Physics of Life Reviews最新文献

{"title":"But does humanity have a choice?: Comment on “To Enhance or not to Enhance” by Grinschgl S., Ninaus, M., Wood. G. & Neubauer, AC (2025)","authors":"Michael Laakasuo , Paolo Buttazzoni , Marianna Drosinou","doi":"10.1016/j.plrev.2025.10.002","DOIUrl":"10.1016/j.plrev.2025.10.002","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 213-214"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein post-translational modifications and tumor immunity: A pan-cancer perspective","authors":"Haoling Zhang ,&nbsp;Qilu Yan ,&nbsp;Shuya Jiang ,&nbsp;Dan Hu ,&nbsp;Ping Lu ,&nbsp;Shaowei Li ,&nbsp;Doblin Sandai ,&nbsp;Haolong Zhang ,&nbsp;Wangzheqi Zhang ,&nbsp;Chenglong Zhu","doi":"10.1016/j.plrev.2025.10.001","DOIUrl":"10.1016/j.plrev.2025.10.001","url":null,"abstract":"<div><div>Protein post-translational modifications (PTMs), which involve the covalent attachment of specific chemical groups to amino acid residues, significantly reshape protein structure and function. These modifications play a crucial role in fundamental physiological processes such as signal transduction, metabolic regulation, and protein homeostasis. In the context of pan-cancer, various types of PTMs, including phosphorylation, acetylation, glycosylation, and ubiquitination, create an intricate crosstalk network that finely tunes the stability and function of immune checkpoint molecules, directly influencing tumor immune evasion and immune cell recognition. Additionally, PTMs exert multilayered regulation over the functional states of key immune cells, such as T cells, macrophages, and dendritic cells (DCs), thereby determining the intensity and nature of immune responses within the tumor microenvironment (TME). Furthermore, PTMs are pivotal in antigen processing and presentation by influencing antigen diversity and epitope display, which facilitates tumor cell escape from immune surveillance. Dynamic analyses reveal that PTM landscapes exhibit spatiotemporal specificity during tumor initiation, progression, and metastasis, closely correlating with tumor stage and the establishment of an immunosuppressive microenvironment. Based on these findings, immunotherapeutic strategies targeting key PTM-modifying enzymes, such as kinases, deacetylases, and deubiquitinases, are rapidly emerging. However, these approaches still face challenges, including drug specificity, resistance, and off-target effects. The exploration of synergistic effects through the combinational targeting of distinct PTM pathways, along with a deeper understanding of the interactive regulatory networks among PTMs, opens promising avenues for the development of next-generation precision immunotherapies. This review aims to systematically elucidate the multifaceted roles and dynamic regulation of PTMs in tumor immunity, providing a theoretical foundation and research direction for identifying novel immunotherapeutic targets and optimizing therapeutic strategies.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 142-209"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What challenges remain after 25 years of the enhancement debate?","authors":"Stephan Schleim ,&nbsp;Boris B. Quednow","doi":"10.1016/j.plrev.2025.10.004","DOIUrl":"10.1016/j.plrev.2025.10.004","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 210-212"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeling the flow of time: Unraveling the time-dependent mechanics of living cells","authors":"Yulong Han ,&nbsp;Xin Chen ,&nbsp;Xuechao Sun ,&nbsp;Tian Jian Lu","doi":"10.1016/j.plrev.2025.08.014","DOIUrl":"10.1016/j.plrev.2025.08.014","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 83-86"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensing the unsensed: Ionizing radiation at the boundaries of human perception","authors":"Marco Durante","doi":"10.1016/j.plrev.2025.09.003","DOIUrl":"10.1016/j.plrev.2025.09.003","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 90-91"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On not forgetting: Comment on “Thoughts and thinkers: On the complementarity between objects and processes” by Fields and Levin","authors":"Pamela Lyon","doi":"10.1016/j.plrev.2025.09.006","DOIUrl":"10.1016/j.plrev.2025.09.006","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 120-122"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive control under active inference: from habits to metacognition. Comment on \"Active inference and cognitive control: Balancing deliberation and habits through precision optimization” by Riccardo Proietti, Thomas Parr, Allessia Tessari, Karl Friston & Giovanni Pezzulo","authors":"Anna-Lena Eckert","doi":"10.1016/j.plrev.2025.09.004","DOIUrl":"10.1016/j.plrev.2025.09.004","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 92-94"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the private public: external grounding in inner States","authors":"Friedemann Pulvermüller ,&nbsp;Michael Pauen","doi":"10.1016/j.plrev.2025.10.005","DOIUrl":"10.1016/j.plrev.2025.10.005","url":null,"abstract":"<div><div>Recent discussions about the nature of meaning and concepts focus on abstract semantic knowledge including key information about inner states of the individual. Classic cognitive approaches anchor the meaning of words in universal concepts, semantic networks or semantic features encapsulated in the individual’s own mind. However, this does not explain how symbols become interpretable during language development. Embodiment theorists acknowledge the relevance of semantic grounding of concrete referential symbols in perceptions and actions during learning, but, similar to classic cognitivism, assume internal anchoring of mental terms in introspection, thus once again implicating a main role of privileged access to ‘private’ inner states in language learning. This raises the basic question as to how a public language can be founded in private inner access.</div><div>Here, we argue that, in semantic learning, a purely introspection-based classification of inner states is neither possible nor required, and even less so a first-person privilege in accessing these states. Rather, classification and semantic learning of symbols for mentalistic concepts is an interactive process between the learner and an external observer who can employ contextual knowledge and behavioral information for recognizing and categorizing the learner’s mental states. In support of this ‘extrospective’ mental grounding account, we review observations that, in case of doubt about internal states, third-person evidence can play a decisive role. We also highlight supporting empirical studies showing that individuals in whom the link between first-person experience and externally observable behavior is broken may suffer from deficits in processing and understanding the related mentalistic vocabulary.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 235-249"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple rules for simple models","authors":"Arnaud Messé ,&nbsp;Claus C. Hilgetag ,&nbsp;Marc-Thorsten Hütt","doi":"10.1016/j.plrev.2025.10.006","DOIUrl":"10.1016/j.plrev.2025.10.006","url":null,"abstract":"<div><div>In a world dominated by large-scale numerical simulations and applications of machine learning to biology, medicine and neuroscience (and complex systems, in general), each driven by the availability of ‘big data’ and decreasing costs of computation, the art form of constructing simple models is no longer in the focus of scientific attention. Yet, the most successful of these ‘minimal models’ have brought about a revolution of our understanding of complex systems, in particular in the life sciences, and are still shaping our view of the world today. It is hard to look at a power-law distribution without thinking of the Bak-Tang-Wiesenfeld sandpile model. And it is near impossible to reflect on synchronization without imagining coupled phase oscillators. Here we have put together a few ideas on how to formulate and analyze simple models and to draw conclusions from them.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"55 ","pages":"Pages 217-228"},"PeriodicalIF":14.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible contribution to data-driven primate research: Comment on “Kinematic coding: Measuring information in naturalistic behaviour” by Becchio, Pullar, Scaliti, and Panzeri","authors":"Koki Mimura ,&nbsp;Ken Nakae ,&nbsp;Kenji Doya","doi":"10.1016/j.plrev.2025.05.012","DOIUrl":"10.1016/j.plrev.2025.05.012","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"54 ","pages":"Pages 80-82"},"PeriodicalIF":13.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}