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Groundwater CSI: Unravelling Pollution Sources in Complex Environments with Liquid Chromatography Triple Quadrupole Mass Spectrometry 地下水CSI:用液相色谱三重四极杆质谱分析复杂环境中的污染源
LCGC Europe Pub Date : 2021-12-01 DOI: 10.56530/lcgc.eu.yf5973v7
Lewis Botcherby, Oliver A.H. Jones, M. Currell, W. McCance
{"title":"Groundwater CSI: Unravelling Pollution Sources in Complex Environments with Liquid Chromatography Triple Quadrupole Mass Spectrometry","authors":"Lewis Botcherby, Oliver A.H. Jones, M. Currell, W. McCance","doi":"10.56530/lcgc.eu.yf5973v7","DOIUrl":"https://doi.org/10.56530/lcgc.eu.yf5973v7","url":null,"abstract":"Wastewater treatment plants (WWTP) are used worldwide to purify domestic and industrial wastewater before it is returned to the environment. Even after treatment, wastewater may still contain a variety of contaminants, including nutrients (usually nitrogen and phosphorus) and organic pollutants, such as endocrine disruptors and pesticides. These compounds can leak into groundwater via old and/or damaged infrastructure, leaching from biosolids storage areas and/or release of effluents. However, similar contaminant impacts can come from other sources, such as agriculture. It is often very difficult to distinguish the true source of such contamination, especially where wastewater treatment plants are located in agricultural areas. Robust and sensitive techniques are needed to characterize impacts where there are multiple potential sources. This study analyzed a variety of synthetic chemicals using liquid chromatography triple quadrupole mass spectrometry (LC–QQQ–MS) to generate unique fingerprints of pollution. These were used to distinguish the impact on the local groundwater of a WWTP in southeast Victoria (Australia) from that of local agriculture. The use of such novel tracers could become a valuable tool in environmental monitoring, management, and remediation in the future.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132905452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combating Olive Oil Fraud Using GC–IMS and FGC-Enose 用GC-IMS和FGC-Enose打击橄榄油欺诈
LCGC Europe Pub Date : 2021-12-01 DOI: 10.56530/lcgc.eu.cz9789p2
M. Suman
{"title":"Combating Olive Oil Fraud Using GC–IMS and FGC-Enose","authors":"M. Suman","doi":"10.56530/lcgc.eu.cz9789p2","DOIUrl":"https://doi.org/10.56530/lcgc.eu.cz9789p2","url":null,"abstract":"The adulteration of high-quality foods is big business. Typical adulteration of olive oil involves the use of other types of oil, such as seed oils or pomace oils, the introduction of re-esterified oils, or the creation of mixtures with refined oils to create a lower quality product that can still be sold at a premium price. Fortunately, these processes can be easily detected using standard methods. However, fraudsters now seek more advanced methods using soft refined oils or oils with a tailored composition, making detection with existing procedures difficult. LCGC spoke to Michele Suman about novel screening and confirmatory analytical strategies he has investigated to regain the upper hand in the fight against olive oil adulteration.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128828208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated High-Resolution Semi-Preparative Gradient Recycling Liquid Chromatography: Principles, Design, and Applications 自动化高分辨率半制备梯度回收液相色谱:原理，设计和应用
LCGC Europe Pub Date : 2021-11-01 DOI: 10.56530/lcgc.eu.fl3785e9
F. Gritti
{"title":"Automated High-Resolution Semi-Preparative Gradient Recycling Liquid Chromatography: Principles, Design, and Applications","authors":"F. Gritti","doi":"10.56530/lcgc.eu.fl3785e9","DOIUrl":"https://doi.org/10.56530/lcgc.eu.fl3785e9","url":null,"abstract":"A semi-preparative twin-column recycling liquid chromatography (TCRLC) process was extended from isocratic to gradient elution mode. The main separation challenge is when the sample mixture contains early, nearly coeluting, and late impurities, all at the same time. To further improve classical isocratic TCRLC, the gradient TCRLC (GTCRLC) process was implemented with a 2-position 4-port valve in order to better shave the targeted sample from all these impurities. Prior to fully resolving the target compound(s) from the closest impurities by classical isocratic TCRLC, the added valve enabled full elimination by gradient elution mode of not only the early impurities but also any highly retained late impurities that could contaminate the collected fractions of the target compound(s). This GTCRLC process was entirely automated regarding the initial gradient applied, the recycling conditions, and the actuation times of the two valves. The GTCRLC process was applied for the isolation of a single polycyclic aromatic hydrocarbon (PAH), chrysene, present in a complex PAH mixture. In addition, the GTCRLC process was successfully applied to clean vitamins D2 and D3 from a milk extract and to baseline resolve them.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126908447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
It’s Qualification, But Not As We Know It? 这是资格，但不是我们所知道的?
LCGC Europe Pub Date : 2021-11-01 DOI: 10.56530/lcgc.eu.kg7881s2
Chris Burgess, R. Mcdowall
{"title":"It’s Qualification, But Not As We Know It?","authors":"Chris Burgess, R. Mcdowall","doi":"10.56530/lcgc.eu.kg7881s2","DOIUrl":"https://doi.org/10.56530/lcgc.eu.kg7881s2","url":null,"abstract":"Qualification and calibration of high performance liquid chromatography (HPLC) chromatographs is a regulatory requirement, but how proscriptive should guidance be?","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125768471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Non-Targeted Food Analysis: How HRMS and Advanced Data Processing Tools Address the Current Challenges 非目标食品分析:HRMS和先进数据处理工具如何应对当前挑战
LCGC Europe Pub Date : 2021-10-01 DOI: 10.56530/lcgc.eu.zs6970z2
Christine Fisher
{"title":"Non-Targeted Food Analysis: How HRMS and Advanced Data Processing Tools Address the Current Challenges","authors":"Christine Fisher","doi":"10.56530/lcgc.eu.zs6970z2","DOIUrl":"https://doi.org/10.56530/lcgc.eu.zs6970z2","url":null,"abstract":"LCGC Europe spoke to Christine Fisher about the challenges and solutions associated with developing non-targeted food analysis methods, why data quality is so important, and how data processing software and algorithms are helping to tackle the current challenges in food analysis.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116818294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hidden Factory in Your Laboratory? 你实验室里隐藏的工厂?
LCGC Europe Pub Date : 2021-08-01 DOI: 10.56530/lcgc.eu.fw7482b7
R. Mcdowall
{"title":"The Hidden Factory in Your Laboratory?","authors":"R. Mcdowall","doi":"10.56530/lcgc.eu.fw7482b7","DOIUrl":"https://doi.org/10.56530/lcgc.eu.fw7482b7","url":null,"abstract":"There is a hidden factory in plain sight in many laboratories. Not many people know of its existence, yet it stares back at you when you work. What is the output from this hidden factory? Paper.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134295730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Low-Level Determination of Mutagenic Nitrosamine Impurities in Drug Substances by LC–MS/MS LC-MS /MS低浓度测定原料药中致突变性亚硝胺杂质
LCGC Europe Pub Date : 2021-07-01 DOI: 10.56530/lcgc.eu.dd3576s1
Matthew James, T. Edge
{"title":"Low-Level Determination of Mutagenic Nitrosamine Impurities in Drug Substances by LC–MS/MS","authors":"Matthew James, T. Edge","doi":"10.56530/lcgc.eu.dd3576s1","DOIUrl":"https://doi.org/10.56530/lcgc.eu.dd3576s1","url":null,"abstract":"Since the detection of N-nitrosodimethylamine (NDMA) in a batch of valsartan in 2018, at levels exceeding ICH acceptable intake limits for mutagenic impurities, the analysis of nitrosamines has become an intense focus point for the pharmaceutical industry. The identification and low-level determination of nitrosamines in potentially affected materials is challenging and requires the application of highly sensitive analytical techniques. This article reviews the chronological development of the story and the regulatory landscape that has evolved. It will then discuss the development of analytical methods for the determination of a series of nitrosamines referenced by regulatory authorities, demonstrating separation of these compounds from the active pharmaceutical ingredient (API) and looking at how mass spectrometry (MS) can be applied to ensure that the required detection limits can be reached.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126565600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fast GC–MS for Analyzing Antioxidants and Industrial Food Analysis Applications 快速气相色谱-质谱分析抗氧化剂和工业食品分析应用
LCGC Europe Pub Date : 2021-07-01 DOI: 10.56530/lcgc.eu.ic4573z3
H. Janssen
{"title":"Fast GC–MS for Analyzing Antioxidants and Industrial Food Analysis Applications","authors":"H. Janssen","doi":"10.56530/lcgc.eu.ic4573z3","DOIUrl":"https://doi.org/10.56530/lcgc.eu.ic4573z3","url":null,"abstract":"LCGC Europe spoke to Hans-Gerd Janssen from the Unilever Foods Innovation Centre in The Netherlands, about the advantages of a novel, rapid method to analyze antioxidants that inhibit oxidation, and he explains that the maturity of gas chromatography (GC) technology is actually an advantage to the analyst.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"26 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132273739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining Material Used in Biopharmaceutical Analysis 定义用于生物制药分析的材料
LCGC Europe Pub Date : 2021-06-01 DOI: 10.56530/lcgc.eu.bq1982p9
S. Fekete
{"title":"Defining Material Used in Biopharmaceutical Analysis","authors":"S. Fekete","doi":"10.56530/lcgc.eu.bq1982p9","DOIUrl":"https://doi.org/10.56530/lcgc.eu.bq1982p9","url":null,"abstract":"There is a need to use more descriptive and precise terms to describe some of the properties of the products used for biopharmaceutical analysis. It is probably more correct to say “low adsorption” and “corrosion-resistant” systems.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126208464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Development of a “Freeze-Pour” Sample Preparation Method for the GC Analysis of Semivolatile Flavouring Chemicals Present in E-cigarette Refill Liquids 电子烟补充液中半挥发性调味物质气相色谱分析用“冷冻倒”制样方法的建立
LCGC Europe Pub Date : 2021-06-01 DOI: 10.56530/lcgc.eu.nf5078t7
Sophia Barhdadi, M. Canfyn, Sanae El Merabety, P. Courselle, V. Rogiers, T. Vanhaecke, E. Deconinck
{"title":"Development of a “Freeze-Pour” Sample Preparation Method for the GC Analysis of Semivolatile Flavouring Chemicals Present in E-cigarette Refill Liquids","authors":"Sophia Barhdadi, M. Canfyn, Sanae El Merabety, P. Courselle, V. Rogiers, T. Vanhaecke, E. Deconinck","doi":"10.56530/lcgc.eu.nf5078t7","DOIUrl":"https://doi.org/10.56530/lcgc.eu.nf5078t7","url":null,"abstract":"During the past decade, e-cigarettes have become increasingly popular. To guarantee their safe use and to comply with the notification requirements of the EU Tobacco Product Directive, the EU member state regulatory authorities need information about the exact composition of the e-liquids and their emissions. However, one of the challenges encountered during the analysis of e-liquids is the presence of the highly abundant e-liquid matrix components propylene glycol and glycerol. In this study, headspace gas chromatography (HS-GC) analysis is presented as an excellent method for the analysis of high volatile components in e-liquids. For the analysis of semivolatile ingredients, an additional sample preparation step is proposed based on a liquid–liquid extraction (LLE) followed by a freeze-out of the matrix components. The developed method was successfully validated in accordance with the validation requirements of ICH guidelines for the quantification of four flavourings with a potential health concern for e-cigarette users.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123203506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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