{"title":"System analysis of the fast global coronavirus disease 2019 (COVID-19) spread. Can we avoid future pandemics under global climate change?","authors":"V. Volkov","doi":"10.1080/19420889.2022.2082735","DOIUrl":"https://doi.org/10.1080/19420889.2022.2082735","url":null,"abstract":"ABSTRACT The recent fast global spread of COVID-19 caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) questions why and how the disease managed to be so effective against existing health protection measures. These measures, developed by many countries over centuries and strengthened over the last decades, proved to be ineffective against COVID-19. The sharp increase in human longevity and current transport systems in economically developing countries with the background of persisting cultural frameworks and stable local pools of high bacterial and viral mutations generated the wide gap between the established health protection systems and the new emerging diseases. SARS-CoV-2 targets human populations over the world with long incubation periods, often without symptoms, and serious outcomes. Hence, novel strategies are necessary to meet the demands of developing economic and social environments. Moreover, the ongoing climate change adds extra challenges while altering the existing system of interactions in biological populations and in human society. Climate change may lead to new sources of viral and microbial mutations, new ways of zoonotic disease transmission and to huge social and economic transformations in many countries. The present short Opinion applies a system approach linking biomedical, climate change, social and economic aspects and, accordingly, discusses the measures and more efficient means to avoid future pandemics.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"150 - 157"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46289143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dwi Atmoko Agung Nugroho, D. Sajuthi, Sri Supraptini Mansjoer, E. Iskandar, Huda Shalahudin Darusman
{"title":"Long-tailed macaques: an unfairness model for humans","authors":"Dwi Atmoko Agung Nugroho, D. Sajuthi, Sri Supraptini Mansjoer, E. Iskandar, Huda Shalahudin Darusman","doi":"10.1080/19420889.2022.2070902","DOIUrl":"https://doi.org/10.1080/19420889.2022.2070902","url":null,"abstract":"ABSTRACT The current study was designed to predict why human primates often behave unfairly (equity aversion) by not exhibiting equity preference (the ability to equally distribute outcomes 1:1 among participants). Parallel to humans, besides inequity aversion, lab monkeys such as kin of long-tailed macaques (Macaca fascicularis) also demonstrate equity aversion depending on their preference for the outcome (food) type. During the pre-experiment phase, a food-preference test was conducted to determine the most preferred income per individual monkey. Red grapes were the most preferred outcome (100%) when compared to vanilla wafers (0%). The first set of experiments used a 1:1 ratio (equity condition) of grape distribution among six kin-pairs of female long-tailed macaques, and we compared their aversion (Av) versus acceptance (Ac). In the second experiment, we assessed the response to the 0:2 and 1:3 ratio distribution of grapes (inequity condition). A total of 60 trials were conducted for each condition with N = 6 pairs. Our results show aversion to the inequity conditions (1:3 ratios) in long-tailed macaques was not significantly different from aversion to the equity conditions (1:1 ratios). We suggest that the aversion observed in this species was associated with the degree of preference for the outcome (food type) offered rather than the distribution ratio. The subjective preferences for outcome types could bring this species into irrationality; they failed to share foods with an equal ratio of 1:1.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"137 - 149"},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45511561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subrata Ghosh, Pushpendra Singh, J. Manna, Komal Saxena, Pathik Sahoo, Soami Daya Krishnanda, K. Ray, Jonathan P. Hill, A. Bandyopadhyay
{"title":"The century-old picture of a nerve spike is wrong: filaments fire, before membrane","authors":"Subrata Ghosh, Pushpendra Singh, J. Manna, Komal Saxena, Pathik Sahoo, Soami Daya Krishnanda, K. Ray, Jonathan P. Hill, A. Bandyopadhyay","doi":"10.1080/19420889.2022.2071101","DOIUrl":"https://doi.org/10.1080/19420889.2022.2071101","url":null,"abstract":"ABSTRACT In 1907, Lapicque proposed that an electric field passes through the neuronal membrane and transmits a signal. Subsequently, a “snake curve” or spike was used to depict the means by which a linear flat current undergoes a sudden Gaussian or Laplacian peak. This concept has been the accepted scenario for more than 115 years even appearing in textbooks on the subject. It was not noted that the membrane spike should have a cylindrical shape. A nerve spike having a dot shape on membrane surface cannot propagate through a cylindrical surface since it would dissipate instantaneously. A nerve spike should have the appearance of a ring, encompassing the diameter of a cylindrical axon or dendron. However, this subtle change has remarkable implications. Maintaining a circular form of an electric field is not easy, especially at the surface of an organic object. Here, we suggest that neuroscience could redefine itself if we accept that a nerve spike is not a localized 3D Gaussian or Laplacian wave packet, rather it is a 3D ring encompassing the diameter of a neural branch.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"115 - 120"},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43648131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitalism and cognition in a conscious universe","authors":"M. Masi","doi":"10.1080/19420889.2022.2071102","DOIUrl":"https://doi.org/10.1080/19420889.2022.2071102","url":null,"abstract":"ABSTRACT According to the current scientific paradigm, what we call ‘life’, ‘mind’, and ‘consciousness’ are considered epiphenomenal occurrences, or emergent properties or functions of matter and energy. Science does not associate these with an inherent and distinct existence beyond a materialistic/energetic conception. ‘Life’ is a word pointing at cellular and multicellular processes forming organisms capable of specific functions and skills. ‘Mind’ is a cognitive ability emerging from a matrix of complex interactions of neuronal processes, while ‘consciousness’ is an even more elusive concept, deemed a subjective epiphenomenon of brain activity. Historically, however, this has not always been the case, even in the scientific and academic context. Several prominent figures took vitalism seriously, while some schools of Western philosophical idealism and Eastern traditions promoted conceptions in which reality is reducible to mind or consciousness rather than matter. We will argue that current biological sciences did not falsify these alternative paradigms and that some forms of vitalism could be linked to some forms of idealism if we posit life and cognition as two distinct aspects of consciousness preeminent over matter. However, we will not argue in favor of vitalistic and idealistic conceptions. Rather, contrary to a physicalist doctrine, these were and remain coherent worldviews and cannot be ruled out by modern science.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"121 - 136"},"PeriodicalIF":0.0,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41398821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Rhizosphere upheaval after tree cutting: Soil sugar flux and microbial behavior\".","authors":"Enny Widyati, Ragil Sb Irianto, Adi Susilo","doi":"10.1080/19420889.2022.2068110","DOIUrl":"10.1080/19420889.2022.2068110","url":null,"abstract":"<p><p>Cutting trees removes all parts of their photosynthetic area, which affects rhizosphere assembly. However, information regarding the underground alteration process after tree cutting is insufficient. This study aimed to observe the fate of both root exudation and the rhizosphere microbial community following tree cutting. The study included 540 <i>Calliandra calothyrsus</i> Meissn. The experimental layout was a completely randomized block design with 3 blocks (cutting age) × 2 (cutting and not cutting) × 180 trees. Composite soil samples were collected from trees at 0-20 cm depth and stumps at 0, 2, 4, 8, and 12 weeks after cutting to observe the soil sugar content, pH, and functional group population. This study demonstrated that cutting reduced the flux of sugars below ground by 80% and caused rapid acidification (pH less than 5.0) of the soil. Total soil sugar depletion is presumed to be a mechanism by which <i>C. calothyrsus</i> survives and regrows after cutting. Sugar depletion affects significant shifts in the size and structure of the rhizosphere microbial community. Increasing soil acidity is another survival strategy to limit close competitor populations in the rhizosphere. This study confirms that <i>C. calothyrsus</i> is a proper species for developing in the coppice-harvesting-system (CHS) energy estate.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43217531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thus spoke peptides: SARS-CoV-2 spike gene evolved in humans and then shortly in rats while the rest of its genome in horseshoe bats and then in treeshrews","authors":"J. Flegr, D. Zahradník, Michaela Zemková","doi":"10.1080/19420889.2022.2057010","DOIUrl":"https://doi.org/10.1080/19420889.2022.2057010","url":null,"abstract":"ABSTRACT SARS-CoV-2 is suspected to be the product of a natural or artificial recombination of two viruses – one adapted to the horseshoe bat and the other, donor of the spike protein gene, adapted to an unknown species. Here we used a new method to search for the original host of the ancestor of the SARS-CoV-2 virus and for the donor of its gene for the spike protein, the molecule responsible for binding to and entering human cells. We computed immunological T-distances (the number of different peptides that are present in the viral proteins but absent in proteins of the host) between 11 species of coronaviruses and 38 representatives of the main mammal clades. Analyses of pentapeptides, the presumed principal targets of T-cell non-self recognition, showed the smallest T-distance of the spike protein of SARS-CoV-2 to humans, while the rest of SARS-CoV-2 proteome to the horseshoe bat. This suggests that the ancestor of SARS-CoV-2 was adapted to bats, but the spike gene donor was adapted to humans. Further analyses suggest that the ancestral coronavirus adapted to bats was shortly passaged in treeshrews, while the donor of the spike gene was shortly passaged in rats before the recombination event.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"96 - 104"},"PeriodicalIF":0.0,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49074689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arabidopsis AGO4 loses its Cajal body localization when heterologously expressed in Nicotiana benthamiana","authors":"Liping Wang, Rosa Lozano-Durán","doi":"10.1080/19420889.2022.2051843","DOIUrl":"https://doi.org/10.1080/19420889.2022.2051843","url":null,"abstract":"ABSTRACT In plants, the RNA-directed DNA methylation (RdDM) pathway plays a major role in establishing DNA methylation. At least some components of the RdDM machinery, including the central component AGO4, are known to concentrate in a subnuclear compartment called the Cajal body in the model plant Arabidopsis thaliana. The molecular underpinnings of Cajal body localization, however, have remained elusive so far. Here, we found that Arabidopsis AGO4 (AtAGO4) fused to GFP does not present its typical Cajal body localization, when transiently expressed in Nicotiana benthamiana. Nevertheless, the endogenous AGO4 protein from N. benthamiana shows a clear accumulation in the Cajal body. Thus, our results suggest that the Cajal body localization of AtAGO4 requires specific molecular machinery that cannot be replaced by orthologues in N. benthamiana. This study presents an experimental system that could lead to mechanistic insights into the targeting of proteins to and localization in the Cajal body in plants.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"88 - 91"},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44127136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Insights regarding sirtuin-dependent gene regulation during white koji production.","authors":"Taiki Futagami, Masatoshi Goto","doi":"10.1080/19420889.2022.2051844","DOIUrl":"https://doi.org/10.1080/19420889.2022.2051844","url":null,"abstract":"<p><p>White koji, a solid-state culture of <i>Aspergillus luchuensis</i> mut. <i>kawachii</i> using grains such as rice and barley, is used as a source of amylolytic enzymes and citric acid for the production of shochu, a traditional Japanese distilled spirit. We previously characterized changes in gene expression that affect the properties of white koji during the shochu production process; however, the underlying regulatory mechanisms were not determined. We then characterized the NAD<sup>+</sup>-dependent histone deacetylase sirtuin, an epigenetic regulator of various biological phenomena, in <i>A. l</i>. mut. <i>kawachii</i> and found that sirtuin SirD is involved in expression of α-amylase activity and citric acid accumulation. In this addendum study, we measured the NAD<sup>+</sup>/NADH redox state and found that the NAD<sup>+</sup> level and NAD<sup>+</sup>/NADH ratio decrease during koji production, indicating that sirtuin activity declines in the late stages of koji culture. By comparing these results with transcriptomic data obtained in our previous studies, we estimate that approximately 35% of the gene expression changes during white koji production are SirD dependent. This study provides clues to the mechanism of gene expression regulation in <i>A. l</i>. mut. <i>kawachii</i> during the production of white koji.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":" ","pages":"92-95"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40309109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhoopander Giri, R. Rawat, G. Saxena, Preet Manchanda, Qiangsheng Wu, Anuradha Sharma
{"title":"Effect of Rhizoglomus fasciculatum and Paecilomyces lilacinus in the biocontrol of root-knot nematode, Meloidogyne incognita in Capsicum annuum L","authors":"Bhoopander Giri, R. Rawat, G. Saxena, Preet Manchanda, Qiangsheng Wu, Anuradha Sharma","doi":"10.1080/19420889.2021.2025195","DOIUrl":"https://doi.org/10.1080/19420889.2021.2025195","url":null,"abstract":"ABSTRACT Root-knot nematodes possess a major threat to agricultural production of various crops worldwide. The intensive use of chemical nematicides to control plant parasitic nematodes has adverse effects on our environment and human health. Owing to the importance of developing new strategies, an experiment was conducted to reveal the influence of arbuscular mycorrhizal fungus, Rhizoglomus fasciculatum and nematophagous fungus, Paecilomyces lilacinus alone or in combination with various organic amendments such as superphosphate, green and organic manure to control the infection of root-knot, nematode Meloidogyne incognita in a vegetable crop Capsicum annuum. These two fungi along with soil amendments significantly improved plant growth and fruit yield and effectively controlled infection of M. incognita. The dual inoculation of P. lilacinus and R. fasciculatum reduced the number of galls and egg masses, thereby revealing the controlled proliferation of M. incognita infection in C. annuum roots. The beneficial effect of these fungi further increased on supplementation of soil with organic or green manures. Inoculation of C. annuum with these two fungi showed a significant increase in egg parasitization; however, maximum effect was detected on dual inoculation. Amongst the soil amendments, the best response was obtained in case of green manure along with mycorrhizal fungus and P. lilacinus. Present study revealed that nematophagous and AM fungi, in combination with green manure were effective in controlling M. incognita, thus suggesting the use of such agents for biocontrol of plant parasitic nematodes in agriculture.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"15 1","pages":"75 - 87"},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48646191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feelings of Knowing - Fundamental Interoceptive Patterns (FoK-FIP): a magnetic monopole-like \"pure mental\" process fundamental to subjective feelings and self-awareness.","authors":"Holly Pollard-Wright","doi":"10.1080/19420889.2021.2023280","DOIUrl":"https://doi.org/10.1080/19420889.2021.2023280","url":null,"abstract":"<p><p>The Feelings of Knowing - Fundamental Interoceptive Patterns (FoK-FIP) is a transdisciplinary theory developed to explain elusive phenomena suspected to exist that do not easily lend themselves to empirical measurement. The FoK-FIP theory posits that specialized self-generated biomagnetism and \"pure mental\" process share similarities with the hypothetical elementary particle described in particle physics, magnetic monopoles with a magnetic charge. Feelings of Knowing (FoK) are \"awareness charge\" that are self-generated events. Fundamental Interoceptive Patterns (FIP) are restricted oscillatory magnetic fields that are FoK caused phenomena. Further, FoK produces \"cognitive force,\" an observing ego representing specialized interoceptive awareness. Through embodied states, FoK-FIP acts as a \"biological node,\" an informational processing unit in which physiological signals and an observing ego's sensations or feelings are centered. An observing ego cognitively broadcasts using specialized small magnetic signals and four phases of a narrowed range of interoceptive signals. By defining interoceptive signals (i.e., signals of the body's internal state) using FoK-FIP through cognitive broadcasting, an observing ego creates a world it projects around itself. This process is understood through the components map with interoceptive markers (IMs), a novel algorithm based on biological evolution. FoK-FIP-related predictions are described as are empirical studies to test aspects of the theory. The FoK-FIP theory details a path to wellbeing based on a sense of control and capacity for self-care. Mental stability is thought to change as a function of an observing ego's volitional reactions.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":" ","pages":"1-54"},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39814792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}