JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan"最新文献

{"title":"PENGARUH BUAH NANAS (ANANAS COMOSUS L. MERR) TERHADAP PENINGKATAN PH SALIVA YANGTERPAPAR MINUMAN BERKARBONASI","authors":"A. Syauqy, Hanina Hanina","doi":"10.22437/jmj.v9i1.11110","DOIUrl":"https://doi.org/10.22437/jmj.v9i1.11110","url":null,"abstract":"ABSTRAK \u0000Latar Belakang: Kebanyakan masalah rongga mulut di Indonesia adalah terkait karies gigi dan penyakit periodontal. Salah satu faktor yang mempengaruhi timbulnya penyakit tersebut adalah pH saliva. Stimulus mekanik dan kimiawi dari makanan adalah salah satu faktor yang mempengaruhi pH saliva. Cuci mulut dengan mengkonsumsi buah adalah salah satu cara menjaga pH saliva agar dalam kondisi optimum dalam mencegah terjadinya penyakit gigi. Dari penelitian sebelumnya diketahui bahwa buah nanas dan buah belimbing efektif dalam meningkatkan laju aliran saliva. Namun belum ada penelitian yang membandingkan pengaruh buah tersebut terhadap pH saliva. Penelitian ini bertujuan untuk membandingkan pH saliva setelah mengkonsumsi kedua buah tersebut. \u0000Metode Penelitian: Penelitian ini adalah penelitian experimental dengan menggunakan pretest and postest group design dan dilakukan di Laboratorium Biomedik FKIK UNJA. Populasi yang digunakan adalah mahasiswa Fakultas Kedokteran FKIK UNJA angkatan 2017 dan 2018. Pengambilan sampel dilakukan dengan metode purposif sampling sebanyak 36 orang yang dibagi menjadi dua kelompok yaitu kelompok perlakuan mengkonsumsi buah nanas dan kelompok perlakuan mengkonsumsi buah belimbing. Hasil pemeriksaan pH saliva kedua kelompok dianalisis menggunakan program komputer. \u0000Hasil: Uji statistik meunjukkan tidak terdapat perbedaan yang signifikan antara kelompok buah nanas dengan kelompok buah belimbing dalam meningkatkan pH saliva dengan nilai P 0,855. \u0000Kesimpulan: Konsumsi buah nanas dan belimbing dapat meningkatkan pH saliva, namun tidak terdapat perbedaan yang signifikan antara kelompok buah nanas dengan kelompok buah belimbing. \u0000Kata kunci :  pH, Saliva, Nanas, Belimbing \u0000  \u0000ABSTRACT \u0000ackground: Most oral problems in Indonesia are related to dental caries and periodontal disease. One of the factors that influence the onset of the disease is the pH of saliva. Mechanical and chemical stimuli from food are one of the factors that influence the pH of saliva. Washing the mouth with fruit is one way to maintain the pH of the saliva so that it is in optimum condition to prevent dental disease. From previous research it was found that pineapple and star fruit were effective in increasing the salivary flow rate. However, no studies have compared the effect of these fruits on salivary pH. This study aims to compare the pH of saliva after consuming the two fruits. Research Methods: This study was an experimental study using a pretest and postest group design and was carried out in the Biomedical Laboratory of FKIK UNJA. The population used was students of the Faculty of Medicine FKIK UNJA class of 2017 and 2018. Sampling was carried out by purposive sampling method of 36 people who were divided into two groups, namely the treatment group consuming pineapple fruit and the treatment group consuming star fruit. The results of the saliva pH examination of the two groups were analyzed using a computer program. Results: The statistical test ","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113962205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRINCIPLE OF REHABILITATION & COMPLICATION PREVENTION AFTER MUSCULOSKELETAL TRAUMA","authors":"Pamudji Utomo, Hillan Akbar","doi":"10.22437/jmj.v9i1.12325","DOIUrl":"https://doi.org/10.22437/jmj.v9i1.12325","url":null,"abstract":"Rehabilitation plays a major role to maximize outcome and prevent complications following musculoskeletal trauma and its interventions. It is reported in several studies that mortality risk in patients not receiving rehabilitation was higher compared with patients who received one. The key principles include adequate pain management, anti-infection measures, early ambulation and physical therapy, establishing proper milestones and goals, well-communicated multi-disciplinary approach, and the establishment of standardized and personalized treatment protocol. Early mobilization is supported, as long as wound healing has been taken into consideration. Holistic approach to ensure both physical and psychosocial well-being is recommended, along with special care for geriatric and paediatric populations. Furthermore, alternative medicines such as acupuncture and meditation are currently gaining popularity and subsequently advocated as adjunct therapies.","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132382011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMUNODEFISIENSI PRIMER DAN DETEKSI DININYA","authors":"Cipta Mahendra","doi":"10.22437/jmj.v9i1.12473","DOIUrl":"https://doi.org/10.22437/jmj.v9i1.12473","url":null,"abstract":"Penyakit imunodefisiensi primer (primary immunodeficiency disease/PID) merupakan keadaan terjadinya defek sistem imun yang disebabkan mutasi pada kode genetik yang mengode komponen-komponen penyusun sistem imun tubuh. Kelainan ini tergolong jarang/langka namun menurunkan kualitas hidup atau bahkan bisa juga mengancam nyawa bagi penderita-penderitanya. Terapi definitif yang tersedia hingga kini pun juga masih terbatas dan berbiaya tinggi. Artikel ini dimaksudkan terutama bagi dokter umum/layanan primer sebagai pengantar agar mengenali penyakit ini sebagai sebuah kelainan langka, yang mungkin jarang atau bahkan belum pernah mendengar tentang keadaan ini sebelumnya.","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131408315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERBANDINGAN KADAR NITRIC OXIDE PADA PEROKOK DAN BUKAN PEROKOK","authors":"Maria Estela Karolina, Armaidi Darmawan, Wahyu Indah Dewi Aurora","doi":"10.22437/JMJ.V7I1.7148","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7148","url":null,"abstract":"Abstract \u0000Background: Cigarette smoke can affect macrophage metabolism by activating macrophages to release leukotrien B4, IL-8 and TNFα which lead to increased production of superoxide (O2-) and H2O2 and also cause oxidative damage to macromolecules such as lipids, proteins, DNA that can eliminate antioxidants and form free radicals such as Nitric Oxide (NO). NO has an important contribution in the occurrence of infection where NO will be produced more by iNOS. \u0000Methods: This study is a cross sectional study with a sample of samples taken in total sampling from medical students of Jambi University as many as 22 people with smokers and 22 non-smokers. Conducted NO examination by using microplate reader on wave 595. Research data obtained then tested by statistical analysis with mann whitney and wilcoxon test. \u0000Results : NO levels in smokers were higher than nonsmoker group NO levels. Based on normality test data with Mann Whitney obtained significant difference between both groups value of sig 0.030. Furthermore, Wilcoxon analysis. The result of wilcoxon analysis shows statistic test output where sig (<0,05). \u0000Conclusion : NO levels in the smoker group were higher than in the nonsmokers group. NO levels between smokers and nonsmokers were significantly different. \u0000Keywords : Smokers, non-smokers, nitric oxide \u0000  \u0000Abstrak \u0000Pendahuluan : Asap rokok dapat mempengaruhi metabolisme makrofag dengan mengaktifkan makrofag untuk melepaskan leukotrien B4, IL-8 dan TNFα yang menyebabkan meningkatnya produksi superoksida (O2-) dan H2O2 dan juga menyebabkan kerusakan oksidatif makromolekul seperti lipid, protein, DNA yang dapat   menghilangkan  antioksidan  serta  membentuk radikal  bebas seperti Nitrit  Oxide  (NO).  NO mempunyai kontribusi yang penting dalam terjadinya infeksi dimana NO akan diproduksi lebih banyak oleh iNOS. \u0000Metode : Penelitian ini merupakan penelitian cross sectional dengan sampel penelitian yang diambil secara total sampling dari mahasiswa kedokteran Universitas Jambi sebanyak 22 orang dengan perokok dan 22 orang bukan perokok. Dilakukan pemeriksaan NO dengan menggunakan microplate reader pada gelombang 595. Data penelitian yang di dapatkan kemudian di uji dengan analisis statistic dengan uji mann whitney dan wilcoxon. \u0000Hasil : Kadar NO pada perokok lebih tinggi dibandingkan dengan kadar NO kelompok bukan perokok. Berdasarkan uji normalitas data dengan Mann whitney diperoleh perbedaan yang bermakna diantara kedua kelompok nilai sig 0.030. Selanjutnya dilakukan Analisis Wilcoxon. Hasil analisis wilcoxon menunjukkan output test statistic dimana sig (<0,05). \u0000Kesimpulan  :  Kadar  NO  pada  kelompok  perokok  lebih  tinggi  dibandingkan  dengan  kelompok  bukan perokok. Kadar NO antara kelompok perokok dan bukan perokok terdapat perbedaan yang signifikan. \u0000Kata Kunci : Perokok, bukan perokok, Nitric Oxide","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125217096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFEK SALEP EKSTRAK PINANG TERHADAP LEVEL FIBROBLAST DAN KOLAGEN PADA PROSES PENYEMBUHAN LUKA","authors":"A. Rahman, Humaryanto Humaryanto","doi":"10.22437/JMJ.V7I1.7121","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7121","url":null,"abstract":"ABSTRACT \u0000Background: Some plants, such as betel nuts (Areca catechu), is used as traditional antiseptic. Betel nut mash is applied on ulcus wound.  Fibroblast and collagen are important factor in wound healing.  Research objective : this study is to determine the effect of betel nuts extract on fibroblast and collagen level in full thickness wound healing processs. Methodology: this study used male rats Sprague dawney that randomly divided into 3 groups. Groups I received no treatment, groups II and III received areca catechu extracts with concentration 15% and 30%  respectively. There are 12 rats in each groups. The treatment is given every day without wound’s debridement. Incision were made full thickness with diameter size 1,5 cm, on right back skin was made by lidocain anesthesia subcutaneously. Wound area were measured every days. Termination of rats were done in day 7 and day 16 to histopathology assessment with Haematoxylin-Eosin stain for fibroblast and collagen level by semiqualitative score. Results: level of collagen were higher in group that received extract but level of fibroblast were lower than control group in histopathology of day 7th. Conclusion:  Extract of betel nut increased level of collagen. \u0000Keyword : areca catechu, betel nuts, wound, fibroblast, collagen, histopathology \u0000  \u0000ABSTRAK \u0000Latar belakang :  Beberapa tanaman digunakan sebagai antiseptik luka, salah satunya biji pinang  untuk penyembuhan luka ulkus. Fibroblast dan kolagen merupakan salah satu faktor penting dalam penyembuhan luka. Tujuan : Penelitian ini bertujuan mengetahui efek ekstrak biji pinang terhadap level fibroblast dan kolagen pada proses penyembuhan luka full thickness  Metode : Penelitian ini menggunakan tikus galur Sprague dawney jantan berusia 2-3 bulan dan telah mendapatkan persetujuan etik. Setelah aklimatisasi, tikus dibagi secara acak masing-masing 12 ekor dalam 3 kelompok, yaitu kelompok I tanpa perlakuan, kelompok II diberikan salep ekstrak biji pinang 15%, kelompok III diberikan salep ekstrak biji pinang 30%. Luka full thickness dibuat dengan diameter 1,5 cm di daerah punggung belakang bagian kanan dengan anestesi lidokain subkutan. Perlakuan dilakukan setiap hari tanpa debridemen luka. Luas luka diukur  setiap hari. Terminasi dilakukan pada hari ke 7 dan 16 untuk pemeriksaan histopatologi jaringan luka dengan pengecatan Haematoxylin-Eosin. Skoring secara semikualitatif untuk menilai fibroblast dan kolagen. Hasil : Pada kelompok ekstrak pinang terdapat peningkatan level kolagen, akan tetapi tidak terjadi peningkatan level fibroblast pada hasil histopatologi luka kulit hari ke-7.  Kesimpulan :  terjadi peningkatan level kolagen pada pemberian ekstrak biji pinang. \u0000Kata kunci : biji pinang, luka, histopatologi, fibroblast, kolagen","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128477848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH DIET KETOGENIK TERHADAP PROLIFERASI DAN KETAHANAN SEL PADA JARINGAN PANKREAS","authors":"Esa Indah Ayudia Tan, Irfannuddin Irfannuddin, Krisna Murti","doi":"10.22437/JMJ.V7I1.7127","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7127","url":null,"abstract":"ABSTRACT       The ketogenic diet is a diet that uses a lot of fat as an energy source and reduces carbohydrate and protein consumption when the body does not get enough glucose from carbohydrates, the body usually uses alternative energy sourced from the ketone body, namely acetoacetate and b-hydroxybutyrate. The ketone body comes from the breakdown of fatty acid metabolism in the liver where at the moment the concentration is low in the blood. Ketogenic diet is a diet that uses a lot of fat as an energy source and reduces carbohydrate consumption. The ketogenic diet makes the body burn fat instead of carbohydrates. The pancreas is the center of control of energy metabolism. The role of metabolism affected by endocrine function of the pancreas is located on the islands of langerhans, in the form of epithelial cells spread throughout the organs. Changes in diet patterns will certainly have an impact on proliferation and apoptosis cell in pancreas. Keywords: ketogenic diet, pancreas, proliferation, cell resistance   ABSTRAK Diet ketogenik adalah diet yang menggunakan banyak lemak sebagai sumber energi dan mengurangi konsumsi karbohidrat dan protein ketika tubuh tidak mendapatkan cukup glukosa dari karbohidrat, tubuh biasanya menggunakan energi alternatif yang bersumber dari tubuh keton, yaitu asetoasetat dan b- hidroksibutirat. Tubuh keton berasal dari pemecahan metabolisme asam lemak di hati di mana saat ini konsentrasi rendah dalam darah. Diet ketogenik adalah diet yang menggunakan banyak lemak sebagai sumber energi dan mengurangi konsumsi karbohidrat. Diet ketogenik membuat tubuh membakar lemak, bukan karbohidrat. Pankreas adalah pusat kendali metabolisme energi. Peran metabolisme yang dipengaruhi oleh fungsi endokrin pankreas terletak di pulau-pulau langerhans, dalam bentuk sel-sel epitel yang menyebar ke seluruh organ. Perubahan pola diet tentu akan berdampak pada proliferasi dan sel apoptosis pada pankreas. Kata Kunci: diet ketogenik, pankreas, proliferasi, resistensi sel","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129054997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Terapi Gizi Klinik Intensif Terhadap Penurunan Berat Badan, Komposisi Tubuh, dan Profil Lipid pada Remaja Overweight dan Obesitas","authors":"Rita Halim, Raihanah Suzan, Maria Estela Karolina","doi":"10.22437/JMJ.V7I1.7126","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7126","url":null,"abstract":"ABSTRACT \u0000Background: Current nutritional status issues are no longer focused on malnutrition, but also on excess nutrition that can occur in all age groups, especially vulnerable to occur at a young age. Objective: to assess the effect of intensive clinical nutrition therapy on weight loss, body composition and lipid profile in overweight and obese adolescents. Method: This study was a case control study and was carried out during the months of August - September 2018, where the sample of the study would be antopometric examination, body composition and lipid profile before and after the intervention. Results: there was no significant difference in the effect of intervention between intensive nutrition therapy compared to only nutrition counseling in weight loss, body composition, and lipid profile. Conclusion: Nutritional intervention in the form of intensive nutrition therapy and counseling conducted in this study had significant results in weight loss, lipid profile and body composition in overweight and obese adolescents, although no significant effect was found on the two interventions. \u0000Keywords: Nutritional intervention, weight loss, body compotition, lipid profile, overweight, obesitas \u0000  \u0000ABSTRAK \u0000Latar belakang: Permasalahan status gizi saat ini bukan lagi hanya terpusat pada kekurangan gizi saja, namun juga pada kelebihan gizi yang dapat terjadi pada semua golongan usia, terutama rentan terjadi pada usia muda. Tujuan: menilai pengaruh terapi gizi klinik intensif terhadap penurunan berat badan, komposisi tubuh dan profil lipid pada remaja overweight dan obesitas. Metode: Penelitian ini merupakan penelitian case control dan dilakukan selama bulan Agustus – September 2018, dimana sampel penelitian akan dilakukan pemeriksaan antopometri, komposisi tubuh dan profil lipid sebelum dan sesudah intervensi. Hasil: tidak terdapat perbedaan pengaruh intervensi secara bermakna antara terapi gizi intensif dibandingkan dengan hanya penyuluhan gizi saja dalam menurunkan berat badan, komposisi tubuh, dan profil lipid. Kesimpulan : intervensi gizi berupa terapi gizi intensif dan penyuluhan yang dilakukan pada penelitian ini memiliki hasil yang bermakna terhadap penurunan berat badan, profil lipid dan komposisi tubuh pada remaja overweight dan obesitas walaupun tidak ditemukan perbedaan yang bermakna dari kedua intervensi tersebut. \u0000Kata Kunci: intervensi gizi, penurunan berat badan, komposisi tubuh, profil lipid, overweight, obesitas","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133591957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supervisi Klinik Stase Mayor Pada Rumah Sakit Pendidikan Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi","authors":"N. N. A. Shafira, A. Syauqy","doi":"10.22437/JMJ.V7I1.7112","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7112","url":null,"abstract":"  \u0000ABSTRACT \u0000Background: Clinical phase in  medical education  is education that carried out through the teaching and learning process in the form of clinical and community learning that employs various forms and levels of  health services. At  clinical phase learning , students are given the opportunity to be involved in health services with the guidance and supervision of clinical supervisors. Clinical supervision has a positive impact on patient health and the knowledge development of medical students. \u0000Research Objective: This study aims to determine the clinical supervision overview in the major stage at Teaching Hospital of Faculty of Medicine and Health Sciences Jambi University based on student perceptions. \u0000Method: This research is a combination of quantitative research and qualitative research. Quantitative research conducted was a cross sectional study using the Clinical Teaching Effectiveness Instrument (CTEI) questionnaire. The usage of the CTEI questionnaire in this study was to find out the clinical supervision overview in the major stage at Teaching Hospital based on student perceptions. Furthermore, qualitative research was conducted with focus group discussions (FGD) to confirm and explore the perceptions of the students based on the results of questionnaire analysis. \u0000Results: Overall, for every 15 items of clinical supervision in each major stage had a mean CTEI score > 3 with a score range of 3.6- 4.1. Range of scores on the Internal Medicine Department  3.2 - 4.7; Pediatric  Department 3.4 - 3.8; Surgery Department 3.6 - 4 and Obgyn Department 3.7- 4. \u0000Conclusion: Based on the results, it can be concluded that the clinical supervision of the major stages at  Teaching Hospital of Faculty of Medicine and Health Sciences Jambi University has been run well. \u0000Keywords: clinical supervision, CTEI, medical students \u0000  \u0000ABSTRAK \u0000Latar Belakang: Pendidikan kedokteran fase klinik adalah pendidikan kedokteran yang dilaksanakan melalui proses belajar mengajar dalam bentuk pembelajaran klinik dan pembelajaran komunitas yang menggunakan berbagai bentuk dan tingkat pelayanan kesehatan nyata. Pada pembelajaran fase klinik  mahasiswa diberi kesempatan terlibat dalam pelayanan kesehatan dengan  bimbingan dan pengawasan supervisor klinik . Supervisi klinik memiliki dampak yang positif terhadap kesehatan pasien dan perkembangan pengetahuan mahasiswa kedokteran. \u0000Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui gambaran supervisi klinik di stase mayor Rumah Sakit pendidikan Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi berdasarkan persepsi mahasiswa \u0000Metode: Penelitian ini merupakan gabungan antara penelitian kuantitatif dan penelitian kualitatif. Penelitian kuantitatif yang dilakukan merupakan, studi cross sectional dengan menggunakan kuesioner Clinical Teaching Effectiveness Instrument (CTEI). Penggunaan kuesioner CTEI pada penelitian ini untuk mengetahui gambaran supervisi klinik di stase mayor Rumah Sakit pendidikan be","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131721660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Kurma Muda (Phoenix dactylifera) Terhadap Kadar Esterogen Pada Tikus Putih (Rattus norvegicus)","authors":"A. Fitri, Herlambang Herlambang","doi":"10.22437/JMJ.V7I1.7124","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7124","url":null,"abstract":"ABSTRACT \u0000Background: Infertility may give an impact on psychosocial. In Indonesia, the habit of consuming young dates is often done by couples to increase fertility. Estrogen is one of the factors that play a role in the menstrual cycle. The lack of scientific evidence of young dates consumption effects on female reproduction has led to this study. \u0000Method: This study used an experimental design using 28 female Sprague-Dawley rats which were randomly divided into 4 groups. Group I to III was given young dates in successive doses: 17 mg, 34 mg, 68 mg per 200 grams of body weight and group IV was given distilled water (aqua dest). The treatment was carried out for 28 days. Estradiol levels were examined before treatment during the proestrus phase which was known from microscopic examination of rat vaginal swabs. The treatment begins during the proestrus phase. \u0000Result: There is an increase of mean baseline and post-treatment estradiol levels 24.48 and 25.03 respectively \u0000Conclusion: There is no significant increase of B-Estradiol levels of female Spague-Dawley rat uterus as the effect of giving young dates (Phoenix Dactylifera). \u0000Keywords: Dates, Β-Estrodiol, Rats \u0000  \u0000ABSTRAK \u0000Latar Belakang : Infertilitas dapat memberikan dampak psikososial. Di Indonesia, Kebiasaan mengkonsumsi kurma muda sering dilakukan oleh pasangan untuk meningkatkan kesuburan. Hormon estrogen merupakan salah satu faktor yang berperan dalam siklus menstruasi. Belum adanya bukti ilmiah efek konsumsi buah kurma muda terhadap reproduksi wanita mendorong dilakukannya studi ini. \u0000Metode: Penelitian ini menggunakan desain ekperimental menggunakan tikus Sprague dawney betina sebanyak 28 ekor yang dibagi secara acak menjadi 4 kelompok. Kelompok I-III diberikan kurma muda dosis berturut -turut 17 mg, 34 mg, 68 mg per 200 gram BB dan kelompok IV diberikan aquadest. Perlakuan dilakukan selama 28 hari. Kadar hormon estradiol diperiksa sebelum perlakuan saat fase proestrus yang diketahui dari pemeriksaan mikroskopis swab vagina tikus dan sebelum terminasi. Perlakuan dimulai saat fase proestrus. Terminasi dilakukan pada hari ke-29 saat fase proestrus. \u0000Hasil: Terdapat peningkatan rerata kadar estradiol baseline dan paska perlakuan adalah 24,48 dan 25,03. \u0000Kesimpulan: Tidak terdapat peningkatan yang signifikan kadar B-Estradiol pada uterus tikus Spague Dawney terhadap efek pemberian buah kurma muda (Phoenix Dactylifera). \u0000Kata kunci: Kurma, Β-Estrodiol, Tikus","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129461367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUBUNGAN ANTARA KADAR TGF-Β1 DENGAN KADAR ALBUMIN DALAM URIN PASIEN DM TIPE-2 DENGAN NEFROPATI DIABETIK","authors":"Elfiani Elfiani, Rita Halim, M. H. Hakir","doi":"10.22437/JMJ.V7I1.7070","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7070","url":null,"abstract":"ABSTRACT \u0000Background: Diabetic nephropathy (DN) is a complication of diabetes in the kidney that frequently causes terminal kidney disease. This kidney disease caused by diabetes is a syndrome characterized by albumin in urine (albuminuria). Growth factor-β1 (TGF- β1) is a multifunctional cytokine that controls many biological processes, including immunity, differentiation, tumor suppression, tumor metastasis, aging, migration, wound healing, apoptosis, adipogenesis, and osteogenesis. Previous studies had showed that TGF-β1 plays a role in albuminuria, where TGF-β1 expression in the kidney increases in diabetes patients. Elevation of cytokine level, especially transforming growth factor beta-1 (TGF-β1) that induces the increase of several extra cellular matrices (ECM), i.e. fibronectin, integrin-linked kinase (ILK) and type IV collagen. This TGF-β1 activity causes the accumulation of ECM, which leads to thickened glomerular basement membrane (GBM). Thickening of GBM and changes in kidney structure in the form of hypertrophy and reduced glomerular podocytes caused by apoptosis and attachment in GBM causes protein components to exit through urine (albuminuria). This study aimed to prove the correlation between transforming growth factor-β1 and albumin level in urine of diabetic nephropathy. \u0000Metode : This study a observasional with desain Cross-sectional  comparative study. \u0000Results: Mean TGF-β1 level in type 2 DM patients with diabetic nephropathy in this study was 47.30 ± 14.70 ng/ml, with similar value between men and women with 43.1 ng/ml and 44.7 ng/ml, respectively. Out of 60 type 2 DM participants with ND, the mean albuminuria level according to ACR was 722.53 ± 1854.96 mg/g. The result of male participants was lower compared to female participants, with 667.8 mg/mg and 777.2 mg/g, respectively. \u0000Conclusion: There was insignificant correlation between TGF-β1 in diabetic nephropathy (DN) and albumin level in urine measured using albumin and urine creatinine ratio (ACR) (p = 0.066). \u0000Keywords: Diabetic Nephropathy, Albuminuria, TGF-β1 \u0000  \u0000ABSTRAK \u0000Latar Belakang : Nefropati diabetik (ND) merupakan komplikasi diabetes pada ginjal yang paling sering menyebabkan terjadinya penyakit ginjal terminal. Penyakit ginjal akibat diabetes ini merupakan sindroma dengan karakteristik terdapatnya albumin dalam urine (albuminuria). Faktor pertumbuhan-β1 (TGF-β1) adalah sebuah sitokin multifungsi yang mengendalikan banyak proses biologis termasuk kekebalan, diferensiasi, tumor supresi, tumor metastasis, penuaan, migrasi, penyembuhan luka, apoptosis, adipogenesis, dan osteogenesis. Sejumlah penelitian sebelumnya menunjukkan bahwa TGF-β1 berperan terhadap terjadinya albuminuria, dimana pasien diabetes didapatkan ekspresi TGF-β1 di ginjal meningkat. Peningkatan kadar cytokine terutama Transforming Growth Factor Beta-1 (TGF-β1) yang menginduksi peningkatan beberapa Extra Cellular Matrix (ECM) antara lain fibronectin, integrin-linked kinase (ILK) dan collagen tipe-","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131026948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}