Brazilian Journal of Oncology最新文献_第9页

Using chemotherapy against metastatic pancreatic neuroendocrine neoplasm: how aggressively do we treat it? Real world data from a Brazilian Cancer Center 使用化疗治疗转移性胰腺神经内分泌肿瘤:我们如何积极地治疗它?来自巴西癌症中心的真实数据

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220285

M. Donadio, V. Jesus, M. Barros

引用次数: 0

Impacto prognóstico das mutações de egfr e kras na sobrevivência do câncer pulmonar na era pré-tki: o cenário real em um centro público de câncer de referência no Brasil egfr和kras突变对tki前肺癌生存的预后影响:巴西公共参考癌症中心的真实情况

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20190004

Thais Abreu de Almeida, J. M. Nardin, Amanda Jurgensen, Janaina Takahashi, J. Jung, G. Losso, J. C. Casali-da-Rocha

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Physiotherapy in the context of palliative care in oncology: a pooled analysis 肿瘤学姑息治疗中的物理治疗:一项汇总分析

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20210020

Claudia Melo Canto, Yandra Alves Prestes, Maria Gabriela de Andrade Lucena, H. L. M. Campos

{"title":"Physiotherapy in the context of palliative care in oncology: a pooled analysis","authors":"Claudia Melo Canto, Yandra Alves Prestes, Maria Gabriela de Andrade Lucena, H. L. M. Campos","doi":"10.5935/2526-8732.20210020","DOIUrl":"https://doi.org/10.5935/2526-8732.20210020","url":null,"abstract":"Objective: To document the role of physiotherapy in the context of palliative care in cancer through an integrative literature review, as the prevalence and survival of cancer are increasing and physiotherapy can significantly contribute to the treatment of these patients. Methods: A search was made in the literature for scientific articles that substantiated the physiotherapist’s role in palliative care in oncology, and an assessment of the methodological quality of the selected clinical trials. Results: Studies demonstrate positive results, as they propose effective protocols that mostly include exercises in different modalities asso ciated or not with other resources such as PNF, TENS, manual therapy, ultrasound, ther-motherapy, acupuncture, and oxygen therapy, which help in reducing symptoms such as cancer fatigue, pain, and dyspnea, improving the patient’s quality of life. The average score for clinical trials was reasonably low. Conclusion: The results reaffirm the importance of physiotherapeutic interventions in cancer patients receiving palliative care. ABSTRACT Objetivo: fisioterapia er fisioterapia significativamente o amento pacientes. Métodos: Foi literatura de artigos científicos fisioterapeuta nos cuidados paliativos em oncologia e avaliação qualidade metodológica ensaios clínicos selecionados. Resultados: Os demonstram resultados positivos, pois propõem protocolos eficazes que, em sua maioria, incluem exercícios em diferentes modalidades associados ou não a outros recursos como FNP, TENS, terapia manual, ultrassom, termoterapia, acupuntura e oxige-noterapia, que auxiliam redução de sintomas como como câncer, fadiga, e dispneia, melhorando a qualidade de paciente. A pontuação clínicos foi razoavelmente resultados reafirmam a importância intervenções fisioterapêuticas","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128119142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world data suggest that geriatric assessment fails to stratify risk in treating older adults with lung cancer 现实世界的数据表明，老年评估不能对治疗老年肺癌患者的风险进行分层

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20210030

M. Donadio, Audrey Oliveira, Luciana Coelho Leite Moura, V. Jesus, Tiago Cordeiro Felisimino, A. Dettino

{"title":"Real-world data suggest that geriatric assessment fails to stratify risk in treating older adults with lung cancer","authors":"M. Donadio, Audrey Oliveira, Luciana Coelho Leite Moura, V. Jesus, Tiago Cordeiro Felisimino, A. Dettino","doi":"10.5935/2526-8732.20210030","DOIUrl":"https://doi.org/10.5935/2526-8732.20210030","url":null,"abstract":"Introduction: Older adults require attention to risks of treatment toxicity. The purpose of this study was to evaluate epidemiological data and clinical outcomes of patients with lung cancer treated with non-curative intent assessed by geriatric assessment (GA) and restricted access to new therapies. Methods: We evaluated older adults with non-small cell lung cancer treated with palliative chemotherapy or first generation target therapy who underwent GA. Overall survival (OS) was calculated and we performed univariate and multivariate analysis to determine prognostic factors for OS. Results: Fifty-four patients aged ≥70 years had a median age of 76 years, 76% was classified as Katz A and 50% as Lawton <27. 68.5% were at risk of malnutrition or malnourished; 61.1% had ≥2 comorbidities. The mean OS was 17.1 months. In the univariate analysis, lower survival results were observed for patients with ECOG≥2 (HR=5.9; p<0.001), higher number of metastasis sites (HR=2.0; p=0.04) and liver metastasis (HR=12.6; p<0.001). In multivariate analysis, male gender, ECOG≥2, more than 2 metastatic sites and liver metastases were associated with higher risk of death. We did not observe differences in survival according to functional capacity. Conclusion: GA showed no prognostic relationship in our small population. Patients with ECOG≥2, more than 2 metastatic sites and hepatic metastasis presented higher risk of death. For the older population, new treatment modalities are fundamental and outweigh the prognostic importance of the clinical factors of GA.","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"88 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131437205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Year in Review: The studies that changed the oncology practice in 2018: focus on radiation therapy 年度回顾:2018年改变肿瘤学实践的研究:重点是放射治疗

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20190007

B. Salvajoli, C. Ramos, F. Gabrielli, K. Vasconcelos, F. Moraes, G. Marta

引用次数: 0

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220292

Ariádne Sousa Albuquerque, L. Okumura, Nelci Rodrigues Betin-de-Moraes, M. Ricieri, Tais Tereziano Barros, M. Fachi

引用次数: 1

Outcomes of patients with metastatic neuroendocrine lung neoplasms: typical versus atypical carcinoids 转移性神经内分泌肺肿瘤患者的预后:典型与非典型类癌

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20200041

Hugo Tanaka, M. Corassa, H. Freitas, M. Barros, Riechelmann, R. P.

{"title":"Outcomes of patients with metastatic neuroendocrine lung neoplasms: typical versus atypical carcinoids","authors":"Hugo Tanaka, M. Corassa, H. Freitas, M. Barros, Riechelmann, R. P.","doi":"10.5935/2526-8732.20200041","DOIUrl":"https://doi.org/10.5935/2526-8732.20200041","url":null,"abstract":"neuroendocrine pulmonary tumours are morphologically classiﬁed as typical carcinoid (TC) and atypical carcinoid (AC). There are limited data on systemic treatment for metastatic disease. Objective: Our study evaluated the median progression-free survival of patients with metastatic tumours, comparing TC and AC status for diﬀerent treatments. Methods: Retrospective series of patients with metastatic NETp treated from 2002 to 2019 in a large cancer centre were analysed. Our primary endpoint was progression-free survival according to morphological classiﬁcation (TC vs. AC). All patients received at least one treatment modality (e.g., somatostatin analogue [SSA], chemotherapy [ChP], and everolimus [Eve]). Variables were analysed using the chi-square test, median progression-free survival (mPFS) rates (months), with comparisons evaluated by the log-rank test. Results: Twenty-seven patients were included: 44% with TC and 56% with AC. TC patients were on average 58-years-old, 83.3% were female, and 33.3% received more than one treatment. AC patients were on average 61-years-old, 66.7% were female, and 20% received more than one treatment. All patients were treated more frequently with SSA (TC: 75% vs. AC: 80%, p=0.756). Cisplatin and etoposide were the most frequent ChP regimen (TC: 75% vs. AC: 30%, p=0.248). Patients with TC and AC treated with SSA had higher mPFS in months (TC mPFS SSA: 14.5, Eve: 2.50, ChP: 4.0, SSA + Eve: 4.50; AC mPFS SSA: 7.50, Eve: 4.50, ChP: 7.50, SSA + Eve: 7.00). Conclusion: Although the statistical analyses did not show a signiﬁcant diﬀerence between treatment, numerically, more patients with TC or AC experienced tumor control with SSAs, where the mPFS pairs showed a possible tendency to diﬀerentiate themselves from the other regimes (Eve and ChP). ABSTRACT","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124599131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Culture and its influence on an increase of cervical cancer cases in Angola 文化及其对安哥拉宫颈癌病例增加的影响

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20200049

J. Rocha

引用次数: 1

Epidermoid squamous cell carcinoma after pulmonary tuberculosis infection 肺结核感染后的表皮样鳞状细胞癌

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20190017

M. Dourado, Murilo Lima Barbosa Diniz Romero, Marlon Ferreira Santos, Ronan Lacerda Barbosa, Adriano Rêgo Lima de Medeiros

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Clinical characterization of the Dermatofibrosarcomas at Barretos Cancer Hospital in São Paulo 圣保罗巴雷托斯肿瘤医院皮肤纤维肉瘤的临床特征

Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220342

Larissa de Matos Fernandes, Vinícius de Lima Vazquez

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