Phytotherapie最新文献_第9页

Leishmanicidal Activity of Plant Extracts from Sefrou, a Moroccan Focus of Leishmaniasis, against Various Leishmania Parasites in the Promastigote Stage 摩洛哥利什曼病焦点植物Sefrou提取物对Promastigote期多种利什曼原虫的杀利什曼活性研究

Phytotherapie Pub Date : 2018-11-18 DOI: 10.3166/PHYTO-2018-0085

I. Zeouk, A. Et-Touys, M. Balouiri, H. Fellah, A. E. Lalami, K. Bekhti

{"title":"Leishmanicidal Activity of Plant Extracts from Sefrou, a Moroccan Focus of Leishmaniasis, against Various Leishmania Parasites in the Promastigote Stage","authors":"I. Zeouk, A. Et-Touys, M. Balouiri, H. Fellah, A. E. Lalami, K. Bekhti","doi":"10.3166/PHYTO-2018-0085","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0085","url":null,"abstract":"According to the World Health Organization, leishmaniasis remains a major worldwide public health problem. The province of Sefrou located in the center of Morocco is a focus of cutaneous leishmaniasis. The present study aims at evaluating the antileishmanial potential of Berberis sp.,Crataegus oxyacantha, Cistus salviifolius, Ephedra altissima and Lavandula dentatafrequently used by the local population. Methanolic extracts were tested against the promastigote form ofLeishmania tropica, Leishmania majorandLeishmania infantumusing tetrazolium-based colorimetric (MTT) assay. The total phenol and flavonoids content of all extracts were determined using the Folin–Ciocalteu reagent, aluminum chloride, and potassium acetate solutions respectively. The plant extracts exhibited antileishmanial activity with variability depending on the tested strain and the plant species compared to Glucantime® used as control (IC50 (the half maximal inhibitory concentration) > 1,000 μg/mL). The best inhibition was observed with Berberis sp., againstLeishmania major(IC50 = 394.40 ± 3.02 μg/ml), andEphedra altissima(reported for the first time) againstLeishmania infantum(IC50 = 490.84 ± 3.15 μg/mL).Leishmania tropicahas shown the same sensitivity behavior toward the five extracts (in average IC50 = 540 ± 11.20 μg/mL). The total phenolic content was higher forCrataegus oxyacanthaandCistus salviifolius(140.67 ± 3.17 μg eq Gallic Acid (GA)/ mg of Extract (E) and 133.83 ± 9.03 μg eq GA/mg of E respectively), while flavonoid was higher forCistus salviifoliusandLavandula dentata(57.92 ± 2.46 μg eq Quercetin (Que)/ mg of Extract (E) and 41.53 ± 1.74 μg eq Que/mg of E). All the tested extracts present some promising aspects that may cure cutaneous leishmaniasis in the center of Morocco; further bioguided assays are needed to isolate the fractions and the bioactive molecule.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43492273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Probiotics, Stress, and Irritable Bowel Syndrome 益生菌、压力和肠易激综合征

Phytotherapie Pub Date : 2018-11-18 DOI: 10.3166/PHYTO-2018-0087

V. Théodorou

{"title":"Probiotics, Stress, and Irritable Bowel Syndrome","authors":"V. Théodorou","doi":"10.3166/PHYTO-2018-0087","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0087","url":null,"abstract":"Irritable bowel syndrome (IBS) is a functional, gastrointestinal disease characterized by a combination of chronic or recurrent symptoms such as abdominal pain and abnormal bowel habit. Most of the IBS features occur without identifiable organic cause and are strongly influenced by stress and anxiety suggesting the involvement of brain–gut interactions in this disease. Microbiota changes have also been reported such as decreased abundance of the genera Bifidobacterium and Lactobacillus and increased firmicutes: bacteroidetes ratio but there is no consensus on a specific IBS microbiota signature. Psychological stress in rodents impacts intestinal epithelial barrier integrity as well as the composition of microbial communities and induces visceral pain, providing an interesting model for IBS pathophysiology investigation. Modulation of the intestinal microbiota using probiotics in preclinical trials prevents stress-induced visceral hypersensitivity directly through probiotic metabolites production or indirectly through prevention of the intestinal barrier function impairment. The clinical efficacy of probiotic treatments has also been suggested but the use of different scales to analyze the mean differences of symptoms in various studies has limited the ability of all existing meta-analyses in IBS to confirm the effectiveness of probiotics on major IBS symptoms and patient quality of life.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43924368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Laurus nobilisL. and the Study of its Biological Activityin vitro 月桂。及其体外生物活性研究

Phytotherapie Pub Date : 2018-11-05 DOI: 10.3166/PHYTO-2018-0084

M. Mehani, Z. Goumni, A. Salhi, N. Salhi, L. Segni, V. Terzi, C. Morcia

引用次数: 0

Détermination des effets synergiques ou antagonistes de plusieurs substances antimicrobiennes : application d’un plan d’expériences factoriel 几种抗菌物质协同或拮抗作用的测定:因子实验设计的应用

Phytotherapie Pub Date : 2018-11-04 DOI: 10.3166/PHYTO-2018-0076

T. Belaiche, F. Leriche

引用次数: 0

Phytochemical Screening, Phenolic Compounds Content, Antioxidant, Anti-inflammatory, and Antimicrobial Properties of Pachylobus balsamifera Guillaum from Gabon 加蓬香膏的植物化学筛选、酚类化合物含量、抗氧化、抗炎和抗菌特性

Phytotherapie Pub Date : 2018-10-26 DOI: 10.3166/PHYTO-2018-0059

Cédric Sima-Obiang, Rick-Leonid Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, J. Ondo, Louis-Clément Obame-Engonga, E. Nsi-Emvo

{"title":"Phytochemical Screening, Phenolic Compounds Content, Antioxidant, Anti-inflammatory, and Antimicrobial Properties of Pachylobus balsamifera Guillaum from Gabon","authors":"Cédric Sima-Obiang, Rick-Leonid Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, J. Ondo, Louis-Clément Obame-Engonga, E. Nsi-Emvo","doi":"10.3166/PHYTO-2018-0059","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0059","url":null,"abstract":"The goal of this work is to evaluate the antioxidant anti-inflammatory properties, the phenolic compounds content, and antimicrobial potential of water–acetone, water–ethanol, and water extracts of Pachylobus balsamifera. The phenolic compounds content was evaluated to estimate their effect on the antioxidant, anti-inflammatory, and antimicrobial potential of the plant. Antioxidant activities were examined by DPPH (2,2-diphenyl-1- picrylhydrazyl) and ABTS (2,2′-azino-bis) assays. Antiinflammatory activity was determined by the proteins denaturation inhibition method. All plant extracts were evaluated against six reference strains, eleven clinical isolates, and two fungal strains. Phenols content was highest in the water–acetone and water–ethanol extracts. The water extract showed strong anti-inflammatory effect. The water–acetone extract presented a strong antioxidant property and the highest antimicrobial activities against Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella Sp., and Neisseria meningitidis. The tested microorganisms showed sensitivity to all extracts of the plant with the exception of Escherichia coli 105182 CIP, Listeria innocua LMG 135668 BHI, Salmonella enterica, Salmonella typhi, and Neisseria gonorrhea. Our results suggest that Pachylobus balsamifera extracts contain antioxidant, anti-inflammatory, and antimicrobial properties.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44233048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Étude comparative de la composition chimique des huiles essentielles de Tetraclinis articulata (Vahl) Masters du Maroc 摩洛哥关节四角菌(Vahl)精油化学成分的比较研究

Phytotherapie Pub Date : 2018-10-26 DOI: 10.3166/PHYTO-2018-0082

M. Bourkhiss, A. Chaouch, M. Ouhssine, B.Bourkhiss

引用次数: 2

Chemical Profile, in vitro Antibacterial and Antioxidant Activities ofJuniperus phoeniceaL. and Cotula cinerea (Del.) Essential Oils from Southwestern Algeria 刺柏的化学性质、体外抗菌和抗氧化活性。和花椰菜(Del.)阿尔及利亚西南部的精油

Phytotherapie Pub Date : 2018-10-25 DOI: 10.3166/PHYTO-2018-0061

D. Ghouti, H. A. Lazouni, A. Moussaoui, D. C. Sari

{"title":"Chemical Profile, in vitro Antibacterial and Antioxidant Activities ofJuniperus phoeniceaL. and Cotula cinerea (Del.) Essential Oils from Southwestern Algeria","authors":"D. Ghouti, H. A. Lazouni, A. Moussaoui, D. C. Sari","doi":"10.3166/PHYTO-2018-0061","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0061","url":null,"abstract":"This work aims to study the chemical composition, antimicrobial and antioxidant activities ofJuniperus phoeniceaL. andCotula cinerea(Del.) essential oils from southwestern Algeria. The hydrodistilled oils obtained were characterized by gas chromatography–mass spectrometry (GC– MS). A total of 45 and 25 compounds were identified representing 100% ofJuniperus phoeniceaL. andCotula cinerea(Del.) respectively. The dominant component was α-pinene (46.437%) forJuniperus phoeniceaL. and α-thujone (32.35%) forCotula cinerea(Del.). The in vitro antibacterial activity of the essential oils was evaluated against nine foodborne pathogenic bacteria and one yeast, Candida albicans, using the disk diffusion method; the minimum inhibitory concentration (MIC) values were examined (micro dilution). The results suggest that the essential oil ofJuniperus phoeniceahas a significant to moderate antibacterial activity on all strains of bacteria. The most sensitive strains were Bacillus cereus, Bacillus subtilis,Micrococcus luteus,Pseudomonas aeruginosa, andCandida albicanswith (MIC = 0.04 to 0.63 mg/ml).Cotula cinereaoil showed moderate to low sensitivity to the test strains. Its best activity was against Bacillus subtilis (MIC = 0.303 mg/ml). The DPPH test conducted to evaluate the antioxidant activity of both oils showed a good to moderate capacity forJuniperus phoeniceaL. (concentration of an inhibitor when the response is reduced by half, IC50 = 0.76 mg/ml) andCotula cinerea(Del.) [IC50 = 28. mg/ml] oils respectively. The promising bioactivities of these plants suggest that they may be a new source of preservative molecules.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43433532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Chemical Composition and Antimicrobial Activity of the Saharo-endemic Species: Ammodaucus leucotrichus subsp. leucotrichus Coss & Dur (Apiaceae) 撒哈拉特有种白毛杉亚种的化学成分及抑菌活性。白毛茛(蜂科)

Phytotherapie Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0079

M. Touaibia, F. Saidi, D. Abdellali, F. Z. Raber Elmaizi

引用次数: 2

Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L. 摩洛哥蛇麻草的神经药理特征及化学分析。

Phytotherapie Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0058

Ghizlane Hajjaj, A. Bahlouli, M. Tajani, K. Alaoui, Y. Cherrah, A. Zellou

引用次数: 1

Antioxidant Activity and Determination of Gallic Acid and Quercetin in Osyris alba L. Root Extract. The Root Oil Contains Essential Fatty Acids Osyris alba L.根提取物抗氧化活性及没食子酸和槲皮素含量的测定。根油含有必需脂肪酸

Phytotherapie Pub Date : 2018-10-17 DOI: 10.3166/PHYTO-2018-0072

D. Khaldi, Meriem Belarbi, I. E. Haci, F. Atik, W. Zeriouh, F. Z. Ghanemi, A. Nani, A. Hichami

{"title":"Antioxidant Activity and Determination of Gallic Acid and Quercetin in Osyris alba L. Root Extract. The Root Oil Contains Essential Fatty Acids","authors":"D. Khaldi, Meriem Belarbi, I. E. Haci, F. Atik, W. Zeriouh, F. Z. Ghanemi, A. Nani, A. Hichami","doi":"10.3166/PHYTO-2018-0072","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0072","url":null,"abstract":"Osyris alba L. (Santalaceae) is a shrub that grows wildly in southern Europe, North Africa and South-west Asia. In Algeria, the decoction of the root bark of this plant has been used since ancient times in folk medicine by the local population in the region of the mountains of Béni- Snousse (South west of Tlemcen), as a fortifying, antianaemic and as an anti-inflammatory agent. The aim of this work was to evaluate the antioxidant activity of the phenolic compounds of the root by using DPPH, FRAP, TAC methods. Determination of the phenolic profile of the root extract was assessed using HPLC-DAD technique (High Performance Liquid Chromatography-Diode Array Detection). While the determination of total fatty acid composition of the root oil was performed using Gas Chromatography (GC-FID). From the results, the total poly-phenol extract of the root bark has shown the highest antioxidant power which exceeds the standard, namely, ascorbic acid and Trolox. The chromatographic analysis of the total poly-phenol extract has found that the Gallic acid and Quercetin are the major compounds. These results demonstrate that the phenolic compounds of Osyris alba root bark have a great potential as sources for natural health products. Gaseous Chromatography Assay of the oil has revealed the presence of two groups of fatty acids: arachidic acid (C20:0) and linoleic acid (C18: 9.12) known for its pro-inflammatory effect against oleic acid C18:1, linolénic acid C18: 9.12.15, and eicosatrienoic acid (ETA) C20:3 which are known for their pro-anti-inflammatory effect. For this reason, we need to test the effect of this oil on inflammatory models.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42992555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1