Ceska a Slovenska Oftalmologie最新文献

{"title":"Quantifying Gaze Tracking for Visual Field Reliability Estimation. A Systematic Review.","authors":"Luisa Fernanda Peña-Pulgar, Alejandro Tello, María Fernanda Acuña, Virgilio Galvis","doi":"10.31348/2025/38","DOIUrl":"10.31348/2025/38","url":null,"abstract":"<p><strong>Aims: </strong>This systematic review aimed to investigate whether quantitative metrics derived from gaze tracking (GT) outputs during visual field (VF) testing with an automated perimeter could enhance the evaluation of test reliability.</p><p><strong>Materials and methods: </strong>A systematic search of PubMed, Cochrane, LILACS, and IBECS databases, from inception to August 31, 2024, was conducted.</p><p><strong>Results: </strong>Eight studies - four cross-sectional and four cohort - met the inclusion criteria, comprising 8,181 visual field tests from 3,687 patients. The studies were categorized based on testing strategy: SITA Standard, Fast, and Faster. In the SITA Standard group, GT parameters were associated with visual field result reproducibility and the structure-function relationship in glaucoma, but were influenced by ocular surface variables. In the SITA Fast and Faster group, results were mixed: some studies suggested GT metrics could complement conventional reliability parameters, while others concluded that GT quantitative metrics did not offer clinically meaningful insights beyond existing methods.</p><p><strong>Conclusion: </strong>GT trace quantification shows promise as an objective reliability parameter for VF testing, particularly within the SITA Standard framework. Advanced image analysis techniques, including artificial intelligence, could facilitate automated GT parameter quantification, streamlining processes and supporting further studies to evaluate their impact on VF data reliability and clinical decision-making.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"81 Ahead of Print","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customized Cryotherapy for Ocular Salvage in Descemetocele and Iris Prolapse: A 17-Year Retrospective Study.","authors":"Gede Pardianto, Prajna Cindy Metta, Audric Kristo Hadi Sugiaman, Clarissa Lister, Diyah Purworini","doi":"10.31348/2026/6","DOIUrl":"https://doi.org/10.31348/2026/6","url":null,"abstract":"<p><strong>Aim: </strong> To evaluate the efficacy of a customized cryotherapy technique in enhancing ocular salvage and reducing evisceration rates in patients with descemetocele and iris prolapse.</p><p><strong>Material and methods: </strong> A retrospective, observational study was conducted at SMEC Eye Hospital, Medan, including 467 eyes from 467 patients treated with customized cryotherapy between January 2008 and July 2025. The procedure integrated standardized cryotherapy with adjunctive perioperative protocols, including antiseptic preparation, postoperative antibiotic, anti-inflammatory, and beta-blocker eyedrops, as well as strict environmental precautions and protective eyewear. Outcomes assessed were the need for repeated cryotherapy and evisceration.</p><p><strong>Results: </strong> Of the 467 treated eyes, 454 (97.2%) were successfully preserved without requiring evisceration. Repeated cryotherapy was required in 11 eyes (2.2%), of which 10 achieved ocular preservation. Evisceration was ultimately required in 13 eyes (2.8%), primarily due to spontaneous ocular content prolapse. Most treated eyes demonstrated corneal wall thickening and scarring, with regression of iris prolapse, thereby restoring ocular contour.</p><p><strong>Conclusion: </strong> Customized cryotherapy is a highly effective intervention for preventing evisceration in eyes with descemetocele and iris prolapse. By stabilizing the corneal wall and mitigating the risk of spontaneous ocular prolapse, this technique represents a valuable strategy for ocular salvage. Further prospective and controlled studies are warranted to validate long-term outcomes and to optimize treatment protocols.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"82 Ahead of Print","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the ACE inhibitor Zofenopril on the Oxidative Status of the Eye in Animals with Experimental Glaucoma.","authors":"Irina Mikheytseva, Serhii Kolomiichuk, Tаtiana Siroshtanenko, Nataliia Storozhuk, Maxim Kuznetsov, Mayyar Alobaisi","doi":"10.31348/2026/1","DOIUrl":"https://doi.org/10.31348/2026/1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt; To evaluate the effect of zofenopril on oxidative stress markers and antioxidant enzyme activity in ocular tissues of rabbits with experimentally induced glaucoma.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt; An experimental model of adrenaline-induced glaucoma (AIG) was developed in 2-2.5-year-old rabbits. Zofenopril, an angiotensin-converting enzyme (ACE) inhibitor, was administered orally as an aqueous suspension (1 mg/kg body weight) daily for three months. Oxidative stress was assessed by measuring malondialdehyde (MDA) levels as a marker of lipid peroxidation (LPO), hydroxyl and superoxide radical generation, and the activity of antioxidant enzymes (glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT)). Intraocular pressure (IOP) in rabbits was measured using an applanation tonometer under local anesthesia with 0.5% Alcaine. Spectrophotometric analysis was performed on the retina, optic nerve, and drainage zone tissues.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt; In the AIG modeling group, a dynamic increase in IOP was observed: by 28.3% after 30 days, by 34.2% and 46.7% after 60 and 90 days, respectively, compared to baseline data. Oral administration of zofenopril suspension during AIG modeling resulted in a milder elevation of IOP - by 17.4% on day 30 (p &lt; 0.05) - followed by a gradual decline to 110.1% and 105.4% of baseline values on days 60 and 90, respectively. On day 90 of the study, rabbits with AIG exhibited significant activation of LPO and elevated MDA levels in ocular tissues: by 54.1% in the retina, 39.9% in the optic nerve, and 70.1% in the drainage zone, compared to controls (intact animals) (p &lt; 0.01). Enhanced free radical generation was observed: hydroxyl radical levels increased by 71.3% in the retina, 58.9% in the optic nerve, and 81.8% in the drainage zone; superoxide radical levels increased by 78.4%, 64.4%, and 94.2%, respectively. Antioxidant enzyme activity declined in the retina, with GPx decreasing by 35.9%, SOD by 42.4%, and CAT by 30.7%, compared to the controls. Zofenopril administration during glaucoma modeling resulted in reduced MDA levels: by 19.3% in the retina, 16.1% in the optic nerve, and 28.1% in the drainage zone, compared to the untreated AIG group. Hydroxyl radical generation also decreased by 23.0% in the retina, 21.9% in the optic nerve, and 23.9% in the drainage zone. Superoxide radical levels were reduced by 20.3% in the retina and 24.9% in the drainage zone. In contrast, antioxidant enzyme activity increased in the retina: GPx rose by 33.6%, SOD by 26.2%, and CAT by 21.6%, compared to the untreated AIG group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt; Prolonged systemic administration of zofenopril in a rabbit model of glaucoma effectively attenuated oxidative stress and stabilized intraocular pressure. Zofenopril prevented a progressive rise in IOP observed in untreated animals, maintaining IOP values close to physiological levels throughout the experi","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"82 Ahead of Print","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Neovascular Membrane in Pediatric Patients: Long-Term Outcomes of Anti-VEGF Therapy.","authors":"Kamila Pavlíková, Inka Krejčířová, Rudolf Autrata, Kateřina Šenková, Veronika Matušková","doi":"10.31348/2025/33","DOIUrl":"10.31348/2025/33","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the epidemiological data, etiology and clinical characteristics, and to assess the efficacy and safety of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy in the treatment of choroidal neovascular membrane (CNV) in children and adolescents. The results are compared with data from previously published studies and case reports.</p><p><strong>Material and methods: </strong>Retrospective analysis of medical records of patients treated for CNV at the Department of Pediatric Ophthalmology, University Hospital Brno, between January 2015 and April 2025. The cohort consisted of 12 patients, including 7 males and 5 females. All the cases involved unilateral disease; the right eye was affected in 7 patients and the left eye in 5. The mean age at onset was 11.8 years (range: 3-17 years). All underwent a comprehensive ophthalmological examination including optical coherence tomography (OCT); in 7 cases the diagnosis was confirmed by fluorescein angiography. The evaluated parameters included epidemiological data, clinical and morphological characteristics of CNV before and after anti-VEGF therapy. The etiology of CNV in our cohort was as follows: post-inflammatory/post-infectious in 6 cases, idiopathic in 3 cases, and one case each of myopic, post-traumatic, and neoplastic origin. The most common localization was subfoveal. All CNV lesions were classified as classic (type 2).</p><p><strong>Results: </strong>All patients achieved either anatomical or functional improvement. No ocular or systemic adverse effects related to intravitreal anti-VEGF therapy were observed during the study period.</p><p><strong>Conclusion: </strong>Early diagnosis and intervention with anti-VEGF therapy show favorable outcomes, including stabilization and remission of the disease. In our cohort, no adverse events or complications associated with intravitreal anti-VEGF administration were recorded. Continued research is essential in order to gain a further understanding of the pathogenesis of pediatric CNV and to optimize treatment strategies in children.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"81 Ahead of Print","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Therapeutic Alternatives in Eyes with Secondary Vasoproliferative Tumors: A Single-Center Turkish Perspective.","authors":"Gorkem Polat, Omer Karti, Ziya Ayhan, Murat Tunc, Remzi Avci, Ali Osman Saatci","doi":"10.31348/2026/18","DOIUrl":"10.31348/2026/18","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate retrospectively the clinical characteristics and therapeutic outcomes in eyes with secondary vasoproliferative retinal tumors (VPRT) at a tertiary center in Turkey.</p><p><strong>Material and methods: </strong>Patients diagnosed with secondary VPRT between 2005 and 2025 with a follow-up of 6 months or more were included. 24 eyes of 21 patients were evaluated. Their charts and multimodal imaging features were analyzed, and treatments noted.</p><p><strong>Results: </strong>Mean age was 26.1 years (6-57). Mean follow-up was 61.1 months (6-151). Baseline BCVA was 0.77 LogMAR (0.00-2.30). VPRT was linked to non-infectious uveitis in 12 patients, retinitis pigmentosa in 5 patients, X-linked Juvenile Retinoschisis, Coats' disease, retinal dystrophy and retinopathy of prematurity in 1 patient each. The inferotemporal quadrant was the most common site (66.7%). Treatments included dexamethasone implant, transscleral cryotherapy, systemic immunosuppressive therapy, laser photocoagulation, CyberKnife, intravitreal anti-VEGF, vitreoretinal surgery, photodynamic therapy, intravitreal triamcinolone acetonide and enucleation. At baseline, 15 eyes had macular intraretinal fluid. At the final visit, dry macula was achieved in 9 of 15 eyes. Mean final BCVA was 1.01 LogMAR (0.00-3.00). Two eyes deteriorated to no light perception. One was enucleated.</p><p><strong>Conclusion: </strong>This largest cohort of patients from Turkey with secondary VPRT reflects the diverse underlying etiologic associations and heterogeneous clinical manifestations at a tertiary center. Various therapeutic techniques were required to cope with this difficult-to-treat, challenging disease entity.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"82 Ahead of Print","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Morphological Changes in the Retina Using OCTA in Patients with Diabetic Macular Edema Treated with anti-VEGF Using ImageJ Software.","authors":"David Beran, Libor Hejsek, Jan Studnička","doi":"10.31348/2025/28","DOIUrl":"10.31348/2025/28","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate changes in the vascular density of the deep and superficial capillary plexus of the retina, the area of the foveal avascular zone, central retinal thickness, and best corrected visual acuity in patients with diabetic macular edema treated with anti-VEGF agents.</p><p><strong>Material and methods: </strong>In a prospective study at the Ophthalmology Clinic of FNHK, we evaluated a group of 41 eyes of 30 patients (19 men and 11 women) with diabetic macular edema treated with Lucentis or Eylea. The average age of the patients was 61.7 ±11.3 years. Average initial visual acuity was 64.4 ±9.1 letters on ETDRS optotypes. During the one-year follow-up period we monitored the density of the deep and superficial retinal capillary plexus using OCTA. We evaluated OCTA scans with the ImageJ program at 3, 6, 9, and 12 months. Additionally, the area of the foveal avascular zone, central retinal thickness, and best-corrected visual acuity were measured.</p><p><strong>Results: </strong>During the one-year follow-up period there was a statistically significant change in both retinal capillary plexuses, with the density of the deep capillary plexus increasing (p.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"81 Ahead of Print","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Intravitreal Application of an Ozurdex Implant in Patients with Macular Edema due to Retinal Vein Occlusion.","authors":"Martin Lada, Renata Ženíšková, Zuzana Hradcová, Jana Schützová, Jan Tesař, Jan Grygar, Jan Havlik, Martin Šín","doi":"10.31348/2026/8","DOIUrl":"https://doi.org/10.31348/2026/8","url":null,"abstract":"<p><strong>Aims: </strong>A retrospective evaluation of the outcomes and safety of the Ozurdex implant in patients with cystoid macular edema (CME) due to retinal vein occlusion (RVO).</p><p><strong>Material and methods: </strong>A retrospective analysis of 14 eyes (10 male patients, 4 female patients) treated with the Ozurdex implant at the application center of the Department of Ophthalmology at the Military University Hospital, with the indication of RVO. The period of monitored applications was from 2022 to 2024. Patients were followed up every two months for at least one year after the first application. The primary efficacy parameters assessed were: Best-corrected visual acuity (BCVA), Central retinal thickness (CRT), Intraocular pressure (IOP), Changes in the diameter of intraretinal cysts (IR), as the main OCT biomarker.</p><p><strong>Results: </strong>At the first follow-up, two months after Ozurdex application, there was a statistically significant functional improvement, with an average increase of 4.7 letters ETDRS letters (p = 0.042). Six months after application, the average BCVA reached 58 letters ETDRS letters. CRT decreased by an average of 100 µm two months after the initial DEX implant. The highest and statistically significant increase in IOP (p = 0.008) was recorded two months after the application (with an average value of 20.9 mmHg).</p><p><strong>Conclusion: </strong>Our results indicate that Ozurdex is a safe and effective second-line treatment for macular edema (ME) due to RVO. In our group, the best functional and anatomical results were achieved two months after application. By the fourth month, a decline in BCVA and an increase in CRT were observed. Between the fifth and sixth month, retreatment was necessary in some patients. Additionally, we confirmed that the greatest rise in IOP occurred two months post-application, which resolved spontaneously by the sixth month. In four patients, IOP values above 30 mmHg were recorded during follow-up, and the intraocular pressure was managed with medication.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"82 Ahead of Print","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Tear Film in Refraction: Quantitative Evaluation Before and After Rexon-Eye Therapy.","authors":"Veronika Stankovičová, Viktor Ladislav Nováček, Pavel Rozsíval","doi":"10.31348/2026/3","DOIUrl":"https://doi.org/10.31348/2026/3","url":null,"abstract":"<p><strong>Aim: </strong> The aim of this study was to assess the effect of Rexon-Eye therapy, based on quantum molecular resonance (QMR) technology, optical parameters, tear film stability, and patients' subjective symptoms.</p><p><strong>Material and methods: </strong> A total of 30 patients (20 women, mean age 64.9 years; 10 men, mean age 64.6 years) diagnosed with dry eye syndrome were included in the study. Common systemic comorbidities were recorded, most frequently arterial hypertension, hypercholesterolemia, thyroid disorders, type 2 diabetes mellitus, and hyperuricemia. Each patient underwent four treatment sessions (once weekly for 20 minutes) according to the manufacturer's recommended protocol. Objective parameters - including objective scatter index (OSI), modulation transfer function cutoff (MTF cutoff), potential visual acuity (PVA), and vision break-up time (VBUT) - were assessed using the HD Analyzer before therapy and again 1 to 3 months after treatment completion. Subjective symptoms were evaluated using the standardized Ocular Surface Disease Index (OSDI) questionnaire.</p><p><strong>Results: </strong> No statistically significant changes were observed in OSI, MTF cutoff, or PVA. VBUT remained unchanged. By contrast, OSDI scores improved both statistically and clinically significantly.</p><p><strong>Conclusion: </strong> QMR therapy with the Rexon-Eye device led to significant improvement in subjective symptoms, while objective optical quality parameters showed no statistically significant changes. QMR therapy appears to be a safe and well-tolerated method that may expand therapeutic options in clinical practice.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"82 Ahead of Print","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear Film Dysfunction and its Association with Smartphone Usage in Adolescents.","authors":"Srishti Sharma, Anupam Singh, Shreya Mishra, Kirti Narang, Ajai Agrawal, Ranjeeta Kumari, Kumar Barun","doi":"10.31348/2025/32","DOIUrl":"10.31348/2025/32","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to explore the association between duration of smartphone usage and tear film parameters in adolescents through a hospitalbased cross-sectional study.</p><p><strong>Material and methods: </strong>A detailed history regarding smartphone usage was obtained, followed by tear film assessment for all the study participants. Tear meniscus height (TMH), Tear film break up time (TBUT), and Schirmer's I test were done for all participants. Then they were classified into four groups, based on daily smartphone usage: &lt; 2 hours/day, 2-4 hours/day, 4-6 hours/day, and &gt; 6 hours/day.</p><p><strong>Results: </strong>123 smartphone users of the adolescent age group aged 10-19 years (mean age: 16.6 ±2.8 years) were included. The mean values of tear film parameters were as follows: TMH was 0.25 ±0.1 mm, Schirmer's I was 17.7 ±9.2 mm, and TBUT was 10.5 ±5.7 seconds. Participants using smartphones for &gt; 6 hours/day had a significantly higher prevalence of reduced TMH (&lt; 0.25 mm) compared to those with lower usage durations (p &lt; 0.0001). Similar trends were observed for Schirmer's I and TBUT values, indicating a statistically significant association between prolonged smartphone use and tear film dysfunction (p &lt; 0.0001). Notably, 72.7% of eyes in the &gt; 6 hours/day group exhibited tear film dysfunction, significantly higher than in other groups.</p><p><strong>Conclusion: </strong>Prolonged smartphone use adversely affects tear film stability and ocular surface health in adolescents. Awareness and appropriate measures to limit excessive screen time are essential to prevent tear film dysfunction and associated ocular discomfort.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"81 Ahead of Print","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Properties of Citicoline in Patients with Unexplained Visual Acuity Loss Related to Silicone Oil Tamponade. Our Experience.","authors":"Zlatica Fellner, Veronika Kurilová, Adriana Takáčová, Lucia Herdová, Petr Kolář, Nora Majtánová","doi":"10.31348/2025/36","DOIUrl":"10.31348/2025/36","url":null,"abstract":"<p><strong>Aims: </strong>To review the findings in the professional literature on unexplained loss of visual acuity (VA) in patients with silicone oil (SO) tamponade and post-removal, and assess the efficacy and safety of citicoline as a neuroprotective agent on anatomical changes and visual function in patients undergoing 25-gauge pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment with large/multiple tears (macula-on/off).</p><p><strong>Materials and methods: </strong>We studied 96 eyes, 64 receiving citicoline (5 ml orally 3x daily) after PPV with SO tamponade, performed from 01.01.2023 to 30.06.2023 at the Eye Clinic of SZU and UNB. Best corrected visual acuity (BCVA) was measured using ETDRS charts, and changes in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were assessed using OCT at 1, 3 and 6 months. Complications were monitored and results analyzed statistically.</p><p><strong>Results: </strong>BCVA improved (citicoline: 19 to 48 letters; non-citicoline: 13 to 42 letters, p.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"81 Ahead of Print","pages":"14-24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}