Physics of Life Reviews最新文献_第2页

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-02-07 DOI: 10.1016/j.plrev.2025.02.002

Caleb Rowe , Nathan Santiago , Jeffrey Warner , Vassiliy Tsytsarev , Elena A. Rozhkova , Ogechukwu Ngwu-Hyacinth , Mark Bolding

{"title":"Human perception of ionizing radiation","authors":"Caleb Rowe , Nathan Santiago , Jeffrey Warner , Vassiliy Tsytsarev , Elena A. Rozhkova , Ogechukwu Ngwu-Hyacinth , Mark Bolding","doi":"10.1016/j.plrev.2025.02.002","DOIUrl":"10.1016/j.plrev.2025.02.002","url":null,"abstract":"<div><div>Here we address the question of whether humans can perceive ionizing radiation. We conducted a thorough review of the clinical and experimental literature related to ionizing radiation, with a focus on its acute effects. Specifically, we examined the three domains of X-ray perception found in animals (abdominal, olfactory, and retinal), which led us to instances of ionizing radiation-induced hearing and taste sensory phenomena in humans thus suggesting that humans can perceive X-rays across various sensory modalities via multiple mechanisms. We also analyzed literature to understand the mechanisms associated with reported symptoms, this led us to the concept of radiomodulation, an understudied modulatory effect of sub-ablative ionizing radiation doses on neurons. Based on this review of the literature we propose the hypothesis that a significant radiomodulation mechanism is the formation of reactive oxygen species from radiolysis which activates immune and sensory signal transduction mechanisms specifically related to the redox activity in TRP and K<sup>+</sup> channels. Additionally, we find evidence to support the previous claims of perception stemming from Cherenkov radiation and ozone production which are perceived using canonical sensory modalities. Finally, for we provide a concise summary of the applications of ionizing radiation in clinical imaging and therapy, as well as prospects for future developments of radiation technologies for biomedical and fundamental research.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"53 ","pages":"Pages 1-21"},"PeriodicalIF":13.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dark brain energy: Toward an integrative model of spontaneous slow oscillations

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-02-07 DOI: 10.1016/j.plrev.2025.02.001

Zhu-Qing Gong , Xi-Nian Zuo

{"title":"Dark brain energy: Toward an integrative model of spontaneous slow oscillations","authors":"Zhu-Qing Gong , Xi-Nian Zuo","doi":"10.1016/j.plrev.2025.02.001","DOIUrl":"10.1016/j.plrev.2025.02.001","url":null,"abstract":"<div><div>Neural oscillations facilitate the functioning of the human brain in spatial and temporal dimensions at various frequencies. These oscillations feature a universal frequency architecture that is governed by brain anatomy, ensuring frequency specificity remains invariant across different measurement techniques. Initial magnetic resonance imaging (MRI) methodology constrained functional MRI (fMRI) investigations to a singular frequency range, thereby neglecting the frequency characteristics inherent in blood oxygen level-dependent oscillations. With advancements in MRI technology, it has become feasible to decode intricate brain activities via multi-band frequency analysis (MBFA). During the past decade, the utilization of MBFA in fMRI studies has surged, unveiling frequency-dependent characteristics of spontaneous slow oscillations (SSOs) believed to base dark energy in the brain. There remains a dearth of conclusive insights and hypotheses pertaining to the properties and functionalities of SSOs in distinct bands. We surveyed the SSO MBFA studies during the past 15 years to delineate the attributes of SSOs and enlighten their correlated functions. We further proposed a model to elucidate the hierarchical organization of multi-band SSOs by integrating their function, aimed at bridging theoretical gaps and guiding future MBFA research endeavors.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"52 ","pages":"Pages 278-297"},"PeriodicalIF":13.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoughts, loud and silent. Comment on “The sound of thought: Form matters – The prosody of inner speech” by Kreiner and Eviatar

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-24 DOI: 10.1016/j.plrev.2025.01.011

Jutta L. Mueller

引用次数: 0

Speech: A skeleton for thought? Comment on “The sound of thought: Form matters – The prosody of inner speech” by Hamutal Kreiner, Zohar Eviatar

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-23 DOI: 10.1016/j.plrev.2025.01.010

Anne-Lise Giraud

引用次数: 0

Reasonings on multiple strategies in differential systems

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-21 DOI: 10.1016/j.plrev.2025.01.009

Nisrine Outada

引用次数: 0

Thoughts and thinkers: On the complementarity between objects and processes

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-17 DOI: 10.1016/j.plrev.2025.01.008

Chris Fields , Michael Levin

引用次数: 0

Is sharing always caring? Entropy, boundaries and the plurality of psychotherapeutic process 分享总是关爱吗？熵、界限和心理治疗过程的多元性。

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-16 DOI: 10.1016/j.plrev.2025.01.007

Lena Adel , Ana Gomez-Carrillo , Jonas Mago , Michael Lifshitz , Guillaume Dumas

引用次数: 0

On evolution of non-binding commitments 论非约束性承诺的演化：评Y. Lu等人的“复杂系统研究中的llm和基于生成主体的模型”

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-15 DOI: 10.1016/j.plrev.2025.01.006

Zhao Song, The Anh Han

引用次数: 0

Mathematical models on Alzheimer's disease and its treatment: A review 阿尔茨海默病的数学模型及其治疗综述。

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-10 DOI: 10.1016/j.plrev.2025.01.004

Mitali Maji, Subhas Khajanchi

{"title":"Mathematical models on Alzheimer's disease and its treatment: A review","authors":"Mitali Maji, Subhas Khajanchi","doi":"10.1016/j.plrev.2025.01.004","DOIUrl":"10.1016/j.plrev.2025.01.004","url":null,"abstract":"<div><div>Alzheimer's disease is a gradually advancing neurodegenerative disease. According to the report by “World Health Organization (WHO)”, there are over 55 million individuals currently living with Alzheimer's disease and other dementia globally, and the number of sufferers is increasing every day. In absence of effective cures and preventive measures, this number is predicted to triple by 2050. The disease's origin is still unclear, and also no such treatment is available for eradicating the disease. Based on the crucial factors that are connected to the disease's progression, the authors developed several types of mathematical models. We review such mathematical models that are utilized to better understand the pathophysiology of Alzheimer's disease. Section-wise, we categorize the mathematical models in terms of different components that might be responsible for Alzheimer's disease. We explain the mathematical models with their descriptions and respective conclusions. In addition to mathematical models, we concentrate on biological aspects of the disease and possible therapeutic targets. We explore the disease's biological basis primarily to understand how proteins, glial cells, cytokines, genes, calcium signaling and oxidative stress contribute to the disease. We go through several treatment targets that might stop the progression of the disease or at least slow it down. We present a table that summarizes the mathematical models in terms of their formalisms, highlighting key components and important remarks.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"52 ","pages":"Pages 207-244"},"PeriodicalIF":13.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From affective landscape to social meaning: The role of vitality forms in the APER model. Comment on “The affective grounds of the mind. The Affective Pertinentization (APER) model” by Salvatore et al. 2024 从情感景观到社会意义：活力在APER模型中形成的作用。评《心灵的情感基础》情感针对性（APER）模型”，Salvatore et al. 2024。

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-01-08 DOI: 10.1016/j.plrev.2025.01.005

Cuccio Valentina, Montalti Martina

引用次数: 0