Online Türk Sağlık Bilimleri Dergisi最新文献_第9页

İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı LncRNA’ların ve İnvazyonun Baskılanması 施用硼酸可抑制某些 LncRNAs 和人胰腺癌的侵袭

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-09 DOI: 10.26453/otjhs.1200978

Canan Eroğlu

{"title":"İnsan Pankreas Kanserinde Borik Asit Uygulaması ile Bazı LncRNA’ların ve İnvazyonun Baskılanması","authors":"Canan Eroğlu","doi":"10.26453/otjhs.1200978","DOIUrl":"https://doi.org/10.26453/otjhs.1200978","url":null,"abstract":"Amaç: Borik asidin bazı lncRNA'lar ve invazyon üzerine etkisinin PANC-1 ve MIA PaCa-2 pankreas kanseri hücrelerinde araştırılması amaçlanmıştır. \u0000Materyal ve Metot: Borik asitin hücre canlılığı ve invazyon üzerine etkileri sırası ile XTT testi ve invazyon kuyucukları kullanılarak araştırılmıştır. TCGA verileri kullanılarak pankreas kanserinde lncRNA H19 ve UCA1 ifadeleri değerlendirilmiştir. Bu lncRNA’ların ve invazyon genlerinin ifadeleri üzerine etkileri qRT-PZR ile belirlenmiştir. \u0000Bulgular: PANC-1 hücrelerinde borik asitin IC50 dozu 14248,8 µM, MIA PaCa-2 de 15707,5 µM olarak hesaplanmıştır. TCGA verileri H19 ve UCA1 ifadelerinin pankreas kanserinde yüksek olduğunu göstermiştir. Borik asit muamelesi ile H19 ve UCA1 lncRNA seviyeleri azalmıştır. Ayrıca borik asit iki hücre hattında CDH1 ve TIMP1 ifadesini arttırmıştır. CDH2 ifadesi ise baskılanmıştır. Borik asit PANC-1 hücrelerinde TIMP2, MIA PaCa-2 hücrelerinde TIMP3 ifadesini arttırmıştır. İnvazyon testinde borik asit her iki hücrede invazyonu anlamlı derecede baskılanmıştır. \u0000Sonuç: Borik asit pankreas kanseri hücrelerinde ifadesinin yüksek olduğu görülen H19 ve UCA1 ifadelerini baskılamıştır. Ayrıca invazyonda önemli olan genlerin ifadelerini değiştirerek anti-invazif etki göstermiştir.","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134629492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Pupil Dilation on Ocular Biometry Measurements in the Senile Cataractous Eyes 瞳孔扩张对老年性白内障眼生物测量的影响

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-06 DOI: 10.26453/otjhs.1161706

M. Üçer, E. Bozkurt, Hülya Gökmen

{"title":"The Effect of Pupil Dilation on Ocular Biometry Measurements in the Senile Cataractous Eyes","authors":"M. Üçer, E. Bozkurt, Hülya Gökmen","doi":"10.26453/otjhs.1161706","DOIUrl":"https://doi.org/10.26453/otjhs.1161706","url":null,"abstract":"Objective: The study aimed to evaluate the effect of cycloplegia on the ocular biometric parameters and intraocular lens (IOL) power calculated by Sanders–Retzlaff–Kraff/theoretical (SRK/T) formula in the cataractous eyes. \u0000Materials and Methods: This cross-sectional study included 68 senile cataractous eyes of 68 patients scheduled to undergo cataract surgery. Measurements of anterior chamber depth (ACD), axial length (AL), white to white (WtW) diameter, keratometry (K1, K2, Kmean), central corneal thickness (CCT), and pupil size (PS) were obtained with AL-Scan (Nidek Co., Ltd, Gamagori, Japan) before and after cycloplegia. The SRK/T formula was used to calculate IOL power with target refraction of 0 D. Cycloplegia induced by cyclopentolate hydrochloride %1. \u0000Results: The mean age of the patients was 70.60±4.07 years (range 65 to 80). A significant increase was observed in ACD after cycloplegia (p< 0.001). There was no statistically significant difference between pre-dilation and post-dilation AL, WtW, CCT, K1, K2, Kmean, and IOL power readings (p> 0.05). Two cases observed a decrease above 0.5 D of IOL power after cycloplegia. \u0000Conclusion: Cycloplegia induced by cyclopentolate hydrochloride %1 does not affect the measurement of the AL, WtW, CCT, keratometry, and SRK/T calculated IOL power except ACD in senile cataractous eyes.","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121525212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC 硫-二硫稳态对早期NSCLC患者预后的影响

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-05 DOI: 10.26453/otjhs.1226101

M. Kavas, Cansel Atinkaya Baytemir, M. Alışık, A. Öztürk, Sümeyye ALPARSLAN BEKİR, Selma Aydogan Eroglu, Elçin Ersöz Köse, İ. Yalçınkaya, Ö. Erel

引用次数: 0

Cytotoxic Effects of Cisplatin and Carboplatin Loaded Albumin Nanoparticles on Breast Cancer Cells 顺铂和卡铂负载白蛋白纳米颗粒对乳腺癌细胞的细胞毒性作用

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-02 DOI: 10.26453/otjhs.1217364

Ferdane Danışman Kalındemirtaş, I. Kariper

{"title":"Cytotoxic Effects of Cisplatin and Carboplatin Loaded Albumin Nanoparticles on Breast Cancer Cells","authors":"Ferdane Danışman Kalındemirtaş, I. Kariper","doi":"10.26453/otjhs.1217364","DOIUrl":"https://doi.org/10.26453/otjhs.1217364","url":null,"abstract":"Objective: This study aims to investigate and compare the anticancer effects of carboplatin and cisplatin, frequently used in cancer treatment, by loading them on albumin nanocarrier. \u0000Materials and Methods: Carboplatin (CP) and Cisplatin (Cis) loaded albumin nanoparticles were synthesized using ultrasonication as CP-NPs and Cis-NPs, respectively. Nanoparticle size and distribution were evaluated by Dynamic light scattering (DLS). Cytotoxicities of NPs were evaluated in MDA-MB-231 and MCF-7 breast cancer cells and HUVEC using MTT test and their morphological images were compared. \u0000Results: While the average size of CP-NPs was around 2-3 nm, Cis-NPs was 7-8 nm. It was observed that both NPs groups were homogeneously dispersed. According to the cytotoxicity results, both CP-NPs and Cis-NPs were more cytotoxic on MCF-7 breast cancer cells. In addition, CP-NPs and Cis-NPs showed significant cytotoxicity on MCF-7, MDA-MB-231 breast cancer cells, while low cytotoxicity was detected in normal HUVEC cells. The NPs treated MCF-7 was compared with the untreated MCF-7 and statistical significance was calculated as P","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121548790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Pain, Function, Anxiety And Depression Levels in Patients with Total Knee Arthroplasty Before Discharge 全膝关节置换术患者出院前疼痛、功能、焦虑和抑郁水平的调查

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-01 DOI: 10.26453/otjhs.1115958

Dilara Özen Oruk, K. Bayar

引用次数: 0

Relationship Between Loneliness, Social Support, and Readiness to Hygienic Care of the Newborn in Pregnant Women 孕妇孤独感、社会支持与新生儿卫生护理意愿的关系

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-01-31 DOI: 10.26453/otjhs.1133951

Sinem Yalnızoğlu Çaka, H. Uslu Yuvacı, Sultan Pekşen, N. Çınar

引用次数: 0

Secondary Bacterial Agents and Antibiotic Resistance Profiles in Respiratory Tract Specimens of Patients with COVID-19 Pneumonia COVID-19肺炎患者呼吸道标本继发细菌及耐药性分析

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-01-25 DOI: 10.26453/otjhs.1094238

Oya Akkaya, Ayşenur Uğur, Habibe Övet, Feyza Alp, Mustafa Önder Gönen

{"title":"Secondary Bacterial Agents and Antibiotic Resistance Profiles in Respiratory Tract Specimens of Patients with COVID-19 Pneumonia","authors":"Oya Akkaya, Ayşenur Uğur, Habibe Övet, Feyza Alp, Mustafa Önder Gönen","doi":"10.26453/otjhs.1094238","DOIUrl":"https://doi.org/10.26453/otjhs.1094238","url":null,"abstract":"ABSTRACT \u0000Objective: The aim of the study is to determine which bacteria are the causative agents and the antibiotic resistance rates in the respiratory tract secretions of patients who have diagnosed with COVID-19 and to compare these results with before the pandemic. \u0000Method: This study is a retrospective study comparing bacteria grown in bronchoalveolar lavage (BAL) fluid and endotracheal aspirate(ETA) fluids coming from adult clinical services and intensive care units and their antibiotic resistance profiles between January 2019 and December 2019 before the pandemic, with the results between January 2020 and December 2020 during the pandemic period. \u0000Results: A total of 900 culture results were examined in 2019; Acinetobacter baumannii was detected in 36%, Klebsiella pneumoniae in 23%, Pseudomonas aeruginosa in 14%, and Staphylococcus aureus in 8%. In 2020, during the pandemic, 660 culture results were examined, and same bacteria was detected in 43%, 23%,16% and 5%, respectively. K.pneumoniae's 3rd generation cephalosporin resistance, A. baumannii's resistance to tigecycline, gentamycin, tobramycin and P. aeruginosa's resistance to ceftazidime were found to have increased significantly during the pandemic compared to the pre-pandemic period. \u0000Conclusion: In hospitalized patients with COVID-19, secondary bacterial agents are mostly multidrug-resistant Gram-negative bacteria. For this reason,in patients with COVID-19 disease, appropriate empirical treatment should be selected by knowing the local bacterial agents and antibiotic resistance profiles.","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129213598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Domestic Violence towards Women and Depression 女性家庭暴力与抑郁症的关系

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-01-18 DOI: 10.26453/otjhs.1056892

Hacer Ünver, Hilal Yıldırım, Kevser Işık

{"title":"The Relationship between Domestic Violence towards Women and Depression","authors":"Hacer Ünver, Hilal Yıldırım, Kevser Işık","doi":"10.26453/otjhs.1056892","DOIUrl":"https://doi.org/10.26453/otjhs.1056892","url":null,"abstract":"Objective: This study was conducted to determine the relationship between domestic violence towards women and depression. \u0000Materials and Methods: This descriptive study was carried out with 464 married women. A Descriptive Information Form, the Domestic Violence Scale and Beck Depression Inventory were used as the data collection instruments. In the statistical analysis, frequencies, percentages, means, ANOVA, t-test, correlation analysis and regression analysis were utilized. \u0000Results: The mean domestic violence and depression scores of the women were found to be low. There was a positive and significant relationship between domestic violence and depression. Factors such as the age of the woman and her spouse, status of being subjected to violence, employment status, educational level and form of marriage were determined as factors that were effective on domestic violence and depression. \u0000Conclusion: Domestic violence is a significant factor leading women to experience depression. It is believed that it is needed to create social policies regarding the problem of violence, develop awareness in healthcare professionals, and healthcare professionals need to take responsibility regarding violence in their professional lives.","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123998895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interatrial Block and Ventricular Repolarization Parameters in Young Patients with Mild Acute Myocarditis 青年轻度急性心肌炎患者的房间传导阻滞和心室复极参数

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-01-15 DOI: 10.26453/otjhs.1182107

Yusuf Hoşoğlu, Ayşe Hoşoğlu, M. Göl, A. Afşin

引用次数: 0

Evaluation of Receptor Relationships of Some Drugs Used in the Treatment of COVID-19 by Modeling Studies 通过模型研究评估某些治疗COVID-19药物的受体关系

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-01-15 DOI: 10.26453/otjhs.1158441

T. Karaduman, M. Karataş, Merve Özcan Türkmen

{"title":"Evaluation of Receptor Relationships of Some Drugs Used in the Treatment of COVID-19 by Modeling Studies","authors":"T. Karaduman, M. Karataş, Merve Özcan Türkmen","doi":"10.26453/otjhs.1158441","DOIUrl":"https://doi.org/10.26453/otjhs.1158441","url":null,"abstract":"Objective: It is important to investigate the interactions of drugs used in the treatment process of COVID-19 with cellular mechanisms. In this study, the aim was to investigate the interactions of Dexamethasone, Favipiravir, and Hydroxychloroquine drugs used in the treatment of COVID-19 with the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2). \u0000Materials and Methods: Within the scope of the study, firstly, 3-dimensional structures of receptors and drug molecules were formed. Then the interactions of each of the receptor and drug molecules at the binding site were examined by molecular docking studies, which is a computer-aided drug design method, and their binding affinities were evaluated. \u0000Results: As a result of the analyses, it was determined that the drug named Hydroxychloroquine has the highest and the drug called Dexamethasone has the lowest binding affinity for all three receptors. In addition, it has been determined that Dexamethasone develops inappropriate interactions with ER and HER2 receptor active site amino acids. \u0000Conclusion: In this study, preliminary data on how receptor interactions can occur when normal individuals and breast cancer patients use Dexamethasone, Favipiravir, and Hydroxychloroquine are presented.","PeriodicalId":404662,"journal":{"name":"Online Türk Sağlık Bilimleri Dergisi","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127337109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0