Physics of Life Reviews最新文献

Protein post-translational modifications in tumor immunity: a multi-layered regulatory network deserving systematic decoding Comment on “Protein post-translational modifications and tumor immunity: A pan-cancer perspective” 蛋白质翻译后修饰与肿瘤免疫：一个值得系统解码的多层调控网络

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.plrev.2026.01.001

Xiuluan Du , Yuansheng Lin

引用次数: 0

Comment on " Protein post-translational modifications and tumor immunity: A pan-cancer perspective" “蛋白质翻译后修饰与肿瘤免疫：泛癌症视角”评论

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.plrev.2026.01.002

Yongzheng Han , Chengming Li , Yuanhua Qin , Guangzhen Wu

引用次数: 0

Beyond behavioral studies: Exploring the multi-omics impact of music on human health.: Comment on Can arts-based interventions improve health? A conceptual and methodological critique by Martin Skov and Marcos Nadal 超越行为研究：探索音乐对人类健康的多组学影响。基于艺术的干预措施能改善健康吗？马丁·斯科夫（Martin Skov）和马科斯·巴布（Marcos bbb）的概念和方法批判。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-09-11 DOI: 10.1016/j.plrev.2025.09.002

Antonio Salas , Laura Navarro , Federico Martinón-Torres , Alberto Gómez-Carballa

引用次数: 0

Cooperation versus social welfare 合作与社会福利

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-11-22 DOI: 10.1016/j.plrev.2025.11.006

The Anh Han , Zhao Song , Theodor Cimpeanu , Manh Hong Duong , Marcus Krellner , Valerio Capraro , Matjaz Perc

{"title":"Cooperation versus social welfare","authors":"The Anh Han , Zhao Song , Theodor Cimpeanu , Manh Hong Duong , Marcus Krellner , Valerio Capraro , Matjaz Perc","doi":"10.1016/j.plrev.2025.11.006","DOIUrl":"10.1016/j.plrev.2025.11.006","url":null,"abstract":"<div><div>Understanding and promoting cooperative behaviour among self-interested individuals is a critical concern in physical, biological, and social sciences. Numerous foundational mechanisms for the evolution of cooperation have been identified, and these mechanisms have served as the basis for developing tools and interventions designed to sustain and enhance cooperative behaviour. However, since both foundational mechanisms and the derived tools and interventions often involve costs affecting individuals or institutions, striving for maximum cooperation can sometimes harm social welfare, defined as the total population payoff. Herein, we review existing evolutionary mechanisms for the evolution of cooperation as well as tools and interventions based on these mechanisms, emphasising the often-overlooked hidden costs that may lead to a misalignment between cooperation and social welfare. By explicitly incorporating these hidden factors into the models, we analyse the conditions under which they reduce social welfare, across a broad range of social dilemma games and evolutionary forces. Additionally, we review experimental studies that support and inform mathematical models and agent-based simulations. We highlight when considering social welfare is crucial, as misalignment is most likely to occur. Ultimately, we argue that social welfare, not just cooperation, should be the primary optimisation objective when designing interventions for social good. We also suggest several key directions to further explore this often-overlooked issue in the literature. Overall, we reveal that hidden costs often influence the alignment between cooperation and social welfare, challenging the common prioritisation of cooperation alone.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 33-60"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating thalamic contributions to pain: A translational framework for precision neuromodulation 重新评估丘脑对疼痛的贡献：精确神经调节的翻译框架

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1016/j.plrev.2026.02.001

Zhenjiang Li , Fengrui Zhang , Jie Ren , Xuejing Lu , Li Hu

{"title":"Reevaluating thalamic contributions to pain: A translational framework for precision neuromodulation","authors":"Zhenjiang Li , Fengrui Zhang , Jie Ren , Xuejing Lu , Li Hu","doi":"10.1016/j.plrev.2026.02.001","DOIUrl":"10.1016/j.plrev.2026.02.001","url":null,"abstract":"<div><div>The thalamus plays a central role in processing both acute and chronic pain. Yet, identifying specific thalamic targets and effective strategies for pain management remains a pivotal challenge. By integrating cross-species evidence, this review synthesizes both a functional re-examination of thalamic nuclei in pain and a critical evaluation of targeted neuromodulation strategies, aiming to guide the advancement of precision pain medicine. We emphasize that the sensory and affective dimensions of pain are functionally intertwined and context-dependent, supporting a re-evaluation of thalamic pain pathways as integrated components of cortico-limbic networks rather than segregated sensory or affective relays. Specifically, while ventral and posterior thalamic nuclei (VPTN) contribute not only to sensory discrimination but also to hypersensitivity states, medial and intralaminar nuclei (MITN) integrate sensory-affective signals and facilitate pain-related emotional comorbidities. Our systematic evaluation highlighted several key translational challenges: poorly delineated anatomical boundaries and overlapping microcircuits within thalamic nuclei, undefined stimulation parameter spaces, translational barriers from species differences, and the complex interplay between neuroplasticity and individual differences in pain networks. To address these challenges, we propose a precision neuromodulation framework incorporating high-resolution targeting, multidimensional parameter optimization, cross-species validation, alongside artificial intelligence (AI)-driven adaptive closed-loop systems. This integrated approach may advance chronic pain therapy from generalized symptom control toward mechanism-based and personalized pain therapies.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 258-280"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysical approaches to cancer diagnostics: Collagen biomarkers in colorectal cancer 癌症诊断的生物物理方法：结直肠癌中的胶原生物标志物。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.plrev.2026.01.009

Shimul Biswas, Krishna Kishore Mahato

{"title":"Biophysical approaches to cancer diagnostics: Collagen biomarkers in colorectal cancer","authors":"Shimul Biswas, Krishna Kishore Mahato","doi":"10.1016/j.plrev.2026.01.009","DOIUrl":"10.1016/j.plrev.2026.01.009","url":null,"abstract":"<div><div>Collagen remodeling in the extracellular matrix drives alterations in the physical, mechanical, and optical properties of tissues, representing a fundamental biophysical hallmark of colorectal cancer (CRC) progression. These changes, reflected in variations in collagen composition, molecular orientation, and cross-linking density, transform tissue stiffness, elasticity, and anisotropy, directly influencing cancer cell behavior and mechanotransduction. Understanding these structural and physical transitions requires analytical methods capable of probing the molecular origins of biomechanical alteration <em>in situ</em>. Spectroscopic and optical methodologies provide high-resolution, label-free detection of the vibrational, optical, and mechanical alteration associated with collagen remodeling. These techniques capture the shifts in molecular vibrational modes, nonlinear optical responses, and scattering anisotropy that arise from collagen fibril alignment, structural disorder, and cross-link formation, thereby connecting molecular architecture to measurable macroscale biomechanics. The integration of multimodal spectroscopy and incorporation of machine learning algorithms further enhance diagnostic performance by resolving complex tissue heterogeneity and improving tumor margin detection. Overall, this review demonstrates how spectroscopic techniques can be applied in the biomedical field for cancer detection by analyzing collagen remodeling and structural alterations.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 239-257"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relating computational models and experiments in peripersonal space: Comment on “computational models of peripersonal space representation”, by Bertoni et al. 将计算模型和实验与周围个人空间联系起来：评论Bertoni等人的“周围个人空间表示的计算模型”。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1016/j.plrev.2025.12.003

Raffaele Tucciarelli, Matthew R. Longo

引用次数: 0

On the minimal theory of consciousness implicit in active inference 论主动推理中隐含的最小意识理论。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-11-03 DOI: 10.1016/j.plrev.2025.11.002

Christopher J. Whyte , Andrew W. Corcoran , Jonathan Robinson , Ryan Smith , Rosalyn J. Moran , Thomas Parr , Karl J. Friston , Anil K. Seth , Jakob Hohwy

{"title":"On the minimal theory of consciousness implicit in active inference","authors":"Christopher J. Whyte , Andrew W. Corcoran , Jonathan Robinson , Ryan Smith , Rosalyn J. Moran , Thomas Parr , Karl J. Friston , Anil K. Seth , Jakob Hohwy","doi":"10.1016/j.plrev.2025.11.002","DOIUrl":"10.1016/j.plrev.2025.11.002","url":null,"abstract":"<div><div>The multifaceted nature of subjective experience poses a challenge to the study of consciousness. Traditional neuroscientific approaches often concentrate on isolated facets, such as perceptual awareness or the global state of consciousness and construct a theory around the relevant empirical paradigms and findings. Theories of consciousness are, therefore, often difficult to compare; indeed, there might be little overlap in the phenomena such theories aim to explain. Here, we take a different approach: starting with active inference, a first principles framework for modelling behaviour as (approximate) Bayesian inference, and building up to a minimal theory of consciousness, which emerges from the shared features of computational models derived under active inference. We review a body of work applying active inference models to the study of consciousness and argue that there is implicit in all these models a small set of theoretical commitments that point to a minimal (and testable) theory of consciousness.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"56 ","pages":"Pages 4-28"},"PeriodicalIF":14.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The unbearable hardness of inferring being: Comment on “preliminaries to artificial consciousness” by Evers et al. 难以承受的存在推理之难——评埃弗斯等人的“人工意识的初步考察”。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1016/j.plrev.2025.12.004

Robert Chis-Ciure

引用次数: 0

From adaptive networks to expanding state spaces: Comment on “Beyond networks: Toward adaptive models of biological complexity” by Pessoa 从自适应网络到扩展状态空间：评Pessoa的《超越网络：迈向生物复杂性的自适应模型》。

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI: 10.1016/j.plrev.2025.12.010

Jincan Che

引用次数: 0