Particuology最新文献

{"title":"Exploring the role of cationic lipids in modulating immunogenicity and vaccine efficacy of mRNA-LNP","authors":"Yan Zhou ,&nbsp;Xiangfei Shan ,&nbsp;Renji Gu ,&nbsp;Yufei Xia ,&nbsp;Xiaonan Huang","doi":"10.1016/j.partic.2024.11.011","DOIUrl":"10.1016/j.partic.2024.11.011","url":null,"abstract":"<div><div>The mRNA vaccines have become a transformative platform in medicine, with their success during the COVID-19 pandemic accelerating research in viral prevention and cancer therapy. Lipid nanoparticles (LNPs) enhance the stability and efficacy of mRNA vaccines, but achieving an optimal balance between innate immune activation and mRNA expression is crucial for their effectiveness. Classical cationic lipids, although largely replaced by ionizable lipids due to concerns over excessive immunogenicity, have demonstrated potential in cancer immunotherapy by inducing strong immune responses. In this study, we investigated whether incorporating cationic lipids into mRNA-LNP formulations could enhance immunogenicity without requiring new lipid designs. We introduced varying proportions of cationic lipids into D-Lin-MC3-DMA and SM-102-based LNPs and evaluated their impact on innate immune activation, along with long-term humoral and cellular immune responses. Our results showed that in MC3-based LNPs, cationic lipids significantly improved anti-tumor efficacy, though slightly diminished long-term humoral and cellular immunity. In contrast, in SM-102-based LNPs, cationic lipids enhanced anti-tumor effects without negatively impacting long-term immunity. These findings suggest that adding cationic lipid as an additional component allows for the fine-tuning of mRNA-LNP immunogenicity, expanding the potential applications of mRNA vaccines and simplifying LNP design.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"97 ","pages":"Pages 1-11"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable synthesis of uniform small-sized MgCO3 from Mg2+ concentrated seawater brine for the preparation of epoxy resin composite and high purity MgO","authors":"Shuo Yan,&nbsp;Hongfei Guo,&nbsp;Dapeng Zhang,&nbsp;Yun Li,&nbsp;Jilin Cao","doi":"10.1016/j.partic.2024.12.012","DOIUrl":"10.1016/j.partic.2024.12.012","url":null,"abstract":"<div><div>The large and uneven grain size of anhydrous magnesium carbonate (MgCO₃) seriously restricts its application ranges and performances. In this study, we proposed a controllable and cost-effective strategy to synthesize uniform small-sized MgCO₃ from Mg²⁺ concentrated seawater brine in the absence of crystal modifiers. In this process, solid NaOH was directly added to Mg²⁺ concentrated seawater brine to completely and rapidly convert Mg²⁺ to magnesium hydroxide (Mg(OH)₂) nanoparticles. These nanoparticles are redispersed in water to form the colloidal system, where Mg(OH)₂ nanoparticles hydrothermally reacts with urea to obtain uniform small-sized MgCO₃ particles. The influence of reaction temperature, reaction time, and the molar ratio of magnesium ions to urea on the synthesis of MgCO₃ is systematically investigated. In the highly-dispersed and stable colloidal system, Mg(OH)₂ nanoparticles could exert an effective and sustained retarding effect on the hydrolysis rate of urea by attracting free water, resulting in the controllable release of NH₄⁺, CO₃²⁻, and Mg²⁺. This study presents a simple route to realize the controllable synthesis of uniform small-sized MgCO₃ particles, and demonstrates the feasibility of using MgCO₃ as an ideal filler for enhancing the performance of polymers as well as an ideal precursor for high-purity MgO production.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"97 ","pages":"Pages 154-166"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of a novel activated carbon from wheat dust and its adsorption mechanism for tetracycline hydrochloride","authors":"Hailong Fu ,&nbsp;Xue Song ,&nbsp;Yongde Liu ,&nbsp;Jie Zhang ,&nbsp;Jihong Zhao ,&nbsp;Feiyue Wang ,&nbsp;Zeying Zhang ,&nbsp;Zengchen Su ,&nbsp;Han Zhang","doi":"10.1016/j.partic.2024.11.017","DOIUrl":"10.1016/j.partic.2024.11.017","url":null,"abstract":"<div><div>In this study, a method for preparing activated carbon (AC) from wheat dust (WD) was developed to achieve efficient removal of tetracycline hydrochloride (TCH). The AC, prepared through response surface methodology with a carbonization temperature of 590 °C, a NaOH to WD ratio of 4:1, and an activation temperature of 800 °C, exhibited a high specific surface area of 2821.58 m²/g. It demonstrated a remarkable TCH removal capacity of 1414.65 mg/g in aqueous solution. The AC retained an adsorption capacity of 1035.36 mg/g after five cycles and maintained over 80% of its adsorption capacity in different water bodies. The adsorption of TCH by AC, primarily controlled by surface sites through chemical and physical interactions, involved mechanisms such as pore-filling, electrostatic interactions, hydrogen bonding, π-cation interactions, and π-π interactions. This study highlights the potential of WD in preparing effective adsorbents, providing valuable insights for the comprehensive utilization of similar byproducts.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"97 ","pages":"Pages 12-24"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistically enhanced capture of perfluorooctanoic acid using a novel dual metal-organic framework adsorbent","authors":"Heng Lin ,&nbsp;Zhouheng Xia ,&nbsp;Kunpeng Xue ,&nbsp;Xiaojing Zhou ,&nbsp;Yifan Yao ,&nbsp;Na Ma ,&nbsp;Wei Dai","doi":"10.1016/j.partic.2024.12.009","DOIUrl":"10.1016/j.partic.2024.12.009","url":null,"abstract":"<div><div>Metal-Organic Framework (MOF) have gained widespread attention as potential adsorbents for the removal of perfluorooctanoic acid (PFOA). However, single-component MOF often exhibit limitations in adsorption capacity, functionality, and pore structure. Hereby, we innovatively designed and synthesized a dual-metal core-shell MOF composite adsorbent, MIL-101(Cr)@ZIF-8 (a chromium-zinc bimetallic MOF, CZDM), which exhibits an excellent adsorption removal performance of PFOA from aqueous solutions. The results showed that the CZDM composite material has a high specific surface area (2091 m²/g), with pore structures exhibiting typical micropores (∼1.16 nm) and mesopores (∼3.4 nm), which are crucial for the efficient adsorption of PFOA. SEM and TEM images revealed that CZDM has a uniform core-shell morphology, with MIL-101(Cr) as the core and ZIF-8 as the shell, maintaining a stable and intact structure. EDX analysis further confirmed the successful incorporation of Cr and Zn elements. Batch experiments evaluated the effects of temperature, solution pH, and PFOA concentration on adsorption efficiency. The results demonstrated that the CZDM-3 adsorbent exhibited rapid adsorption kinetics and good PFOA removal efficiency across a wide pH range. The superior adsorption performance of CZDM is attributed to the synergistic effect of the dual-metal active sites, optimized pore structure, electrostatic interactions, and coordination bonds. The maximum adsorption capacity for PFOA reached 625.5 mg/g, with equilibrium achieved within 60 min, outperforming some related reported adsorbents. The experimental data of the adsorption process fit well with both Langmuir adsorption isotherms and pseudo-second-order kinetics models, indicating that the adsorption process is spontaneous, endothermic, and accompanied by an increase in entropy. Notably, even after five cycles, the CZDM material maintained high removal efficiency toward PFOA. This study advances a new synthesizing strategy of the MOF@MOF, and the CZDM exhibits a potential application in PFOA elimination from water.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"97 ","pages":"Pages 130-142"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segregation mechanism of 0–1 mm fine coal in vibration separation fluidized bed and its influence on the fluidization stability","authors":"Ziyi Guo ,&nbsp;Rongmiao Zhang ,&nbsp;Yifan Wang ,&nbsp;Yu Wang ,&nbsp;Zhibin Guo ,&nbsp;Ruikang Fan ,&nbsp;Yadong Zhang ,&nbsp;Enhui Zhou ,&nbsp;Chenlong Duan","doi":"10.1016/j.partic.2024.12.004","DOIUrl":"10.1016/j.partic.2024.12.004","url":null,"abstract":"<div><div>This study investigates the impact of mixing 0–1 mm fine coal with 0.15–0.3 mm magnetite powder to form a binary dense medium. The aim is to examine how the 0–1 mm fine coal influences the stability of vibration separation in a fluidized bed and to achieve steady-state control of vibration fluidization. The vibration segregation behaviour of the binary dense medium under varying fine coal contents is analyzed in this work. The study discovers that the primary contributor to segregation is coal particles smaller than 0.5 mm. As the proportion of fine coal increases, upward movement becomes more pronounced, especially for particles smaller than 0.15 mm, where the upward segregation is most noticeable, with a peak mixing index of 8.06. The study confirms that the larger the particle size of fine coal, the higher the content limit for mixing with magnetite powder. According to studies on the process of fine coal segregation, coal particles larger than 0.5 mm move with the magnetite powder, and the mixing index remains below 3. Coal particles smaller than 0.5 mm fine coal will separate at a uniform speed in a stable environment produced by low vibration energy, with the top-level mixing index remaining constant at 26 after 6 min. Additionally, the study also examines how the fluidization of vibration separation is influenced by the segregation of 0–1 mm fine coal. The evidence shows that longitudinal density segregation within the binary dense medium competes with instantaneous density fluctuation. The longitudinal density distribution of the binary dense medium was found to be nearly uniform when the frequency was set to 25 Hz, amplitude to 2 mm, and upward gas velocity to 1.4 times the minimum fluidization velocity. The density fluctuation was found to be between 0 and 0.1 g/cm³. The best separation effect was achieved with fine coal particles ranging from 6 to 1 mm in size under these conditions.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"97 ","pages":"Pages 167-182"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology control and crystal structure and properties analysis of FOX-7/HMX composite crystals prepared by rotary evaporation method","authors":"Penglin Kang,&nbsp;Wenjie Liu,&nbsp;Wenyu Wu,&nbsp;Xiaodong Li,&nbsp;Xiaona Cui,&nbsp;Fengze Cai,&nbsp;Qicong Jiang","doi":"10.1016/j.partic.2025.01.004","DOIUrl":"10.1016/j.partic.2025.01.004","url":null,"abstract":"<div><div>Enhancing the safety of high-energy explosives (EMs) is crucial for the secure handling of energetic materials during storage, transportation, and use. Compositing multiple energetic materials effectively enhances the insensitivity of explosives. This study used N,N-dimethylformamide (DMF) as a solvent in the rotary evaporation method to prepare 1,1-diamino-2,2-dinitroethene/1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (FOX-7/HMX) composite crystals. By varying the molar ratios of FOX-7 and HMX, this study investigated their effects on the morphology of the composite crystals, and the formation mechanism of the composite crystal was analyzed. The study characterized and tested the crystal structure, thermal decomposition, cook-off performance, and impact sensitivity of the composite crystal. The results indicate that at a 5:5 M ratio of FOX-7 to HMX, the compound degree is 90.79%, and FOX-7 exhibits uniform adhering to the surface of the HMX crystal. FT-IR and XRD patterns analyses revealed shifts in the absorption peak of the composite crystal and the characteristic peak of the XRD curve. FOX-7 crystals were embedded on the surface of HMX crystals, forming a co-crystal layer and altering the crystal structure. Differential scanning calorimetry tests demonstrate that the thermal decomposition temperature of FOX-7/HMX composite crystals is 1.77 °C higher than the raw FOX-7, and during the cook-off test, the composite crystal reaction level is combustion, accompanied by an increase in characteristic drop height to 62.6 cm, indicating improved thermal stability and impact safety.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 1-12"},"PeriodicalIF":4.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of hexanitrostilbene/aluminum microspheres with interconnected multi-cavity structure for enhanced safety and combustion performance","authors":"Yi Liu,&nbsp;Yunyan Guo,&nbsp;Fan Wang,&nbsp;Zhihua Xue,&nbsp;Chongwei An,&nbsp;Zhongliang Ma,&nbsp;Bidong Wu","doi":"10.1016/j.partic.2025.01.003","DOIUrl":"10.1016/j.partic.2025.01.003","url":null,"abstract":"<div><div>Achieving performance optimization of aluminized explosives through structural regulation is of great significance for enhancing their practical application value. In this study, hexanitrostilbene/aluminum (HNS/Al) microspheres with interconnected multi-cavity structures were prepared using microjet droplet technology, and the effect of solvent ratio on microsphere morphology and multi-cavity formation was investigated. Furthermore, the impact of the multi-cavity structure on microsphere dispersibility, specific surface area, thermal properties, mechanical sensitivity, and combustion performance was examined. The results indicate that, compared to raw HNS, the multi-cavity HNS/Al microspheres exhibit improved dispersibility while retaining the crystal structure, chemical composition, and thermal stability of the raw material. In comparison to solid HNS/Al microspheres, the multi-cavity HNS/Al microspheres demonstrate a higher specific surface area (26.432 vs. 30.987 m² g⁻¹) and improved safety performance (3.5 vs. 15 J). Ignition test results reveal that the addition of aluminum powder significantly reduces the ignition delay of HNS (275 vs. 5.0 ms) and inhibits carbon cluster formation during combustion, thereby enhancing the burning efficiency of HNS. Notably, microspheres with a multi-cavity structure exhibit superior combustion efficiency. This study provides a method for preparing multi-structured aluminized explosives.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 21-30"},"PeriodicalIF":4.1,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted and pH-sensitive polyzwitterionic liposomes for oral anticancer drug delivery","authors":"Mingyang Hu ,&nbsp;Rui Zheng ,&nbsp;Qi Pan ,&nbsp;Chen Peng ,&nbsp;Xinyue Zhang ,&nbsp;Wei He ,&nbsp;Wenlong Yao ,&nbsp;Yan Li","doi":"10.1016/j.partic.2025.01.001","DOIUrl":"10.1016/j.partic.2025.01.001","url":null,"abstract":"<div><div>Compared to intravenous injection, oral administration is attractive due to its many advantages for cancer therapy. Taken physiological barriers and other profiles of oral anticancer drug carriers into consideration, targeted and pH-sensitive polyzwitterionic liposomes (ZL) based on zwitterionic poly(carboxybetaine) (PCB) were constructed for oral delivery of doxorubicin hydrochloride (DOX·HCl) for cancer therapy. The DOX-ZL with 40% trehalose had good lyophilization stability, which would be packaged into enteric capsules to enhance their stability in stomach. In addition, DOX-ZL exhibited good storage stability and serum stability. The DOX-ZL could achieve controlled release of DOX·HCl at the endosomal pH 5.0 due to the pH-sensitive of zwitterionic PCB. Importantly, DOX-ZL could targeted deliver DOX·HCl to Caco-2 cells to cross the intestinal epithelial cell layer. The empty ZL had good biocompatibility, while DOX-ZL significantly inhibited tumor cells growth due to their high cellular uptake and controlled drug release ability. Therefore, this work provided a promising approach for oral cancer therapy.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 13-20"},"PeriodicalIF":4.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143137681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the polydispersion of TiO2 materials on their particle size calculated from specific surface area results obtained during an interlaboratory comparison exercise","authors":"Sébastien Bau ,&nbsp;Sébastien Artous ,&nbsp;Sébastien Jacquinot ,&nbsp;Dominique Locatelli ,&nbsp;Jean-François Hochepied ,&nbsp;Nicolas Feltin ,&nbsp;Carine Chivas-Joly","doi":"10.1016/j.partic.2025.01.002","DOIUrl":"10.1016/j.partic.2025.01.002","url":null,"abstract":"<div><div>In this work, four samples of TiO₂ powder materials with different structures (rutile, anatase), surface coatings and morphologies (rod, pseudo-spherical) were characterized by four partners involving complementary methods. With the aim of producing inter-laboratory reproducibility data, the specific surface-area, bulk density, and number size distribution were measured, yielding a satisfying agreement between partners. The equivalent diameter of constituent particles was determined from the sample volume specific surface area (<em>VSSA</em>) – accounting for polydispersion – and compared to electron microscopy (EM). Constituent particle diameters ranged from 15 to 225 nm according to EM analyses. The relative discrepancies between <em>VSSA</em>-based and EM-based diameters were found within ±20%. Out of the four samples under study, TiO₂ μ-rutile leads to a larger deviation, which was attributed to surface coating thanks to complementary analysis. Assuming that the sample is pure, an equivalent diameter based on the <em>VSSA</em> can be determined, provided that the shape of constituent particles is known or supposed.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 31-40"},"PeriodicalIF":4.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143360822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of surface-active agents on the dynamic wetting film rupture: Gas migration and surface nanobubbles formation","authors":"Baonan Zhou ,&nbsp;Binglong Zhao ,&nbsp;Changning Wu ,&nbsp;Junguo Li ,&nbsp;Ke Liu","doi":"10.1016/j.partic.2024.11.004","DOIUrl":"10.1016/j.partic.2024.11.004","url":null,"abstract":"<div><div>In this research, precise motion control and synchronized high-speed microscopic dual-wavelength interferometry were employed to investigate the impact of surface-active components on the rupture behavior of wetting films. The findings unveiled a novel mechanism for wetting film rupture at hydrophobic interfaces, propelled by gas migration towards the solid-liquid interface, resulting in the nucleation and growth of surface nanobubble. Salt ions accelerate film rupture by reducing electrostatic interactions and enhancing gas transfer, whereas surfactant adsorption immobilizes the gas-liquid interface through the Marangoni effect, thereby postponing rupture by impeding gas migration and surface nanobubble formation. Furthermore, surfactants influence the kinetics of three-phase contact line formation, where variations in molecular structure, solubility, and ionic properties contributing to differing levels of friction, and thereby affecting the overall dynamics of wetting films.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"96 ","pages":"Pages 171-179"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}