硫-二硫稳态对早期NSCLC患者预后的影响

Online Türk Sağlık Bilimleri Dergisi Pub Date : 2023-02-05 DOI:10.26453/otjhs.1226101

M. Kavas, Cansel Atinkaya Baytemir, M. Alışık, A. Öztürk, Sümeyye ALPARSLAN BEKİR, Selma Aydogan Eroglu, Elçin Ersöz Köse, İ. Yalçınkaya, Ö. Erel

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引用次数: 0

摘要

巯基二硫稳态对早期非小细胞肺癌患者预后的影响目的:肺癌预后差。巯基具有较高的抗氧化能力，通过生化反应转化为二硫醇(DS)基团，可以中和不同的氧化化合物。硫醇/二硫醇稳态(TDH)对细胞机制、转录和凋亡有重要影响。我们提出动态TDH在非小细胞肺癌手术患者预后中的作用。方法:采用自动分光光度法对早期非小细胞肺癌手术患者进行前瞻性tdh检测。结果:77例患者和61名志愿者参加了本研究。患者组的天然硫醇(NT)和总硫醇(TT)水平明显降低。作为TDH氧化应激指标的SS/NT比值在患者中也达到了统计学意义(p

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The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC

The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC Objective: Lung cancer has a poor prognosis. Thiol groups which have high antioxidant capacity, turn to disulpide (DS) groups with biochemical reactions that neutralize different oxidant compounds. Thiol/Disulpide homeostasis (TDH) has significant effects on cell mechanisms, transcription and apoptosis. We present the role of prognosis of dynamic TDH in patients operated for NSCLC. Methods: The patients who operated for early stage with NSCLC prospectively analysedTDH tests were measured by the automated spectrophotometric method. Results: 77 patients patients, 61 volunteer controls participated in this study. Native thiol (NT) and total thiol (TT) levels were significantly lower in the patient group. SS/NT ratio which is the indicator of oxidative stress of TDH also reached statistical significance in the patients (p

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Online Türk Sağlık Bilimleri Dergisi

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