Tunicates: A model organism to investigate the effects of associated-microbiota on the production of pharmaceuticals

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2018-06-01 DOI:10.1016/j.ddmod.2019.08.008

Anelize Bauermeister , Paola Cristina Branco , Luciana Costa Furtado , Paula Christine Jimenez , Leticia Veras Costa-Lotufo , Tito Monteiro da Cruz Lotufo

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引用次数: 12

Abstract

Ascidians are marine invertebrates closely related to vertebrates. These animals have been studied to address complex processes, including evolution of the immune system and developmental biology. As holobionts, housing millions of bacteria in a close relationship that drives adaptive fitness to environmental conditions, ascidians are successful invaders and dominant components of the benthic communities. Further, tunicates and their associated microbiota are recognized as producers of chemical structures with pharmacological potential, and over 1000 such molecules have been described so far. This review covers aspects of ascidian biology that make them promising model organisms in various fields and important for drug discovery.

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被囊动物:研究相关微生物群对药物生产影响的模式生物

海鞘是与脊椎动物密切相关的海洋无脊椎动物。对这些动物进行了研究，以解决复杂的过程，包括免疫系统的进化和发育生物学。海鞘是底栖生物群落中成功的入侵者和主要组成部分，是数百万细菌的亲密关系，推动了对环境条件的适应性。此外，被囊动物及其相关微生物群被认为是具有药理潜力的化学结构的生产者，到目前为止已经描述了1000多个这样的分子。本文综述了海鞘生物学的各个方面，这些方面使海鞘成为在各个领域有前景的模式生物，并对药物发现具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.