Recent Results in Cancer Research最新文献_第10页

Optical and Optoacoustic Imaging. 光学和光声成像。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_5

Daniel Razansky, Vasilis Ntziachristos

{"title":"Optical and Optoacoustic Imaging.","authors":"Daniel Razansky, Vasilis Ntziachristos","doi":"10.1007/978-3-030-42618-7_5","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_5","url":null,"abstract":"The present chapter summarizes progress with optical methods that go beyond human vision. The focus is on two particular technologies: fluorescence molecular imaging and optoacoustic (photoacoustic) imaging. The rationale for the selection of these two methods is that in contrast to optical microscopy techniques, both fluorescence and optoacoustic imaging can achieve large fields of view, i.e., spanning several centimeters in two or three dimensions. Such fields of views relate better to human vision and can visualize large parts of tissue, a necessary premise for clinical detection. Conversely, optical microscopy methods only scan millimeter-sized dimensions or smaller. With such operational capacity, optical microscopy methods need to be guided by another visualization technique in order to scan a very specific area in tissue and typically only provide superficial measurements, i.e., information from depths that are of the order of 0.05-1 mm. This practice has generally limited their clinical applicability to some niche applications, such as optical coherence tomography of the retina. On the other hand, fluorescence molecular imaging and optoacoustic imaging emerge as more global optical imaging methods with wide applications in surgery, endoscopy, and non-invasive clinical imaging, as summarized in the following. The current progress in this field is based on a volume of recent review and other literature that highlights key advances achieved in technology and biomedical applications. Context and figures from references from the authors of this chapter have been used here, as it reflects our general view of the current status of the field.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"155-187"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38097979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multifunctional Magnetic Resonance Imaging Probes. 多功能磁共振成像探头。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_6

Philipp Biegger, Mark E Ladd, Dorde Komljenovic

{"title":"Multifunctional Magnetic Resonance Imaging Probes.","authors":"Philipp Biegger, Mark E Ladd, Dorde Komljenovic","doi":"10.1007/978-3-030-42618-7_6","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_6","url":null,"abstract":"Magnetic resonance imaging is characterized by high spatial resolution and unsurpassed soft tissue discrimination. Development and characterization of both intrinsic and extrinsic magnetic resonance (MR) imaging probes in the last decade has further strengthened the pivotal role MR imaging holds in the assessment of cancer in preclinical and translational settings. Sophisticated chemical modifications of a variety of nanoparticulate probes hold the potential to deliver valuable multifunctional tools applicable in diagnostics and/or treatment in human oncology. MR imaging suffers from a lack of sensitivity achievable by, e.g., nuclear medicine imaging methods. Advantages of including additional functionality/functionalities in a probe suitable for MR imaging are thus numerous, comprising the addition of fundamentally different imaging information (diagnostics), drug delivery (therapy), or the combination of both (theranostics). In recent years, we have witnessed a plethora of preclinical multimodal or multifunctional imaging probes being published mainly as proof-of-principle studies, yet only a handful are readily applicable in clinical settings. This chapter summarizes recent innovations in the development of multifunctional MR imaging probes and discusses the suitability of these probes for clinical transfer.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"189-226"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38097980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Advanced X-ray Imaging Technology. 先进的x射线成像技术。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_1

Daniela Pfeiffer, Franz Pfeiffer, Ernst Rummeny

{"title":"Advanced X-ray Imaging Technology.","authors":"Daniela Pfeiffer, Franz Pfeiffer, Ernst Rummeny","doi":"10.1007/978-3-030-42618-7_1","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_1","url":null,"abstract":"Since their discovery by Wilhelm Conrad Röntgen in 1895, X-rays have become the most widely available, typically fastest, and usually most cost-effective medical imaging modality today. From the early radiographic approaches using X-ray films as detectors, the portfolio of medical X-ray imaging devices developed into a large range of dedicated instrumentation for various applications. While X-ray imaging has come a long way, there are some physical properties of X-rays, which have not yet been fully exploited, and which may offer quite some room for further enhancements of current X-ray imaging equipment. Firstly, X-ray imaging today is mainly black and white, despite the fact that X-ray generators actually create a full spectrum of X-ray energies, and that the interactions of X-rays that occur within the human body are not the same for all energies and every material. Exploiting these spectral dependencies allows to not only obtain a black and white CT image, but also to obtain more molecularly specific information, which is relevant particularly in oncological precision radiology. The second aspect of X-rays, and so far in radiology mainly neglected and unused, is the physical fact that X-rays can also be interpreted in the wave picture, and not only as presently been done in the particle picture. If interpreted as waves, X-rays-just like visible light-experience a phase shift in matter, and this-if exploited correctly-can produce a new class of X-ray images, which then depict the wave interactions of X-rays with matter, rather than only the attenuating properties, as done until now.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"3-30"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38098003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Extracellular Vesicles: Recent Developments in Technology and Perspectives for Cancer Liquid Biopsy. 细胞外囊泡:癌症液体活检技术的最新进展和前景。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_17

I. Nazarenko

引用次数: 22

Circulating Tumor Cell Enrichment Technologies. 循环肿瘤细胞富集技术。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_2

Mert Boya, Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov, A. F. Sarioglu

引用次数: 15

Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis. 循环肿瘤细胞:CTCs的高通量成像和生物信息学分析。

Recent Results in Cancer Research Pub Date : 2019-10-12 DOI: 10.1007/978-3-030-26439-0_5

Kevin Keomanee-Dizon, S. Shishido, P. Kuhn

引用次数: 6

Circulating Tumor Cells in Breast Cancer. 乳腺癌中的循环肿瘤细胞。

Recent Results in Cancer Research Pub Date : 2019-10-12 DOI: 10.1007/978-3-030-26439-0_7

D. Liang, C. Hall, A. Lucci

引用次数: 11

Circulating MicroRNAs as Potential Biomarkers for Lung Cancer. 循环microrna作为肺癌潜在的生物标志物。

Recent Results in Cancer Research Pub Date : 2019-10-12 DOI: 10.1007/978-3-030-26439-0_16

Sabrina Müller, F. Janke, S. Dietz, H. Sültmann

引用次数: 24

Colorectal cancer. 结直肠癌。

Recent Results in Cancer Research Pub Date : 2019-05-01 DOI: 10.1007/978-1-84628-504-2_5

B. Greef, E. Smyth

引用次数: 0

Regulatory and Evidence Requirements and the Changing Landscape in Regulation for Marketing Authorisation. 监管和证据要求以及上市许可监管的变化。

Recent Results in Cancer Research Pub Date : 2019-01-01 DOI: 10.1007/978-3-030-01207-6_11

Francesco Pignatti, Elias Péan

引用次数: 1