Recent Results in Cancer Research最新文献_第10页

Epidemiology of Virus Infection and Human Cancer. 病毒感染与人类癌症的流行病学。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-57362-1_2

Chien-Jen Chen, San-Lin You, Wan-Lun Hsu, Hwai-I Yang, Mei-Hsuan Lee, Hui-Chi Chen, Yun-Yuan Chen, Jessica Liu, Hui-Han Hu, Yu-Ju Lin, Yu-Ju Chu, Yen-Tsung Huang, Chun-Ju Chiang, Yin-Chu Chien

{"title":"Epidemiology of Virus Infection and Human Cancer.","authors":"Chien-Jen Chen, San-Lin You, Wan-Lun Hsu, Hwai-I Yang, Mei-Hsuan Lee, Hui-Chi Chen, Yun-Yuan Chen, Jessica Liu, Hui-Han Hu, Yu-Ju Lin, Yu-Ju Chu, Yen-Tsung Huang, Chun-Ju Chiang, Yin-Chu Chien","doi":"10.1007/978-3-030-57362-1_2","DOIUrl":"https://doi.org/10.1007/978-3-030-57362-1_2","url":null,"abstract":"Seven viruses including the Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), Kaposi's sarcoma herpes virus (KSHV), human immunodeficiency virus, type-1 (HIV-1), human T cell lymphotrophic virus, type-1 (HTLV-1), and human papillomavirus (HPV) have been classified as Group 1 human carcinogens by the International Agency for Research on Cancer (IARC). The conclusions are based on the findings of epidemiological and mechanistic studies. EBV, HPV, HTLV-1, and KSHV are direct carcinogens; HBV and HCV are indirect carcinogens through chronic inflammation; and HIV-1 is an indirect carcinogen through immune suppression. Some viruses may cause more than one cancer, while some cancers may be caused by more than one virus. However, only a proportion of persons infected by these oncogenic viruses will develop specific cancers. A series of studies have been carried out to assess the viral, host, and environmental cofactors of EBV-associated nasopharyngeal carcinoma, HBV/HCV-associated hepatocellular carcinoma, and HPV-associated cervical carcinoma. Persistent infection, high viral load, and viral genotype are important risk predictors of these virus-caused cancers. Risk calculators incorporating host and viral risk predictors have been developed for the prediction of long-term risk of hepatocellular carcinoma, nasopharyngeal carcinoma and cervical cancer. These risk calculators are useful for the triage and clinical management of infected patients. Both clinical trials and national programs of immunization, antiviral therapy and screening have demonstrated a significant reduction in the incidence of cancers caused by HBV, HCV, and HPV. Future research on gene-gene and gene-environment interactions of oncogenic viruses and the human host using large-scale longitudinal studies with serial measurements of biosignatures are in urgent need.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":" ","pages":"13-45"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38610144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Merkel Cell Polyomavirus and Human Merkel Cell Carcinoma. 梅克尔细胞多瘤病毒与人梅克尔细胞癌。

Recent Results in Cancer Research Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-57362-1_12

Wei Liu, Jianxin You

引用次数: 3

Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer. 乳腺肿瘤和胃肠道肿瘤的荧光成像。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_18

Dirk Grosenick, Christoph Bremer

{"title":"Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer.","authors":"Dirk Grosenick, Christoph Bremer","doi":"10.1007/978-3-030-42618-7_18","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_18","url":null,"abstract":"Optical imaging offers a high potential for noninvasive detection and therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging was made applicable as a sensitive technique to image molecular probes in vivo. We review recent developments in the detection of breast cancer and fluorescence-guided surgery of the breast by contrast agents available for application on humans. Detection of cancer has been investigated with the unspecific contrast agents \"indocyanine green\" and \"omocianine\" so far. Hereby, indocyanine green was found to offer high potential for the differentiation of malignant and benign lesions by exploiting vessel permeability for macromolecules as a cancer-specific feature. Tumor-specific molecular targeting and activatable probes have been investigated in clinical trials for fluorescence-guided tumor margin detection. In this application, high spatial resolution can be achieved, since tumor regions are visualized mainly at the tissue surface. As another example of superficial tumor tissue, imaging of lesions in the gastrointestinal tract is discussed. Promising results have been obtained on high-risk patients with Barrett´s esophagus and with ulcerative colitis by administering 5-aminolevulinic acid which induces accumulation of protoporphyrin IX serving as a tumor-specific fluorescent marker. Time-gated fluorescence imaging and spectroscopy are effective ways to suppress underlying background from tissue autofluorescence. Furthermore, recently developed tumor-specific molecular probes have been demonstrated to be superior to white-light endoscopy offering new ways for early detection of malignancies in the gastrointestinal tract.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"591-624"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38092861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

¹⁸F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer. 18f标记的小分子和低分子量PET示踪剂用于癌症的无创检测。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_8

Christopher M Waldmann, Klaus Kopka, Stefan Wagner

{"title":"18F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer.","authors":"Christopher M Waldmann, Klaus Kopka, Stefan Wagner","doi":"10.1007/978-3-030-42618-7_8","DOIUrl":"https://doi.org/10.1007/978-3-030-42618-7_8","url":null,"abstract":"Noninvasive molecular imaging of cancer by means of the scintigraphic imaging modalities PET, PET/CT, and PET/MRI represents a powerful diagnostic tool in modern nuclear medicine. Radiotracers labeled with the prominent positron emitter fluorine-18 are routinely used to target and visualize discrete biological structures dysregulated in the progression of cancer. Such tracers are therefore capable of detecting oncological pathologies in vivo at the cellular and subcellular level in a timely manner and are thereby used for early detection of cancer as well as monitoring for treatment response. This chapter describes a variety of important 18F-labeled radiopharmaceuticals that are frequently used in oncological PET imaging. Small-molecule and low-molecular-weight radiotracers for the detection of glucose utilization, amino acid transport, protein synthesis, membrane lipid synthesis, cell proliferation, cell death, hypoxia, estrogen receptor status, prostate-specific membrane antigen (PSMA) expression, and bone mineralization of tumors are introduced. The structural properties, common radiochemical synthesis approaches as well as in vivo metabolism and accumulation mechanisms of the clinically most important 18F-labeled radiotracers are described.","PeriodicalId":39880,"journal":{"name":"Recent Results in Cancer Research","volume":"216 ","pages":"283-318"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38094392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC. 肿瘤细胞释放进入循环的病理生理及CTC的特性。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_1

T. Todenhöfer, K. Pantel, A. Stenzl, S. Werner

引用次数: 3

Dynamic Treatment Stratification Using ctDNA. 利用ctDNA进行动态治疗分层。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_14

J. Vidal, Á. Taus, C. Montagut

引用次数: 11

Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications. ctDNA释放进入循环的病理生理学及其特征:对临床应用的重要意义。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_9

N. Papadopoulos

引用次数: 22

Computational Analysis of DNA and RNA Sequencing Data Obtained from Liquid Biopsies. 液体活检获得的DNA和RNA测序数据的计算分析。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-26439-0_18

F. Marass, F. Castro-Giner, B. Szczerba, Katharina Jahn, Jack Kuipers, N. Aceto, N. Beerenwinkel

引用次数: 1

The Era of Checkpoint Inhibition: Lessons Learned from Melanoma. 检查点抑制的时代:从黑色素瘤中吸取的教训。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-23765-3_6

A. Paschen, D. Schadendorf

引用次数: 6

Advanced Ultrasound Imaging for Patients in Oncology: DCE-US. 肿瘤患者的高级超声成像:DCE-US。

Recent Results in Cancer Research Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-42618-7_23

Nathalie Lassau

引用次数: 0