JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan"最新文献

{"title":"KEMAMPUAN CLINICAL REASONING PADA UJIAN OSCE MAHASISWA KEDOKTERAN TAHUN KETIGA","authors":"Diani Puspa Wijaya","doi":"10.22437/JMJ.V7I1.7057","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7057","url":null,"abstract":"ABSTRACT \u0000Background : Clinical reasoning is one of the clinical skill competencies that must be owned by a doctor so it needs to be studied and tested. The OSCE is one method of assessment that can be used to assess the achievement of clinical reasoning. OSCE in the third year at Faculty of Medicine Islamic University of Indonesia (FM IUI)  has been using clinical case OSCE so that can be used to assess clinical reasoning skill in addition to others clinical skills such as   physical examination and clinical procedural skills. This study aimed to evaluate the clinical reasoning skills of students in the third year of the OSCE exam at FM IUI. \u0000Methods : The cross sectional study method was used in this study. OSCE test result semesters 5 and 6 of the academic year 2015/2016 collected. Clinical reasoning skills of students in  OSCE obtained from the score of the diagnosis ability in clinical case OSCE station. The difference between clinical reasoning skill on each  OSCE station and its correlation with the written test on the corresponding block were analyzed. \u0000Results: There is differences between clinical reasoning skill in OSCE stations semester 5 and 6. There was no relationship between the score clinical reasoning skills  at the OSCE  with written test achievement on the corresponding block. \u0000Conclusion: The clinical reasoning skills on the OSCE  semesters 5 and 6 do not illustrate the clinical reasoning skills of third-year medical students in this study. This study supports the need for   further development of the assessment of clinical reasoning skills on the OSCE  for medical students. \u0000Keywords : clinical reasoning, OSCE, medical student \u0000  \u0000ABSTRAK \u0000Latar Belakang: Penalaran klinis atau clinical reasoning merupakan salah satu kompetensi keterampilan klinis yang harus dimiliki oleh seorang dokter sehingga perlu dipelajari dan diujikan. OSCE merupakan salah satu metode assessment yang dapat digunakan untuk menilai pencapaian clinical reasoning. OSCE pada tahun ketiga di FK UII telah menggunakan kasus klinis untuk dapat juga menilai clinical reasoning disamping keterampilan klinis yang lain seperti  pemeriksaan fisik dan tindakan prosedural.   Penelitian ini bertujuan mengevaluasi kemampuan clinical reasoning mahasiswa kedokteran pada ujian OSCE tahun ketiga di FK UII. \u0000Metode : Metode yang digunakan adalah cross sectional dari hasil ujian OSCE semester 5 dan 6 tahun akademik 2015/2016. Kemampuan clinical reasoning mahasiswa pada ujian OSCE didapatkan dari nilai kemampuan menegakkan diagnosis pada stasion OSCE yang berupa manajemen kasus klinis. Nilai OSCE direkap pada semua mahasiswa yang mengikuti ujian  pada periode tersebut. Analisis dilakukan dengan melihat perbedaan kemampuan clinical reasoning antar station OSCE dan menilai korelasinya dengan ujian tulis pada blok yang bersesuain . \u0000Hasil: Terdapat perbedaan kemampuan clinical reasoning antar stasion OSCE baik di semester ke 5 maupun ke 6. Tidak terdapat hubungan antara nilai kema","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132162300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperosmolar Hyperglycemic State (HHS)","authors":"Rahayu Oktaliani, Aywar Zamri","doi":"10.22437/JMJ.V7I1.7060","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7060","url":null,"abstract":"ABSTRACK \u0000Introduction: The Hyperosmolar Hyperglycemic State (HHS) is rare case and the most serious acute hyperglycemic emergency in patients with type 2 diabetes, are characterized by severe hyperglycemia, hyperosmolality, and dehydration in the absence of ketoacidosis. Immediately treatment is necessary to reinstate hemodynamic stability, as mortality rates for HHS are exceptionally high and can have multiple complications. \u0000Case Presentation: In this case report, a 63-year-old man with a chiefly complaint from the body became weaker. Patients present with compos mentis, blood pressure 100/70 mmHg, regular pulse rate 110 times per minute with sufficient content and respiration 20 times per minute, and temperature 37,90C. Physical examination shows signs of dehydration. Investigation found white blood cell 12.580 103/mm3, plasma glucose 741 mg / dL, and a negative urine ketone. \u0000Conclusion: Case has been reported, a 63-year-old man with a diagnosis of HHS, the trigger factor for HHS in these patient are the discovery of infections as bronchopneumonia, elderly, and irregular diabetes treatment. The importance of treatment in this case is because the patient is elderly, treatment must be right because where too rapid rehydration may precipitate heart failure but insufficient may fail to reverse acute kidney injury. \u0000Keywords: Diabetes Mellitus, Hyperosmolar Hyperglycemic State, Hyperglycemia \u0000  \u0000ABSTRAK \u0000Latar Belakang : Hyperosmolar Hyperglycemic State (HHS) merupakan kasus yang jarang dan komplikasi emergensi akut dari pasien diabetes melitus tipe 2, dengan karakteristik hiperglikemi, hiperosmolar dan dehidrasi atau tidak adanya ketoasidosis. Tatalaksana segera penting dilakukan untuk menstabilkan hemodinamik, mortalitas dari HHS tinggi dan dapat menyebabkan banyak komplikasi. \u0000Presentasi Klinis : Pada laporan kasus ini, seorang laki-laki berusia 63 tahun dengan keluhan utama badan semakin lemas. Pasien datang dengan kesadaran kompos mentis, tekanan darah 100/70 mmHg, nadi teraba 110 kali per menit kuat regular dengan isi cukup dan respirasi 20 kali per menit, dan suhu 37,90C . Pemeriksaan fisik didapatkan tanda-tanda dehidrasi. Pemeriksaan penunjang dijumpai sel darah putih 12.580, glukosa plasma 741 mg/dL, dan keton urine negatif. \u0000Kesimpulan : Telah dilaporkan kasus, laki-laki usia 63 tahun dengan diagnosa HHS, faktor pencetus terjadinya HHS pada pasien ini yaitu ditemukannya infeksi berupa bronkopneumonia, usia lanjut, pengobatan diabetes yang tidak teratur. Pentingnya perawatan dalam kasus ini adalah karena pasien berusia lanjut, pengobatan harus benar karena ketika rehidrasi yang terlalu cepat dapat memicu gagal jantung tetapi tidak cukup dapat gagal untuk membalikkan cedera ginjal akut. \u0000Kata Kunci : Diabetes Melitus, Hyperglycemic Hyperosmolar State, Hiperglikemi","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125791373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDI KASUS: OBSERVASI PENERAPAN METODE BEDSIDE PADA PROSES BEDSIDE TEACHING DI BANGSAL PENYAKIT DALAM RUMAH SAKIT SARDJITO YOGYAKARTA","authors":"Rhendy Wijayanto","doi":"10.22437/JMJ.V7I1.7061","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7061","url":null,"abstract":"ABSTRACT \u0000Bedside teaching is an excellent opportunitiy for spontaneuous interaction between student, clinical supervisor, and patient.  In bedside teaching sessions there are possibilities for appropriate and inappropriate encounter.  Clinical supervisor observes and gives feedback  in order to create a useful bedside teaching session for student.  Bedside teaching session observed in Internal Ward of Sardjito Hospitol has applied Briefing, Expectation, Demonstration, Specific feedback, Inclusion of microskill teaching, Debriefing and Education accordingly.  Student has obtained optimal  learning opportunity from the event. \u0000Keywords: Bedside teaching, clinical, feedback \u0000  \u0000ABSTRAK \u0000Bedside teaching adalah suatu kondisi yang baik untuk interaksi yang spontan antara mahasiswa, pembimbing klinik, dan pasien. Dalam sesi Bedside teaching terdapat kemungkinan terjadi prosedur yang sesuai ataupun yang kurang sesuai.   Seseorang pembimbing klinik berperan untuk mengamati dan memberi umpan balik sehingga dapat menjadi sesi bedside teaching yang berguna bagi mahasiswa. Pelaksanaan Bedside teaching di Bangsal Penyakit Dalam RS Sardjito menerapkan tahapan Briefing, Ekspektasi, Demonstrasi, Umpan balik spesifik, Penerapan pengajaran microskill, Debriefing, dan Edukasi telah diterapkan dengan baik.  Mahasiswa memperoleh manfaat yang optimal dari proses tersebut.    \u0000Kata kunci: Bedside teaching, klinik, umpan balik","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130916729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KADAR INTERFERON GAMMA (IFNγ) PADA PASIEN TOKSOPLASMOSIS YANG ASIMPTOMATIK","authors":"Armaidi Darmawan, Maria Estela Karolina, H. Hanina","doi":"10.22437/JMJ.V7I1.7062","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7062","url":null,"abstract":"ABSTRACT \u0000Background: Toxoplasma gondii is a species that is able to modulate its host immune system. T.gondii infection causes an increased Th1 response to produce IFNγ, TNFα and IL-12 secreted by T. IFNγ lymphocytes which are activated and cause increased production of Nitric Oxide (NO) which can cause cell apoptosis and IFNγ can destroy T.gondii with several mechanisms. The aim of this study was to determine IFN levels in patients with positive IgG and asymptomatic IgG toxoplasmosis.Methods: Case control research with experimental laboratories that use human blood as the object of research. The subjects were initially checked for blood with IgG Rapid Test to determine the positive or negative Toxoplasma infection. IFNγ levels are checked by the ELISA method. To analyze the average comparison of IFNγ levels using computer software. Test the data normality with Saphiro-wilk and comparison of IFNγ levels with Wilcoxon test.Results: IFNγ levels in the negative IgG group (4.69) were slightly lower on average compared to the positive IgG group (4.79). Wilcoxon test results of p> 0.05 (0.399) means that the hypothesis is rejected.Conclusion: There was no difference between IFNγ levels in the positive IgG group and the negative IgG group.Keywords: Toxoplasmosis, IFNγ level, IgG toxoplasmosis. \u0000  \u0000ABSTRAK \u0000Latar belakang: Toksoplasma gondii merupakan spesies yang mampu memodulasi sistem imun inangnya. Infeksi T.gondii menyebabkan respon Th1 meningkat untuk memproduksi IFNγ, TNFα dan IL-12 yang disekresi oleh sel limfosit T. IFNγ diaaktifkan dan menyebabkan meningkatnya produksi Nitric Oxide (NO) yang bisa menyebabkan apoptosis sel dan IFNγ bisa memusnahkan T.gondii dengan beberapa mekanisme. Tujuan penelitian ini untuk menentukan kadar IFNγ pada pasien IgG positif dan IgG Toksoplasmosis yang asimptomatik. \u0000Metode: Penelitian case control dengan eksperimental laboratorik yang mengunakan darah manusia sebagai objek penelitian. Subjek awalnya di cek darahnya dengan Rapid Test IgG untuk menentukan positif atau negatif infeksi toksoplasma. Kadar IFNγ dicek dengan metode ELISA. Untuk menganalisa perbandingan rerata kadar IFNγ menggunakan perangkat lunak komputer. Uji normalitas data dengan Saphiro-wilk dan perbandingan kadar IFNγ dengan uji Wilcoxon. \u0000Hasil: Kadar IFNγ pada kelompok  IgG negatif (4,69) rata-rata lebih rendah sedikit dibandingkan dengan kelompok IgG positif (4,79). Uji Wilcoxon hasil p>0,05 (0,399) artinya hipotesis ditolak. \u0000Kesimpulan: Tidak ada perbedaan antara kadar IFNγ pada kelompok IgG positif dengan kelompok IgG negatif. \u0000Kata Kunci : Toksoplasmosis, Kadar IFNγ, IgG Toksoplasmosis","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124194985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Imunoekspresi Annexin V (ANX V) dengan Histopatologi Jaringan Kuretase pada Abortus Berulang","authors":"Fairuz M C Quzwain, Hasna Dewi, Suhair Quzwain","doi":"10.22437/JMJ.V7I1.7058","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7058","url":null,"abstract":"   ABSTRACT \u0000Background : Abortion the ending of pregnancy due to removing an embryo or fetus before it can survive outside the uterus. Examination on placental tissue currently does not provide much information. Annexin V (ANX V), formerly known as placenta anticoagulant protein and alpha coagulant vascular, is found in the placenta and vascular endothelium and several other tissues. This ANX V is found at the top of the placenta syncytiotrophoblast, and it is also found that this protein content freely decreases with the antiphospholipid syndrome (APS). This study aimed to assess the relationship between the description of ANX V expression and histopathology of curettage tissue in patients with recurrent abortion. \u0000Methods : This study was conducted using curettage tissue samples of patients with recurrent abortion in the Obstetrics and Gynecology section of Abdul Manap Hospital and Baiturahim Hospital in February to August 2018. The collected samples were diagnosed with HE preparations, to determine histopathological features in each group, villi infarction. hydrophic villi, sincytial knots, fibrin stroma and inter villi thrombus with the highest total score were 15. Then immunohistochemical assessment with Annexin V (ANX V) results compared with positive controls and negative controls with cut-off points 10%. \u0000Results: We have found a recurrent abortion sample with positive Annexin V immunoexpression, which is the most common histopathological score of 11-15 on recurrent abortion (p = 0.001 and r = -0.784) \u0000Conclusion: There is a relationship between immunohistochemistry ANX V with histopathological features of recurrent abortion curettage. \u0000Keywords: Annexin V, Histopathology, Recurrent abortion \u0000  \u0000ABSTRAK \u0000Latar Belakang: Abortus adalah keadaan pengeluaran hasil konsepsi sebelum janin dapat hidup di luar kandungan. Pemeriksaan pada jaringan plasenta saat ini tidak banyak memberikan informasi. Annexin V (ANX V), dulu dikenal dengan placental  anticoagulant protein I dan vascular coagulant alfa,   ditemukan di plasenta dan endotel vaskular dan beberapa jaringan yang lain. ANX V ini ditemukan di puncak permukaan sinsitiotrofoblas plasenta, dan  ditemukan pula bahwa kadar protein ini secara bermakna menurun di villi plasenta penderita abortus dengan antiphospholipid syndrome (APS). Penelitian ini bertujuan melihat hubungan gambaran ekspresi ANX V dengan histopatologi jaringan kuretase  pada penderita abortus berulang. \u0000Metode : Penelitian ini dilakukan dengan menggunakan sampel jaringan kuretase pasien abortus berulang di bagian Obstetri dan Ginekologi RS Abdul manap dan RS Baiturahim periode februari sampai agustus 2018. Sampel yang terkumpul dilakukan diagnosis terhadap sediaan HE, untuk menetukan gambaran histopatologis  pada masing-masing kelompok yaitu infark villi, hidrofik villi,  sincytial knots, fibrin stroma serta trombus inter villi dengan skor total tertinggi adalah 15. Kemudian dilakukan pemulasan dan penilaian imunohistokimia den","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134272157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Fenomenologi tentang Faktor Risiko Penularan Tuberculosis Paru di Perumnas Way Kandis Lampung","authors":"F. Saftarina, A. Fitri","doi":"10.22437/JMJ.V7I1.7117","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7117","url":null,"abstract":"Abstract \u0000Pulmonary tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis with the highest mortality rate in worldwide. Indonesia is one of big five country with the highest incidency. Based on distribution per province, Lampung was in the tenth with 7,627 new TB cases in 2017. The purpose of this research was to determine the risk factors of pulmonary tuberculosis in Perumnas Way Kandis Subdistrict. Methods:This is a qualitative research with phenomenological approach. Samples was determined purposively based on appropriateness and adequateness. This research involved 5 people with BTA (+) who are undergoing treatment and 5 people who are the patients’ close family as informant. Data was collected by observation and interview. Data validity was maintained with triangulation and analysed with Milles and Huberman Model. \u0000Results: Based on indepth interview, understanding of the informants of TB was good; most of informants did not know the ways and the sources of TB transmission; informants had a habit of not using masks; most of informants with TB do a routine treatment; the close family of informants with TB support and remind them taking medication; distance of the houses between informants with TB is close enough, do not have good sun lighting and air circullation. Conclusion: The priority cause of TB is the low compliance in using masks so the priority solution is to distribute masks for TB patients. \u0000Keywords: Indepth interview, mask, tuberculosis \u0000  \u0000Abstrak \u0000Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis dengan angka kematian tertinggi di dunia. Indonesia termasuk dalam lima besar negara dengan insiden tertinggi. Berdasarkan sebaran per provinsi, Lampung berada di posisi kesepuluh dengan 7.627 kasus TB baru pada tahun 2017. Penelitian ini bertujuan untuk mengetahui faktor risiko penularan TB paru di Kelurahan Perumnas Way Kandis. Penelitian ini merupakan penelitian kualitatif dengan pendekatan fenomenologi. Pemilihan sampel ditetapkan secara langsung (purposive) dengan prinsip kesesuaian (appropriateness) dan kecukupan (adequateness). Jumlah sampel terdiri dari 5 orang pasien BTA (+) yang sedang menjalani pengobatan dan 5 orang keluarga terdekat pasien sebagai informan. Pengumpulan data dilakukan dengan observasi dan wawancara. Validitas data dijaga dengan triangulasi dan analisis data menggunakan model Milles dan Huberman. \u0000Hasil: Berdasarkan indepth interview, pengetahuan informan mengenai TB sudah baik; sebagian informan tidak mengetahui cara dan sumber penularan TB; informan memiliki kebiasaan tidak menggunakan masker; sebagian besar informan dengan penyakit TB melakukan pengobatan secara rutin; keluarga besar informan dengan penyakit TB mendukung dan mengingatkan untuk minum obat; jarak rumah antarpenderita TB berdekatan serta tidak memiliki pencahayaan matahari dan sirkulasi udara yang baik. \u0000Kesimpulan: Prioritas penyebab TB adalah rendahnya kepatuhan menggunakan","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124922396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE HIGH DOSE TOXICITY OF BETEL NUT (Areca catechu L.) ON REPRODUCTION ORGAN OF RATS","authors":"A. Rahman, Herlambang Herlambang, C. A. Simanjuntak, H. Dewi, A. Syauqy, Lipinwati Lipinwati","doi":"10.22437/JMJ.V7I1.7059","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7059","url":null,"abstract":"ABSTRACT \u0000Background : The use of long-term herbal medicines and high doses can damage organs, including the reproductive organs. Betel nut (Areca catechu L.) is one of the herbal ingredients that is consumed as a stamina enhancing beverage. The purpose of this study was to determine the effect of longterm treatment of raw betel nut at a dose of 10,000 mg/kg on testicular and ovary tissue of rats. Rats were Rattus norvegicus, Sprague Dawley strain, 2-3 months.  Methods : Tweenty rats divided into 2 groups, each groups were 5 male and 5 female. Control group was given aquades and the treatment group was given raw betel nut with a dose of 10,000 mg/kgBW for 45 days with a gastrictube. Histopathological examination with Haematoxylin-Eosin staining was used to assses testicular and ovary tissues.  Results: The ovaries of treatment groups had significantly lower de graff follicle compared to the control group (p < 0,05). The testis of treatment groups had significantly smaller diameter of tubulus seminifery, significantly higher necrosis of spermatogonia and spermatosit (p<0,05). Conclusion: Treatment of raw betel nut dose 10,000 mg /kgBW along 45 days causes damage of  testicular and ovary tissues of rats.Keywords:  Betel Nut, Areca Catechu L., Histopathology, Testicular, Ovary, Herbal Toxicity \u0000  \u0000ABSTRAK \u0000Latar Belakang: Pemakaian obat herbal jangka panjang dan dosis tinggi dapat menyebabkan kerusakan organ tubuh, termasuk organ reproduksi. Biji pinang (Areca catechu L.) merupakan salah satu bahan herbal yang dikonsumsi sebagai minuman penambah stamina.Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian biji pinang muda dosis 10.000 mg/ kgBB selama 45 hari terhadap gambaran histopatologis testis dan ovarium tikus. \u0000Metode : Tikus yang digunakan adalah Rattus norvegicus galur Spague Dawley, usia 2-3 bulan, sebanyak 10 ekor jantan dan 10 ekor betina yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol diberikan aquades dan kelompok perlakuan diberikan biji pinang dosis 10.000 mg/ kgBB  dengan sonde. Pemeriksaan histopatologi dengan pewarnaan Haematoxylin-Eosin untuk organ testis dan organ ovarium. Hasil: Jumlah folikel de draf pada kelompok perlakuan  lebih sedikit dibandingkan kelompok kontrol (p<0,05).  Persentase nekrosis spermatogonia dan spermatosit pada kelompok perlakuan  lebih tinggi dibandingkan kelompok kontrol (p<0,05), diameter tubulus seminifeus pada kelompok perlakuan juga lebih kecil dibandingkan kelompok kontrol (p<0,05). \u0000Kesimpulan: Pemberian biji pinang 10.000 mg/kgBB selama 45 hari menyebabkan kerusakan pada jaringan testis dan ovarium pada tikus.  \u0000Kata Kunci           :  Biji Pinang,  Areca Catechu L, Histopatologi, Ovarium, Testis, Toksisitas herbal","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132951611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Kurma Muda (Phoenix dactylifera) Terhadap Kadar FSH dan Reseptor FSH Ovarium Tikus Putih (Rattus norvegicus)","authors":"Herlambang Herlambang, Ave Olivia Rahman, Erny Kusdiyah","doi":"10.22437/JMJ.V7I1.7128","DOIUrl":"https://doi.org/10.22437/JMJ.V7I1.7128","url":null,"abstract":"ABSTRACT \u0000Background: Infertility may give an impact on psychosocial. In Indonesia, the habit of consuming young dates is often done by couples to increase fertility. FSH is one of the factors that play a role in folliculogenesis. The lack of scientific evidence of young dates consumption effects on female reproduction has led to this study. This study aims to determine the levels of FSH hormone and the picture of ovarian tissue in mice after administration of young dates. \u0000Method: This study used an experimental design using 28 female Sprague-Dawley rats which were randomly divided into 4 groups. Group I to III was given young dates in successive doses: 17 mg, 34 mg, 68 mg per 200 grams of body weight and group IV was given distilled water. The treatment was carried out for 28 days. FSH levels were examined before treatment during the proestrus phase which was known from microscopic examination of rat vaginal swabs. The treatment begins during the proestrus phase. \u0000Result: The mean baseline and post-treatment FSH levels were 0.08 and 0.09 respectively \u0000Conclusion: There is no significant increase of FSH levels and FSH receptors as the effect of giving young dates (Phoenix Dactylifera) to female Sprague-Dawley rats \u0000Keywords: Dates, FSH, FSH receptors, Rats \u0000  \u0000ABSTRAK \u0000Latar Belakang: Infertilitas dapat memberikan dampak psikososial. Di Indonesia, kebiasaan mengkonsumsi kurma muda sering dilakukan oleh pasangan untuk meningkatkan kesuburan. Hormon FSH merupakan salah satu faktor yang berperan dalam folikelgenesis.  Belum adanya bukti ilmiah efek konsumsi buah kurma muda terhadap reproduksi wanita mendorong dilakukannya studi ini. Studi ini bertujuan mengetahui kadar hormon FSH dan gambaran jaringan ovarium pada tikus setelah pemberian kurma muda. \u0000Metode: Penelitian ini menggunakan desain ekperimental menggunakan tikus Sprague dawney betina sebanyak 28 ekor yang dibagi secara acak menjadi 4 kelompok. Kelompok I-III diberikan kurma muda dosis berturut -turut 17 mg, 34 mg, 68 mg per 200 gram BB dan kelompok IV diberikan aquadest. Perlakuan dilakukan selama 28 hari. Kadar hormon FSH diperiksa sebelum perlakuan saat fase proestrus yang diketahui dari pemeriksaan mikroskopis swab vagina tikus. Perlakuan dimulai saat fase proestrus. \u0000Hasil: Rerata kadar FSH baseline dan paska perlakuan adalah 0,08 dan 0,09 \u0000Kesimpulan: Tidak terdapat peningkatan yang signifikan kadar FSH dan reseptor FSH terhadap efek pemberian buah kurma muda (Phoenix Dactylifera) pada uterus tikus Spague Dawney \u0000Kata kunci : kurma, FSH, Reseptor FSH, tikus","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126509905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUBUNGAN ANTARA DERAJAT OSTEOARTRITIS DENGAN GAMBARAN USG TULANG RAWAN PADA PASIEN OSTEOARTRITIS LUTUT DI RSU AL FAUZAN PERIODE TAHUN 2016-2017","authors":"Riza Amalia","doi":"10.22437/jmj.v9i1.5254","DOIUrl":"https://doi.org/10.22437/jmj.v9i1.5254","url":null,"abstract":"Osteoarthritis is a degenerative joint disease which is related with the damage of cartilage. X-Ray is one of the osteoarthritis radiological examinations but only to see the damage of bone not cartilage. One of an effective examination to visualize the damage of cartilage is Ultrasound. The objective of this study is to determine the relation between osteoarthritis grading scale with cartilage ultrasonographic in knee osteoarthritis patients. This was a Cross-sectional study on 32 knee osteoarthritis patients based on Total Sampling technique at RSU Al Fauzan period of 2016-2017. Statistical analysis was performed using Fisher test showed there was a correlation between osteoarthritis grading scale with cartilage ultrasonographic. The conclusion in this study, there is a significant correlation between osteoarthritis grading scale with cartilage ultrasonographic in knee osteoarthritis patients. \u0000Keywords: Knee Osteoarthritis, Ultrasound, X-Ray","PeriodicalId":409923,"journal":{"name":"JAMBI MEDICAL JOURNAL \"Jurnal Kedokteran dan Kesehatan\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114870571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}