The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC

Abstract

The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC Objective: Lung cancer has a poor prognosis. Thiol groups which have high antioxidant capacity, turn to disulpide (DS) groups with biochemical reactions that neutralize different oxidant compounds. Thiol/Disulpide homeostasis (TDH) has significant effects on cell mechanisms, transcription and apoptosis. We present the role of prognosis of dynamic TDH in patients operated for NSCLC. Methods: The patients who operated for early stage with NSCLC prospectively analysedTDH tests were measured by the automated spectrophotometric method. Results: 77 patients patients, 61 volunteer controls participated in this study. Native thiol (NT) and total thiol (TT) levels were significantly lower in the patient group. SS/NT ratio which is the indicator of oxidative stress of TDH also reached statistical significance in the patients (p