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Recent Results in Cancer Research最新文献

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Clinical Applications of Circulating Tumor Cells in Breast Cancer. 循环肿瘤细胞在乳腺癌中的临床应用。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_8
E. Cobain, C. Paoletti, J. Smerage, D. Hayes
{"title":"Clinical Applications of Circulating Tumor Cells in Breast Cancer.","authors":"E. Cobain, C. Paoletti, J. Smerage, D. Hayes","doi":"10.1007/978-3-030-26439-0_8","DOIUrl":"https://doi.org/10.1007/978-3-030-26439-0_8","url":null,"abstract":"","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"28 1","pages":"147-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87098725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Non-FDG PET/CT. Non-FDG PET / CT。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_20
Egesta Lopci, Stefano Fanti
{"title":"Non-FDG PET/CT.","authors":"Egesta Lopci,&nbsp;Stefano Fanti","doi":"10.1007/978-3-030-42618-7_20","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_20","url":null,"abstract":"<p><p>The major applications for molecular imaging with PET in clinical practice concern cancer imaging. Undoubtedly, 18F-FDG represents the backbone of nuclear oncology as it remains so far the most widely employed positron emitter compound. The acquired knowledge on cancer features, however, allowed the recognition in the last decades of multiple metabolic or pathogenic pathways within the cancer cells, which stimulated the development of novel radiopharmaceuticals. An endless list of PET tracers, substantially covering all hallmarks of cancer, has entered clinical routine or is being investigated in diagnostic trials. Some of them guard significant clinical applications, whereas others mostly bear a huge potential. This chapter summarizes a selected list of non-FDG PET tracers, described based on their introduction into and impact on clinical practice.</p>","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"669-718"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38092863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Clinical MR Biomarkers. 临床MR生物标志物。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_21
Daniel Paech, Heinz-Peter Schlemmer
{"title":"Clinical MR Biomarkers.","authors":"Daniel Paech,&nbsp;Heinz-Peter Schlemmer","doi":"10.1007/978-3-030-42618-7_21","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_21","url":null,"abstract":"<p><p>Non-invasive magnetic resonance imaging (MRI) techniques are increasingly applied in the clinic with a fast growing body of evidence regarding its value for clinical decision making. In contrast to biochemical or histological markers, the key advantages of imaging biomarkers are the non-invasive nature and the spatial and temporal resolution of these approaches. The following chapter focuses on clinical applications of novel MR biomarkers in humans with a strong focus on oncologic diseases. These include both clinically established biomarkers (part 1-4) and novel MRI techniques that recently demonstrated high potential for clinical utility (part 5-7).</p>","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"719-745"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38092864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Preclinical SPECT and SPECT-CT in Oncology. 肿瘤学的临床前SPECT和SPECT- ct。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_11
Benjamin L Franc, Youngho Seo, Robert Flavell, Carina Mari Aparici
{"title":"Preclinical SPECT and SPECT-CT in Oncology.","authors":"Benjamin L Franc,&nbsp;Youngho Seo,&nbsp;Robert Flavell,&nbsp;Carina Mari Aparici","doi":"10.1007/978-3-030-42618-7_11","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_11","url":null,"abstract":"<p><p>Molecular imaging enables both spatial and temporal understanding of the complex biologic systems underlying carcinogenesis and malignant spread. Single-photon emission tomography (SPECT) is a versatile nuclear imaging-based technique with ideal properties to study these processes in vivo in small animal models, as well as to identify potential drug candidates and characterize their antitumor action and potential adverse effects. Small animal SPECT and SPECT-CT (single-photon emission tomography combined with computer tomography) systems continue to evolve, as do the numerous SPECT radiopharmaceutical agents, allowing unprecedented sensitivity and quantitative molecular imaging capabilities. Several of these advances, their specific applications in oncology as well as new areas of exploration are highlighted in this chapter.</p>","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"359-404"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38094395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling. 通过循环肿瘤DNA分析捕获肿瘤异质性和克隆进化。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_11
F. Scherer
{"title":"Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling.","authors":"F. Scherer","doi":"10.1007/978-3-030-26439-0_11","DOIUrl":"https://doi.org/10.1007/978-3-030-26439-0_11","url":null,"abstract":"","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"3586 1","pages":"213-230"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86670998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring. 基于rna数字评分的循环肿瘤细胞定量分析。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_4
M. Kalinich, T. Kwan, M. Toner, D. Haber, S. Maheswaran
{"title":"Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring.","authors":"M. Kalinich, T. Kwan, M. Toner, D. Haber, S. Maheswaran","doi":"10.1007/978-3-030-26439-0_4","DOIUrl":"https://doi.org/10.1007/978-3-030-26439-0_4","url":null,"abstract":"","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"41 2 1","pages":"77-88"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75508839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internal Radiation Therapy. 内部放射治疗。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_29
Uwe Haberkorn, Clemens Kratochwil, Frederik Giesel
{"title":"Internal Radiation Therapy.","authors":"Uwe Haberkorn,&nbsp;Clemens Kratochwil,&nbsp;Frederik Giesel","doi":"10.1007/978-3-030-42618-7_29","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_29","url":null,"abstract":"<p><p>Targeted therapies are applied to increase the efficiency of antitumor treatment by simultaneously decreasing side effects. This can be achieved using carrier molecules which specifically bind to target structures or areas with remodeling activity. These carrier molecules may be coupled to chemotherapeutic drugs or to radioactive isotopes. In most cases, these carrier molecules are antibodies against tumor antigens, peptides, or small molecules which are binders for overexpressed receptors on tumor cells. The paradigm of endoradiotherapy is exemplified by the peptidic tracer DOTATOC which binds to somatostatin receptors and recently also small molecule inhibitors with high affinity for the prostate-specific membrane antigen.</p>","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"881-902"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38092264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Optical and Optoacoustic Imaging. 光学和光声成像。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_13
Joanna Napp, Andrea Markus, Frauke Alves
{"title":"Optical and Optoacoustic Imaging.","authors":"Joanna Napp,&nbsp;Andrea Markus,&nbsp;Frauke Alves","doi":"10.1007/978-3-030-42618-7_13","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_13","url":null,"abstract":"<p><p>The spatiotemporal determination of molecular events and cells is important for understanding disease processes, especially in oncology, and thus for the development of novel treatments. Equally important is the knowledge of the biodistribution, localization, and targeted accumulation of novel therapies as well as monitoring of tumor growth and therapeutic response. Optical imaging provides an ideal versatile platform for imaging of all these problems and questions.</p>","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"439-492"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38094397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Review ctDNA and Breast Cancer. 回顾ctDNA和乳腺癌。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_12
F. Clatot
{"title":"Review ctDNA and Breast Cancer.","authors":"F. Clatot","doi":"10.1007/978-3-030-26439-0_12","DOIUrl":"https://doi.org/10.1007/978-3-030-26439-0_12","url":null,"abstract":"","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"45 1","pages":"231-252"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84152072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Advances and Challenges of CAR T Cells in Clinical Trials. CAR - T细胞在临床试验中的进展和挑战。
Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-23765-3_3
A. Holzinger, H. Abken
{"title":"Advances and Challenges of CAR T Cells in Clinical Trials.","authors":"A. Holzinger, H. Abken","doi":"10.1007/978-3-030-23765-3_3","DOIUrl":"https://doi.org/10.1007/978-3-030-23765-3_3","url":null,"abstract":"","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"1 4 1","pages":"93-128"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88323463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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