Medical Perspectives-Medicni Perspektivi最新文献

{"title":"Application of diagnostic methods in the verification of Lyme carditis (clinical case)","authors":"K.V. Myndziv, N.I. Yarema, N.Ya. Vereshchahina, V.I. Bondarchuk, U.P. Hevko, O.V. Vayda","doi":"10.26641/2307-0404.2023.3.289228","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289228","url":null,"abstract":"The aim of the reserch was to investigate the genotype of the pathogen in a patient with Lyme carditis and to analyze the course of the disease in the process of etiotropic treatment. The article describes a clinical case of infectious myocarditis associated with Lyme disease in a 49-year-old patient. The value of modern diagnostics technologies in diagnosis determination was described. The course of the disease and the results of treatment of the patient were analyzed. The severe rhythm and conduction disorders were revealed with the method of Holter monitoring: AV-block of the first degree, transient AV-block of the II degree (Mobitz 2) and III degree, polytopic extrasystoles. The morphological changes in the heart were diagnosed with ultrasonography and cardiac MRI in order to confirm the diagnosis and to monitor the patient's subsequent course. Total antibodies to antigens of the B. burgdorferi sensu lato complex in blood serum were determined by the ELISA method with test systems Euroimmun AG (Germany). At the second stage, the immunoblot method was applied using the EUROLINE Borrelia RN-AT test system. Due to timely diagnosis, including serological, prescribed etiotropic antibacterial treatment, the patient achieved a significant improvement in both clinical condition and positive serological and ECG dynamics with improved AV conduction. The most frequent ECG changes in Lyme carditis are conduction disorders with development of blockades of various stages. The application of the modern technologies in patients with myocarditis made it possible to determine the etiological factor of the disease with the establishment of genotypes, which caused Lyme carditis.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic-medical determination of the severity of closed injuries of the hyoid-laryngeal complex according to the data of a specialized clinic","authors":"M.V. Gubin, V.O. Olkhovskyi, G.I. Garyuk, V.M. Gubin","doi":"10.26641/2307-0404.2023.3.289205","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289205","url":null,"abstract":"Victims with closed blunt trauma of the hyoid-laryngeal complex often become the object of forensic examination. The purpose of the work was the forensic determination of the severity of injuries of the hyoid-laryngeal complex based on the materials of a specialized otolaryngological clinic in order to establish ways to improve the effectiveness of forensic diagnostics. 62 medical inpatient and outpatient cards of patients with injuries of the hyoid-laryngeal complex, who were treated in the Kharkiv clinical otolaryngological hospital No. 30 during 2011-2021, were processed. The mechanism of occurrence of injuries of the hyoid-laryngeal complex was as follows: in 51 (82.3% of cases there were blows to the neck with blunt hard objects (blows with fists and other objects), in 11 (17.7%) cases – squeezing of the neck with hands or blunt hard objects. The severity of injuries of the hyoid-laryngeal complex was determined from a forensic-medical point of view based on the observations of patients in a specialized hospital. Injuries of the hyoid-laryngeal complex in 3 (4.8%) patients with the occurrence of life-threatening phenomena, namely acute respiratory failure, were assessed as serious ones. Injuries in 8 (12.9%) patients were assessed as injuries of medium severity, mainly in cases of laryngeal cartilage fractures due to the lack of danger to life. Injuries in 38 (61.3%) patients were assessed as slight physical injuries that caused a short-term health disorder, mainly in cases of damage to the soft tissues of the larynx (hematoma, hemorrhage, swelling). Injuries in 13 (20.9%) patients in cases of acute post-traumatic laryngitis without pronounced morphological changes were assessed as slight ones. It was determined that additional diagnostic criteria for determining the severity of injuries of the hyoid-laryngeal complex, which have to be considered are: the dynamics and terms of restoration of post-traumatic morphological-clinical, and functional changes, the occurrence of life-threatening phenomena. The conducted scientific work made it possible to determine the ways of further improvement of diagnostics in the forensic-medical determination of the severity of the investigated injuries.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The using of genetic markers as a possibility of predicting the rate of progress of liver fibrosis in patients with chronic hepatitis B","authors":"К.М. Usychenko","doi":"10.26641/2307-0404.2023.3.288931","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.288931","url":null,"abstract":"According to recent WHO estimates, chronic HBV infection is one of the leading causes of death and disability in patients with infectious diseases. From 780 thousand to 1 million deaths are annually recorded in the world as a result of cirrhosis of the liver and hepatocellular carcinoma. Pathogenetic features of the course and outcomes of chronic hepatitis B are determined by the immunological, genetic factors of the host, as well as the molecular biological structure of the virus. The aim of the work was to study the interaction of polymorphic loci of the cytokine genes SMAD 7 (rs4939827), TNFα (rs1800620), IL-10 (rs1800896), IL-4 (rs2243250) and the degree of structural changes in the liver based on the non-invasive Fibrotest technique in patients with chronic hepatitis B as part of a search for possible predictors of predisposition to the rapid progression of liver fibrosis. The study included 82 patients with chronic hepatitis B. Assessment of morphological changes (stage of fibrosis) was carried out by the method of non-invasive diagnosis of FibroScan, which is an alternative to puncture biopsy of the liver. It has been suggested that homozygous alleles СС IL-4 (rs2243250), GG TNFα (rs1800620), СС SMAD family member 7 (rs4939827) have a protective effect on the course of chronic hepatitis B, as these variants of allelic polymorphism of cytokine genes were found mainly in patients with CHB with a degree of fibrosis F0-F1. The heterozygous genotypes СТ IL-4 (rs2243250) and GA TNFα (rs1800620), the mutant homozygous ТТ SMAD family member 7 (rs4939827) have a profibrotic effect on the course of chronic hepatitis B, as they are found mainly in patients with chronic hepatitis B with degree of fibrosis F3. The established relationship between the liver fibrosis stage according to the METAVIR scale and the polymorphism of the cytokine genes SMAD 7 (rs4939827), TNFα (rs1800620) and IL-4 (rs2243250) made it possible to create a prognostic scale for assessing the individual risk of rapid progression of liver fibrosis. The proposed scale, due to a comprehensive assessment of the polymorphism of cytokine gene alleles and the stage of liver fibrosis using the METAVIR scale, makes it possible to carry out an individual assessment of the risk of progression of chronic hepatitis and, possibly, draw up a personalized treatment plan for the patient. Coding of the studied polymorphisms and subsequent counting can be automated, which does not require significant financial investments. The possibilities of the prognostic scale are proven on the example of a group of patients who received the antifibrotic agent bicyclol in comparison with the control group.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical case of asymptomatic pancreatic hyperenzymemia on the background of taking a Glucagon-like peptide-1 analogue (GLP-1)","authors":"N.A. Sanina, N.O. Hondulenko, S.S. Panina, V.S. Shulha","doi":"10.26641/2307-0404.2023.3.289229","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289229","url":null,"abstract":"According to current statistics, the incidence of type 2 diabetes has increased significantly over the past few years. The number of drugs prescribed to correct carbohydrate metabolism is also increasing, and new groups of hypoglycemic drugs are appearing. This prompts a more detailed study and analysis of the possible side effects of the prescribed therapy. One of the modern groups of medications f or treating type 2 diabetes are analogues of glucagon-like peptide-1 receptor agonists, which, in addition to correcting carbohydrate metabolism, have a beneficial effect on the risk of developing cardiovascular events. Despite this, there is evidence that their use may be associated with the development of undesirable adverse effects from the pancreas, particularly acute pancreatitis, pancreatopathy, or asymptomatic hyperenzymemia. The aim of our work was the analysis of a clinical case of an asymptomatic increase in the level of pancreatic enzymes (Gullo's syndrome) in a patient with type 2 diabetes, who used a glucagon-like peptide-1 receptor analogue for treatment according to the usual scheme (dulaglutide 0.75 mg subcutaneously once a week during 2 years). As a result, the patient developed a side effect that could be related to taking this medicine. This did not lead to the withdrawal of the drug but required a more thorough examination of the patient and regular further screening for the timely detection of the development of possible organic pathology of the pancreas in the future. So, after analyzing this clinical case, it is possible to see the possibility of developing asymptomatic pancreatic hyperenzymopathy during the treatment of type 2 diabetes mellitus with glucagon-like peptide-1 receptor agonist analogues, which should be taken into account when determining the treatment tactics.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy nutrition as a disease prevention factor: WHO Policy and National Experience (to mark the 75th anniversary of WHO in Ukraine)","authors":"M.P. Gulich, O.D. Petrenko","doi":"10.26641/2307-0404.2023.3.289218","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289218","url":null,"abstract":"In the context of the constant increase in the burden of chronic non-communicable diseases, the World Health Organization's (WHO) activities are aimed at developing policies and strategies in the field of non-communicable disease (NCD) prevention, which have been continuously evolving. The work is dedicated to examining the sequential policy of the WHO outlined in documents regarding the link between nutrition and the development of non-communicable diseases. The objective of this study is to identify the main stages of WHO's policy on healthy nutrition as a key prerequisite for preventing the development of non-communicable diseases and outline the corresponding measures in Ukraine. Materials and methods: informational, bibliographic, normative-legal. The study utilized systematic-structural, formal-logical, bibliographic, and non-forma­lized (traditional) analysis methods. An analysis of WHO's policy on healthy nutrition as a factor in preventing the development of chronic non-communicable diseases has been conducted. The key stages of policy development and decision-making at the global level over the past three decades have been identified. It has been determined that the evolution of the role of nutrition within WHO's policy has progressed from urging governments to develop national food policies and create national action plans in the 1990s to global strategies and actions that have taken place in the 21st century. The basic WHO documents regarding the link between nutrition and the development of chronic diseases have been examined, as well as the expansion of understanding the content and necessity of healthy nutrition. The implementation of WHO's policy in Ukraine has been highlighted: the \"National Action Plan on Non-communicable Diseases to Achieve the Sustainable Development Goals by 2030\" (2018) has been developed and implemented, serving as a roadmap for the development of a series of guiding documents. The most important of these documents pertain to the organization and standards of healthy nutrition for children. However, the formation of a national regulatory and legal framework regarding healthy nutrition has not yet been completed. It has been determined that Ukraine needs to improve its policy on limiting the use of saturated fats, industrially produced trans fatty acids, and marketing unhealthy food and non-alcoholic beverages targeted at children. There is a need for extensive informational and educational activities to promote WHO's recommendations on healthy nutrition.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the feeling of anxiety and the phenomenon of inferiority","authors":"O.R. Berezyuk, O.O. Filts","doi":"10.26641/2307-0404.2023.3.289202","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289202","url":null,"abstract":"The phenomenon of inferiority as a key concept of Adler's theory of psychology can contribute to the appearance of social anxiety. Since both anxiety and feeling of inferiority have an impact on mental and somatic health, the aim of the study was to investigate the association of the phenomenon of inferiority with the feeling of anxiety. During October-November 2021 in the course of the study, a questionnaire survey of 612 students of higher education institutions of Lviv was conducted. Two questionnaires were used for the survey: the Comparative Feeling of Inferiority Index and Beck's Anxiety Inventory. The analysis of the findings was performed using the methods of descriptive (median, 25% and 75% quartiles, percentages with 95% confidence intervals) and analytical statistics (Kruskal-Wallis test, Dunn's post-hoc paired test, Pearson's test). The research established that the feeling of anxiety is characteristic of 54.95% [45.67-64.07] of the respondents with the Index of Superiority, 48.84% [34.17-63.61] of the respondents with the Index of Inferiority and 43.91% [39.60-48.28] of respondents with the absence of the phenomenon of altered self-esteem (Norma). Median scores on Beck's Anxiety Inventory were significantly higher in individuals with the index of superiority – 8.5 [5; 16.3] points. A comparison of the presence of anxiety by gender showed that anxiety symptoms are significantly more common in women than in men: 57.85% [51.82-63.77] vs 37.04% [32.07-42.15] respectively, p<0.001. Anxiety is most often characteristic of women with the index of superiority – 76.67% [60.16-89.79]) of women in this group. The value of the findings is determined by the fact that in Ukraine this is the first scientific study regarding the research of the association of the phenomenon of inferiority and anxiety in adult population with using proven and valid questionnaires that are actively used by scientists around the world.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of ultrasonography in the diagnosis of pigmented villonodular synovitis. Clinical case","authors":"V.M. Zhdan, I.V. Ivanytskyi, M.Y. Babanina, T.A. Ivanytska, Y.M. Kitura, H.V. Volchenko, M.V. Tkachenko, O.A. Kyrian, V.H. Lebid","doi":"10.26641/2307-0404.2023.3.289260","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289260","url":null,"abstract":"Pigmented villonodular synovitis is a rare proliferative disease of the synovial membrane, which most often affects the knee joints. Being a benign disease, at the same time, this pathology is often aggressive, and in some cases spreads to the soft tissues outside the joint. There are two forms of monoarticular damage: localized and diffuse. The diffuse form gives frequent relapses. To date, there are no standards for the management of this disease, just as there are no early markers for the detection of pigmented villonodular synovitis. This joint lesion has a long asymptomatic course, or it has symptoms of non-specific recurrent arthritis, so the patients can later be referred for magnetic resonance imaging, which is the only non-invasive method of diagnosing this pathology. At the same time, in modern conditions, most patients with recurrent synovitis will undergo an ultrasound examination of the joint according to the diagnostic standards. Ultrasonography made for abovementioned synovitis is insufficiently described in the medical literature. The aim of our study was to highlight the current data on the diagnosis and management of patients with pigmented villonodular synovitis and to describe our own clinical case. A feature of our clinical case was the detection of characteristic symptoms using ultrasonography. Irregular thickening of the synovial membrane with nodular forma­tions and villous growths, with the length of villi up to 7 mm near the patella with single loci of blood flow, was revealed by ultrasound examination and power Doppler mapping. Shear wave elastometry of the synovial membrane was performed. It demonstrated a significant increase in the stiffness of the synovial membrane, which can be a patho­gnomonic symptom of this pathology. The diagnosis of villonodular synovitis was confirmed histologically after surgical treatment. Subsequently, the patient had a recurrence of the pigmented villonodular synovitis, which was also detected by ultrasound diagnostics. Thus, pigmented villonodular synovitis of the knee joint is a rather rare pathology that requires differential diagnosis with inflammatory joint diseases. The final diagnosis is based on histological exa­mination. MRI and ultrasound diagnostics are non-invasive methods that can detect this pathology with high accuracy. The advantage of ultrasonography is its availability and non-invasiveness. The increase in stiffness of the synovial membrane along with its proliferation, which we found, can serve as an additional criterion of villonodular synovitis, and, according to the data available to us, has not been described in the literature so far.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral lichen planus post COVID-19 vaccination: report of two cases","authors":"A.V. Samoilenko, V.Yu. Oryshchenko, T.M. Strelchenia","doi":"10.26641/2307-0404.2023.3.289265","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289265","url":null,"abstract":"Manifestations of сoronavirus disease 2019, caused by SARS-CoV-2 virus, are diverse and can vary from asymptomatic infection to respiratory failure needing intensive care. Vaccines against SARS‐CoV‐2 focusing on the spike glycoprotein have shown promise in diminishing the spread of Covid‐19. Adverse effects, however, are associated with every vaccination. Currently, there are literature reports of some cases of lichen planus eruption following COVID-19 vaccine injection. Oral lichen planus is a relatively common immune-mediated dermatologic disorder that can occur isolated or associated with cutaneous lichen planus. Postvaccination lichen planus has previously been reported in the literature as a rare adverse event following various vaccinations, especially hepatitis A and B, influenza, and varicella. The majority of patients presented with classic cutaneous lichen planus, although some reports highlighted primarily mucosal involvement. Herein we describe two rare cases of erosive-ulcerous oral lichen planus among SARS-CoV-2 vaccine recipients. The first is a case of a 67-year-old male who developed mucocutaneous lichen planus 5 days after administration of the single-dose of Ad26.COV2.S COVID-19 vaccine. In the second case, a 56-year-old female presented with reactivation of oral lichen planus after receiving a first dose of Pfizer COVID-19 vaccination 2 days earlier. The mechanism of the association between vaccines and lichen planus is not known, it is attributed to cell-mediated autoimmunity. Although there is currently no evidence of a causal relationship between SARS-CoV-2 vaccination and lichen planus, these clinical observations suggest that the COVID-19 vaccine is a possible key initiating event leading to the development or recurrence of this disease.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of meningoencephalitis of Epstein-Barr viral etiology in an immunocompetent patient","authors":"O.O. Popovych, L.V. Moroz, F.A. Chabanov, O.S. Androsova, S.M. Kulias, K.D. Chichirelo-Konstantynovych, L.P. Plotytsia","doi":"10.26641/2307-0404.2023.3.289264","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289264","url":null,"abstract":"The article describes a rare clinical case of meningoencephalitis of Epstein-Barr viral (EBV) etiology in an immunocompetent patient. The purpose of the work was to acquaint practitioners with the problems of diagnosis and treatment of EBV-neuroinfection, features of the course and management of EBV-meningoencephalitis. The woman, 46 years old, was admitted to the intensive care unit with a diagnosis of mushroom poisoning. Based on clinical-laboratory-instrumental examinations the diagnosis of EBV-meningoencephalitis was made. EBV DNA was detected in the cerebrospinal fluid by polymerase chain reaction (PCR) and magnetic resonance imaging (MRI) of the brain showed focal changes in the left temporal-insular region with signs of leptomeningitis. Taking into account the specifics of this case, the authors of the article came to the following conclusions: EBV-meningoencephalitis can occur in people with normal immune status under conditions of psychological and physical stress; delayed diagnosis of meningoencephalitis at the onset of the disease in this case is associated with the prevalence of clinical manifestations of general brain syndrome, mistakenly regarded as symptoms of intoxication and dyspepsia due to food poisoning; meningoencephalitis of EBV-etiology is ac­companied by signs of convulsive, atactic, cognitive and mental syndromes; temporal-insular localization of focal brain changes may be characteristic for EBV-meningoencephalitis; treatment with acyclovir and glucocorticoids may have be­nefits; complicated vascular anamnesis, bed rest and glucocorticoid therapy predict an increased risk of venous thrombosis, which in this patient was realized as acute sural phlebothrombosis; according to MRI the resolution of leptomeningitis and focal brain changes with gliosis formation occurred 3 months after manifestation of the disease; the risk of the following neurological pathologies due to specific localization of gliosis should be considered and requires medical control.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hygienic assessment of dangerous chlorites in drinking water treated with chlorine dioxide and the risk of its consumption to the health of the population","authors":"V.О. Prokopov, О.B. Lypovetska, T.V. Kulish","doi":"10.26641/2307-0404.2023.3.289220","DOIUrl":"https://doi.org/10.26641/2307-0404.2023.3.289220","url":null,"abstract":"Today, chlorine dioxide has begun to be more widely implemented in water treatment technologies on river running water systems of Ukraine. Chlorine dioxide is used in traditional water treatment technology for both primary and secondary water treatment on the Dnipro running water system in Kyiv. Objective – to analyze the results of the content of dangerous chlorites in tap drinking water of certain districts of the city of Kyiv, and calculate and assess non-carcinogenic risk of this drinking water for human health. It was shown that in the drinking water from the running water networks of Svyatoshynskyi, Shevchenkivskyi, Obolonskyi and Podilskyi districts of the city, into which it enters after treatment with chlorine dioxide from the Dnipro running water system, the levels of chlorites were the lowest in winter and spring. In summer, the concentrations of chlorites in the water from the studied networks were the highest and averaged from 0.32 to 0.45 mg/dm3. In autumn, chlorites in the water from these systems were at the level of 0.22-0.28 mg/dm3. In spring (May) and especially in summer, the levels of chlorites in drinking water, according to average data, exceeded the national hygienic standard (0.2 mg/dm3) by 1.5-2 times, but they were never higher than the chlorite standard (0.7 mg/dm3) recommended by WHO. Our analysis of sanitary-chemical and microbiological indicators in drinking water showed that the water is characterized by high quality and safety during the entire period of observation. The risk assessment of the development of non-carcinogenic effects for the oral route of intake of chlorites with drinking water from the specified water networks based on average annual data showed the value of the danger coefficient (HQ) at the level of 0.24-0.38, that is, it was lower than 1.0. The danger coefficient for chlorite content in drinking water was also determined at the level of 0.2 mg/dm3 and 0.7 mg/dm3. According to this indicator, the lifetime use of drinking water with a chlorite content of 0.2 mg/dm3 and even 0.7 mg/dm3 does not pose a threat to human health, since the danger coefficient is within 1.0, which is a permissible (acceptable) risk by degree of danger. Thus, the use of chlorine dioxide in traditional water treatment technology ensures high quality and safety of drinking water in terms of microbiological and sanitary-chemical indicators. There is a periodic (mainly in summer) excess of chlorite content in drinking water in relation to the national standard (0.2 mg/dm3), but its level was never higher than the standard recommended by WHO (0.7 mg/dm3). It has been shown that the existing levels of chlorites in drinking water and its use with such a toxic load do not pose a threat to human health.","PeriodicalId":41059,"journal":{"name":"Medical Perspectives-Medicni Perspektivi","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135297462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}