Neuropsychopharmacologia Hungarica最新文献

筛选
英文 中文
Post traumatic stress disorder, Depression, and Post-migration stress behavioral pattern among Arabic immigrants and refugee populations: a review. 阿拉伯移民和难民人群的创伤后应激障碍、抑郁和迁移后应激行为模式综述。
Neuropsychopharmacologia Hungarica Pub Date : 2026-03-01
Mania Mekhail, Katalin Csigo
{"title":"Post traumatic stress disorder, Depression, and Post-migration stress behavioral pattern among Arabic immigrants and refugee populations: a review.","authors":"Mania Mekhail, Katalin Csigo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The global refugee crisis has led to a significant influx of Arabic-speaking immigrants and refugees (ASIR) into Europe and North America, particularly from conflict-affected regions such as Syria. This review examines the prevalence and determinants of post-traumatic stress disorder (PTSD), depression, and post-migration stress behavioural patterns among Arabic immigrant and refugee populations. Drawing on existing literature and data from countries such as Hungary, Germany, and Sweden, this paper highlights the significant mental health challenges faced by these populations. Key findings indicate high prevalence rates of PTSD (ranging from 11.4% to 83.4%) and depression (ranging from 14.5% to 60%), influenced by pre-migration trauma, post-migration living difficulties, and sociodemographic factors such as gender and age. Post-migration stressors, including language barriers, social isolation, discrimination, and uncertain legal status, are identified as critical contributors to mental health outcomes. The review underscores the need for culturally sensitive mental health interventions and policies that address both pre- and post-migration stressors to improve the well-being of Arabic immigrant and refugee populations. (Neuropsychopharmacol Hung 2026; 28(1): 37-46) Keywords: arab, immigrants, refugees, post-traumatic stress disorder (PTSD), depression, post-migration stress, mental health, cultural adaptation, resilience.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"28 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prediction of future suicide risk using the 6-item short suicide questionnaire among formerly discharged psychiatric inpatients: a 91-95 month follow-up]. [用6项简短自杀问卷预测精神科出院住院患者未来自杀风险:91-95个月随访]。
Neuropsychopharmacologia Hungarica Pub Date : 2026-03-01
Zoltán Rihmer, Zsuzsanna Bélteczky
{"title":"[Prediction of future suicide risk using the 6-item short suicide questionnaire among formerly discharged psychiatric inpatients: a 91-95 month follow-up].","authors":"Zoltán Rihmer, Zsuzsanna Bélteczky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors analyse the predictive utility of their self-developed, 6-item Short Suicide Questionnaire among 151 discharged psychiatric inpatients during a 91-95 month follow-up. During this time-frame, 3 patients (2%) died by suicide and 15 (10%) attempted suicide. The results show that reaching 22 points or more from the maximum total score of 28 is a reliable indicator not only the current but also the future suicidal risk. Keywords: suicide, suicide attempt, psychiatric patients, questionnaire, prediction.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"28 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Significance of Informant Discrepancies in Psychological Evaluation]. 心理评价中被调查者差异的意义
Neuropsychopharmacologia Hungarica Pub Date : 2026-03-01
Róza Sára Sulyok, Mónika Miklósi
{"title":"[The Significance of Informant Discrepancies in Psychological Evaluation].","authors":"Róza Sára Sulyok, Mónika Miklósi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>In the clinical practice and research of childhood and adolescent mental health disorders, there is a common practice of involving multiple informants, including parents, teachers, and the child or adolescent themselves. However, data obtained from these different sources typically show low to moderate levels of agreement. The aim of this study is to interpret the discrepancies between data provided by different informants in the diagnostic process of psychological disorders, and to examine which theoretical models can explain these discrepancies and what clinical significance they may hold.</p><p><strong>Methods: </strong>In the course of this literature review, two interpretative frameworks are presented: first, the Operation Triad Model, which examines the identifiable patterns in the data derived from different informants, and second, the Attribution Bias Context Model, which organizes the possible causes of discrepancies among informants. The review placed particular emphasis on the clinical and prognostic relevance of the observed patterns.</p><p><strong>Results: </strong>The Operation Triad Model identifies three types of operations: convergent operations, where the data point in the same direction; compensatory operations, where divergent data suggest methodological issues; and divergent operations, where the data differ in a way that can be meaningfully interpreted and may provide valuable additional information. Divergent operations can contribute to the identification of new risk factors and facilitate a deeper, contextually grounded understanding of pathologies. Based on the findings, integrating data and discrepancies from multiple informants enriches the interpretation of psychopathological phenomena and enables more accurate prognosis.</p><p><strong>Conclusions: </strong>The discrepant data obtained through the involvement of multiple informants cannot always be simply explained as measurement error but may reflect phenomena that contribute to a deeper understanding of the nature and context of symptoms. Integrating the conscious interpretation of these discrepancies into clinical practice can improve diagnostic accuracy and enhance the effectiveness of treatment planning.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"28 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preliminary experience with the SCID-5-AMPD clinical interview in clinical and non-clinical adolescent samples]. [对临床和非临床青少年样本进行SCID-5-AMPD临床访谈的初步经验]。
Neuropsychopharmacologia Hungarica Pub Date : 2026-03-01
Máté Gergely Hosszú, Brigitta Szabó
{"title":"[Preliminary experience with the SCID-5-AMPD clinical interview in clinical and non-clinical adolescent samples].","authors":"Máté Gergely Hosszú, Brigitta Szabó","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>With the increasing prominence of the alternative, dimensional model of personality disorders, developmental aspects have also gained importance in the diagnosis of personality disorders. Researchers and practicing clinicians are paying growing attention to adolescents showing signs of disharmonious personality development. Although the study of personality pathology in adolescence remains a debated area both domestically and internationally, timely and appropriate diagnostics can form the basis for adequate therapy. The Structured Clinical Interview for DSM-5 Alternative Model for Personality Disorders (SCID-5-AMPD) is recommended for assessing adolescents with signs of disharmonious personality development. However, to the best of our knowledge, the SCID-5-AMPD has not yet been applied in adolescent populations in Hungary. The aim of our study is to administer the SCID-5-AMPD to a psychiatric adolescent sample at risk for disharmonious personality development aged 14 and older, as well as to a control group without psychiatric diagnoses.</p><p><strong>Method: </strong>Our study has been approved by the Scientific and Research Ethics Committee of the Health Scientific Council (reference number: BM/9184-1/2024). Considering the developmental characteristics of adolescence, our research focuses on a dimensional approach, i.e., exploring the functioning of personality and the degree of maladaptive personality traits. Therefore, the first and second modules of the SCID-5-AMPD were administered. After obtaining written informed consent from both the guardian and the adolescent, the adolescents and their parents completed a questionnaire package, followed by the administration of the first two modules of the SCID-5-AMPD with the adolescent. Written notes were taken during the interviews. The clinical sample included 14 participants, while the control group consisted of 17 participants. The study involved 8 boys (25.8%) and 23 girls (74.2%), with a mean age of 16.06 years (SD = 1.24 years).</p><p><strong>Results: </strong>The items proved to be understandable and relevant for adolescents. Feedback from adolescents with disharmonious personality development indicated that the structured format of the interview and the coherence created by the standardized questions helped them better understand their otherwise hard-to-define difficulties. The duration of the interviews varied widely. Interviewers were able to learn how to administer a structured clinical interview, apply the concepts of the SCID-AMPD, and gain a closer understanding of the dimensional approach to personality disorders and its practical application.</p><p><strong>Conclusions: </strong>Based on our preliminary experience, the first two modules of the SCID-5-AMPD may be applicable for assessing adolescents. Further investigation of its psychometric properties among Hungarian adolescents is essential for future use.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"28 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Narratives of Harm and Hope: Understanding Media's Role in Suicide Risk]. [伤害与希望的叙述:理解媒体在自杀风险中的作用]。
Neuropsychopharmacologia Hungarica Pub Date : 2026-03-01
Márk Bérdi
{"title":"[Narratives of Harm and Hope: Understanding Media's Role in Suicide Risk].","authors":"Márk Bérdi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study examines the role of media in shaping suicidal behavior, with particular emphasis on the Werther and Papageno effects. Drawing on current research, it explores how media coverage can either increase or decrease the risk of suicide, depending on the narrative it conveys. Using the Fluid Vulnerability Model of Suicide as a framework to interpret these effects, the paper analyzes the characteristics of risk-enhancing and protective media content. Based on these insights, it provides practical recommendations for responsible communication practices aimed at suicide prevention. The aim of this paper is to contribute to the development of evidence-based media policy and prevention strategies, especially to protect vulnerable populations. Keywords: suicide, media effect, Werther effect, Papageno effect, prevention, mental health.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"28 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a model of Students' Academic Burnout Based on academic Support: The Intermediating Role of Academic Engagement. 基于学业支持的学生学业倦怠模型构建:学业投入的中介作用。
Neuropsychopharmacologia Hungarica Pub Date : 2025-12-01
Vahideh Sadat Vahedi, Mohammad Tahan
{"title":"Developing a model of Students' Academic Burnout Based on academic Support: The Intermediating Role of Academic Engagement.","authors":"Vahideh Sadat Vahedi, Mohammad Tahan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One of the serious problems in educational systems around the world is the increase in academic burnout among university students. The aim of the present study was to investigate the relationship between academic support and students' academic burnout through the mediating variable of academic engagement. The research method was descriptive-correlational. The population included all undergraduate students of Islamic Azad University, Qaenat Branch during the academic year of 1998-99, from which 205 (98 females and 107 males) were selected based on stratified random sampling. To collect data, three questionnaires were used, including the Sands and Plankt (2005) Academic Support Scale, the Modified Maslach Academic Burnout Questionnaire (2002) and the Academic Engagement Questionnaire (Reeve, 2013). Data analysis was performed using AMOS software (version 20) and structural equation modeling method. The results of data analysis revealed that the model has a good fit with research data. According to the findings, the direct path of academic support to academic burnout was significant. The indirect path from academic support to academic burnout through the mediating variable of academic engagement was also significant. Overall, the results of the present study show that academic support through influencing students' academic engagement as well as reducing their academic burnout can lead to active involvement of students in academic activities. \u0000Neuropsychopharmacol Hung 2025; 27(4): 270-281)</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"27 4","pages":"270-281"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The National Survey on Addiction Problems in Hungary 2023 (NSAPH): Methodology and sample description]. [全国调查成瘾问题在匈牙利2023年(naph):方法和样本描述]。
Neuropsychopharmacologia Hungarica Pub Date : 2025-12-01
Borbala Paksi, Zsolt Demetrovics
{"title":"[The National Survey on Addiction Problems in Hungary 2023 (NSAPH): Methodology and sample description].","authors":"Borbala Paksi, Zsolt Demetrovics","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The paper presents the general methodological background and main methodological results of the 2023 wave of the National Survey on Addiction Problems in Hungary (NSAPH). The ultimate aim of the research was to provide a comprehensive epidemiological overview of addictive problems, including substance use-related behaviours and behavioural addictions) among the adult population in Hungary, complemented by some objectives to develop/refresh the conceptual framework and indicators. The study presents the measurement instruments used in the research, the sampling and data collection strategy employed, and the methodological results related to sample selection and the reliability and validity of the measurement instruments used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The survey was conducted on a nationally representative sample of 2200 gross, 1800 net population aged 18-64, using a mixed survey technique combining face-to-face interviewing with self-completion elements. The theoretical margin of error at the 95% confidence level is ±2.3%. Sample outliers were corrected by matrix weighting by stratum category. The data collection battery used in the survey covered substance use behaviours (smoking, alcohol and other psychoactive substance use), different behavioural addictions (problematic internet use, gaming disorder, problem social media use, problematic mobile phone use, gambling disorder, exercise addiction, eating disorders, work addiction, compulsive buying-shopping behaviour) and included instruments to map socio-demographic and psychological background. The reliability and validity of the data obtained along the target variables were analysed by means of indicators calculated on the basis of the correlations between the answers to the different logically related questions in the questionnaire, the proportion of missing and invalid answers, the proportion of consumption responses to a so-called dummy drug, and by examining the internal consistency of the standard scales used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Based on the proportion of consistent users in relation to the lifetime prevalence value, it can be concluded that for the majority of the substances tested, the lifetime prevalence values contain a higher proportion of consistent data. Compared to sociodemographic questions, which can be considered neutral, the proportion of missing and invalid responses for the addictive behaviours studied can be considered relatively high, but good compared to other sensitive questions. The degree of overestimation is negligible.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Ove-rall, the methodological results of the OLAAP 2023 survey suggest that valid and reliable conclusions can be drawn from the survey data with regard to the current characteristics and patterns of the addictive behaviours under investigation. The trends in out-of-sample errors in substance use behaviour indicate that, in addition to the increased attention that is still neede","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"27 4","pages":"230-258"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Development of the Bipolar Spectrum Theory: Concept, Clinical Presentation, and Diagnostics. 双相情感障碍理论的发展:概念、临床表现和诊断。
Neuropsychopharmacologia Hungarica Pub Date : 2025-12-01
Zsuzsanna Belteczki
{"title":"The Development of the Bipolar Spectrum Theory: Concept, Clinical Presentation, and Diagnostics.","authors":"Zsuzsanna Belteczki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In my narrative paper, I describe the development of the bipolar spectrum concept and its clinical heterogeneity observed in everyday practice. I review relevant findings from biological marker research and phenomenology-based screening tools. Furthermore, I provide an overview of the advantages and disadvantages of the bipolar spectrum theory, as well as the challenges of diagnosis.\u0000(Neuropsychopharmacol Hung 2025; 27(4): 282-295)</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"27 4","pages":"282-295"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Results of the evaluation of cognitive functions in acute haemorrhagic stroke]. [急性出血性中风患者认知功能评估结果]。
Neuropsychopharmacologia Hungarica Pub Date : 2025-12-01
Reka Majer, Mate Heja, Zsuzsa Bagoly, Laszlo Olah, Laszlo Csiba, Klara Fekete
{"title":"[Results of the evaluation of cognitive functions in acute haemorrhagic stroke].","authors":"Reka Majer, Mate Heja, Zsuzsa Bagoly, Laszlo Olah, Laszlo Csiba, Klara Fekete","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prevalence of neurocognitive impairment subsequent to haemorrhagic stroke is notably high, thus constituting a significant predictor of survival and functionality. To date, however, there has been a paucity of studies that have described the profile of specific cognitive impairments in patients suffering from haemorrhagic strokes. The objective of the present study is twofold: firstly, to analyse in detail cognitive impairment after haemorrhagic stroke; secondly, to investigate the improvement in cognitive function and to determine its association with potential prognostic factors. The present pilot study comprised 17 haemorrhagic stroke patients who underwent a detailed cognitive assessment on day 14 and 3 months after the haemorrhage using the Montreal Cognitive Test, Rey Auditory-Verbal Learning Test, Letter Fluency and Semantic Fluency Tests, Number Span Test and CANTAB. At baseline, 18.8% of patients exhibited minor neurocognitive impairment, while 43.8% demonstrated major neurocognitive impairment. A number of significant changes were observed between the two time points in spatial-visual abilities, executive functions, attention/concentration, short-term memory and orientation. A subsequent investigation into the laterality of the haemorrhage revealed a significant discrepancy, as determined by the t-test results. Specifically, the right hemisphere haemorrhage exhibited a reduced degree of cognitive impairment. Among the factors influencing improvement, a significant correlation was identified between residual bleeding and perifocal edema size as seen on the 3rd month CT. The findings of our subsequent study demonstrated considerable neurocognitive and domain-specific impairments subsequent to haemorrhagic stroke. It is important to note that improvement was observed in several cognitive domains three months after the event, and we were able to identify prognostic factors influencing recovery. It is hypothesised that these findings may inform the design of rehabilitation programmes. This is due to the fact that they provide clinicians with a more precise understanding of the cognitive status of patients suffering from post-haemorrhagic stroke.</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"27 4","pages":"259-269"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A neutrophil-to-lymphocyte ratio higher than 3 may identify infl ammation during clozapine titrations: A re-analysis of five published cases of myocarditis. 中性粒细胞与淋巴细胞比值高于3可能在氯氮平滴定时识别炎症:对已发表的5例心肌炎病例的再分析。
Neuropsychopharmacologia Hungarica Pub Date : 2025-12-01
Jose de Leon, Robert O Cotes, David R Goldsmith, Charles Shelton, Betsy McCollum
{"title":"A neutrophil-to-lymphocyte ratio higher than 3 may identify infl ammation during clozapine titrations: A re-analysis of five published cases of myocarditis.","authors":"Jose de Leon, Robert O Cotes, David R Goldsmith, Charles Shelton, Betsy McCollum","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation. A NLR≥3 is considered abnormal (and ≥1.8 for benign ethnic neutropenia, BEN).</p><p><strong>Methods: </strong>NLR values were added to longitudinal data including c-reactive protein (CRP) in 5 published clozapine-induced myocarditis cases.</p><p><strong>Results: </strong>Case 1 had two NLRs with normal values, but on clozapine day 19, the CRP became abnormal (10.0 μg/d, ≤0.9) and the NLR=3.9. Clozapine was stopped on day 26. Case 2 had three normal NLRs before myocarditis, but on day 19 clozapine was stopped due to abnormal CRP (16. μg/dL, ≤0.9) with abnormal NLR (6.7). Case 3 received 25 mg on the first day (on valproic acid and quetiapine) with a NLR=3.4 on day 2. On day 11, CRP and NLR were normal. On day 14, he had chest pain, abnormal CRP (4.9 μg/dL,≤0.9) and abnormal NLR (7.4). Clozapine was discontinued on day 17. CRP and NLR finally normalized on day 35. Skin abscesses led to abnormal CRP and NLR values. On day 148, 12.5 mg of clozapine was restarted leading to a skin rash the next day. On day 155, this dose was stopped. Case 4 had two normal NLRs before myocarditis, but on day 16, clozapine was stopped (abnormal CRP, 15.8 μg/dL, ≤0.5 and abnormal NLR=4.4). Case 5 had BEN. NLR was normal on day 7, but became abnormal (NLR=1.9) on day 11 on 250 mg/day. He died five days later.</p><p><strong>Conclusions: </strong>An abnormal NLR during titration may suggest clozapine-induced inflammation and/or infection. \u0000\u0000(Neuropsychopharmacol Hung 2025; 27(4): 296-311)</p>","PeriodicalId":39762,"journal":{"name":"Neuropsychopharmacologia Hungarica","volume":"27 4","pages":"296-311"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书