitis with subsequent pathological changes are contributing factors in the disorder of the body’s immune response. The content of IL-6 on admission was 759.72±28.06%, which is almost 3.4-fold higher than the indices in the comparison group (p<0.002). After surgery, this index gradually decreased and during the seventh day was 438.63±19.84% (p<0.002). The results obtained on such indices of non-specific resistance and cytokine regulation as CD3+, CD4+, CD8+, CD11a, CD162, CD95, CD16, HLA-DR+, IL-2, IL-4, IL-6 showed their significant differences between the subgroups studied (p<0.002), indicating their high sensitivity for diagnosing and predicting the development of secondary peritonitis.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical course of pro-oxidant processes in brain structures in rats under conditions of experimental hyperthyroxinemia in age-related dynamics","authors":"Ya.S.  Voichenko, O.H. Rodynskyi","doi":"10.26641/2307-0404.2023.3.288923","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288923","url":null,"abstract":"The search for a connection between changes in the indicators of the pro-oxidant system of brain structures and the thyroid gland as a target organ is an urgent issue. The goal is to investigate the features of the pro-oxidant system against the background of experimental hyperthyroxinemia and to evaluate the age-related changes of malondialdehyde and diene conjugates in brain structures. Among Wistar rats (n=50) intact animals (\"control\", Σ=20) and experimental animals (under simulated hyperthyroxinemia, Σ=30) were selected for observation. The principle of the model of experimental hyperthyroxinemia lies in the addition of levothyroxine in a dosage of 20 μg/day (manufactured by \"Berlin-Chemie AG\", Germany) in the form of tablets with subsequent grinding at 9 o'clock in the morning with food. On day 14, hyperthyroxinemia in the animals was found, while the thyroxine level in the peripheral blood was &gt;10 μg/dL in the first 48 hours and further, being &gt;25 μg/dL (the results were verified in the laboratory, confirmed by immunoenzymatic method with the participation of the \"Humarlander\" test system). After functional testing in rats, highly specific parameters (malondialdehyde, diene conjugates) in the cortex, trunk, and hippocampus were further recorded and evaluated. The humane treatment of animals is certified by the local protocol of the meeting of the commission of the Dnipro State Medical University No. 10 dated 21.06.2023, bioethical principles and rules are taken into account during the experimental research. In the presented work, the results of the biochemical method were used to discuss the importance of the pro-oxidant system at the stage of protection against manifestations of stress and anxiety. Functional dependence on the accumulation of intermediate and final products of lipid peroxidation in the structures of the brain during the study of the state of the pro-oxidant system was found; the age-related dynamics of the activity of malondialdehyde and diene conjugates from young to middle-aged rats under conditions of experimental hyperthyroxinemia was observed; age-related changes contribute to a certain depletion of the activity of pro-oxidant compounds in response to stress as a principle of nervous system protection.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxidized non-coding RNAs of the epigenome in the development of human diseases (literature review)","authors":"S.S. Ostrovska, Ye.N. Dychko, T.Ye. Shumna, G.I. Titov, O.S. Trushenko, P.G. Gerasymchuk, I.Y. Burega","doi":"10.26641/2307-0404.2023.3.288926","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288926","url":null,"abstract":"The attention of scientists to the role of the epigenome in the development of human diseases is associated with the discovery of new non-coding RNA molecules of the epigenome that affect gene expression with changes in protein function and the development of diseases. The study analyzed current scientific data on the effect of oxidative stress induced by cadmium on the regulatory mechanisms of the epigenome, resulting in the development of pathological changes in the body. The results of the study showed that cadmium manifests its toxicity by oxidizing micro RNAs and long RNAs that regulate gene expression without changing DNA/histone complexes. It has been shown that epigenetic disorders under the influence of cadmium-induced oxidative stress can be transmitted to offspring without changing the genotype, and these aberrant changes in non-coding RNA expression patterns are associated with aging, cancer, neurodegenerative, cardiovascular diseases, etc. Circulating micro RNAs that are sensitive to oxidative stress are reported to be potential biomarkers of cardiovascular diseases, including myocardial infarction, hyper­trophy, ischemia/reperfusion, and heart failure. Many studies are aimed at using microRNAs for therapeutic purposes. The complete expression profile of microRNAs in human atherosclerotic plaques was studied, and the mechanisms affecting their formation were identified. Specific microRNAs and reactive oxygen species were identified as potential biomarkers in human malignancies, which expands the possibilities of their use as therapeutic targets. Unlike micro RNAs, the expression of long RNAs has tissue and species specificity, making them important candidates for specific disease markers. The role of these RNAs in carcinogenesis is being actively studied. A large number of them are disrupted at various types of cancer and may play an im­portant role in the onset, metastasis, and therapeutic response of cancer. Thus, oxidative stress induced by cad­mium affects non-coding RNAs, which disrupts the regulatory mechanisms of the epigenome and affects the deve­lopment of cardiovascular, oncological, pulmonary and other human diseases. The search for the impact of non-coding RNAs on the epigenome is constantly growing and has great scientific and practical prospects in medicine.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of gastrointestinal bleedings compared in Ukraine and in the Poltava region","authors":"R.A. Yaroshenko, S.I. Panasenko, I.O. Chorna, M.V. Khorosh, O.V. Ligonenko","doi":"10.26641/2307-0404.2023.3.289227","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289227","url":null,"abstract":"Acute gastrointestinal bleeding was and remains one of the severe emergency surgical diseases both in Ukraine and in other countries. The study of epidemiology, namely of the prevalence of gastrointestinal bleedings is relevant and will allow to intensify the diagnostic stage and create clearer algorithms for the treatment of this pathology. The aim of the work was to study the dynamics of emergency medical care for patients with gastrointestinal bleedings in Ukraine and the Poltava region. A statistical retrospective study of indicators of emergency medical care for patients with gastrointestinal bleedings in Ukraine and the Poltava region was conducted using data from official sources of the Center for Medical Statistics of the Ministry of Health of Ukraine. The wave-like nature of the increase in hospitalization of patients with gastrointestinal bleedings was observed in Ukraine and the Poltava region. The growth rates obtained as a result of the alignment of the dynamic series gave a clear trend towards the acceleration of the decline of this indicator: from -1.25 to -1.36 in Ukraine; and in the Poltava region before increasing the rate: from 4.85 to 3.62. During the entire studied period, the average level of hospitalization of patients with gastrointestinal bleeding after 24 hours was consistently higher in the Poltava region than in Ukraine (in Ukraine – 36.13% versus 43.16% in the Poltava region) (р<0.05). The rate of postoperative mortality in these patients in Ukraine increased (from 5.02% to 6.30%) (р<0.05)with gradual inhibition (the growth rate decreased). In the Poltava region, the level of the indicator exceeded the national level and the leveling of the dynamic series had a downward trend (from 12.4% to 10.38%) (р<0.05). Thus, the problem of gastrointestinal bleeding remains relevant at the present time, as it continues to remain one of the severe urgent surgical diseases, both in Ukraine as a whole and in its individual regions, in particular in the Poltava region. Peptic ulcer disease of the stomach and duodenum continues to remain the first nosology that causes gastrointestinal bleeding. Postoperative mortality remains high and ranges from 5% to 12%. The time of hospitalization from the onset of the disease to hospitalization is consistently higher in the Poltava region than in Ukraine (the average level in Ukraine is 36.13% versus 43.16% in Poltava region) (р<0.05).","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}