The Association Between Inflammation and Angiogenesis in Human Pancreatic Adenocarcinoma

C. Tanase, L. Necula, A. Neagu, R. Albulescu
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引用次数: 1

Abstract

Pancreatic cancer represents one of the deadliest cancers with a high mortality rate, characterized by an aggressive local invasion and early metastases. This malignancy is poorly responsive to chemotherapy or chemo-radiotherapy. Several proangiogenic factors were associated with pancreatic carcinogenesis, highlighting the importance of using antiangiogenic agents as therapeutic strategy. Further studies suggest the involvement of chronic inflammation in angiogenesis processes in pancreatic carcinogenesis and inflammatory cytokines should be considered as potential biomarkers, as well as therapeutic targets in pancreatic cancer patients.
人胰腺腺癌炎症与血管生成的关系
胰腺癌是最致命的癌症之一,具有高死亡率,其特点是局部侵袭性和早期转移。这种恶性肿瘤对化疗或放化疗反应较差。几种促血管生成因子与胰腺癌的发生有关,强调了使用抗血管生成药物作为治疗策略的重要性。进一步的研究表明,慢性炎症参与胰腺癌血管生成过程和炎症因子应被视为潜在的生物标志物,以及胰腺癌患者的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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