Recent Results in Cancer Research最新文献_第2页

Pathology of Cholangiocarcinoma. 胆管癌的病理。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_5

Supinda Koonmee, Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri, Waritta Kunprom, Piyapharom Intarawichian, Walailak Bamrungkit, Sakkarn Sangkhamanon, Malinee Thanee

引用次数: 0

Digital Innovations (Isan Cohort). 数字创新(Isan Cohort)。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_10

Bandit Thinkhamrop, Kavin Thinkhamrop, Chaiwat Tawarungrueng, Panuwat Prathumkham

引用次数: 0

Synopsis. 剧情简介。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_13

Narong Khuntikeo, Ross H Andrews, Trevor N Petney, Shahid A Khan

{"title":"Synopsis.","authors":"Narong Khuntikeo, Ross H Andrews, Trevor N Petney, Shahid A Khan","doi":"10.1007/978-3-031-35166-2_13","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_13","url":null,"abstract":"Cholangiocarcinoma (CCA) is the second most common primary liver cancer worldwide. Despite the severity of the disease and its impact on individuals, families, and communities, there remains an overall lack of awareness and interest in this disease. The information contained in the chapters of this book shows that this is indeed a significant public health and socioeconomic problem with varying levels of country-specific awareness. In Southeast Asia liver fluke, O. viverrini related CCA is endemic with the highest incidence worldwide in northeast Thailand, yet it is treatable and preventable. The chapters highlight significant advances in our knowledge of the biology and epidemiology of the O. viverrini species complex, intermediate hosts, systematics, population genetics, and the complexity of the three-host life cycle. A comprehensive conceptual framework has been developed to assist in understanding the complexity of molecular mechanisms of CCA carcinogenesis and cancer development which can result in improvement of targeted CCA therapy. There have been many advances in understanding the pathology of CCA in the biliary tract, including advances in prognosis and molecular pathogenesis. The development of different modalities and their advantages for diagnosis have increased diagnostic accuracy, providing reliable information allowing appropriate treatment and management programs to be selected for each patient. Particularly exciting is the recent development of a urine antigen assay which has revolutionized the diagnostic approach of opisthorchiasis due to its simplicity, the non-invasive nature of sample collection, and its ease of use in field settings. Significant in-roads and advances have been made in the surgical and systemic treatment of CCA patients. Additionally, a sophisticated data collection and analysis system, the Isan Cohort, has been developed and established for the treatment and control of CCA. Importantly, a greater understanding has been made of the social, community, religious, and anthropological issues initiating and sustaining the eating behavior of raw, partially cooked, and/or fermented fresh water fish. Specially designed education programs/curricula, based on currently available multidisciplinary hard data targeting school children, have been introduced since the inception of the Cholangiocarcinoma Screening and Care Program (CASCAP) and the subsequent strategic Fluke Free Thailand Model. The education program is being expanded to other provinces in Thailand and in the near future to other Southeast Asian countries, initially to Lao PDR, where the Fluke Free Lao PDR program has already been implemented. Despite advances that have been made in many disciplines focused on O. viverrini related CCA, raising awareness of CCA at all levels, particularly across endemic regions, is still needed, as is raising the awareness of CCA globally. As parasites and parasite related diseases have no borders, it is critical that ","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"219 ","pages":"361-367"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Functions and Virus-Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8. 与人类疱疹病毒发病和复制有关的新功能和病毒-宿主相互作用

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-57362-1_11

Young Bong Choi, Emily Cousins, John Nicholas

{"title":"Novel Functions and Virus-Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8.","authors":"Young Bong Choi, Emily Cousins, John Nicholas","doi":"10.1007/978-3-030-57362-1_11","DOIUrl":"https://doi.org/10.1007/978-3-030-57362-1_11","url":null,"abstract":"Human herpesvirus 8 (HHV-8) is classified as a γ2-herpesvirus and is related to Epstein-Barr virus (EBV), a γ1-herpesvirus. One important aspect of the γ-herpesviruses is their association with neoplasia, either naturally or in animal model systems. HHV-8 is associated with B-cell-derived primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD), endothelial-derived Kaposi's sarcoma (KS), and KSHV inflammatory cytokine syndrome (KICS). EBV is also associated with a number of B-cell malignancies, such as Burkitt's lymphoma, Hodgkin's lymphoma, and posttransplant lymphoproliferative disease, in addition to epithelial nasopharyngeal and gastric carcinomas. Despite the similarities between these viruses and their associated malignancies, the particular protein functions and activities involved in key aspects of virus biology and neoplastic transformation appear to be quite distinct. Indeed, HHV-8 specifies a number of proteins for which counterparts had not previously been identified in EBV, other herpesviruses, or even viruses in general, and these proteins are believed to play vital functions in virus biology and to be involved centrally in viral pathogenesis. Additionally, a set of microRNAs encoded by HHV-8 appears to modulate the expression of multiple host proteins to provide conditions conductive to virus persistence within the host and possibly contributing to HHV-8-induced neoplasia. Here, we review the molecular biology underlying these novel virus-host interactions and their potential roles in both virus biology and virus-associated disease.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":" ","pages":"245-301"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38610571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Chapter XX Antiviral Treatment and Cancer Control. 第二十章抗病毒治疗与肿瘤控制。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-57362-1_13

Wei-Liang Shih, Chi-Tai Fang, Pei-Jer Chen

{"title":"Chapter XX Antiviral Treatment and Cancer Control.","authors":"Wei-Liang Shih, Chi-Tai Fang, Pei-Jer Chen","doi":"10.1007/978-3-030-57362-1_13","DOIUrl":"https://doi.org/10.1007/978-3-030-57362-1_13","url":null,"abstract":"Hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), Epstein-Barr virus (EBV), human T-cell lymphotropic virus type 1 (HTLV-1), Kaposi's sarcoma-associated herpesvirus (KSHV), and Merkel cell polyomavirus (MCV) contribute to about 10-15% global burden of human cancers. Conventional chemotherapy or molecular target therapies have been used to treat virus-associated cancers. However, a more proactive approach would be the use of antiviral treatment to suppress or eliminate viral infections to prevent the occurrence of cancer in the first place. Antiviral treatments against chronic HBV and HCV infection have achieved this goal, with significant reduction in the incidence of hepatocellular carcinoma in treated patients. Antiviral treatments for EBV, KSHV, and HTLV-1 had limited success in treating refractory EBV-associated lymphoma and post-transplant lymphoproliferative disorder, KSHV-associated Kaposi's sarcoma in AIDS patients, and HTLV-1-associated acute, chronic, and smoldering subtypes of adult T-cell lymphoma, respectively. Therapeutic HPV vaccine and RNA interference-based therapies for treating HPV-associated infection or cervical cancers also showed some encouraging results. Taken together, antiviral therapies have yielded promising results in cancer prevention and treatment. More large-scale studies in a real-world setting are necessary to confirm the efficacy of antiviral therapy. Further investigation for more effective and convenient antiviral regimens warrants more attention.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":" ","pages":"325-354"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38610573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experiencing Cancer. An Ethnographic Study on Illness and Disease. 经历过癌症。疾病与疾病的民族志研究。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-63749-1_16

Christine Holmberg

{"title":"Experiencing Cancer. An Ethnographic Study on Illness and Disease.","authors":"Christine Holmberg","doi":"10.1007/978-3-030-63749-1_16","DOIUrl":"https://doi.org/10.1007/978-3-030-63749-1_16","url":null,"abstract":"Cancer is seen as a 'dread disease' with a long and powerful history that remains resistant to defeat. It is a byword for suffering, pain and death. An unprecedented level of research spending and biomedical engagement offering new treatment options and hopes for a cure goes hand in hand with patient-led movements disseminating widespread public narratives of hope and survivorship. A key paradigm in these public narratives of hope and cure has been early detection of disease, with breast cancer, as the most frequent cancer among women, at the forefront of early detection campaigns. This chapter investigates the experiences behind the public face of breast cancer. It interrogates what it means to have breast cancer in the light of heroic stories of survivorship and fight using the theoretical concepts of illness-the subjective experience of feeling unwell-and disease-bodily pathologies that are identified through biomedical diagnostic technologies. With early detection becoming the primary mode of practice in breast cancer, illness has to be re-conceptualized. If a woman is to undergo treatment after a diagnosis of asymptomatic disease-without symptoms being present in her lifeworld-she has to cognitively understand the severity of the disease, and assume that she would die without treatment. The absence of bodily experiences of symptoms is irrelevant: it is the provision of information through which illness can manifest. The shock of diagnosis, as so often illustrated in cancer narratives, is therefore necessary in order to transform disease into an illness trajectory associated with biomedical treatment. The particular illness experiencehas profound and long-lasting consequences for a woman's life. Understanding the suffering associated with such disease conceptions as a necessary part of the illness experience could help us to improve health care services for those afflicted.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"218 ","pages":"245-257"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39005799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

'The King of Diseases': An Essay on the Special Attention Paid to Cancer Patients and How It Came About. “疾病之王”:对癌症患者的特别关注及其由来的随笔。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-63749-1_1

Wolfgang U Eckart

{"title":"'The King of Diseases': An Essay on the Special Attention Paid to Cancer Patients and How It Came About.","authors":"Wolfgang U Eckart","doi":"10.1007/978-3-030-63749-1_1","DOIUrl":"https://doi.org/10.1007/978-3-030-63749-1_1","url":null,"abstract":"The history of cancer during the twentieth century demonstrates that various factors have contributed to the perception of cancer as the 'Emperor of All Maladies', although this has never been true from an epidemiological perspective. Depending on the geographical area, infectious diseases such as tuberculosis, malaria or cardiovascular disease still head the list of the most common illnesses. Within the group of chronic-degenerative diseases, however, cancer has outdistanced the widespread classic infectious diseases as a result of the epidemiologic transition around 1900, at least in the more developed countries. Under the Nazi dictatorship from 1933 to 1945, the perception of cancer in Germany was particularly promoted for propaganda purposes. In the atomic era, cancer began to attract strong public interest as a worthwhile object of research in radiation therapies using large-scale facilities (electron accelerators, 'electron guns'). A further upsurge of interest in cancer was then registered in the context of the debate about the pathogenic role of environmental factors. The remarkable thing is that this increased perception of cancer has not yet been significantly associated with any overarching success in cancer treatment, but it has been associated with ideologies, hopes and advances in technology.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"218 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39005903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer, the Media and Dealing with Knowledge. 巨蟹座、媒体和知识处理。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-63749-1_8

Florian Steger, Maximilian Schochow

引用次数: 0

Routine Oncology Treatment and Its Human Deficits. 常规肿瘤治疗及其人类缺陷。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-63749-1_15

Ralf-Dieter Hofheinz

引用次数: 0

Prevention of Hepatitis B Virus Infection and Liver Cancer. 预防乙型肝炎病毒感染和肝癌。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-57362-1_4

Mei-Hwei Chang

{"title":"Prevention of Hepatitis B Virus Infection and Liver Cancer.","authors":"Mei-Hwei Chang","doi":"10.1007/978-3-030-57362-1_4","DOIUrl":"https://doi.org/10.1007/978-3-030-57362-1_4","url":null,"abstract":"Hepatocellular carcinoma (HCC) is one of the five leading causes of cancer death in human. Hepatitis B virus (HBV) is the most common etiologic agent of HCC in the world. Prevention is the best way to control cancer. There are three levels of liver cancer prevention, i.e., primary prevention by HBV vaccination targeting the general population starting from birth dose, secondary prevention by antiviral agent for high-risk subjects with chronic HBV infection, and tertiary prevention by antiviral agent to prevent recurrence for patients who have been successfully treated for liver cancer. Primary prevention by hepatitis B vaccination is most cost effective, the cancer preventive efficacy support it as the first successful example of cancer preventive vaccine in human. Addition of hepatitis B immunoglobulin immediately after birth and antiviral agent during the third trimester of pregnancy to block mother-to-infant transmission of HBV are existing or possible emerging strategies to enhance the prevention efficacy of HBV infection and its related liver cancer. Secondary prevention with current antiviral agents may reduce the risk or delay the onset of HCC development, but could not eradicate HBV infection and HCC. Better antiviral therapeutic agents are needed for better secondary prevention.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":" ","pages":"71-90"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38705915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3