Recent Results in Cancer Research最新文献

Systemic Treatment for Cholangiocarcinoma. 胆管癌的全身治疗。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_8

Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Piyakarn Watcharenwong, Thanachai Sanlung, Siraphong Putraveephong

{"title":"Systemic Treatment for Cholangiocarcinoma.","authors":"Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Piyakarn Watcharenwong, Thanachai Sanlung, Siraphong Putraveephong","doi":"10.1007/978-3-031-35166-2_8","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_8","url":null,"abstract":"Cholangiocarcinoma (CCA) is a diverse group of epithelial cancers that affect the biliary tree. The incidence of CCA is low in Western countries but significantly higher in endemic regions such as China and Thailand. Various risk factors contribute to the development of CCA. Recent studies have revealed molecular alterations in biliary tract cancers, providing insights into cholangiocarcinogenesis and potential targeted therapies. Surgical resection is the primary curative treatment for CCA. Adjuvant chemotherapy has been extensively studied, and some regimens have proven to be beneficial. Neoadjuvant chemotherapy has shown potential benefits in select cases, but its role remains controversial. In advanced stages, chemotherapy is the standard of care, and molecular profiling has identified potential targets such as FGFR, IDH1, HER2, and other tumor-agnostic therapies. Immunotherapy has demonstrated limited benefit in advanced CCA. This chapter provides an overview of the current evidence and ongoing research evaluating various chemotherapy regimens, targeted therapies, and immunotherapies across different stages of CCA.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and Control of Opisthorchis viverrini Infection: Implications for Cholangiocarcinoma Prevention. 猪瘟弧菌感染的流行病学和控制:对胆管癌预防的意义。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_3

Narong Khuntikeo, Bandit Thinkhamrop, Thomas Crellen, Chatanun Eamudomkarn, Trevor N Petney, Ross H Andrews, Paiboon Sithithaworn

{"title":"Epidemiology and Control of Opisthorchis viverrini Infection: Implications for Cholangiocarcinoma Prevention.","authors":"Narong Khuntikeo, Bandit Thinkhamrop, Thomas Crellen, Chatanun Eamudomkarn, Trevor N Petney, Ross H Andrews, Paiboon Sithithaworn","doi":"10.1007/978-3-031-35166-2_3","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_3","url":null,"abstract":"It is known that Opisthorchis viverrini (OV) is the most significant risk factor for the development of cholangiocarcinoma (CCA); hence, it is also known as carcinogenic parasite. Effective control and elimination of OV infection should significantly reduce O. viverrini-related CCA. This chapter includes details of the three recently developed innovative tools, namely the Isan cohort database software, an OV-RDT for screening of O. viverrini, and an ultrasound telecommunication system. Past and current control programs, i.e., education, medication, and sanitation were discussed and stressed the need for a comprehensive control program which encompasses primary, secondary, and tertiary patient care programs for confirmation and management of suspected CCA cases. The approach of mathematical modeling for control of OV and CCA was also briefly described. Additionally, we highlighted the current progress toward control of OV and CCA in Thailand and potential for expansion into nearby countries in Southeast Asia.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative Care in Cholangiocarcinoma. 胆管癌的姑息治疗。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_9

Attakorn Raksasataya, Anucha Ahooja, Vivian Krangbunkrong, Apiwat Jareanrat, Attapol Titapun, Narong Khuntikeo

引用次数: 1

RAW ATTITUDES: Socio-Cultures, Altered Landscapes, and Changing Perceptions of an Underestimated Disease. 原始的态度:社会文化、改变的景观和对一种被低估的疾病不断变化的看法。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_11

Carl Grundy-Warr, Ross H Andrews, Narong Khuntikeo, Trevor N Petney

{"title":"RAW ATTITUDES: Socio-Cultures, Altered Landscapes, and Changing Perceptions of an Underestimated Disease.","authors":"Carl Grundy-Warr, Ross H Andrews, Narong Khuntikeo, Trevor N Petney","doi":"10.1007/978-3-031-35166-2_11","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_11","url":null,"abstract":"Raw attitudes relate to the food cultures, eating habits, and behaviours of people in relation to the consumption of raw, partially cooked, and fermented freshwater fish dishes, which puts people at risk of Ophistochis viverrini and other parasitic infections. The chapter reviews raw attitudes within the countries and across the borders of the greater Mekong region, particularly northeast Thailand, Lao PDR, Vietnam, and Cambodia. Rather than treat each nation-state as an isolated epidemiological box, the chapter explores transborder complexity in relation to multiple anthropogenic transformations to the landscapes of the region and developmental impacts upon ecosystems and life cycles. Economic projects such as multiple hydropower dams, irrigation schemes, water-diversions, roads, and aquaculture ponds have significant impacts on FTZ life-cycle dynamics. In addition, many ecological changes are transboundary ones, and there are added complications relating human mobility, altered agrarian landscapes, and significant numbers of migrant workers. The chapter also examines public health programmes and educational interventions which are altering perceptions of O. viverrini and cholangiocarcinoma over time. A key argument is the need for transdisciplinary scientific and social science strategies alongside multi-pronged health interventions, such as 'the CASCAP model'. There exist many unknowns and gaps relating to widespread anthropogenic modifications upon life cycles, upon lifestyles, livelihoods, and human behaviours, which require research projects that span socio-economic, ecological, geographical, and public health dynamics of disease.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Imaging Techniques. 新成像技术。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_6

Nittaya Chamadol, Richard Syms, Vallop Laopaiboon, Julaluck Promsorn, Kulyada Eurboonyanun

引用次数: 0

Opisthorchis viverrini Life Cycle, Distribution, Systematics, and Population Genetics. viverrini阿片类动物的生命周期、分布、系统学和群体遗传学。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_2

Weerachai Saijuntha, Ross H Andrews, Paiboon Sithithaworn, Trevor N Petney

{"title":"Opisthorchis viverrini Life Cycle, Distribution, Systematics, and Population Genetics.","authors":"Weerachai Saijuntha, Ross H Andrews, Paiboon Sithithaworn, Trevor N Petney","doi":"10.1007/978-3-031-35166-2_2","DOIUrl":"10.1007/978-3-031-35166-2_2","url":null,"abstract":"Opisthorchis viverrini plays a key role as the carcinogenic liver fluke causing bile duct cancer in Southeast Asia. A comprehensive understanding of its life cycle, distribution, systematics, and population genetics is critically important as they underpin the effective development and establishment of future prevention and control programs that center on opisthorchiasis and cholangiocarcinoma. This chapter provides detailed information concerning the basic biology and updated information of O. viverrini related to its host life cycle, transmission route via raw, partially cooked or fermented freshwater cyprinid fish, endemic areas, and the discovery of new foci. Previous sequential studies over the last two decades on the phylogenetic and systematic relationships, genetic variation, and population genetics of O. viverrini as well as its snail intermediate host Bithynia spp. are presented and discussed, which have led to the currently known complex species level systematics and population genetics framework of this host-parasite system. Additionally, further directions for comprehensive research are suggested to provide a more complete understanding of liver fluke, O. viverrini-related cholangiocarcinoma.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery. 手术。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_7

Narong Khuntikeo, Ake Pugkhem, Tharatip Srisuk, Vor Luvira, Attapol Titapun, Theerawee Tipwaratorn, Vasin Thanasukarn, Vivian Klungboonkrong, Jitraporn Wongwiwatchai

引用次数: 0

Community Awareness and Education: In the West and Southeast Asia. 社区意识和教育:在西方和东南亚。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_12

Helen Morement, Narong Khuntikeo

引用次数: 0

The Hallmarks of Liver Fluke Related Cholangiocarcinoma: Insight into Drug Target Possibility. 肝吸虫相关胆管癌的特征:对药物靶点可能性的洞察。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_4

Watcharin Loilome, Nisana Namwat, Apinya Jusakul, Anchalee Techasen, Poramate Klanrit, Jutarop Phetcharaburanin, Arporn Wangwiwatsin

引用次数: 0

Introduction. 介绍。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_1

Narong Khuntikeo, Ross H Andrews, Trevor N Petney, Shahid A Khan

{"title":"Introduction.","authors":"Narong Khuntikeo, Ross H Andrews, Trevor N Petney, Shahid A Khan","doi":"10.1007/978-3-031-35166-2_1","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_1","url":null,"abstract":"Cholangiocarcinoma (CCA) is a lethal cancer arising in the bile ducts within and just outside the liver. It occurs worldwide and falls into two etiologically defined groups, one related to chronic liver fluke infection and the other not. Liver fluke-related CCA is found in continental Southeast Asia (caused by Opisthorchis viverrini with infection leading to opisthorchiasis), East Asia (Clonorchis sinensis), and Eastern Europe and Russia (Opisthorchis felineus). Both O. viverrini and C. sinensis are classified as group one carcinogens, while recent data from O. felineus suggest the same. In Southeast Asia, an estimated 67.3 million people are at risk of O. viverrini infection and subsequently developing CCA. When the three liver fluke species are considered, an estimated 700 million people are at risk of infection and developing CCA globally. The northeast of Thailand (Isan) is the world's hot spot of liver fluke infection and CCA. Early detection, diagnosis, and surgical intervention/curative treatment of CCA are critical to increase life expectancy and quality of life of people in the region and globally. Despite concentrated recent efforts focusing on a multidisciplinary approach to understand the ecology, epidemiology, biology, public health, and social significance of infection by cancer causing liver flukes, it remains an underestimated and under-resourced public health problem. In addition, it is still believed to be a regional problem without global significance-this is not the case. This book focuses on O. viverrini as the main causative agent of CCA in Southeast Asia, but many aspects detailed in the following chapters also relate to the two other liver fluke species. Our aim is to produce a holistic framework including the basic biology of O. viverrini and its relation to the epidemiology of the disease through diagnosis to treatment, including palliative methods, pathology, and control.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0