Annals of the ICRP最新文献_第2页

The 2021 Bo Lindell Lecture: Inclusive, accountable, transparent: the direction we should take for the benefit of present and future generations. 2021 年博-林德尔讲座：包容、负责、透明：为了当代人和子孙后代的利益，我们应该把握的方向。

Annals of the ICRP Pub Date : 2023-03-01 DOI: 10.1177/01466453231211068

H Ogino

{"title":"The 2021 Bo Lindell Lecture: Inclusive, accountable, transparent: the direction we should take for the benefit of present and future generations.","authors":"H Ogino","doi":"10.1177/01466453231211068","DOIUrl":"10.1177/01466453231211068","url":null,"abstract":"The International Commission on Radiological Protection (ICRP) is recognised as the de-facto world authority in the field of radiological protection. The ICRP Recommendations have been used as a basis for regulations and policy in almost every country, and with the current review and revision of the System of Radiological Protection, it will continue to make significant contributions in radiation safety for patients, workers, the public, and the environment. In a society undergoing significant change, it is necessary to give careful thought to which groups will be perceived as authoritative organisations by the constituents of the future. The ideal form of an authoritative organisation in the new society of the future is to continue to show how it came to make such recommendations, how it reflected the opinions of interested parties in the process, and how it discloses its records with as much transparency as possible. The question now is what we must do to ensure that decision-making advances in a way that not only makes sense to the present generation, but will be easily consumed by future generations. The path that ICRP is taking to formulate the next set of General Recommendations is doing just that, in line with the key procedural values of INCLUSIVE, ACCOUNTABLE, AND TRANSPARENT.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"52 1-2","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discussion of uncertainties and the impact of different neutron RBEs on all solid cancer radiation incidence risks obtained from the Japanese A-bomb survivor data. 讨论从日本原子弹爆炸幸存者数据中获得的不确定性以及不同中子 RBE 对所有实体癌辐射发病风险的影响。

Annals of the ICRP Pub Date : 2023-03-01 DOI: 10.1177/01466453231211216

L Hafner, L Walsh, W Rühm

{"title":"Discussion of uncertainties and the impact of different neutron RBEs on all solid cancer radiation incidence risks obtained from the Japanese A-bomb survivor data.","authors":"L Hafner, L Walsh, W Rühm","doi":"10.1177/01466453231211216","DOIUrl":"10.1177/01466453231211216","url":null,"abstract":"The most recent publicly available data on all solid cancer incidence from the Life Span Study (LSS) of Japanese A-bomb survivors provides colon dose contributions weighted with a relative biological effectiveness (RBE) of 10 for neutrons, relative to gammas. However, there is evidence from several investigations that the neutron RBE for A-bomb survivors may be higher than 10. The change in the shape of the corresponding dose-response curves was evaluated by Hafner and co-workers in a previous study by applying sex-specific linear-quadratic dose models to previous LSS data for all solid cancer incidence that include separate neutron and gamma absorbed doses for several organs, in contrast to the most recent data. The resulting curvature change became significantly negative for males at an RBE of 140 for colon, 100 for liver, and 80 for organ averaged dose. For females, the corresponding RBE values were 110, 80, and 60 for colon, liver, and organ averaged doses. The present study compares three different methods to calculate the 95% confidence intervals in an analysis of the curvature with increasing RBE. Further, the impact of a higher neutron RBE on the work of the International Commission on Radiological Protection, and the importance of including uncertainties and performing sensitivity analysis of different parameters in radiation risk assessment are discussed.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"52 1-2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laying the foundations for Radiological Protection in Veterinary Practice. 为兽医放射防护工作奠定基础。

Annals of the ICRP Pub Date : 2022-12-01 DOI: 10.1177/01466453231157047

Richard John Jan Pentreath

{"title":"Laying the foundations for Radiological Protection in Veterinary Practice.","authors":"Richard John Jan Pentreath","doi":"10.1177/01466453231157047","DOIUrl":"https://doi.org/10.1177/01466453231157047","url":null,"abstract":"Initially concerned with the application of ionising radiation in medicine, radiological protection has subsequently gone through many phases, and the framework developed by the Commission has evolved continually to embrace other categories of exposure and novel exposure situations. For much of the Western world, medicine is now again the principal source of additional exposures for humans, and it has therefore been the subject of considerable attention in recent years, particularly because the techniques used are advancing so rapidly. What often comes as a surprise, however, is that virtually all of these techniques are being applied increasingly in the field of veterinary medicine. Some advances, such as the use of digital radiography, are to be expected, but the use of computed tomography scanners is increasing enormously, particularly with more second-hand equipment becoming available. The whole gamut of techniques used, from interventional radiology to nuclear medicine, including unsealed source therapy as well as brachyand teletherapy, are now also applied in veterinary practice. Nevertheless, it may still be easy to consider that the subject of radiation exposure in this field is little different from that of human medical practice, given that the equipment is much the same. However, that would be a mistake for a number of reasons.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"51 4","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICRP PUBLICATION 153 Approved by the Commission in September 2022. ICRP第153号出版物于2022年9月获得委员会批准。

Annals of the ICRP Pub Date : 2022-12-01 DOI: 10.1177/01466453221142702

{"title":"ICRP PUBLICATION 153 Approved by the Commission in September 2022.","authors":"","doi":"10.1177/01466453221142702","DOIUrl":"https://doi.org/10.1177/01466453221142702","url":null,"abstract":"Veterinary use of radiation in the diagnosis, management, and treatment of disease has expanded and diversified, as have the corresponding radiological protection concerns. Radiological exposure of personnel involved in veterinary procedures and, where applicable, members of the public providing assistance (e.g. owners or handlers) has always been included within the system of radiological protection. Veterinary practice is now addressed explicitly as the modern complexities associated with this practice warrant dedicated consideration, and there is a need to clarify and strengthen the application of radiological protection principles in this area. The Commission recommends that the system of radiological protection should be applied in veterinary practice principally for the protection of humans, but with explicit attention to the protection of exposed animals. Additionally, consideration should be given to the risk of potential contamination of the environment associated with applications of nuclear medicine in veterinary practice. This publication focuses primarily on justification and optimisation in veterinary practice, and sets the scene for more detailed guidance to follow in future Recommendations. It is intended for a wide-ranging audience, including radiological protection professionals, veterinary staff, students, education and training providers, and members of the public, as an introduction to radiological protection in veterinary practice.© 2022 ICRP. Published by SAGE.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"51 4","pages":"9-95"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICRP PUBLICATION 152 Approved by the Commission in November 2021. ICRP第152号出版物于2021年11月获得委员会批准。

Annals of the ICRP Pub Date : 2022-07-01 DOI: 10.1177/01466453221080101

{"title":"ICRP PUBLICATION 152 Approved by the Commission in November 2021.","authors":"","doi":"10.1177/01466453221080101","DOIUrl":"https://doi.org/10.1177/01466453221080101","url":null,"abstract":"Radiation detriment is a concept developed by the International Commission on Radiological Protection to quantify the burden of stochastic effects from low-dose and/or low-dose-rate exposures to the human population. It is determined from the lifetime risks of cancer for a set of organs and tissues and the risk of heritable effects, taking into account the severity of the consequences. This publication provides a historical review of detriment calculation methodology since ICRP Publication 26, with details of the procedure developed in ICRP Publication 103, which clarifies data sources, risk models, computational methods, and rationale for the choice of parameter values. A selected sensitivity analysis was conducted to identify the parameters and calculation conditions that can be major sources of variation and uncertainty in the calculation of radiation detriment. It has demonstrated that sex, age at exposure, dose and dose-rate effectiveness factor, dose assumption in the calculation of lifetime risk, and lethality fraction have a substantial impact on radiation detriment values. Although the current scheme of radiation detriment calculation is well established, it needs to evolve to better reflect changes in population health statistics and progress in scientific understanding of radiation health effects. In this regard, some key parameters require updating, such as the reference population data and cancer severity. There is also room for improvement in cancer risk models based on the accumulation of recent epidemiological findings. Finally, the importance of improving the comprehensibility of the detriment concept and the transparency of its calculation process is emphasised.© 2022 ICRP. Published by SAGE.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"51 3","pages":"9-103"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40348831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CLARITY, TRANSPARENCY, AND ACCOUNTABILITY. 清晰、透明和问责。

Annals of the ICRP Pub Date : 2022-07-01 DOI: 10.1177/01466453221077415

引用次数: 0

Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models. 在细胞模型中，表观遗传调控蛋白 BRD4 的降解和抑制会加剧阿尔茨海默病相关的神经病理学。

Annals of the ICRP Pub Date : 2022-04-01 Epub Date: 2022-03-03 DOI: 10.1016/j.jbc.2022.101794

Siyi Zhang, Ping Bai, Dan Lei, Yingxia Liang, Sherri Zhen, Grisilda Bakiasi, Hao Pang, Se Hoon Choi, Changning Wang, Rudolph E Tanzi, Can Zhang

{"title":"Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.","authors":"Siyi Zhang, Ping Bai, Dan Lei, Yingxia Liang, Sherri Zhen, Grisilda Bakiasi, Hao Pang, Se Hoon Choi, Changning Wang, Rudolph E Tanzi, Can Zhang","doi":"10.1016/j.jbc.2022.101794","DOIUrl":"10.1016/j.jbc.2022.101794","url":null,"abstract":"Epigenetic regulation plays substantial roles in human pathophysiology, which provides opportunities for intervention in human disorders through the targeting of epigenetic pathways. Recently, emerging evidence from preclinical studies suggested the potential in developing therapeutics of Alzheimer's disease (AD) by targeting bromodomain containing protein 4 (BRD4), an epigenetic regulatory protein. However, further characterization of AD-related pathological events is urgently required. Here, we investigated the effects of pharmacological degradation or inhibition of BRD4 on AD cell models. Interestingly, we found that both degradation and inhibition of BRD4 by ARV-825 and JQ1, respectively, robustly increased the levels of amyloid-beta (Aβ), which has been associated with the neuropathology of AD. Subsequently, we characterized the mechanisms by which downregulation of BRD4 increases Aβ levels. We found that both degradation and inhibition of BRD4 increased the levels of BACE1, the enzyme responsible for cleavage of the amyloid-beta protein precursor (APP) to generate Aβ. Consistent with Aβ increase, we also found that downregulation of BRD4 increased AD-related phosphorylated Tau (pTau) protein in our 3D-AD human neural cell culture model. Therefore, our results suggest that downregulation of BRD4 would not be a viable strategy for AD intervention. Collectively, our study not only shows that BRD4 is a novel epigenetic component that regulates BACE1 and Aβ levels, but also provides novel and translational insights into the targeting of BRD4 for potential clinical applications.","PeriodicalId":39551,"journal":{"name":"Annals of the ICRP","volume":"14 1","pages":"101794"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75536360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Intakes of Radionuclides: Part 5 放射性核素的职业摄入量:第5部分

Annals of the ICRP Pub Date : 2022-03-01 DOI: 10.1177/01466453211028755

F. Paquet, R. W. Leggett, É. Blanchardon, M. Bailey, D. Gregoratto, T. Smith, G. Ratia, E. Davesne, V. Berkovski, J. Harrison

引用次数: 6

CORRIGENDA. 更正。

Annals of the ICRP Pub Date : 2022-02-09 DOI: 10.1177/01466453211070237

引用次数: 0

ICRP Publication 150: Cancer Risks from Plutonium and Uranium Exposure. ICRP出版物150:钚和铀暴露的癌症风险。

Annals of the ICRP Pub Date : 2021-12-01 DOI: 10.1177/01466453211028020

M Tirmarche, I Apostoaei, E Blanchardon, E D Ellis, E Gilbert, J D Harrison, D Laurier, J W Marsh, M Sokolnikov, R Wakeford, S Zhivin

引用次数: 4