{"title":"Microbial communities in the Dead Sea and their potential biotechnological applications.","authors":"Hala I Al-Daghistani, Sima Zein, Manal A Abbas","doi":"10.1080/19420889.2024.2369782","DOIUrl":"10.1080/19420889.2024.2369782","url":null,"abstract":"<p><p>The Dead Sea is unique compared to other extreme halophilic habitats. Its salinity exceeds 34%, and it is getting saltier. The Dead Sea environment is characterized by a dominance of divalent cations, with magnesium chloride (MgCl<sub>2</sub>) levels approaching the predicted 2.3 M upper limit for life, an acidic pH of 6.0, and high levels of absorbed ultraviolet radiation. Consequently, only organisms adapted to such a polyextreme environment can survive in the surface, sinkholes, sediments, muds, and underwater springs of the Dead Sea. Metagenomic sequence analysis and amino acid profiling indicated that the Dead Sea is predominantly composed of halophiles that have various adaptation mechanisms and produce metabolites that can be utilized for biotechnological purposes. A variety of products have been obtained from halophilic microorganisms isolated from the Dead Sea, such as antimicrobials, bioplastics, biofuels, extremozymes, retinal proteins, colored pigments, exopolysaccharides, and compatible solutes. These resources find applications in agriculture, food, biofuel production, industry, and bioremediation for the detoxification of wastewater and soil. Utilizing halophiles as a bioprocessing platform offers advantages such as reduced energy consumption, decreased freshwater demand, minimized capital investment, and continuous production.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2369782"},"PeriodicalIF":0.0,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epistolution: a new principle necessary to a learning-first theory of life.","authors":"Charlie Munford","doi":"10.1080/19420889.2024.2366249","DOIUrl":"10.1080/19420889.2024.2366249","url":null,"abstract":"<p><p>Biological theory assumes the organized appearance of life and the reliable recurrence of traits are due to inheritance. Natural selection acting on blind variations produces phenotypes with heritable traits, one of which may be natural learning. The aim of learning, then, is solving problems related to survival and reproduction. But what if these views confuse cause with effect? Perhaps a learning algorithm is required for any phenotype at all to arise. If so, evolution proceeds learning-first, with individuals pursuing another telos entirely. I argue that this aim may be epistemological, the drive to understand the world through an umwelt. By \"understand\" I mean neither association nor prediction but Karl Popper's concept of explanation through conjecture and refutation. I propose that if only genetic materials are truly heritable, not traits, then testing a successful physical theory of life will depend on building abiotic machines which can perform natural learning without the presence of any inherited materials or conditions. I name this process \"epistolution,\" combining \"epistemology\" and \"evolution,\" to distinguish it from other concepts. Epistolution is an integral consequence of any learning-first view of life, such as the Cellular Basis of Consciousness theory. This type of theory suggests that in all cells during the history of life full-blown agency, involving beliefs, intentions, and desires, generated all the phenotypes that have then been winnowed by natural selection. Unlike in other versions, I posit that the aim of agential living systems is the explanation of reality rather than inductive prediction or survival/reproduction.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2366249"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11174056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sudhakar Deeti, Winnie Man, Johannes J Le Roux, Ken Cheng
{"title":"Inter-turn intervals in <i>Paramecium caudatum</i> display an exponential distribution.","authors":"Sudhakar Deeti, Winnie Man, Johannes J Le Roux, Ken Cheng","doi":"10.1080/19420889.2024.2360961","DOIUrl":"10.1080/19420889.2024.2360961","url":null,"abstract":"<p><p>In navigating to a better location, mobile organisms in diverse taxa change directions of travel occasionally, including bacteria, archaea, single-celled eukaryotes, and small nematode worms such as <i>Caenorhabditis elegans</i>. In perhaps the most common form of goal-orientated movement, the rate of such turns is adjusted in all these taxa to ascend (or descend) a chemical gradient. Basically, the rate of turns is reduced when the movement results in better conditions. In the bacterium <i>Escherichia coli</i> and in <i>C. elegans</i>, the turns are generated by random-rate processes, in which the probability of a turn occurring is constant at every moment. This is evidenced by a distribution of inter-turn intervals that has an exponential distribution. For the first time, we examined the distribution of inter-turn intervals in the single-celled eukaryote, <i>Paramecium caudatum</i>, in a class exercise for first-year university students. We found clear evidence for an exponential distribution of inter-turn intervals, implying a random-rate process in generating turns in <i>Paramecium</i>. The exercise also shows that university laboratory classes can be used to generate scientific data to address research questions whose answers are as yet unknown.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2360961"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11146437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A theory of measuring natural selection and genetic monitoring.","authors":"A I Yuriev","doi":"10.1080/19420889.2022.2124631","DOIUrl":"10.1080/19420889.2022.2124631","url":null,"abstract":"<p><p>Two methods have been compared for determining the value of natural selection in the natural populations. The first method, based on the F<sub>ST</sub>-statistics, employs the dependence of genetic diversity of a species on the value of gene flow between subpopulations of the species, derived from the assumption that all the mutations are close to selective neutrality, and subpopulations effect each other equally. Susceptibility to selection is estimated by the degree of deviation from this relationship between genetic diversity and gene flow in certain species. The second method is based on the probability theory and involves comparison between stabilities of the forms, competing in the population, which is computed using the data about fluctuations in their occurrence in several generations. As applied to the problems of genetic monitoring of rare and valuable species, the first method can be employed for express-assessment of susceptibility of a species to rapid intraspecific changes. The second method is suitable for a long-term and in-depth genetic monitoring of the species subjected to extremely intense natural selection of a disruptive or stabilizing form, which were revealed using the first method. There is a lack of long-term observations of intraspecific genetic variation of rare and protected species. The need for funds that finance long-term genetic research is substantiated.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2124631"},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance.","authors":"Yashika Sarangle, Kiran Bamel, Ram Singh Purty","doi":"10.1080/19420889.2024.2353200","DOIUrl":"10.1080/19420889.2024.2353200","url":null,"abstract":"<p><p>Abiotic stress that plants face may impact their growth and limit their productivity. In response to abiotic stress, several endogenous survival mechanisms get activated, including the synthesis of quaternary amines in plants. Acetylcholine (ACh), a well-known quaternary amine, and its components associated with cholinergic signaling are known to contribute to a variety of physiological functions. However, their role under abiotic stress is not well documented. Even after several studies, there is a lack of a comprehensive understanding of how cholinergic components mitigate abiotic stress in plants. Acetylcholine hydrolyzing enzyme acetylcholinesterase (AChE) belongs to the GDSL lipase/acylhydrolase protein family and has been found in several plant species. Several studies have demonstrated that GDSL members are involved in growth, development, and abiotic stress. This review summarizes all the possible mitigating effects of the ACh-AChE system on abiotic stress tolerance and will try to highlight all the progress made so far in this field.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2353200"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A general theory of consciousness III the human catastrophe.","authors":"Abraham Peper","doi":"10.1080/19420889.2024.2353197","DOIUrl":"10.1080/19420889.2024.2353197","url":null,"abstract":"<p><p>It is generally assumed that verbal communication can articulate concepts like 'fact' and 'truth' accurately. However, language is fundamentally inaccurate and ambiguous and it is not possible to express exact propositions accurately in an ambiguous medium. Whether truth exists or not, language cannot express it in any exact way. A major problem for verbal communication is that words are fundamentally differently interpreted by the sender and the receiver. In addition, intrapersonal verbal communication - the voice in our head - is a useless extension to the thought process and results in misunderstanding our own thoughts. The evolvement of language has had a profound impact on human life. Most consequential has been that it allowed people to question the old human rules of behavior - the pre-language way of living. As language could not accurately express the old rules, they lost their authority and disappeared. A long period without any rules of how to live together must have followed, probably accompanied by complete chaos. Later, new rules were devised in language, but the new rules were also questioned and had to be enforced by punishment. Language changed the peaceful human way of living under the old rules into violent and aggressive forms of living under punitive control. Religion then tried to incorporate the old rules into the harsh verbal world. The rules were expressed in language through parables: imaginary beings - the gods - who possessed the power of the old rules, but who could be related to through their human appearance and behavior.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2353197"},"PeriodicalIF":0.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angelina Deva Adella Putri, Mikael Ham Sembiring, Syahrul Tuba
{"title":"Phytochemical constituents analysis in <i>laminaria digitata</i> for Alzheimer's disease: molecular docking and in-silico toxicity approach.","authors":"Angelina Deva Adella Putri, Mikael Ham Sembiring, Syahrul Tuba","doi":"10.1080/19420889.2024.2357346","DOIUrl":"10.1080/19420889.2024.2357346","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a common brain disease associated with cognitive impairment and dementia. donepezil, an acetylcholinesterase (AChE) inhibitor drug as a commercial AD drug represents a non-cost-effective treatment with the toxic effects reported. As the prevalence of AD increases, the development of effective therapeutic treatments is urgently required. Laminaria digitata is a brown seaweed claimed to be able to prevent and treat neurodegenerative diseases. Therefore, this study measured and compared the binding affinity and toxicity of seven common phytoconstituents in <i>Laminaria digitata</i> against acetylcholinesterase (AChE) with those of donepezil using a molecular docking approach. The binding free energy values of donepezil, dieckol, eckol, fucodiphlorethol G, 7-Phloroecol, laminaran, alginic acid, and fucoidan with acetylcholinesterase (AChE) were -12.3, -13.5, -10.5, -8,7, -9.7, -8.0, -10.3, and -7.4 kcal/mol. All ligands constantly interacted with the AChE amino acid residues, namely Tyr124. Dieckol, with the strongest and most stable interaction, is classified as class IV toxicity, with an LD50 value of 866 mg/kg. It has aryl hydrocarbon receptor (AhR) and mitochondrial membrane potential (MMP) toxicity at certain doses. Theoretically, based on Lipinski's rule, dieckol is likely to have poor absorption and permeation properties; therefore, several considerations during the drug discovery process are needed.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2357346"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11123516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of fast and slow-wilting soybean genotypes on fall armyworm (<i>Spodoptera frugiperda</i>) growth and development.","authors":"Jessica Ayala, Alejandro Vasquez, Devi Balakrishnan, Evelyn Madrigal, Justin George, Rupesh Kariyat","doi":"10.1080/19420889.2024.2354421","DOIUrl":"10.1080/19420889.2024.2354421","url":null,"abstract":"<p><p>Soybean (<i>Glycine max</i>) is the most important plant protein source, and Fall Armyworm (FAW, <i>Spodoptera frugiperda)</i> is considered a major pest. This study aimed to examine the impact of FAW feeding on soybean accessions that vary in their water use efficiency (WUE) traits, by examining FAW growth and life history parameters along with plant growth response to pest damage. Soybean accessions were grown in a greenhouse and exposed to FAW larval feeding for 48 h at three different soybean growth stages: V3, R3, and R6. The growth and development of the FAW and soybeans were monitored. Results showed that faster wilting soybean accessions grow taller and have more leaves than slower wilting accessions, but yield was higher in slower wilting soybean accessions. FAW experienced the highest mortality on mid-stage (R3) soybean plants, but they gained the least mass on early stage (V3) soybean plants. These results can assist in better understanding plant insect-interactions at different life stages in both soybean and FAW with implications for management.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2354421"},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuronal glycolysis: focus on developmental morphogenesis and localized subcellular functions.","authors":"Gianluca Gallo","doi":"10.1080/19420889.2024.2343532","DOIUrl":"https://doi.org/10.1080/19420889.2024.2343532","url":null,"abstract":"<p><p>Glycolysis is a metabolic pathway that directly generates adenosine triphosphate (ATP), provides metabolic intermediates for anabolism, and supports mitochondrial oxidative phosphorylation. This review addresses recent advances in our understanding of the functions of neuronal glycolysis during the development of neuronal morphogenesis, focusing on the emergent concept that neuronal glycolysis serves local subcellular bioenergetic roles in maintaining neuronal function. The current evidence indicates that glycolysis is subcellularly targeted to specific organelles and molecular machinery to locally supply bioenergetic support for defined subcellular mechanisms underlying neuronal morphogenesis (i.e. axon extension, axon retraction and axonal transport). Thus, the concept of glycolysis as a \"housekeeping\" mechanism in neurons would benefit revision and future work aim to further define its subcellular functions at varied developmental stages.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2343532"},"PeriodicalIF":0.0,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11037282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of laughter from play.","authors":"James A Grant-Jacob","doi":"10.1080/19420889.2024.2338073","DOIUrl":"https://doi.org/10.1080/19420889.2024.2338073","url":null,"abstract":"<p><p>In this hypothesis, I discuss how laughter from physical play could have evolved to being induced via visual or even verbal stimuli, and serves as a signal to highlight incongruity that could potentially pose a threat to survival. I suggest how laughter's induction could have negated the need for physical contact in play, evolving from its use in tickling, to tickle-misses, and to taunting, and I discuss how the application of deep learning neural networks trained on images of spectra of a variety of laughter types from a variety of individuals or even species, could be used to determine such evolutionary pathways via the use of latent space exploration.</p>","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2338073"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11005796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}