Trends in Immunotherapy最新文献_第2页

Mucous membrane pemphigoid involving palmoplantar lesions that developed during adjuvant nivolumab for malignant melanoma: A rare case and literature review 治疗恶性黑色素瘤的尼夫单抗辅助治疗期间出现的涉及掌跖病变的粘膜丘疹病：罕见病例和文献综述

Trends in Immunotherapy Pub Date : 2023-12-15 DOI: 10.24294/ti.v7.i2.2779

Mayumi Takata, S. Usui, T. Kogame, Atsushi Otsuka, Kenji Kabashima

{"title":"Mucous membrane pemphigoid involving palmoplantar lesions that developed during adjuvant nivolumab for malignant melanoma: A rare case and literature review","authors":"Mayumi Takata, S. Usui, T. Kogame, Atsushi Otsuka, Kenji Kabashima","doi":"10.24294/ti.v7.i2.2779","DOIUrl":"https://doi.org/10.24294/ti.v7.i2.2779","url":null,"abstract":"Immune checkpoint inhibitors (ICIs), such as nivolumab, which target anti‐programmed cell death-1 (PD-1), have been applied to a variety of cancers and have caused immune‐related adverse events (irAEs). Although an association between ICIs and bullous pemphigoid and mucosal pemphigoid (MMP) has been reported, the complex mechanisms underlying PD-1 inhibition‐induced autoantibody production and autoimmunity remain unelucidated. In this report, we present a unique case of MMP involving the palmoplantar lesions during adjuvant nivolumab therapy. A Japanese woman in her 70s was treated with nivolumab for postoperative vulvar malignant melanoma; after the 12th cycle of treatment, ulcers were seen in the oral cavity, and 4 months later, tense palmoplantar blisters appeared. Microscopic examination of the palmar blister revealed subepidermal vesicles characterized by eosinophil infiltration. Immunofluorescence analysis revealed linear IgG and C3 deposits along the basement membrane; ELISA testing confirmed the presence of anti‐BP180 NC16A IgG antibody, and MMP was diagnosed. The patient’s condition gradually improved with a therapeutic regimen of corticosteroids and immunoglobulins. A review of 10 cases of ICI‐associated MMP, including the present case, revealed clinical similarities to conventional MMP; in cases of persistent oral erosions due to ICI, it is most important to consider mucositis and MMP in the framework of differential diagnosis. Besides, we suggest that we can be more suspicious of MMP by paying attention to examining the palms and soles when the patient receiving ICIs has refractory oral ulcers. This report underscores the importance of careful observation and prompt management of irAE as cancer immunotherapy evolves.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma gangrenosum: A single-center case series study of 32 cases 脓皮病：32 个病例的单中心病例系列研究

Trends in Immunotherapy Pub Date : 2023-11-30 DOI: 10.24294/ti.v7.i2.2415

Malik Güngör, Gülbin Yaşar Subaşı, A. Bilgic, Ayşe Akman, Ertan Yılmaz, E. Alpsoy

引用次数: 0

Potential therapeutic application of probiotics in the treatment of neuropathic pain: A mechanistic aspects of brain-gut axis 益生菌在治疗神经性疼痛中的潜在治疗应用：脑-肠轴的机理

Trends in Immunotherapy Pub Date : 2023-11-23 DOI: 10.24294/ti.v7.i2.2280

Manshi Mishra, Abdus Subhan, Riddhi Mishra, Avijit Mazumder, Bimlesh Kumar, Kardam Joshi

{"title":"Potential therapeutic application of probiotics in the treatment of neuropathic pain: A mechanistic aspects of brain-gut axis","authors":"Manshi Mishra, Abdus Subhan, Riddhi Mishra, Avijit Mazumder, Bimlesh Kumar, Kardam Joshi","doi":"10.24294/ti.v7.i2.2280","DOIUrl":"https://doi.org/10.24294/ti.v7.i2.2280","url":null,"abstract":"The “gut-brain axis” or “brain-gut axis” communication mechanism has a bidirectional approach because it depends on showing top-down or bottom-up channels to function. It is one of the few systems in the body that combines neuronal routes with humoral pathways, which include cytokines, hormones, and neuropeptides as chemical messages. It was also discovered to be diverse because it contains spinal, vagus, sympathetic, and intestinal nerves. The role of microbes as signaling agents in the gut-brain axis has been proven by the most recent research, which is primarily based on animal models. Probiotics are living bacteria that improve one’s health when ingested in large enough doses. Gut microbes are suspected to play a role in a variety of psychiatric disorders, making them a potential therapeutic target. The stomach and the brain are linked via a two-way communication pathway called the microbiota-gut-brain axis. Current interventional research on probiotics and the gut-brain axis has been evaluated for its findings in the treatment of depression, anxiety, and schizophrenia. Neuropathic pain is brought on by a lesion or injury to the nerve system, which is further demonstrated by a malfunction of the somatosensory system. Such a developed form of pain affects both peripheral and central nervous system neurons. According to research, probiotics can enhance the gut’s dynamic environment and are good for both the gut and the brain. Therefore, the focus of this review is on how probiotics, the microbiota-gut-brain axis, and the gut-brain axis relate to neuropathic pain.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139244381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative enzymes and vitamin E in ovarian cancer: Insights from a case-control study 卵巢癌中的氧化酶和维生素 E：病例对照研究的启示

Trends in Immunotherapy Pub Date : 2023-11-22 DOI: 10.24294/ti.v7.i2.2649

W. Y. M. AL-dulaimy, Ebtehal Sabri Mohammed, Saja F. Hassuby, Mohammed Kadhom

引用次数: 0

A sentinel surveillance of adverse events and breakthrough infections following COVID-19 precautionary dose among south Indian healthcare workers 对印度南部医护人员在服用COVID-19预防剂量后的不良事件和突破性感染进行哨点监测

Trends in Immunotherapy Pub Date : 2023-08-31 DOI: 10.24294/ti.v7.i2.2216

Merrin Mathew, J. Sebastian, C. Basavaraja, Devayani Josh, Deleena Varughese, Sidharth Soman, Madhu Sreeja Mahalekshmi

{"title":"A sentinel surveillance of adverse events and breakthrough infections following COVID-19 precautionary dose among south Indian healthcare workers","authors":"Merrin Mathew, J. Sebastian, C. Basavaraja, Devayani Josh, Deleena Varughese, Sidharth Soman, Madhu Sreeja Mahalekshmi","doi":"10.24294/ti.v7.i2.2216","DOIUrl":"https://doi.org/10.24294/ti.v7.i2.2216","url":null,"abstract":"Background: Adverse events following immunization (AEFI) is defined as any untoward medical occurrence which follows immunization and which does not necessarily have a causal relationship with the usage of the vaccine. Break-through infections are referred to as antigen or SARS-CoV-2 RNA positivity of respiratory specimens more than 14 days after receiving all recommended doses. Aim: The study was conducted to identify adverse events and break-through infections following the precautionary dose of the COVID-19 vaccine among healthcare workers. Methodology: The study was designed as a cohort event monitoring; all healthcare professionals who received COVID-19 precautionary dose from the study site were included in the study. The study population was actively followed for any adverse event following immunization (AEFI) through telephonic contact (within 30 days of post-vaccination). Reported adverse events were carefully scrutinized and evaluated by the AEFI investigation team of the study site. Results: Out of 1232 vaccine beneficiaries, a total of 359 (29.14%) individuals were reported with 385 AEFIs. Of which 138 (38.44%) individuals were laboratory-confirmed (RTPCR positive) breakthrough cases. Less severity and low morbidity were observed among all the breakthrough cases. According to the WHO’s new causality assessment algorithm, 183 (47.53%) events were vaccine product-related and 202 (52.46%) were co-incidental events. Conclusion: There was a prevailing outbreak of COVID-19 infection in the study site, which resulted in many breakthrough infections soon after immunization. Initially, all breakthrough infections were misleading as vaccine-related events, where this study helped to break the concerns among the study population.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130119852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing the structural and physicochemical properties of medicinal plants as a proposal for treating of viral malady 鉴定药用植物的结构和理化性质，为治疗病毒性疾病提供建议

Trends in Immunotherapy Pub Date : 2023-08-31 DOI: 10.24294/ti.v7.i2.2329

Fatemeh Mollaamin

{"title":"Characterizing the structural and physicochemical properties of medicinal plants as a proposal for treating of viral malady","authors":"Fatemeh Mollaamin","doi":"10.24294/ti.v7.i2.2329","DOIUrl":"https://doi.org/10.24294/ti.v7.i2.2329","url":null,"abstract":"Regarding coronavirus disease (COVID-19) pandemic, this research article wants to study some herbals as the probable therapy for this disease. Cinnamon leaves, curcuma longa (turmeric), ginger, mentha pulegium (pennyroyal), rosemary, salvia divinorum and thyme including some principal chemical compounds of cynnamil, curcumin, gingerol, pulegone, rosmarinic acid, salvinorina A and thymol, respectively, as a probable anti COVID-19 receptor have been selected. The possible roles of these medicinal plants in COVID-19 treatment have been carried out through quantum sensing methods. Formation of hydrogen bonding between principal substances selected in COVID-19 natural drugs bound to Tyrosine-Methionine-Histidine (Tyr-Met-His) or (TMH) (the database amino acids fragment) as the active area of the COVID-19 protein has been evaluated. In fact, it has been exhibited the role of oxygen, nitrogen, and hydrogen atoms in the active sites of these anti-virus medications towards hydrogen bonding in the active site if “TMH” protein. The physical and chemical attributes of nuclear magnetic resonance, vibrational frequency, the highest occupied molecular orbital energy and the lowest unoccupied molecular orbital energy, partial charges and spin density and have been accomplished using density functional theory (DFT) method and 6-311+G (2d,p) basis set by Gaussian 16 revision C.01 program toward the industry of drug design. This research has exhibited that there is a relative agreement among the results that these medicinal plants could be efficient against COVID-19 symptoms.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"184 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121011268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pediatric case of exudative erythema multiforme probably associated with asymptomatic COVID-19 小儿多形性渗出性红斑1例可能与无症状COVID-19相关

Trends in Immunotherapy Pub Date : 2023-08-31 DOI: 10.24294/ti.v7.i2.2397

Y. Wada, Kayoko Minami, M. Natsuaki, N. Kanazawa

引用次数: 0

Editorial review on Vol. 7 No. 1 第 7 卷第 1 期的编辑评论

Trends in Immunotherapy Pub Date : 2023-07-25 DOI: 10.24294/ti.v7.i1.2896

Zhiling Yu

引用次数: 0

Perspective of 3D printing in dentistry—Exploring the new horizon 3D打印在牙科领域的前景——探索新视野

Trends in Immunotherapy Pub Date : 2023-07-21 DOI: 10.24294/ti.v7.i1.2133

Bharani Krishna Takkella, N. Anusha, Bhavana Sujanamulk, Mohammad Naffizuddin, Rajkishore Jammalamadugu, Hameeda Pinjari, Thakkella Chaitanya Krishna, Lokanathan Balaji, Mummidi Manasa, Vamseedhar Kosuru

{"title":"Perspective of 3D printing in dentistry—Exploring the new horizon","authors":"Bharani Krishna Takkella, N. Anusha, Bhavana Sujanamulk, Mohammad Naffizuddin, Rajkishore Jammalamadugu, Hameeda Pinjari, Thakkella Chaitanya Krishna, Lokanathan Balaji, Mummidi Manasa, Vamseedhar Kosuru","doi":"10.24294/ti.v7.i1.2133","DOIUrl":"https://doi.org/10.24294/ti.v7.i1.2133","url":null,"abstract":"The phrase “3D printing” is frequently used to illustrate a fabrication technique that constructs objects by sequentially adding layers. Additive manufacturing, commonly referred to as rapid prototyping or “solid free-form technology”, is a name that more appropriately reflects this method. As a result of the advancement of this technology, 3D objects are converted into 3D photos that are then precisely and perfectly reproduced as required. Using this technique, normal 2D systems are used to visualise 3D objects that are typically seen in radiology. From the perspectives of numerous dental disciplines, including orthodontics, endodontics, prosthodontics, and periodontics, 3D printing technology has been expanding its application in experimental, clinical, and educational sides of medicine and dentistry. It involves innovation and research, training, treatment modalities and education while utilising the swiftly advancing 3D printing technology. It is a promising clinical tool since it makes it possible to see how treatments are working. The use of 3D-printed models in educational programmes encourages students and trainees to practise their dental skills. The improvement of dental education, clinical treatment, and research could all be made possible by the use of 3D printing.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121488729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel targeted cancer therapy based on β-hydroxybutyric acid associated energy metabolism regulated by intestinal flora 基于肠道菌群调节β-羟基丁酸相关能量代谢的新型靶向癌症治疗

Trends in Immunotherapy Pub Date : 2023-07-18 DOI: 10.24294/ti.v7.i1.2160

Fenfen Zhang, Yifei Lv, Xiaolun Zhou, Yangyang He, Jianshe Yang

引用次数: 1