Communicative and Integrative Biology最新文献_第2页

A general theory of consciousness III the human catastrophe. 意识的一般理论 III 人类灾难。

Communicative and Integrative Biology Pub Date : 2024-05-26 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2024.2353197

Abraham Peper

{"title":"A general theory of consciousness III the human catastrophe.","authors":"Abraham Peper","doi":"10.1080/19420889.2024.2353197","DOIUrl":"10.1080/19420889.2024.2353197","url":null,"abstract":"It is generally assumed that verbal communication can articulate concepts like 'fact' and 'truth' accurately. However, language is fundamentally inaccurate and ambiguous and it is not possible to express exact propositions accurately in an ambiguous medium. Whether truth exists or not, language cannot express it in any exact way. A major problem for verbal communication is that words are fundamentally differently interpreted by the sender and the receiver. In addition, intrapersonal verbal communication - the voice in our head - is a useless extension to the thought process and results in misunderstanding our own thoughts. The evolvement of language has had a profound impact on human life. Most consequential has been that it allowed people to question the old human rules of behavior - the pre-language way of living. As language could not accurately express the old rules, they lost their authority and disappeared. A long period without any rules of how to live together must have followed, probably accompanied by complete chaos. Later, new rules were devised in language, but the new rules were also questioned and had to be enforced by punishment. Language changed the peaceful human way of living under the old rules into violent and aggressive forms of living under punitive control. Religion then tried to incorporate the old rules into the harsh verbal world. The rules were expressed in language through parables: imaginary beings - the gods - who possessed the power of the old rules, but who could be related to through their human appearance and behavior.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2353197"},"PeriodicalIF":0.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical constituents analysis in laminaria digitata for Alzheimer's disease: molecular docking and in-silico toxicity approach. 治疗阿尔茨海默病的板蓝根中的植物化学成分分析：分子对接和体内毒性方法。

Communicative and Integrative Biology Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2024.2357346

Angelina Deva Adella Putri, Mikael Ham Sembiring, Syahrul Tuba

{"title":"Phytochemical constituents analysis in laminaria digitata for Alzheimer's disease: molecular docking and in-silico toxicity approach.","authors":"Angelina Deva Adella Putri, Mikael Ham Sembiring, Syahrul Tuba","doi":"10.1080/19420889.2024.2357346","DOIUrl":"10.1080/19420889.2024.2357346","url":null,"abstract":"Alzheimer's disease (AD) is a common brain disease associated with cognitive impairment and dementia. donepezil, an acetylcholinesterase (AChE) inhibitor drug as a commercial AD drug represents a non-cost-effective treatment with the toxic effects reported. As the prevalence of AD increases, the development of effective therapeutic treatments is urgently required. Laminaria digitata is a brown seaweed claimed to be able to prevent and treat neurodegenerative diseases. Therefore, this study measured and compared the binding affinity and toxicity of seven common phytoconstituents in Laminaria digitata against acetylcholinesterase (AChE) with those of donepezil using a molecular docking approach. The binding free energy values of donepezil, dieckol, eckol, fucodiphlorethol G, 7-Phloroecol, laminaran, alginic acid, and fucoidan with acetylcholinesterase (AChE) were -12.3, -13.5, -10.5, -8,7, -9.7, -8.0, -10.3, and -7.4 kcal/mol. All ligands constantly interacted with the AChE amino acid residues, namely Tyr124. Dieckol, with the strongest and most stable interaction, is classified as class IV toxicity, with an LD50 value of 866 mg/kg. It has aryl hydrocarbon receptor (AhR) and mitochondrial membrane potential (MMP) toxicity at certain doses. Theoretically, based on Lipinski's rule, dieckol is likely to have poor absorption and permeation properties; therefore, several considerations during the drug discovery process are needed.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2357346"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11123516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of fast and slow-wilting soybean genotypes on fall armyworm (Spodoptera frugiperda) growth and development. 快蔫和慢蔫大豆基因型对秋绵虫（Spodoptera frugiperda）生长发育的影响。

Communicative and Integrative Biology Pub Date : 2024-05-19 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2024.2354421

Jessica Ayala, Alejandro Vasquez, Devi Balakrishnan, Evelyn Madrigal, Justin George, Rupesh Kariyat

{"title":"Effects of fast and slow-wilting soybean genotypes on fall armyworm (Spodoptera frugiperda) growth and development.","authors":"Jessica Ayala, Alejandro Vasquez, Devi Balakrishnan, Evelyn Madrigal, Justin George, Rupesh Kariyat","doi":"10.1080/19420889.2024.2354421","DOIUrl":"10.1080/19420889.2024.2354421","url":null,"abstract":"Soybean (Glycine max) is the most important plant protein source, and Fall Armyworm (FAW, Spodoptera frugiperda) is considered a major pest. This study aimed to examine the impact of FAW feeding on soybean accessions that vary in their water use efficiency (WUE) traits, by examining FAW growth and life history parameters along with plant growth response to pest damage. Soybean accessions were grown in a greenhouse and exposed to FAW larval feeding for 48 h at three different soybean growth stages: V3, R3, and R6. The growth and development of the FAW and soybeans were monitored. Results showed that faster wilting soybean accessions grow taller and have more leaves than slower wilting accessions, but yield was higher in slower wilting soybean accessions. FAW experienced the highest mortality on mid-stage (R3) soybean plants, but they gained the least mass on early stage (V3) soybean plants. These results can assist in better understanding plant insect-interactions at different life stages in both soybean and FAW with implications for management.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"17 1","pages":"2354421"},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal glycolysis: focus on developmental morphogenesis and localized subcellular functions. 神经元糖酵解：关注发育形态和局部亚细胞功能。

Communicative and Integrative Biology Pub Date : 2024-04-21 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2024.2343532

Gianluca Gallo

引用次数: 0

Evolution of laughter from play. 笑声从游戏中演变而来。

Communicative and Integrative Biology Pub Date : 2024-04-08 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2024.2338073

James A Grant-Jacob

引用次数: 0

Oscillators and servomechanisms in navigation and orientation. 导航和定向中的振荡器和伺服机械。

Communicative and Integrative Biology Pub Date : 2023-12-13 eCollection Date: 2024-01-01 DOI: 10.1080/19420889.2023.2293268

Ken Cheng

引用次数: 0

The feelings of knowing - fundamental interoceptive patterns (FoK-FIP) system: connecting consciousness to physics. 认知的感觉-基本的内感受模式（FoK-FIP）系统：将意识与物理联系起来。

Communicative and Integrative Biology Pub Date : 2023-09-27 eCollection Date: 2023-01-01 DOI: 10.1080/19420889.2023.2260682

Holly Pollard-Wright

{"title":"The feelings of knowing - fundamental interoceptive patterns (FoK-FIP) system: connecting consciousness to physics.","authors":"Holly Pollard-Wright","doi":"10.1080/19420889.2023.2260682","DOIUrl":"https://doi.org/10.1080/19420889.2023.2260682","url":null,"abstract":"The feelings of knowing - fundamental interoceptive patterns (FoK-FIP) theory is both a theory of the mind and a unification theory. It includes cosmological and cellular frameworks. The cellular frameworks occur through the cosmological frameworks. This framework within a framework approach allows the connection between physics and consciousness to be envisioned in new ways, expanding current understanding and definitions. The cosmological frameworks refer to the astrophysics and theoretical physics constructs (e.g., string theory) that, without the use of mathematical language, conceptually expand the theory. In contrast, the cellular frameworks are the constructs represented by living organism models with DNA. In this way, the FoK-FIP theory represents an efficient framework for understanding consciousness and its phenomena. The transdisciplinary modeling of the FoK-FIP theory creates contextual bridging between classical theory and quantum theory as well as a broad range of empirical research so that biology and information connect, creating new avenues for disease diagnosis, intervention, and prevention. This article intends to render the FoK-FIP theory more robust and accessible for practical application by introducing the FoK-FIP system, which includes figures to promote clarity. Further, the theory aims to stimulate reasoning that challenges current notions about 'life' and the concept of 'self.' Through this process, the theory might contribute to the transdisciplinary collaboration needed to address some of the world's complex issues. It is suggested that a significant contributor to the current complex matters in the world is the lack of understanding of how things are and how they appear.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"16 1","pages":"2260682"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and Natural Viral Engineering in Cognition-Based Evolution. 基于认知的进化中的细胞和自然病毒工程。

Communicative and Integrative Biology Pub Date : 2023-05-02 eCollection Date: 2023-01-01 DOI: 10.1080/19420889.2023.2196145

Miller W B, Reber A S, Marshall P, Baluška F

{"title":"Cellular and Natural Viral Engineering in Cognition-Based Evolution.","authors":"Miller W B, Reber A S, Marshall P, Baluška F","doi":"10.1080/19420889.2023.2196145","DOIUrl":"10.1080/19420889.2023.2196145","url":null,"abstract":"Neo-Darwinism conceptualizes evolution as the continuous succession of predominately random genetic variations disciplined by natural selection. In that frame, the primary interaction between cells and the virome is relegated to host-parasite dynamics governed by selective influences. Cognition-Based Evolution regards biological and evolutionary development as a reciprocating cognition-based informational interactome for the protection of self-referential cells. To sustain cellular homeorhesis, cognitive cells collaborate to assess the validity of ambiguous biological information. That collective interaction involves coordinate measurement, communication, and active deployment of resources as Natural Cellular Engineering. These coordinated activities drive multicellularity, biological development, and evolutionary change. The virome participates as the vital intercessory among the cellular domains to ensure their shared permanent perpetuation. The interactions between the virome and the cellular domains represent active virocellular cross-communications for the continual exchange of resources. Modular genetic transfers between viruses and cells carry bioactive potentials. Those exchanges are deployed as nonrandom flexible tools among the domains in their continuous confrontation with environmental stresses. This alternative framework fundamentally shifts our perspective on viral-cellular interactions, strengthening established principles of viral symbiogenesis. Pathogenesis can now be properly appraised as one expression of a range of outcomes between cells and viruses within a larger conceptual framework of Natural Viral Engineering as a co-engineering participant with cells. It is proposed that Natural Viral Engineering should be viewed as a co-existent facet of Natural Cellular Engineering within Cognition-Based Evolution.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"16 1","pages":"2196145"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational and cellular exploration of the protein-protein interaction between Vibrio fischeri STAS domain protein SypA and serine kinase SypE. 鱼腥弧菌 STAS 结构域蛋白 SypA 与丝氨酸激酶 SypE 之间蛋白质相互作用的计算与细胞学探索。

Communicative and Integrative Biology Pub Date : 2023-04-20 eCollection Date: 2023-01-01 DOI: 10.1080/19420889.2023.2203626

Morgan E Milton, Karen L Visick

{"title":"Computational and cellular exploration of the protein-protein interaction between Vibrio fischeri STAS domain protein SypA and serine kinase SypE.","authors":"Morgan E Milton, Karen L Visick","doi":"10.1080/19420889.2023.2203626","DOIUrl":"10.1080/19420889.2023.2203626","url":null,"abstract":"Anti-sigma factor antagonists SpoIIAA and RsbV from Bacillus subtilis are the archetypes for single-domain STAS proteins in bacteria. The structures and mechanisms of these proteins along with their cognate anti-sigma factors have been well studied. SpoIIAA and RsbV utilize a partner-switching mechanism to regulate gene expression through protein-protein interactions to control the activity of their downstream anti-sigma factor partners. The Vibrio fischeri STAS domain protein SypA is also proposed to employ a partner-switching mechanism with its partner SypE, a serine kinase/phosphatase that controls SypA's phosphorylation state. However, this regulation appears opposite to the canonical pathway, with SypA being the more downstream component rather than SypE. Here we explore the commonalities and differences between SypA and the canonical single-domain STAS proteins SpoIIAA and RsbV. We use a combination of AlphaFold 2 structure predictions and computational modeling to investigate the SypA-SypE binding interface. We then test a subset of our predictions in V.fischeri by generating and expressing SypA variants. Our findings suggest that, while SypA shares many sequence and structural traits with anti-sigma factor antagonist STAS domain proteins, there are significant differences that may account for SypA's distinct regulatory output.","PeriodicalId":39647,"journal":{"name":"Communicative and Integrative Biology","volume":"16 1","pages":"2203626"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a unifying theory of linguistic meaning. 走向语言学意义的统一理论。

Communicative and Integrative Biology Pub Date : 2023-01-01 DOI: 10.1080/19420889.2023.2200666

Prakash Mondal

引用次数: 0