Physics of Life Reviews最新文献

{"title":"Sirtuins as modulators of infection outcomes in the battle of host-pathogen dynamics","authors":"Dipasree Hajra,&nbsp;Dipshikha Chakravortty","doi":"10.1016/j.plrev.2025.03.020","DOIUrl":"10.1016/j.plrev.2025.03.020","url":null,"abstract":"<div><div>Sirtuins's central role in governing metabolic processes has been known for decades. However, over the past two decades, sirtuin functions have been linked to immune regulation and immunity. Sirtuins are NAD+ dependent protein deacylases involved in the regulation of several important biological processes ranging from energy homeostasis, metabolism, aging, apoptosis, autophagy, immunity, adipocyte, and muscle differentiation. Here, in this review, we discuss the role of sirtuins in several infectious diseases including viral, bacterial, and protozoan infections with detailed emphasis on bacterial-host interactions. We have aimed to explore both host and bacterial sirtuin functions contributing to the infection progression, host responses and their influence on the everlasting host-pathogen tug-of-war. In order to manipulate host pathways, pathogens such as intracellular bacteria have evolved parallelly and harbor bacterial sirtuins. The recent discoveries of bacterial sirtuins influencing the host-pathogen interaction outcomes pave the way for the discovery of potential therapeutic targets<strong>.</strong></div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 225-235"},"PeriodicalIF":13.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AI researchers' perspective: At the crossroad of LLMs, agent-based modeling, and complex systems","authors":"Siyue Ren ,&nbsp;Ziyue Gan ,&nbsp;Zhenfei Yin,&nbsp;Jing Shao,&nbsp;Shuyue Hu","doi":"10.1016/j.plrev.2025.03.015","DOIUrl":"10.1016/j.plrev.2025.03.015","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 215-217"},"PeriodicalIF":13.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inner speech is not a simulation of language but an act of speaking: Comment on “The Sound of Thought: Form Matters – The Prosody of Inner Speech” by Hamutal Kreiner, Zohar Eviatar","authors":"Chiara De Livio ,&nbsp;Anna M. Borghi ,&nbsp;Charles Fernyhough","doi":"10.1016/j.plrev.2025.03.013","DOIUrl":"10.1016/j.plrev.2025.03.013","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 218-220"},"PeriodicalIF":13.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goals for kinematic coding: Insights from the posture-based motion planning perspective","authors":"Aviad Ozana ,&nbsp;Frouke Hermens ,&nbsp;David A. Rosenbaum","doi":"10.1016/j.plrev.2025.03.017","DOIUrl":"10.1016/j.plrev.2025.03.017","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 277-278"},"PeriodicalIF":13.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can arts-based interventions improve health? A conceptual and methodological critique","authors":"Martin Skov ,&nbsp;Marcos Nadal","doi":"10.1016/j.plrev.2025.03.003","DOIUrl":"10.1016/j.plrev.2025.03.003","url":null,"abstract":"<div><div>Can art improve health and wellbeing? The claim that there is strong evidence that engaging with art ameliorates symptoms of mental and physical disorders and increases wellbeing is gaining acceptance among researchers and clinicians. This claim deserves thorough scrutiny, as it is used to justify a broad range of arts-based clinical interventions and health policies. Here we show that the evidence cited in favor of the efficacy of arts-based interventions is far weaker than it is claimed to be. First, we examined the methodological and statistical quality of studies that have been cited as proof for the efficacy of arts-based interventions. This analysis found that many of these studies lack key clinical trial features, such as defining the therapeutic agent, randomizing group assignment, controlling for patient or researcher allegiance, controlling for the effects of other concurrent interventions and medications, comparing art-based interventions to other kinds of interventions, or conducting and reporting statistical analyses appropriately. Second, in a broader examination of experiments on arts-based interventions, we looked for the experimental designs that would actually allow demonstrating that the putative health benefits owe to the effect of art. This analysis revealed that (<em>i</em>) most studies fail to define what art is, making it impossible to compare the effects of “art” and “non-art” stimuli and activities on health and wellbeing; (<em>ii</em>) fail to demonstrate that art stimuli and activities elicit a distinct class of art-induced physiological processes capable of modulating the cause of targeted disorders; (<em>iii</em>) and fail to manipulate neural processes believed to be mechanisms of action that could prove that arts-based interventions directly affect the etiology of disorders. These methodological weaknesses and inappropriate experimental designs cast serious doubt on claims that engaging with art can induce physiological changes that improve health and wellbeing. We discuss why arts-based interventions have neglected these problems and the ethical implications for patients who are treated with them.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 239-259"},"PeriodicalIF":13.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LLMs provide a potential pathway for the research of complex systems","authors":"Ju Han,&nbsp;Xiaojie Chen","doi":"10.1016/j.plrev.2025.03.010","DOIUrl":"10.1016/j.plrev.2025.03.010","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 182-183"},"PeriodicalIF":13.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From kinematics to sensorimotor communication: Understanding dual roles of action in social interaction. comment on “Kinematic coding: Measuring information in naturalistic behaviour” by Cristina Becchio, Kiri Pullar, Eugenio Scaliti, Stefano Panzeri","authors":"Giovanni Pezzulo,&nbsp;Laura Barca,&nbsp;Domenico Maisto,&nbsp;Francesco Donnarumma","doi":"10.1016/j.plrev.2025.03.009","DOIUrl":"10.1016/j.plrev.2025.03.009","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 179-181"},"PeriodicalIF":13.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entrainment by transcranial alternating current stimulation: Insights from models of cortical oscillations and dynamical systems theory","authors":"Mojtaba Madadi Asl ,&nbsp;Alireza Valizadeh","doi":"10.1016/j.plrev.2025.03.008","DOIUrl":"10.1016/j.plrev.2025.03.008","url":null,"abstract":"<div><div>Signature of neuronal oscillations can be found in nearly every brain function. However, abnormal oscillatory activity is linked with several brain disorders. Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that can potentially modulate neuronal oscillations and influence behavior both in health and disease. Yet, a complete understanding of how interacting networks of neurons are affected by tACS remains elusive. Entrainment effects by which tACS synchronizes neuronal oscillations is one of the main hypothesized mechanisms, as evidenced in animals and humans. Computational models of cortical oscillations may shed light on the entrainment effects of tACS, but current modeling studies lack specific guidelines to inform experimental investigations. This study addresses the existing gap in understanding the mechanisms of tACS effects on rhythmogenesis within the brain by providing a comprehensive overview of both theoretical and experimental perspectives. We explore the intricate interactions between oscillators and periodic stimulation through the lens of dynamical systems theory. Subsequently, we present a synthesis of experimental findings that demonstrate the effects of tACS on both individual neurons and collective oscillatory patterns in animal models and humans. Our review extends to computational investigations that elucidate the interplay between tACS and neuronal dynamics across diverse cortical network models. To illustrate these concepts, we conclude with a simple oscillatory neuron model, showcasing how fundamental theories of oscillatory behavior derived from dynamical systems, such as phase response of neurons to external perturbation, can account for the entrainment effects observed with tACS. Studies reviewed here render the necessity of integrated experimental and computational approaches for effective neuromodulation by tACS in health and disease.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 147-176"},"PeriodicalIF":13.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring intentions in natural behaviours from body kinematic Comment on “Kinematic coding: Measuring information in naturalistic behaviour” by Cristina Becchio, Kiri Pullar, Eugenio Scaliti, Stefano Panzeri","authors":"R. Storchi","doi":"10.1016/j.plrev.2025.03.012","DOIUrl":"10.1016/j.plrev.2025.03.012","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 223-224"},"PeriodicalIF":13.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extending kinematic decoding approaches to kinetics","authors":"Marco Santello","doi":"10.1016/j.plrev.2025.03.007","DOIUrl":"10.1016/j.plrev.2025.03.007","url":null,"abstract":"","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 177-178"},"PeriodicalIF":13.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}