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The pivotal role of PACAP/PAC1R signaling from the anterior insular cortex to the locus coeruleus on anxiety-related behaviors of mice PACAP/PAC1R信号从前部岛叶皮层传导至小鼠神经节对小鼠焦虑相关行为的关键作用
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-11 DOI: 10.1016/j.neuint.2024.105879
Thi Thu Nguyen , Kohei Hashiguchi , James A. Waschek , Atsuro Miyata , Yuki Kambe
{"title":"The pivotal role of PACAP/PAC1R signaling from the anterior insular cortex to the locus coeruleus on anxiety-related behaviors of mice","authors":"Thi Thu Nguyen ,&nbsp;Kohei Hashiguchi ,&nbsp;James A. Waschek ,&nbsp;Atsuro Miyata ,&nbsp;Yuki Kambe","doi":"10.1016/j.neuint.2024.105879","DOIUrl":"10.1016/j.neuint.2024.105879","url":null,"abstract":"<div><div>The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its specific receptor (PAC1R) are widely present in the central nervous system (CNS), and PACAP/PAC1R signaling has been implicated in anxiety-related behaviors. The locus coeruleus (LC), with its extensive noradrenergic (NA) projections throughout the CNS, is also implicated in anxiety. Although the LC exhibits a high expression of PAC1R, the precise role of PACAP/PAC1R signaling in the LC's involvement in anxiety remains unclear. Histochemical analysis confirmed high levels of PAC1R mRNA in the LC and showed that PAC1R gene transcripts were highly localized to NA neurons. Targeted deletion of PAC1R from these cells led to a hyperactive/low anxiety phenotype in the open field and elevated-plus maze tests. Retrograde neurocircuit tracing indicated PACAP neurons from the anterior insular cortex (aIC) and a few other regions projected axons to the LC. The selective activation of PACAP neurons in the aIC led to significantly increased anxiety behavior without a change in overall locomotor activity. Moreover, shRNA PACAP knockdown in the aIC in wild-type mice led to a selective decrease in anxiety. The present results identify an aIC to LC neurocircuit controlling anxiety that critically requires PACAP/PAC1R signaling.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105879"},"PeriodicalIF":4.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein aggregation and its affecting mechanisms in neurodegenerative diseases 神经退行性疾病中的蛋白质聚集及其影响机制
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-11 DOI: 10.1016/j.neuint.2024.105880
Junyun Wu , Jianan Wu , Tao Chen , Jing Cai , Reng Ren
{"title":"Protein aggregation and its affecting mechanisms in neurodegenerative diseases","authors":"Junyun Wu ,&nbsp;Jianan Wu ,&nbsp;Tao Chen ,&nbsp;Jing Cai ,&nbsp;Reng Ren","doi":"10.1016/j.neuint.2024.105880","DOIUrl":"10.1016/j.neuint.2024.105880","url":null,"abstract":"<div><div>Protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (NDs), including the formation of amyloid β (Aβ) and Tau neurofibrillary tangles in Alzheimer's disease, as well as α-Synuclein (α-Syn) aggregates in Parkinson's disease, Parkinson's disease-related dementia (PDD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). A significant proportion of patients with amyotrophic lateral sclerosis (ALS) exhibit TDP-43 aggregates. Moreover, a confluence of brain protein pathologies, such as Aβ, Tau, α-Syn, and TDP-43, has been identified in individual NDs cases, highlighting the intricate interplay among these proteins that is garnering heightened scrutiny. Importantly, protein aggregation is modulated by an array of factors, with burgeoning evidence suggesting that it frequently results from perturbations in protein homeostasis, influenced by the cellular membrane milieu, metal ion concentrations, post-translational modifications, and genetic mutations. This review delves into the pathological underpinnings of protein aggregation across various NDs and elucidates the intercommunication among disparate proteins within the same disease context. Additionally, we examine the pathogenic mechanisms by which diverse factors impinge upon protein aggregation, offering fresh perspectives for the future therapeutic intervention of NDs.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105880"},"PeriodicalIF":4.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olfactory dysfunction decreased local field potential in the reward system and increased EtOH consumption in mice 嗅觉功能障碍会降低奖赏系统的局部场电位,增加小鼠的乙醇消耗量。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-09 DOI: 10.1016/j.neuint.2024.105875
Jianhong Zhou , Di Luo , Yingjie An , Yuan Gao , Jichuan Zhang , Yanmei Chen
{"title":"Olfactory dysfunction decreased local field potential in the reward system and increased EtOH consumption in mice","authors":"Jianhong Zhou ,&nbsp;Di Luo ,&nbsp;Yingjie An ,&nbsp;Yuan Gao ,&nbsp;Jichuan Zhang ,&nbsp;Yanmei Chen","doi":"10.1016/j.neuint.2024.105875","DOIUrl":"10.1016/j.neuint.2024.105875","url":null,"abstract":"<div><div>The relationship between olfactory dysfunction and alcohol intake is unobvious. Chronic alcohol intake results in reduced olfactory acuity and olfactory discrimination and addiction in humans. However, alcohol is a beverage with distinctive odors, which usually works as a cue to induce addictive memories and craving behavior. Whether olfactory impairment increase or decrease alcohol consumption remains an important but unclear issue. In this study, we measured ethanol (EtOH) consumption in the two-bottle choice EtOH drinking test, two bottle choice EtOH/sucrose drinking test and the drinking in the dark (DID) test during the olfactory loss. We also recorded local field potentials (LFPs) from the brain reward system, the ventral tegmental area (VTA), nucleus accumbens (NAc), and piriform cortex (Pir) one and four weeks after the induction of olfactory epithelium lesions using zinc sulfate (ZnSO<sub>4</sub>) in mice. The results showed that the EtOH consumption and preference were increased during the period of olfactory dysfunction. 1 week after the olfactory injury, LFP powers in the reward system at low- and high-gamma bands decreased significantly, coherence between the Pir and the reward system was also decrease. 4 weeks after the ZnSO<sub>4</sub> treatment, LFP powers were reversed, but the coherence between VTA and NAc was decreased, indicating lasting effects post-recovery. This study demonstrates that olfactory dysfunction increased EtOH consumption in mice, which was accompanied by decreased LFP power and coherence in the reward system, which suggest that olfactory deficits changed activities in the reward system and could alter reward-seeking behaviors, which provide insights into the neurobiology of alcohol addiction.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105875"},"PeriodicalIF":4.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
(Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins (富含(多)酚的葡萄和蓝莓提取物通过调节肠道微生物群衍生的尿毒症毒素,防止 LPS 引起的血脑屏障破坏。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-09 DOI: 10.1016/j.neuint.2024.105878
Emily Connell , Gwénaëlle Le Gall , Simon McArthur , Leonie Lang , Bernadette Breeze , Matthew G. Pontifex , Saber Sami , Line Pourtau , David Gaudout , Michael Müller , David Vauzour
{"title":"(Poly)phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins","authors":"Emily Connell ,&nbsp;Gwénaëlle Le Gall ,&nbsp;Simon McArthur ,&nbsp;Leonie Lang ,&nbsp;Bernadette Breeze ,&nbsp;Matthew G. Pontifex ,&nbsp;Saber Sami ,&nbsp;Line Pourtau ,&nbsp;David Gaudout ,&nbsp;Michael Müller ,&nbsp;David Vauzour","doi":"10.1016/j.neuint.2024.105878","DOIUrl":"10.1016/j.neuint.2024.105878","url":null,"abstract":"<div><div>The dynamic protective capacity of (poly)phenols, attributed to their potent antioxidant and anti-inflammatory properties, has been consistently reported. Due to their capacity to alter gut microbiome composition, further actions of (poly)phenols may be exerted through the modulation of the microbiota-gut-brain axis. However, the underlying mechanisms remain poorly defined. Here, we investigated the protective effect of a (poly)phenol-rich grape and blueberry extract (Memophenol™), on the microbiota-gut-brain axis in a model of chronic low-grade inflammation (0.5 mg/kg/wk lipopolysaccharide (LPS) for 8 weeks). Dietary supplementation of male C57BL/6 J mice with Memophenol™ prevented LPS-induced increases in the microbe-derived uremia-associated molecules, indoxyl sulfate (IS) and trimethylamine <em>N</em>-oxide (TMAO). These changes coincided with shifts in gut microbiome composition, notably <em>Romboutsia</em> and <em>Desulfovibrio</em> abundance, respectively. In the brain, LPS exposure disrupted the marginal localisation of the endothelial tight junction ZO-1 and downregulated ZO-1 mRNA expression to an extent closely correlated with TMAO and IS levels; a process prevented by Memophenol™ intake. Hippocampal mRNA sequencing analysis revealed significant downregulation in regulatory pathways of neurodegeneration with Memophenol™ intake. These findings may indicate a novel protective role of the (poly)phenol-rich grape and blueberry extract on the endothelial tight junction component ZO-1, acting through modulation of gut microbial metabolism.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105878"},"PeriodicalIF":4.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jun modulates endoplasmic reticulum stress-associated ferroptosis in dorsal root ganglia neurons during neuropathic pain by regulating Timp1 Jun通过调控Timp1调节神经病理性疼痛过程中背根神经节神经元中与内质网应激相关的铁突变。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-08 DOI: 10.1016/j.neuint.2024.105877
Ziqiang Lin , Yi Wang , Yingdong Deng , Lu Li , Yu Cao , Suo Wang , Xiangsheng Zhang , Guoda Ding , Jiurong Cheng , Simin Tang , Jun Zhou
{"title":"Jun modulates endoplasmic reticulum stress-associated ferroptosis in dorsal root ganglia neurons during neuropathic pain by regulating Timp1","authors":"Ziqiang Lin ,&nbsp;Yi Wang ,&nbsp;Yingdong Deng ,&nbsp;Lu Li ,&nbsp;Yu Cao ,&nbsp;Suo Wang ,&nbsp;Xiangsheng Zhang ,&nbsp;Guoda Ding ,&nbsp;Jiurong Cheng ,&nbsp;Simin Tang ,&nbsp;Jun Zhou","doi":"10.1016/j.neuint.2024.105877","DOIUrl":"10.1016/j.neuint.2024.105877","url":null,"abstract":"<div><div>Neuropathic pain (NP) is a complex disorder caused by lesions or diseases affecting the somatosensory nervous system, severely impacting patients' quality of life. Recent studies suggest ferroptosis may be involved in NP induction, but its precise mechanisms remain unclear. We used GO and KEGG pathway enrichment analyses to functionally annotate ferroptosis-related differentially expressed genes (FRDs). Through STRING and the maximum cluster centrality (MCC) algorithm, we identified five hub FRDs (Jun, Timp1, Egfr, Cdkn1a, Cdkn2a). Single-cell analysis revealed significant expression of Jun and Timp1 in neurons. Our study confirmed the association between ferroptosis and endoplasmic reticulum stress (ERS) in NP and validated changes in hub FRD expression across various NP animal models. In vitro experiments demonstrated that Jun regulates neuronal ferroptosis and ERS, particularly by modulating Timp1 expression. Transcription factor prediction and JASPAR binding site analysis elucidated the regulatory network involving Jun. ROC curve analysis of external datasets highlighted the diagnostic potential of hub FRDs and ERS-related differentially expressed genes (ERSRDs) in NP. Using the Comparative Toxicogenomics Database (CTD), we identified estradiol (E2) as a potential therapeutic drug targeting hub FRDs and ERSRDs. Molecular docking predicted its binding sites with Jun and Timp1, and in vivo experiments confirmed that E2 alleviated NP and reversed the expression of Jun and Timp1. This study underscores the crucial role of Jun and Timp1 in the interplay between ferroptosis and ERS, offering new insights and promising avenues for NP treatment.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105877"},"PeriodicalIF":4.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy 肝性脑病中阿尔茨海默 II 型星形胶质细胞的发育机制
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-05 DOI: 10.1016/j.neuint.2024.105866
Xiao Y. Tong , Michael D. Norenberg , Michael J. Paidas , Nagarajarao Shamaladevi , Luis Salgueiro , Miklos Jaszberenyi , Binu John , Hussain Hussain , Omar El hiba , El got Abdeljalil , El-Mansoury Bilal , Sampath Natarajan , Rita Romaguera , Stanislav Papayan , Arianna K. Carden , Rajalakshmi Ramamoorthy , Nila Elumalai , Andrew V. Schally , Jayakumar Nithura , Rebecca Patrizio , Arumugam R. Jayakumar
{"title":"Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy","authors":"Xiao Y. Tong ,&nbsp;Michael D. Norenberg ,&nbsp;Michael J. Paidas ,&nbsp;Nagarajarao Shamaladevi ,&nbsp;Luis Salgueiro ,&nbsp;Miklos Jaszberenyi ,&nbsp;Binu John ,&nbsp;Hussain Hussain ,&nbsp;Omar El hiba ,&nbsp;El got Abdeljalil ,&nbsp;El-Mansoury Bilal ,&nbsp;Sampath Natarajan ,&nbsp;Rita Romaguera ,&nbsp;Stanislav Papayan ,&nbsp;Arianna K. Carden ,&nbsp;Rajalakshmi Ramamoorthy ,&nbsp;Nila Elumalai ,&nbsp;Andrew V. Schally ,&nbsp;Jayakumar Nithura ,&nbsp;Rebecca Patrizio ,&nbsp;Arumugam R. Jayakumar","doi":"10.1016/j.neuint.2024.105866","DOIUrl":"10.1016/j.neuint.2024.105866","url":null,"abstract":"<div><div>Type C hepatic encephalopathy (Type C HE) is a major and complex neurological condition that occurs following chronic liver failure. The molecular basis of Type C HE remains elusive. Type C HE is characterized by mental confusion, cognitive and motor disturbances. The presence of Alzheimer type II astrocytes (AT2A) is the key histopathological finding observed in Type C HE. However, nothing is currently known regarding AT2A development and its involvement in cognitive, and motor deficits in Type C HE. We, therefore, examined in rats the mechanisms by which liver failure contributes to the progression of AT2A, and its role in the development of cognitive and motor deficits in thioacetamide (TAA) model of Type C HE. We and others earlier reported increased oxidative/nitrosative stress (ONS), JNK1/2, and cMyc activation in ammonia-treated astrocyte cultures, as well as in brains from chronic liver failure. We now found increased levels of astrocytic glia maturation factor (GMF, a factor strongly implicated in neuroinflammation), as well as various inflammatory factors (IL-1β, TNF-α, IL-6, MMP-3, COX2, CXCL1, and PGE2), and reduced levels of GFAP and increased levels of aggregated nuclear protein Lamin A/C in rat brain cortex post-chronic liver failure. We also found increased levels of GMF and inflammatory factors (MMP-3, COX2, CXCL1, and PGE2) in astrocytes post-ammonia treatment <em>in vitro</em>. Additionally, pharmacological inhibition of upstream signaling of GMF (ONS, JNK1/2, and cMyc) or GMF inhibitors W-7 and trifluoperazine significantly reduced the levels of inflammatory factors, the number of AT2A cells, as well as the cognitive and motor deficits in TAA-treated rats. Increased levels of GMF were also identified in human post-mortem brain sections. These findings strongly suggest that increased levels of astrocytic GMF due to elevated levels of ONS, JNK1/2, and cMyc and the subsequent inflammation contribute to the development of AT2A and the consequent cognitive, and motor deficits in chronic liver failure.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105866"},"PeriodicalIF":4.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of oleanolic acid in modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β signaling pathways and neuroprotection against methylmercury-induced neurodegeneration 齐墩果酸在调节 PI3K/Akt/mTOR/STAT-3/GSK-3β 信号通路和保护神经免受甲基汞诱导的神经退行性病变影响方面的治疗潜力
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-03 DOI: 10.1016/j.neuint.2024.105876
Ramaish Sharma , Sidharth Mehan , Zuber Khan , Ghanshyam Das Gupta , Acharan S. Narula
{"title":"Therapeutic potential of oleanolic acid in modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β signaling pathways and neuroprotection against methylmercury-induced neurodegeneration","authors":"Ramaish Sharma ,&nbsp;Sidharth Mehan ,&nbsp;Zuber Khan ,&nbsp;Ghanshyam Das Gupta ,&nbsp;Acharan S. Narula","doi":"10.1016/j.neuint.2024.105876","DOIUrl":"10.1016/j.neuint.2024.105876","url":null,"abstract":"<div><div>Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that gradually deteriorates motor neurons, leading to demyelination, muscle weakness, and eventually respiratory failure. The disease involves several pathological processes, such as increased glutamate levels, mitochondrial dysfunction, and persistent neuroinflammation, often exacerbated by environmental toxins like mercury. This study explores the therapeutic potential of Olea europaea active phytoconstituents oleanolic acid (OLA) against ALS by targeting the overactivated PI3K/Akt/mTOR/STAT-3/GSK-3β signalling pathways. Methods involved in-silico studies, in vitro and in vivo experiments in which varying doses of methylmercury 5 mg/kg, <em>p.o.</em> and OLA (100 and 200 mg/kg, <em>i.p.</em>) were administered to rats for 42 days. Behavioural assessments, gross morphological, histopathological, and neurochemical parameters were measured in cerebrospinal fluid (CSF), blood plasma, and brain homogenates (cerebral cortex, hippocampus, striatum, midbrain, cerebellum) along with complete blood count (CBC) analysis. Results revealed OLA's significant neuroprotective properties. OLA effectively modulated targeted pathways, reducing pro-inflammatory cytokines, restoring normal levels of myelin basic protein (MBP) and neurofilament light chain (NEFL), and reducing histopathological changes. Gross pathological studies indicated less tissue damage, while CBC analysis showed improved hematology parameters. Additionally, the combination of OLA and edaravone (10 mg/kg, <em>i.p.</em>) demonstrated enhanced efficacy, improving motor functions and extending survival in ALS model rats. In conclusion, OLA exhibits significant therapeutic potential for ALS, acting as a potent modulator of key pathological signaling pathways. The findings suggest the feasibility of integrating OLA into existing treatment regimens, potentially improving clinical outcomes for ALS patients. However, further research must validate these findings in human clinical trials.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105876"},"PeriodicalIF":4.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies 创伤性脑损伤不断发展的病理生理学以及时间引导的综合疗法的优势。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-02 DOI: 10.1016/j.neuint.2024.105874
Laura Zima , Anthony N. Moore , Paul Smolen , Nobuhide Kobori , Brian Noble , Dustin Robinson , Kimberly N. Hood , Ryota Homma , Amar Al Mamun , John B. Redell , Pramod K. Dash
{"title":"The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies","authors":"Laura Zima ,&nbsp;Anthony N. Moore ,&nbsp;Paul Smolen ,&nbsp;Nobuhide Kobori ,&nbsp;Brian Noble ,&nbsp;Dustin Robinson ,&nbsp;Kimberly N. Hood ,&nbsp;Ryota Homma ,&nbsp;Amar Al Mamun ,&nbsp;John B. Redell ,&nbsp;Pramod K. Dash","doi":"10.1016/j.neuint.2024.105874","DOIUrl":"10.1016/j.neuint.2024.105874","url":null,"abstract":"<div><div>Several clinical and experimental studies have demonstrated that traumatic brain injury (TBI) activates cascades of biochemical, molecular, structural, and pathological changes in the brain. These changes combine to contribute to the various outcomes observed after TBI. Given the breadth and complexity of changes, combination treatments may be an effective approach for targeting multiple detrimental pathways to yield meaningful improvements. In order to identify targets for therapy development, the temporally evolving pathophysiology of TBI needs to be elucidated in detail at both the cellular and molecular levels, as it has been shown that the mechanisms contributing to cognitive dysfunction change over time. Thus, a combination of individual mechanism-based therapies is likely to be effective when maintained based on the time courses of the cellular and molecular changes being targeted. In this review, we will discuss the temporal changes of some of the key clinical pathologies of human TBI, the underlying cellular and molecular mechanisms, and the results from preclinical and clinical studies aimed at mitigating their consequences. As most of the pathological events that occur after TBI are likely to have subsided in the chronic stage of the disease, combination treatments aimed at attenuating chronic conditions such as cognitive dysfunction may not require the initiation of individual treatments at a specific time. We propose that a combination of acute, subacute, and chronic interventions may be necessary to maximally improve health-related quality of life (HRQoL) for persons who have sustained a TBI.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105874"},"PeriodicalIF":4.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk between peripheral inflammation and brain: Focus on the responses of microglia and astrocytes to peripheral challenge 外周炎症与大脑之间的相互影响:关注小胶质细胞和星形胶质细胞对外周挑战的反应。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-01 DOI: 10.1016/j.neuint.2024.105872
Maria Concetta Geloso , Luca Zupo , Valentina Corvino
{"title":"Crosstalk between peripheral inflammation and brain: Focus on the responses of microglia and astrocytes to peripheral challenge","authors":"Maria Concetta Geloso ,&nbsp;Luca Zupo ,&nbsp;Valentina Corvino","doi":"10.1016/j.neuint.2024.105872","DOIUrl":"10.1016/j.neuint.2024.105872","url":null,"abstract":"<div><div>A growing body of evidence supports the link between peripheral inflammation and impairment of neurologic functions, including mood and cognitive abilities. The pathogenic event connecting peripheral inflammation and brain dysfunction is represented by neuroinflammation, a pathogenic phenomenon that provides an important contribution to neurodegeneration and cognitive decline also in Alzheimer's, Parkinson's, Huntington's diseases, as well as in Multiple Sclerosis. It is driven by resident brain immune cells, microglia and astrocytes, that acquire an activated phenotype in response to proinflammatory molecules moving from the periphery to the brain parenchyma. Although a huge progress has been made in clarifying cellular and molecular mechanisms bridging peripheral and central inflammation, a clear picture has not been achieved so far. Therefore, experimental models are of crucial relevance to clarify knowledge gaps in this regard. Many findings demonstrate that systemic inflammation induced by pathogen-associated molecular patterns, such as lipopolysaccharide (LPS), is able to trigger neuroinflammation. Therefore, LPS-administration is widely considered a useful tool to study this phenomenon. On this basis, the present review will focus on <em>in vivo</em> studies based on acute and subacute effects of systemic administration of LPS, with special attention on the state of art of microglia and astrocyte response to peripheral challenge.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105872"},"PeriodicalIF":4.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease 在帕金森病小鼠模型中,通过少量总电荷转移刺激迷走神经可改善运动行为并减轻神经炎症。
IF 4.4 3区 医学
Neurochemistry international Pub Date : 2024-10-01 DOI: 10.1016/j.neuint.2024.105871
Wen Cheng , Kexin Fang , Xiaorong Ouyang , Lingjing Jin , Yunping Song , Bin Yu
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