Drug Discovery Today: Disease Models最新文献_第4页

C. elegans and its bacterial diet: An interspecies model to explore the effects of microbiota on drug response 秀丽隐杆线虫及其细菌饮食:探索微生物群对药物反应影响的种间模型

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.001

Cédric Diot, Aurian P. Garcia-Gonzalez, Albertha J.M. Walhout

引用次数: 4

Tunicates: A model organism to investigate the effects of associated-microbiota on the production of pharmaceuticals 被囊动物:研究相关微生物群对药物生产影响的模式生物

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.008

Anelize Bauermeister , Paola Cristina Branco , Luciana Costa Furtado , Paula Christine Jimenez , Leticia Veras Costa-Lotufo , Tito Monteiro da Cruz Lotufo

引用次数: 12

Model systems for the study of how symbiotic associations between animals and extracellular bacterial partners are established and maintained 研究动物和细胞外细菌伙伴之间的共生关系是如何建立和维持的模型系统

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.005

Eric J. Koch, Margaret McFall-Ngai

{"title":"Model systems for the study of how symbiotic associations between animals and extracellular bacterial partners are established and maintained","authors":"Eric J. Koch, Margaret McFall-Ngai","doi":"10.1016/j.ddmod.2019.08.005","DOIUrl":"10.1016/j.ddmod.2019.08.005","url":null,"abstract":"<div>This contribution describes the current state of experimental model development and use as a strategy for gaining insight into the form and function of certain types of host-microbe associations. Development of quality models for the study of symbiotic systems will be critical not only to facilitate an understanding of mechanisms underlying symbiosis, but also for providing insights into how drug development can promote healthy animal–microbe interactions as well as the treatment of pathogenic infections. Because of the growing awareness over the last decade of the importance of symbiosis in biology, a number of model systems has emerged to examine how these partnerships are maintained within and across generations of the host. The focus here will be upon host-bacterial symbiotic systems that, as in humans, (i) are acquired from the environment each generation, or horizontally transmitted, and (ii) are defined by interactions at the interface of their cellular boundaries, i.e., extracellular symbiotic associations. As with the use of models in other fields of biology where complexity is daunting (e.g., developmental biology or brain circuitry), each model has its strengths and weaknesses, i.e., no one model system will provide easy access to all the questions defining what is conserved in cell–cell interactions in symbiosis and what creates diversity within such partnerships. Rather, as discussed here, the more models explored, the richer our understanding of these associations is likely to be.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38318408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Gut microbes as a therapeutic armory 肠道微生物作为治疗的军械库

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.007

Neerupma Bhardwaj , Naama Geva-Zatorsky

{"title":"Gut microbes as a therapeutic armory","authors":"Neerupma Bhardwaj , Naama Geva-Zatorsky","doi":"10.1016/j.ddmod.2019.08.007","DOIUrl":"10.1016/j.ddmod.2019.08.007","url":null,"abstract":"<div>Gut microbes have recently been appreciated to be a possible source of future therapeutics. They have been shown to be associated with a variety of diseases from diverse etiologies. The microbiome can change during the progression of some diseases, and in some cases is linked with disease severity. Following these findings, fecal transplantation has been integrated into treating Clostridium difficile infections with high success rates. These results have become a driving force for studies demonstrating the therapeutic potential of gut bacteria in other clinical indications. However, extensive research and clinical trials are still needed in order to reach the goal of using defined live microbial therapeutics for treatment. A mechanistic understanding of the effects of individual strains and bacterial consortia on the mammalian host, their colonization dynamics, and long-term impact, on both the gut ecosystem and their host, is thus required. In this review, we discuss the potential of individual bacteria or bacterial consortia in therapeutics, mouse models for such studies, and the future directions for deriving valuable therapeutics from the gut microbial armory.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88891725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Drosophila and its gut microbes: A model for drug-microbiome interactions 果蝇及其肠道微生物:药物-微生物组相互作用的模型

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.004

Angela E. Douglas

{"title":"Drosophila and its gut microbes: A model for drug-microbiome interactions","authors":"Angela E. Douglas","doi":"10.1016/j.ddmod.2019.08.004","DOIUrl":"10.1016/j.ddmod.2019.08.004","url":null,"abstract":"<div>Drosophila is an excellent system to investigate how the presence and composition of the gut microbiome influences the efficacy of therapeutic drugs and downstream consequences for host health. These opportunities derive from two key attributes of Drosophila. First, Drosophila is amenable for microbiome research, with simple, standardized methods to produce large numbers of microbiologically-sterile flies and flies with a standardized gut microbiome, thereby facilitating experimental reproducibility. Second, Drosophila is a well-established genetic model that is increasingly used to elucidate the molecular and physiological basis of lesions associated with human disease alleles; this provides the opportunity to link microbiome/drug interactions to previously-described processes shaping health and disease. In this way, Drosophila can fast-track understanding of fundamental biology to generate precise hypotheses for testing in mammalian systems. Drosophila is particularly well-suited to investigate the incidence of microbiome/drug interactions mediated by different mechanisms, including microbial drug metabolism (to active, inactive or toxic derivatives), microbial production of compounds that inhibit drug efficacy, and off-target effects of the drug on the microbiome, resulting in dysbiosis and host ill-health. Drosophila can also be used to investigate how interactions between the microbiome and host genotype may shape responses to therapeutic drugs, informing the reliability of precision medicine based exclusively on human genomic markers.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38318410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Using the natural variation of mouse populations to understand host-gut microbiome interactions 利用小鼠种群的自然变异来了解宿主-肠道微生物组的相互作用

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.003

Elin Org , Aldons J. Lusis

引用次数: 4

Using gnotobiotic mice to discover and validate therapeutically active microbiota to maintain mucosal homeostasis and treat intestinal inflammation 利用益生小鼠发现并验证具有治疗活性的微生物群，以维持粘膜稳态和治疗肠道炎症

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.009

R. Balfour Sartor

引用次数: 1

Animal Models for Microbiome Research and Drug Discovery 微生物组研究和药物发现的动物模型

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.09.001

Philip J. Richter , Pieter C. Dorrestein , Rob Knight

引用次数: 0

Interactions between human microbiome, diet, enteric viruses and immune system: Novel insights from gnotobiotic pig research 人类微生物组、饮食、肠道病毒和免疫系统之间的相互作用:来自非生猪研究的新见解

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.006

Anastasia N. Vlasova, Gireesh Rajashekara, Linda J. Saif

{"title":"Interactions between human microbiome, diet, enteric viruses and immune system: Novel insights from gnotobiotic pig research","authors":"Anastasia N. Vlasova, Gireesh Rajashekara, Linda J. Saif","doi":"10.1016/j.ddmod.2019.08.006","DOIUrl":"10.1016/j.ddmod.2019.08.006","url":null,"abstract":"<div>Studies over the past few decades demonstrated that gnotobiotic (Gn) pigs provide an unprecedented translational model to study human intestinal health and diseases. Due to the high degree of anatomical, physiological, metabolic, immunological, and developmental similarity, the domestic pig closely mimics the human intestinal microenvironment. Also, Gn piglets can be efficiently transplanted with human microbiota from infants, children and adults with resultant microbial profiles remarkably similar to the original human samples, a feat consistently not achievable in rodent models. Finally, Gn and human microbiota-associated (HMA) piglets are susceptible to human enteric viral pathogens (including human rotavirus, HRV) and can be fed authentic human diets, which further increases the translational potential of these models. In this review, we will focus on recent studies that evaluated the pathophysiology of protein malnutrition and the associated dysbiosis and immunological dysfunction in neonatal HMA piglets. Additionally, we will discuss studies of potential dietary interventions that moderate the effects of malnutrition and dysbiosis on antiviral immunity and HRV vaccines in HMA pigs. Such studies provide novel models and novel mechanistic insights critical for development of drug interventions.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38567289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Animal models for understanding microbial decomposition of human remains 了解微生物分解人体遗骸的动物模型

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI: 10.1016/j.ddmod.2019.08.013

Aeriel D. Belk , Heather L. Deel , Zachary M. Burcham , Rob Knight , David O. Carter , Jessica L. Metcalf

{"title":"Animal models for understanding microbial decomposition of human remains","authors":"Aeriel D. Belk , Heather L. Deel , Zachary M. Burcham , Rob Knight , David O. Carter , Jessica L. Metcalf","doi":"10.1016/j.ddmod.2019.08.013","DOIUrl":"10.1016/j.ddmod.2019.08.013","url":null,"abstract":"<div>Animal models are critical for forensic science research, particularly in studies of decomposition. This review examines the studies that have led to the development of using microbiome tools to predict the time since death, or postmortem interval (PMI), of human remains. Estimating PMI is crucial for forensic investigations, and most traditional tools are no longer effective after the first few days postmortem. The development of microbiome tools to estimate PMI has relied on rodents and swine to model human decomposition. The use of these model organisms provides several advantages over studies utilizing human remains, including ease of procurement, large sample sizes, and the ability to control variables. Through studies using model organisms, researchers have been able to answer many fundamental questions regarding postmortem microbial decomposition, including the impacts of soil type, cadaver mass, cadaver clothing, and sampling location. Generally, these studies have been used to provide a proof-of-concept and narrow hypotheses before conducting studies on human remains. Evidence suggests that rodents and swine accurately model human microbial decomposition, but further study should be conducted to directly compare these outcomes. An important open topic that could be addressed with animal models is the role of drugs in changing cadaver-associated microbiomes during decomposition.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77509125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6