Recent Results in Cancer Research最新文献_第2页

Recent Results in Cancer Research Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-80396-3_5

Stefan Delorme, Friedhelm Raue, Bettina Beuthien-Baumann

{"title":"Medullary Thyroid Carcinoma: Imaging.","authors":"Stefan Delorme, Friedhelm Raue, Bettina Beuthien-Baumann","doi":"10.1007/978-3-031-80396-3_5","DOIUrl":"https://doi.org/10.1007/978-3-031-80396-3_5","url":null,"abstract":"Imaging plays an important role in the early detection and staging of medullary thyroid carcinoma (MTC), as well as in follow-up to locate early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy that is often diagnosed by ultrasound and calcitonin screening as part of the routine evaluation of any thyroid nodule. If serum calcitonin is elevated, imaging studies are needed for preoperative staging to guide surgical management. This may include ultrasound of the neck and abdomen. CT or MRI studies for more distant disease are performed preoperatively when calcitonin levels are greater than 500 pg/mL. Neither FDG-PET/CT nor F-DOPA-PET/CT is routinely being used for preoperative staging, but may be helpful in individual cases of doubt. Postoperative elevated calcitonin is associated with persistence or recurrence of MTC. Imaging studies to localize tumor tissue in postoperative follow-up include ultrasound, CT, MRI, and PET scans. However, they should be used judiciously, as the impact of treatment is often limited. In addition, even patients with persistent disease may survive long enough to accumulate significant radiation doses from CT or PET scans. Imaging studies are also useful in diagnosing associated components of hereditary MTC, such as pheochromocytoma and primary hyperparathyroidism.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"223 ","pages":"129-153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Treatment of Medullary Thyroid Cancer.

Recent Results in Cancer Research Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-80396-3_10

Andreas Machens, Henning Dralle

{"title":"Surgical Treatment of Medullary Thyroid Cancer.","authors":"Andreas Machens, Henning Dralle","doi":"10.1007/978-3-031-80396-3_10","DOIUrl":"https://doi.org/10.1007/978-3-031-80396-3_10","url":null,"abstract":"Medullary thyroid cancer (MTC) is an infrequent calcitonin-secreting thyroid malignancy that can vary a great deal in tumor biology and progression. The most important determinant of distant metastases, which represents the single greatest risk factor of poor cancer-specific survival, is lymph node metastasis in the neck and mediastinum. In patients with node-positive MTC, systematic compartment-oriented dissection of central and lateral neck nodes at the initial operation promotes biochemical cure and decreases the risk of locoregional recurrence in previously dissected lymph node compartments. Routine calcitonin screening in nodular thyroid disease and genomic screening, flanked by advances in ultrasound and functional imaging modalities, have been pivotal in making the diagnosis early and enabling risk-reducing surgical interventions in patients with sporadic and hereditary MTC, without compromising clinical outcome. To assess a RET carrier's risk of medullary thyroid cancer, all that is needed is patient age, underlying RET mutation, and biomarker levels. Recently, risk-reducing surgery, consisting in hemithyroidectomy with or without diagnostic ipsilateral central lymph node dissection, has been advocated for sporadic MTC clinically confined to one thyroid lobe that is desmoplasia negative on intraoperative frozen sectioning. These recent developments reflect the current shift from reactive to increasingly preemptive, risk-reducing surgery for MTC.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"223 ","pages":"247-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Treatment for Cholangiocarcinoma. 胆管癌的全身治疗。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_8

Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Piyakarn Watcharenwong, Thanachai Sanlung, Siraphong Putraveephong

{"title":"Systemic Treatment for Cholangiocarcinoma.","authors":"Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Piyakarn Watcharenwong, Thanachai Sanlung, Siraphong Putraveephong","doi":"10.1007/978-3-031-35166-2_8","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_8","url":null,"abstract":"Cholangiocarcinoma (CCA) is a diverse group of epithelial cancers that affect the biliary tree. The incidence of CCA is low in Western countries but significantly higher in endemic regions such as China and Thailand. Various risk factors contribute to the development of CCA. Recent studies have revealed molecular alterations in biliary tract cancers, providing insights into cholangiocarcinogenesis and potential targeted therapies. Surgical resection is the primary curative treatment for CCA. Adjuvant chemotherapy has been extensively studied, and some regimens have proven to be beneficial. Neoadjuvant chemotherapy has shown potential benefits in select cases, but its role remains controversial. In advanced stages, chemotherapy is the standard of care, and molecular profiling has identified potential targets such as FGFR, IDH1, HER2, and other tumor-agnostic therapies. Immunotherapy has demonstrated limited benefit in advanced CCA. This chapter provides an overview of the current evidence and ongoing research evaluating various chemotherapy regimens, targeted therapies, and immunotherapies across different stages of CCA.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"219 ","pages":"223-244"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and Control of Opisthorchis viverrini Infection: Implications for Cholangiocarcinoma Prevention. 猪瘟弧菌感染的流行病学和控制:对胆管癌预防的意义。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_3

Narong Khuntikeo, Bandit Thinkhamrop, Thomas Crellen, Chatanun Eamudomkarn, Trevor N Petney, Ross H Andrews, Paiboon Sithithaworn

{"title":"Epidemiology and Control of Opisthorchis viverrini Infection: Implications for Cholangiocarcinoma Prevention.","authors":"Narong Khuntikeo, Bandit Thinkhamrop, Thomas Crellen, Chatanun Eamudomkarn, Trevor N Petney, Ross H Andrews, Paiboon Sithithaworn","doi":"10.1007/978-3-031-35166-2_3","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_3","url":null,"abstract":"It is known that Opisthorchis viverrini (OV) is the most significant risk factor for the development of cholangiocarcinoma (CCA); hence, it is also known as carcinogenic parasite. Effective control and elimination of OV infection should significantly reduce O. viverrini-related CCA. This chapter includes details of the three recently developed innovative tools, namely the Isan cohort database software, an OV-RDT for screening of O. viverrini, and an ultrasound telecommunication system. Past and current control programs, i.e., education, medication, and sanitation were discussed and stressed the need for a comprehensive control program which encompasses primary, secondary, and tertiary patient care programs for confirmation and management of suspected CCA cases. The approach of mathematical modeling for control of OV and CCA was also briefly described. Additionally, we highlighted the current progress toward control of OV and CCA in Thailand and potential for expansion into nearby countries in Southeast Asia.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"219 ","pages":"27-52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative Care in Cholangiocarcinoma. 胆管癌的姑息治疗。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_9

Attakorn Raksasataya, Anucha Ahooja, Vivian Krangbunkrong, Apiwat Jareanrat, Attapol Titapun, Narong Khuntikeo

引用次数: 1

RAW ATTITUDES: Socio-Cultures, Altered Landscapes, and Changing Perceptions of an Underestimated Disease. 原始的态度:社会文化、改变的景观和对一种被低估的疾病不断变化的看法。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_11

Carl Grundy-Warr, Ross H Andrews, Narong Khuntikeo, Trevor N Petney

{"title":"RAW ATTITUDES: Socio-Cultures, Altered Landscapes, and Changing Perceptions of an Underestimated Disease.","authors":"Carl Grundy-Warr, Ross H Andrews, Narong Khuntikeo, Trevor N Petney","doi":"10.1007/978-3-031-35166-2_11","DOIUrl":"https://doi.org/10.1007/978-3-031-35166-2_11","url":null,"abstract":"Raw attitudes relate to the food cultures, eating habits, and behaviours of people in relation to the consumption of raw, partially cooked, and fermented freshwater fish dishes, which puts people at risk of Ophistochis viverrini and other parasitic infections. The chapter reviews raw attitudes within the countries and across the borders of the greater Mekong region, particularly northeast Thailand, Lao PDR, Vietnam, and Cambodia. Rather than treat each nation-state as an isolated epidemiological box, the chapter explores transborder complexity in relation to multiple anthropogenic transformations to the landscapes of the region and developmental impacts upon ecosystems and life cycles. Economic projects such as multiple hydropower dams, irrigation schemes, water-diversions, roads, and aquaculture ponds have significant impacts on FTZ life-cycle dynamics. In addition, many ecological changes are transboundary ones, and there are added complications relating human mobility, altered agrarian landscapes, and significant numbers of migrant workers. The chapter also examines public health programmes and educational interventions which are altering perceptions of O. viverrini and cholangiocarcinoma over time. A key argument is the need for transdisciplinary scientific and social science strategies alongside multi-pronged health interventions, such as 'the CASCAP model'. There exist many unknowns and gaps relating to widespread anthropogenic modifications upon life cycles, upon lifestyles, livelihoods, and human behaviours, which require research projects that span socio-economic, ecological, geographical, and public health dynamics of disease.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"219 ","pages":"281-347"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Imaging Techniques. 新成像技术。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_6

Nittaya Chamadol, Richard Syms, Vallop Laopaiboon, Julaluck Promsorn, Kulyada Eurboonyanun

引用次数: 0

Opisthorchis viverrini Life Cycle, Distribution, Systematics, and Population Genetics. viverrini阿片类动物的生命周期、分布、系统学和群体遗传学。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_2

Weerachai Saijuntha, Ross H Andrews, Paiboon Sithithaworn, Trevor N Petney

{"title":"Opisthorchis viverrini Life Cycle, Distribution, Systematics, and Population Genetics.","authors":"Weerachai Saijuntha, Ross H Andrews, Paiboon Sithithaworn, Trevor N Petney","doi":"10.1007/978-3-031-35166-2_2","DOIUrl":"10.1007/978-3-031-35166-2_2","url":null,"abstract":"Opisthorchis viverrini plays a key role as the carcinogenic liver fluke causing bile duct cancer in Southeast Asia. A comprehensive understanding of its life cycle, distribution, systematics, and population genetics is critically important as they underpin the effective development and establishment of future prevention and control programs that center on opisthorchiasis and cholangiocarcinoma. This chapter provides detailed information concerning the basic biology and updated information of O. viverrini related to its host life cycle, transmission route via raw, partially cooked or fermented freshwater cyprinid fish, endemic areas, and the discovery of new foci. Previous sequential studies over the last two decades on the phylogenetic and systematic relationships, genetic variation, and population genetics of O. viverrini as well as its snail intermediate host Bithynia spp. are presented and discussed, which have led to the currently known complex species level systematics and population genetics framework of this host-parasite system. Additionally, further directions for comprehensive research are suggested to provide a more complete understanding of liver fluke, O. viverrini-related cholangiocarcinoma.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"219 ","pages":"7-25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery. 手术。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_7

Narong Khuntikeo, Ake Pugkhem, Tharatip Srisuk, Vor Luvira, Attapol Titapun, Theerawee Tipwaratorn, Vasin Thanasukarn, Vivian Klungboonkrong, Jitraporn Wongwiwatchai

引用次数: 0

Community Awareness and Education: In the West and Southeast Asia. 社区意识和教育:在西方和东南亚。

Recent Results in Cancer Research Pub Date : 2023-01-01 DOI: 10.1007/978-3-031-35166-2_12

Helen Morement, Narong Khuntikeo

引用次数: 0