Journal of Translational Medicine and Research最新文献_第9页

The Association Between Inflammation and Angiogenesis in Human Pancreatic Adenocarcinoma 人胰腺腺癌炎症与血管生成的关系

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-78

C. Tanase, L. Necula, A. Neagu, R. Albulescu

引用次数: 1

Portal and Arterial Flushing with HTK and Tacrolimus Can Attenuate the Incidence of Early Liver Allograft Dysfunction HTK和他克莫司联合冲洗门静脉和动脉可减轻早期同种异体肝移植功能障碍的发生率

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-82

A. Shcherba, S. Korotkov, D. Efimov, A. Minou, O. Lebedz, Alla Karytka, D. Fedaruk, Eugeny Santotsky, A. Dzyadzko, O. Rummo

引用次数: 0

Study of Abnormal Anatomical Variations in Extrahepatic Biliary Apparatus and Its Related Vessels in Cadavers 尸体肝外胆管及其相关血管异常解剖变异的研究

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-84

M. Koshariya, S. L. Ahirwar, A. Khan, M. Songra

引用次数: 2

Thoracic Involvement of Liver Hydatid Cyst - Case Series and Review of Literature 肝包虫病累及胸部病例系列及文献回顾

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-83

S. Berbece, C. Blajut, S. Ciurea, C. Stănescu, I. Popescu

{"title":"Thoracic Involvement of Liver Hydatid Cyst - Case Series and Review of Literature","authors":"S. Berbece, C. Blajut, S. Ciurea, C. Stănescu, I. Popescu","doi":"10.21614/JTMR-21-2-83","DOIUrl":"https://doi.org/10.21614/JTMR-21-2-83","url":null,"abstract":"Aims: Hydatidosis, caused by Echinococcus granulosus, is an endemic parasitic disease in Mediterranean countries. The most frequent anatomic locations are liver and lung. Intrathoracic rupture of hydatid cysts situated in the hepatic dome is a serious complication resulting in damage to the pleura, pulmonary parenchyma, and bronchi. Material and Metods: From 2005 to 2014 we operated on 853 patients with liver hydatid cysts, 4 of thme having intrathoracic rupture of a hepatic hydatid cyst. Hepatic and thoracic ultrasonography was performed in all cases. The diagnosis of intrathoracic rupture of a liver cyst was confirmed in all patients. Results: In two cases a combined thoracic and abdominal approach was used, in one case a thoracic approach with phrenotomy was preferred, and in one case an abdominal approach with phrenotomy was chosen. The postoperative course was somewhat uneventful in 3 cases, but 1 patients died due to pulmonary embolism. Conclusions: The therapeutic approach depends on ultrasonographic and computer tomography findings (CT). We believe CT-scan to be the best examination for assessing biliary, hepatic, diaphragmatic, and pleuropulmonary lesions. An abdominal approach is necessary when biliary duct drainage is required, and it may be sufficient in cases of direct rupture into the bronchi.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131030902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Hepatic Lymphoma Resected by ALPPS Procedure (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) ALPPS手术切除原发性肝淋巴瘤(联合肝分割门静脉结扎分阶段肝切除术)

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-88

S. Alexandrescu, L. Stoica, R. Grigorie, D. Tomescu, C. Dobrea, I. Popescu, D. Hrehoreţ

引用次数: 3

Imaging Techniques for Evaluation of Drug Distribution in Solid Tumor 评价实体瘤内药物分布的影像学技术

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-79

Jianfen Gu, N. Jiang, H. Lan, K. Jin

{"title":"Imaging Techniques for Evaluation of Drug Distribution in Solid Tumor","authors":"Jianfen Gu, N. Jiang, H. Lan, K. Jin","doi":"10.21614/JTMR-21-2-79","DOIUrl":"https://doi.org/10.21614/JTMR-21-2-79","url":null,"abstract":"Imaging drug distribution inside a tumor is an important tool to support strategies to improve penetration of anticancer drugs and consequently the outcome of chemotherapy. Methods for mapping the distribution of pharmaceutical compounds and their metabolites in situ are of great interest to researchers and to the pharmaceutical industry. There is a particular interest in the distribution of anti-cancer agents within solid tumors. Direct assessment of the distribution of drugs in tumor tissue is technically challenging, and requires the quantification of drug exposure to cells at specific locations relative to blood vessels. The quantification of drugs in plasma, as well as in tissue homogenates, has relied extensively on well-established analytical methods of high-performance liquid chromatography (HPLC) and liquid chromatography–tandem mass spectrometry (LC-MS-MS). In the last 20 years, imaging techniques such as positron emission tomography (PET), magnetic resonance spectroscopy (MRS), mass spectrometry imaging (MSI), fluorescence microscopy (FM), and autoradiography have evolved as powerful tools for the noninvasive study of drug distribution in vivo as well as for studying drug effects at their target sites. In this article, we review the current state of knowledge of the available imaging techniques to measure intratumor drug","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116380007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori eradication may increase body mass index, but the effect may not last long. A 10-year observation 根除幽门螺杆菌可能会增加体重指数，但效果可能不会持续太久。10年观察

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-86

T. Imada, M. Mizuno, Susumu Take, Kuniharu Ishiki, T. Okuno, Tomowo Yoshida, H. Okada, Kazuhide Yamamoto

引用次数: 0

Developing an Optimal Experimental Model for Immunological Studies in VCA: Vascularized Composite Allotransplants Based on Femoral Vessels in Rats 以大鼠股血管为基础的血管化复合同种异体移植术，建立VCA免疫研究的最佳实验模型

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/jtmr-21-2-85

Andreea GROSU-BULARDA, D. Zamfirescu, A. Stefanescu, M. Stoica, Luana Lăzărescu, I. Lascar

{"title":"Developing an Optimal Experimental Model for Immunological Studies in VCA: Vascularized Composite Allotransplants Based on Femoral Vessels in Rats","authors":"Andreea GROSU-BULARDA, D. Zamfirescu, A. Stefanescu, M. Stoica, Luana Lăzărescu, I. Lascar","doi":"10.21614/jtmr-21-2-85","DOIUrl":"https://doi.org/10.21614/jtmr-21-2-85","url":null,"abstract":"Vascularized composite allotransplantation (VCA) has become a recent therapeutic entity in reconstructive surgery. Long term immunosuppressive therapy ensures graft survival, although, with a risk of serious side effects. Further progress in this field depends on better understanding of basic immunology of composite tissue grafts with the dynamics of rejection and possibilities to induce donor specific-tolerance. Without a vast clinical experience, a possibility for achieving those goals is intensive study in preclinical field. The classical experimental model for VCA is rat hind limb transplantation. We analyzed several microsurgical models in order to determine the most adequate one for immunological studies. We performed both orthotopic and heterotopic hind limb transplantations (we tested different techniques: entire or partial hind limb allotransplantation) and also osteomyocutaneous flaps (with different bone components), noting their advantages and limits. The osteomyocutaneous flap is less morbid and represents a promising experimental model in VCA studies. Also we analyzed other models including epigastric flap allotransplantation and abdominal wall transplant for determine their utility as experimental models for immuno-","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117148859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic and Management in Vesicovaginal Fistulas 膀胱阴道瘘的诊断与治疗

Journal of Translational Medicine and Research Pub Date : 2016-06-30 DOI: 10.21614/JTMR-21-2-80

N. Bacalbaşa, B. Lintoiu, I. Bălescu, M. Dimitriu

引用次数: 1

The estimation of gastric cancer disease status Using array-based comparative genomic hybridization for endoscopic biopsy specimens: Preliminary experience (CGH for gastric cancer biopsy) 基于阵列的比较基因组杂交内镜活检标本评估胃癌疾病状态的初步经验(CGH用于胃癌活检)

Journal of Translational Medicine and Research Pub Date : 2016-04-15 DOI: 10.21614/JTMR-21-1-71

H. Yanai, T. Furuya, T. Furuya, H. Hayashi, K. Sasaki

引用次数: 0